Clinical trials: Preventive Intervention
HIV Infections
A Crossover Adherence and Acceptability Study Assessing a DPP Capsule for HIV and Pregnancy Prevention
A randomized, crossover study to compare adherence, preference and acceptability of an over-encapsulated dual prevention pill (DPP capsule) containing oral pre-exposure prophylaxis (PrEP) and a combined oral contraceptive (COC)…
- Trial name
- NCT04778527
- Testing
- Dual Prevention Pill, PrEP tablet and a COC as two separate tablets
- Where
- South Africa
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Population Council
Anaphylaxis
Desensitization of Human Mast Cells: Mechanisms and Potential Utility for Preventing Anaphylaxis
This is an open-label, single-center study of whether oral penicillin desensitization of healthy sensitive subjects results in allergen cross-desensitization of mast cells by skin testing and desensitization of peripheral blood…
- Trial name
- NCT00868842
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Pregnancy, Urinary Incontinence
Effect of Pelvic Floor Muscle Training Included in General Fitness Classes During Pregnacy
To investigate the effect of pelvic floor muscle training taught in a general exercise class during pregnancy to prevent urinary incontinence in nulliparous continent pregnant women.
- Trial name
- NCT01578369
- Testing
- Exercise classes with pelvic floor muscle training
- Where
- Spain
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Stroke Recurrence, Transient Ischemic Attack
Prevent Return of Stroke Study
The purpose of this study is to evaluate if a peer-led stroke recurrence prevention intervention, versus usual care, will help reduce risk factors for recurrent strokes among adults in Harlem.
- Trial name
- NCT01027273
- Testing
- Prevent Return of Stroke
- Where
- United States
- Volunteers
- 600 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
At Risk for AD-dementia, With Subjective Cognitive Decline, At Risk for Cognitive Decline
High-Velocity Resistance Training for Brain Blood Flow and Cognitive Function in Older Adults
The goal of this clinical trial is to learn whether a 12-week high-velocity resistance training program can improve brain blood flow and thinking skills in adults ages 60 to 79 who are at higher risk for Alzheimer's disease and…
- Trial name
- NCT07444554
- Testing
- High-Velocity Resistance Training
- Volunteers
- 60 people
- Sponsor
- University of Illinois Chicago
Pulmonary Aspergillosis
An Open-label Safety Study of PC945 (Opelconazole) Prophylaxis or Pre-emptive Therapy Against Pulmonary Aspergillosis in Lung Transplant Recipients (OPERA-S Study)
A study to evaluate the safety and tolerability of opelconazole for the prevention of fungal aspergillus infections in the lung in participants who have received a lung transplant.
- Trial name
- NCT05037851
- Testing
- Opelconazole, Standard of Care
- Where
- 19 sites in United States, Canada
- Volunteers
- 102 people
- Sponsor
- Pulmocide Ltd
Asymptomatic Bacteriuria, Bacteriuria
The Bacteriuria in Renal Transplantation (BiRT) Study: A Trial Comparing Antibiotics Versus no Treatment in the Prevention of Symptomatic Urinary Tract Infection in Kidney Transplant Recipients With Asymptomatic Bacteriuria
The purpose of this study is to compare antibiotics versus no-treatment in kidney transplant recipients with asymptomatic bacteriuria.
- Conditions
- Asymptomatic Bacteriuria, Bacteriuria, Urinary Tract Infections, Kidney Transplantation
- Trial name
- BiRT (NCT01871753)
- Testing
- Anti-Infective Agents
- Where
- 15 sites in Belgium, France
- Volunteers
- 198 people
- Sponsor
- Erasme University Hospital
Endophthalmitis
Safety and Efficacy of Intracameral Zimoxin for Prevention of Endophthalmitis After Cataract Surgery
Intracameral injection of 0.1% moxifloxacin solution after cataract surgery to prevent endophthalmitis
- Trial name
- NCT03244072
- Testing
- Moxifloxacin
- Where
- United States
- Volunteers
- 60,000 people, healthy volunteers welcome
- Sponsor
- Jason Ahee, M.D.
Adolescent Behavior, Tobacco Use
Media Literacy for High School Tobacco Prevention
This research project will explore the feasibility and acceptability of a web-based media literacy tobacco prevention program. The project will be conducted with 9th or 10th graders in two high schools in Pittsburgh, Pennsylvania.
- Conditions
- Adolescent Behavior, Tobacco Use, E-Cig Use
- Trial name
- NCT05120466
- Testing
- AD IT UP media literacy intervention, Usual health education curriculum
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Postoperative Nausea and Vomiting
Prevention of Postoperative Nausea and Vomiting (PONV) in Surgical Patients
This study will compare two different drug regimens (oral dronabinol versus intravenous ondanseteron) for the prevention of post-operative nausea and vomiting (PONV).
