Clinical trials: Preventive Intervention
Anxiety, Attachment Disorder
A Good Start to Life - an Early Cross-sectorial Intervention
The aim of the project is to develop and evaluate an interdisciplinary and cross-sectorial intervention targeting pregnant women with psychosocial vulnerabilities.
- Conditions
- Anxiety, Attachment Disorder, Maternal Sensitivity, Depression
- Trial name
- NCT03190707
- Testing
- Intervention
- Where
- Denmark
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Intersectoral Research Unit for Health Services
Oral Mucositis, Nausea
ZeroTolerance Mucositis: Managing Oral and Alimentary Mucositis With High Potency Sucralfate - ProThelial
RATIONALE: Polymerized (cross-linked) sucralfate malate paste (ProThelial) may be an effective single therapy approach for the management of chemoradiation mucositis, treating and preventing its occurrence in the oral cavity…
- Conditions
- Oral Mucositis, Nausea, Vomiting, Diarrhea
- Trial name
- NCT02016807
- Testing
- ProThelial
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Ashley Downs Bioscience
Athletic Injuries, Sprains and Strains
The Design and Evaluation of an Active Intervention for the Prevention of Non-contact ACL Injury
The overall goal of this project is to reduce the risk for anterior cruciate ligament injuries by designing a targeted intervention that will alter the known kinematic and kinetic risk factors associated with ACL injuries.
- Conditions
- Athletic Injuries, Sprains and Strains, Wounds and Injuries, Knee Injuries
- Trial name
- NCT01021111
- Testing
- Activity Training with Feedback
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Stanford University
Prosthetic-joint Infection
Evaluation of PLG0206 in Prevention of Recurrent Infection in Patients Undergoing Debridement, Antibiotics, and Implant Retention (DAIR) for Treatment of a Periprosthetic Joint Infection (PJI) Following Knee Arthroplasty
The goal of this clinical trial is to evaluate whether the investigational drug PLG0206 can help reduce recurrence of infection in adults who have undergone total knee replacement and are receiving a DAIR (Debridement…
- Trial name
- RETAIN (NCT07214311)
- Testing
- PLG0206
- Where
- 21 sites in United States, United Kingdom
- Volunteers
- 240 people
- Sponsor
- Peptilogics
Type 2 Diabetes, Osteoporosis
Impact of Screening and Multicomponent Exercise on Fall Rates, Fractures, and Cardiovascular Health in Diabetes
The DIACTIVE study is a randomized controlled trial with a 5- year follow-up designed to evaluate the impact of comprehensive screening and multicomponent interventions on fall prevention, bone health, nerve function and…
- Conditions
- Type 2 Diabetes, Osteoporosis, Diabetic Neuropathies, Fall Prevention
- Trial name
- DiaACTIVE (NCT06745544)
- Testing
- Rhythm- and Multitask-Based Activity (RYMA) and Activities of Daily Living (ADL)
- Where
- Denmark
- Volunteers
- 490 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Prevention, Atrial Fibrillation
Bisoprolol Versus Corticosteroid and Bisoprolol Combination for Prophylaxis Against Atrial Fibrillation After on Pump Coronary Artery Bypass Surgery
Background: Atrial fibrillation (AF) is the most common cardiac arrhythmia that occurs after on pump coronary artery bypass graft (CABG) surgery.
- Conditions
- Prevention, Atrial Fibrillation, CABG
- Trial name
- NCT03800264
- Testing
- Bisoprolol
- Where
- Egypt
- Volunteers
- 176 people
- Sponsor
- Ain Shams University
Pressure Ulcer, Nursing Caries
Care Package for Preventing Pressure Ulcers in ICU Patients
The aim of this study is to evaluate the effectiveness of the care package (CP) developed to prevent pressure injury (PI) in patients in intensive care and to evaluate the effect of the training given to nurses on their knowledge…
- Trial name
- NCT06509399
- Testing
- care package
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Abant Izzet Baysal University
Depression
Ketamine for Depression Relapse Prevention Following ECT
Depression affects up to 20% of people in their lifetime and can be a severe debilitating illness. Indeed, the World Health Organisation has estimated that depression will soon be the second leading contributor to the burden of…
- Trial name
- KEEP-WELL (NCT02414932)
- Testing
- Ketamine, Midazolam
- Where
- Ireland
- Volunteers
- 6 people
- Sponsor
- St Patrick's Hospital, Ireland
Total Knee Replacement, Total Hip Replacement
New Oral Anticoagulant Therapy for the Prevention of Blood Clots Following Hip or Knee Replacement Surgery
LY517717 (a capsule given by mouth) is a blood thinner that may prevent blood clots from forming in the legs and may prevent those blood clots from traveling to the lungs.
- Trial name
- NCT00074828
- Testing
- LY517717, enoxaparin
- Where
- 8 sites in Australia, Austria and 6 more
- Volunteers
- 511 people
- Sponsor
- Eli Lilly and Company
Venous Thromboembolism
Prevention of Venous Thromboembolism in Subjects Undergoing Hip Fracture Surgery or Surgery in the Lower Extremities
The study objective is to evaluate the efficacy and safety of oral YM150 for prevention of venous thromboembolism in subjects undergoing hip fracture surgery or surgery in the lower extremities.
