Clinical trials: Preventive Intervention
HIV, Risk Reduction Behavior
A Digital Intervention for HIV Prevention in Black Adolescent Girls
The purpose of this study is to develop and evaluate an innovative behavioral HIV prevention videogame intervention to bolster motivation and provide skill-building opportunities to improve Black adolescent girls' ability to…
- Trial name
- NCT04108988
- Testing
- InvestiDate, Non-Health Related Video Game
- Where
- United States
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Yale University
Delirium
The Prevention of Delirium and Complications Associated With Surgical Treatments Multi Center Clinical Trial
Delirium is a medical term or condition that includes a temporary inability to focus attention and to think clearly. Delirium occurs commonly (10% to 70%) in patients older than 60 undergoing large surgeries.
- Trial name
- PODCAST (NCT01690988)
- Testing
- Ketamine (0.5 mg/kg), Ketamine (1 mg/kg)
- Where
- United States
- Volunteers
- 746 people
- Sponsor
- Washington University School of Medicine
Colorectal Cancer
Decision Aid to Technologically Enhance Shared Decision Making
Physicians face a challenge in promoting colorectal cancer screening (CRCS) in the face of multiple competing demands. A decision aid (DA) that clarifies patient preferences and improves decision quality could aid shared decision…
- Trial name
- DATES (NCT01514786)
- Testing
- Colorectal Web
- Where
- 14 sites in United States
- Volunteers
- 570 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Migraines
A Phase III Open-Label, Multi-Center, Long-Term Extension Study of Depakote ER in Subjects Who Either Completed or Prematurely Discontinued Due to Ineffectiveness From Study M02-488.
The purpose of this study is to determine if long-term treatment, up to 1 year, with Depakote ER is safe in the reduction of occurrence of migraine headaches in adolescents.
- Trial name
- NCT00195754
- Testing
- divalproex sodium
- Where
- United States
- Volunteers
- 114 people
- Sponsor
- Abbott
Patients Infected With COVID-19
Vitamin D on Prevention and Treatment of COVID-19
The new outbreak of the SARS-CoV-2 coronavirus is causing an important pandemic affecting a large number of people all-over the world.
- Trial name
- COVITD-19 (NCT04334005)
- Testing
- Vitamin D
- Where
- 2 sites in Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Gastrointestinal Neoplasms, Chemotherapy-induced Nausea and Vomiting
Aprepitant Triple Therapy for the Prevention of CINV in Nondrinking and Young Women Who Received Moderately Emetogenic Chemotherapy
The purpose of this study is to study whether adding Aprepitant to Palonosetron and dexamethasone can further prevent the incidence and severity of nausea and vomiting caused by FOLFIRI or FOLFOX chemotherapy regimen among…
- Trial name
- CINV (NCT03674294)
- Testing
- Aprepitant, Palonosetron, Dexamethasone
- Where
- China
- Volunteers
- 248 people
- Sponsor
- Sun Yat-sen University
Dietary Rice Bran Supplementation
Pilot Feasibility of Rice Bran Supplementation in Children
The purpose of this study is to assess feasibility of rice bran consumption in weaning children and to identify dietary rice bran mediated changes to the stool microbiome and stool metabolome.
- Trial name
- NCT02557373
- Testing
- Vitamin A, Rice Bran + Vitamin A
- Where
- 2 sites in United States, Mali
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Colorado State University
Hand-foot Syndrome
The Efficacy and Safety of Mecobalamin in the Prevention of Capecitabine Induced Hand Foot Syndrome
A multicenter, randomized, placebo-controlled, double-blind, phase III clinical trial will be conducted to explore the efficacy and safety of mecobalamin in the prevention of 2/3 HFS in patients with early breast cancer.
- Trial name
- NCT05165069
- Testing
- Mecobalamin 5 MG Disintegrating Oral Tablet
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Hematologic Neoplasms, Neutropenia
The Relationship of Defeverscence and Itraconazole Plasma Level Study in Immunocompromised Participants
The purpose of this observational study is to investigate whether a sufficient concentration of itraconazole can influence disappearance of a fever (defeverscence) when intravenous (into the vein) itraconazole is administered for…
- Conditions
- Hematologic Neoplasms, Neutropenia, Fever
- Trial name
- NCT01021683
- Testing
- Itraconazole
- Volunteers
- 203 people
- Sponsor
- Janssen Korea, Ltd., Korea
Pit and Fissure Caries, Glass Ionomer Cements
Glass Ionomer Sealant Versus Fluoride Varnish on Occlusal Caries Prevention
The current study compares the efficacy of glass ionomer fissure sealant versus topical application of 5% sodium fluoride varnish in prevention of occlusal caries among preschool children.
- Conditions
- Pit and Fissure Caries, Glass Ionomer Cements, Tooth, Deciduous, Child
- Trial name
- NCT04163354
- Testing
- 5% sodium fluoride varnish (NaF), Glass ionomer sealant (GIS)
- Where
- Hong Kong
- Volunteers
- 348 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vulvar Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vaginal Site
Trial to Evaluate Nonavalent HPV Vaccine as a Secondary Prevention in Patients Treated for Human Papilloma Virus Related High-grade Squamous Intraepithelial Lesions
Randomized, placebo-controlled phase 3 trial to evaluate nonavalent HPV vaccine as a secondary prevention in patients treated for human papilloma virus related high-grade squamous intraepithelial lesions.