- Trial name
- PONV (NCT00757822)
- Testing
- Dronabinol, Ondansetron
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Acute Coronary Syndrome, Cardiac Rehabilitation
Outpatient Cardiac Tele-Rehabilitation in a Public Sports Center
The aim of this study is to establish an innovative Cardiac Tele-Rehabilitation (CTR) model. It could expands assistance resources through coordination with public administrations, developing a physical exercise program (PEP)…
- Conditions
- Acute Coronary Syndrome, Cardiac Rehabilitation, Telerehabilitation, Secondary Prevention
- Trial name
- NCT04121702
- Testing
- Cardiac Rehabilitation
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Juan Izquierdo García
End-stage Chronic Renal Disease, Severe Acute Kidney Failure
Renal Transplantation and Inhaled Anesthetic Sevoflurane (SEVOREIN)
Renal transplantation is characterized by ischemia-reperfusion lesions in allograft. In a previous study, Julier and al. (Anesthesiology 2003) have demonstrated that sevoflurane reduces glomerular lesions in kidney of patients…
- Conditions
- End-stage Chronic Renal Disease, Severe Acute Kidney Failure, Renal Transplantation
- Trial name
- SévoRein (NCT00337051)
- Testing
- Sevoflurane, Propofol
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Bordeaux
Cardiovascular Diseases, Heart Diseases
Evaluating the Effectiveness of a Family Heart Health Educational Program (The FIT-Heart Study)
The primary objective of the FIT Heart Study was to test the effectiveness of a hospital-based standardized screening and educational intervention targeted to family members of patients hospitalized with CVD, to increase…
- Trial name
- FIT-Heart (NCT00728637)
- Testing
- Family Passport to Heart Health Program, General Educational Materials
- Where
- United States
- Volunteers
- 501 people, healthy volunteers welcome
- Sponsor
- Columbia University
Migraine
Migraine Prevention With the Remote Electrical Neuromodulation (REN) Wearable: A Real-world Evidence Study
Preventive pharmacologic therapies for migraine aim to reduce attack frequency and duration and improve quality of life; however, their use, overall benefit and adherence are often limited.
- Trial name
- NCT07487701
- Testing
- Nerivio REN device
- Where
- United States
- Volunteers
- 332 people
- Sponsor
- Theranica
Conduction System Pacing, Conventional Ventricular Pacing
Physiological Pacing for AV Block to Prevent Pacemaker-induced Cardiomyopathy
The implantation of a pacemaker and conventional cardiac pacing from the right ventricle (apex or septum) is an effective and safe therapy for the treatment of patients with atrioventricular block and bradycardia.
- Trial name
- PHYSPAVB (NCT05214365)
- Testing
- Pacemaker implantation and conventional cardiac pacing, Conduction system pacing implant
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Hospital Clinic of Barcelona
Breast Cancer, Skin Reactions Secondary to Radiation Therapy
Dakin's Solution in Preventing Radiation Dermatitis in Patients With Breast Cancer Undergoing Radiation Therapy
This pilot clinical trial studies Dakin's solution in preventing radiation dermatitis in patients with breast cancer undergoing radiation therapy.
- Trial name
- NCT02203565
- Testing
- Dakin's solution, radiation therapy, questionnaire administration
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Distress, Emotional
Universally Delivered Interventions for Young People
Mental health problems are amongst the major contributors to disease burden globally. According to a recent study, 34% of young people worldwide (aged 10-19) suffer from depression and more than half of this population belongs to…
- Trial name
- Mindset-PK (NCT06442007)
- Testing
- Behavioral Activation - single session intervention (BA-SSI), 4-session Mindset intervention
- Where
- Pakistan
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Pakistan Institute of Living and Learning
Nausea and Vomiting, Chemotherapy-Induced
A Study of the Drug Casopitant for the Prevention of Nausea Caused By Cisplatin-Based Highly Emetogenic Chemotherapy
This is a Phase III trial designed to demonstrate that casopitant when added to dexamethasone and ondansetron is more effective in the prevention of vomiting then dexamethasone and ondansetron alone, in patients who receive a…
- Trial name
- NCT00431236
- Testing
- Oral Casopitant (GW679769), IV Casopitant (GW679769), IV ondansetron hydrochloride
- Where
- 80 sites in Argentina, Belgium and 20 more
- Volunteers
- 810 people
- Sponsor
- GlaxoSmithKline
Malaria,Falciparum, Anemia in Children
Comparing Chemoprevention Drugs for School-based Malaria Control
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine (IPT-DP).
- Trial name
- NCT05980156
- Testing
- Dihydroartemisinin-Piperaquine, Chloroquine, Sulfadoxine pyrimethamine
- Where
- Malawi
- Volunteers
- 646 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Cytomegalovirus Infections
A Study of Valcyte (Valganciclovir) CMV Prophylaxis After Renal Transplantation
This 2 arm study will compare the efficacy of 100 days of Valcyte (900mg po daily) prophylaxis with that of no prophylaxis, under the condition of pre-emptive therapy of active CMV infection, in CMV positive renal transplant…
- Trial name
- NCT00372229
- Testing
- Valganciclovir CMV Prophylaxis, Valganciclovir (Pre-emptive CMV Therapy), Ganciclovir
- Where
- 24 sites in Austria, Germany
- Volunteers
- 299 people
- Sponsor
- Hoffmann-La Roche
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