- Trial name
- NCT00937911
- Testing
- YM150
- Where
- 8 sites in Japan
- Volunteers
- 101 people
- Sponsor
- Astellas Pharma Inc
High Risk for Eating Disorder, Eating Disorders in Adolescence
ACT to Prevent Eating Disorders: Evaluating a Gamified Prevention Program
Eating Disorders (ED) constitute a serious public health issue that affects predominantly women and appears typically in adolescence or early adulthood.
- Conditions
- High Risk for Eating Disorder, Eating Disorders in Adolescence, Acceptance Processes
- Trial name
- AcceptME (NCT03693911)
- Testing
- Acceptance and Commitment Therapy
- Where
- Cyprus
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University of Cyprus
Intensive Care Unit Delirium, Postoperative Delirium
Role of Natural Light in the Prevention of Delirium After Cardiac Surgery: a Prospective Observational Study With Historical Control
Postoperative delirium is a common complication that usually occurs acutely within the first 24 hours after surgery and resolves within 72 hours; it is common in all medical areas and particularly affects patients over the age of…
- Conditions
- Intensive Care Unit Delirium, Postoperative Delirium, Cardiac Surgery
- Trial name
- iWOnDer (NCT05936944)
- Testing
- Exposure to totally artificial lighting
- Where
- Italy
- Volunteers
- 448 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Parma
BK Viremia, BK Nephropathy
Using mTOR Inhibitors in the Prevention of BK Nephropathy
BK virus infections after kidney transplant are increasing and can result in damage to the transplanted kidney. Currently, the universally accepted treatment is to decrease the strength of the antirejection medications but it is…
- Trial name
- NCT01649609
- Testing
- Tacrolimus, Mycophenolate acid, Sirolimus
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Columbia University
Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence
Secondary Prevention of Clostridioides Difficile Using Vancomycin
Re-exposure to systemic antibiotics (i.e., antibiotics absorbed into the bloodstream) is common after a Clostridioides difficile infection (CDI) and is the strongest risk factor for a recurrent episode.
- Conditions
- Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence, Clostridoides Difficile Associated Disease
- Trial name
- SPORES-V (NCT06979609)
- Testing
- Oral Vancomycin Prophylaxis
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Human Papilloma Virus
Conversational Agents to Improve HPV Vaccine Acceptance in Primary Care (ECA-HPV)- Clinical Trial
The objective of this study is to assess the use of and satisfaction with the ECA-HPV intervention over a 16-month period, its ability to increase HPV vaccination, and the comparative effectiveness of clinic notification and…
- Trial name
- NCT06367699
- Testing
- Usual Care, ECA-HPV App with Clinic Notification and Adolescent Functions Disabled, ECA-HPV App with Clinic Notification Function Enabled
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Tufts Medical Center
Substance Abuse, Juvenile Delinquency
The Community Youth Development Study: A Test of Communities That Care
The Community Youth Development Study is an experimental test of the Communities That Care (CTC) prevention planning system. It has been designed to find out if communities that were trained to use the CTC system improved public…
- Conditions
- Substance Abuse, Juvenile Delinquency, Sexual Behavior, Criminal Behavior
- Trial name
- CYDS IV (NCT01088542)
- Testing
- Communities That Care
- Where
- United States
- Volunteers
- 52,323 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pressure Ulcer
Trial Comparing SOC +Skin IQ MCM vs SOC for Pressure Ulcer (PU)
The study is a multi-center, prospective, randomized, controlled, clinical study evaluating the effects of microclimate management using Skin IQ™ MCM coverlet placed over commercially available pressure redistribution surfaces…
- Trial name
- NCT02363842
- Testing
- Skin IQ™ MCM Coverlet, Pressure redistribution surface
- Where
- 4 sites in United States, Canada
- Volunteers
- 160 people
- Sponsor
- Arjohuntleigh
Prediabetes
Habit Building Software Application to Increase Engagement of Vulnerable Populations in the National Diabetes Prevention Program (NDPP) Lifestyle Change Program (LCP)
The goal of this clinical trial is to learn whether a companion software application can improve program engagement in the National Diabetes Prevention Program in adults with prediabetes.
- Trial name
- NCT06656273
- Testing
- FT LCP
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- The Institute for Iterative Thinking
Addiction, Alcohol, Addiction, Substance
Efficiency of Prevention Program Dedicated to Addictive Behaviors (PREVENTURE) of Vulnerable Teenagers
At the age of 17, in Brittany, 94.9% of adolescents have experimented alcohol consumption 78.1% within a month and 25.5% report repeated episodes of Intensive Punctual Alcohol.
- Trial name
- PREVADO (NCT04599270)
- Testing
- PREVENTURE Program, Routine care
- Where
- 5 sites in France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Brest
Alcohol Use Disorders
Mindfulness-Based Relapse Prevention for Alcohol Use Disorders in Remission
We propose to conduct a pilot study that will examine the utility and mechanisms of Mindfulness-Based Relapse Prevention in reducing alcohol consumption, relapse rates, and physiological arousal to stress in adults 21 years of…
- Trial name
- MBRP (NCT02147483)
- Testing
- Mindfulness Based Relapse Prevention, Treatment as usual
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Virginia
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