- Conditions
- Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vulvar Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vaginal Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Penile Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Cervical Site
- Trial name
- BioHPV (NCT07431502)
- Testing
- HPV vaccine
- Volunteers
- 984 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Neck Pain, Exercise Therapy
Prevention of Neck Pain in Adults With a Back School-Based Intervention.
The study consists of a theoretical and practical intervention based on the Back School. This intervention will be carried out over 8 weeks with a frequency of two sessions per week, for a total of 16 sessions of 45 minutes…
- Conditions
- Neck Pain, Exercise Therapy, Health Education, Primary Prevention
- Trial name
- NCT05260645
- Testing
- Back School
- Where
- Spain
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Graft Vs Host Disease, Hematopoietic Neoplasm
GVHD Prophylaxis With Methotrexate in Haploidentical HCT Using Posttransplant Cyclophosphamide
Allogeneic hematopoietic cell transplantation (HCT) is an important therapeutic strategy for many malignant and benign hematologic diseases.
- Trial name
- NCT04622956
- Testing
- Methotrexate Injectable Solution
- Where
- 4 sites in Brazil
- Volunteers
- 47 people
- Sponsor
- University of Sao Paulo General Hospital
Acute Pyelonephritis
Dexamethasone Administration in 1st Episode of Febrile Urinary Tract Infection
Hypothesis: Administration of corticoids (dexamethasone) together with the conventional antibiotherapy in the acute phase of a febrile urinary tract infection could reduce the risk of renal scarring after 6 months of the…
- Trial name
- DEXCAR-0212 (NCT02034851)
- Where
- 7 sites in Spain
- Volunteers
- 183 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Concussion, Brain
One Team: Changing the Culture of Youth Sport With Pregame Safety Huddles
Randomized controlled trial of a behavioral intervention (Pre-Game Safety Huddles) designed to study the impact of huddles on concussion safety in youth sport, primarily regarding intention to report concussive symptoms.
- Trial name
- NCT04099329
- Testing
- Pre-game Safety Huddles
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Seattle Children's Hospital
Suicidal Ideations, Suicidal Attempt
Safety Plan in Emergency Department to Prevent Suicidal Attempt Recidive
Suicide is one of the leading causes of death worldwide, with more than 700 000 deaths due to suicide every year, according to the World Health Organisation (WHO).
- Conditions
- Suicidal Ideations, Suicidal Attempt, Prevention, Safety Plan
- Trial name
- PLUS (NCT06499337)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier St Anne
Surgical Site Infections, Lumbar Disc Herniation
The Effect of Number of Showers With 4% Chlorhexidine Gluconate on Prevention of Surgical Site Infections
Surgical site infections (SSIs) are the most common type of nosocomial infection in surgical departments. Although lumbar disc herniation (LDH), which is one of the common cases in neurosurgery, is a serious problem affecting…
- Trial name
- SSI (NCT06801275)
- Testing
- 1 shower with 4% chlorhexidine gluconate, 2 shower with 4% chlorhexidine gluconate
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Çanakkale Onsekiz Mart University
Low-Risk Pregnant Women at Full-Term Gestation, Healthy Fetal Population
Advancing Early Bone Health: New Frontiers for Osteoporosis Prevention
All factors that influence the peak bone mass achieved at skeletal maturity are important in determining an individual's risk of developing osteoporosis later in life.
- Conditions
- Low-Risk Pregnant Women at Full-Term Gestation, Healthy Fetal Population, Healthy Neonatal Population
- Trial name
- REMS-BONE (NCT06750523)
- Testing
- Cord blood sampling, urine sampling, Life style questionnaire
- Where
- 2 sites in Italy
- Volunteers
- 200 people
- Sponsor
- University of Parma
Alzheimer's Disease
Control and Intervention Programme on Alzheimer's Disease Risk Factors
Recent epidemiologic studies are identifying a number of modifiable risk and protective factors that may influence in the incidence of Alzheimer's disease (AD).
- Trial name
- ALFAlife (NCT02772523)
- Testing
- Lifestyle recommendations
- Where
- Spain
- Volunteers
- 409 people, healthy volunteers welcome
- Sponsor
- Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Bronchopulmonary Dysplasia
Restricted Versus Liberal Fluid Intake for Prevention of Bronchopulmonary Dysplasia
The aim of this study is to determine whether restricted fluid intake (135 ±5 mL/kg/day) compared to liberal fluid intake (165 ±5 mL/kg/day) from day 8 of life reduces the incidence of bronchopulmonary dysplasia (BPD) at 36 weeks…
- Trial name
- RELIEF (NCT06954142)
- Testing
- Fluid restriction, Liberal fluid intake
- Where
- 9 sites in Switzerland
- Volunteers
- 750 people
- Sponsor
- University Children's Hospital Basel
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.