Clinical trials: Preventive Intervention
Lymphedema
Prevention of Lymphedema Among Breast Cancer Patients Through Implementation of an Integrative Therapy Program (ITP)
Introduction: Breast cancer women who are treated with axillary node dissection are at increased risk for lymphedema - the lifetime risk in these women is estimated at 15-50% and the risk can significantly increase with…
- Trial name
- NCT02528539
- Testing
- ITP
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Huntington Memorial Hospital
Adhesions, Abdominal Cavity
A-Part® Gel as Adhesion Prophylaxis After Major Abdominal Surgery Versus a Non-treated Group
The safety of applying A-Part® Gel intra-peritoneally under the incision in order to prevent post-surgical adhesions after median laparotomy.
- Trial name
- A-PART (NCT00646412)
- Testing
- A-Part® Gel
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Aesculap AG
Intrauterine Adhesion
Immediate and Delayed Intrauterine Balloon in the Prevention of Adhesion Reformation After Hysteroscopic Adhesiolysis
In this prospective, randomized, controlled study, the investigators wish to compare the efficacy of immediate and delayed intrauterine balloon (IUB) therapy in the prevention of adhesion reformation after hysteroscopic…
- Trial name
- NCT03171454
- Testing
- Delayed Intrauterine Balloon therapy, immediate Intrauterine Balloon therapy
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Venous Thromboembolism
Study of DU-176b, Prevention of Venous Thromboembolism in Patients After Hip Fracture Surgery
The objective of this study is to evaluate the safety and efficacy of DU-176b compared with enoxaparin sodium for the prevention of venous thromboembolism in patients after elective hip fracture surgery.
- Trial name
- NCT01181141
- Testing
- DU-176b (edoxaban), Enoxaparin sodium 20mg
- Where
- Japan
- Volunteers
- 92 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Inflammation at Mini-screw Insertion Site, Mobility, Mini-screw
Antibiotics Prior to Mini-screw Implant Insertion
The investigators plan to use amoxicillin in capsule form, prepared by a pharmacist, for antibiotic prophylaxis to decrease the failure rate of mini-screw implants temporarily placed in the palate of patients involved in Phase II…
- Trial name
- NCT03582605
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- St. Louis University
Recurrent Neural Tube Defects
Prevention of Neural Tube Defects by Inositol in Conjunction With Folic Acid (PONTI Study)
The aim of the study is to develop a randomised, double blind clinical trial to compare (i) folic acid plus inositol, with (ii) folic acid plus placebo, for prevention of recurrent neural tube defects.
- Trial name
- NCT00452829
- Testing
- Folic Acid and inositol
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institute of Child Health
Dental Caries
Early Childhood Caries Prevention at a Pediatric Clinic
This purpose of this study was to evaluate effectiveness of a risk-based dental caries prevention program conducted by dental personnel at an urban pediatric primary care clinic serving largely low-income residents of Baltimore…
- Trial name
- NCT00497029
- Testing
- fluoride varnish, patient education
- Where
- United States
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Antibiotic-Associated Diarrhea
Preventing Childhood Antibiotic-associated Diarrhea by Prebiotics
Prospective randomized double-blind study on the effect of prebiotics (inulin and fructo-oligosaccharides) in the prevention of antibiotic-associated diarrhea in children.
- Trial name
- WGAAD (NCT00826137)
- Testing
- Inulin and fructo-oligosaccharides.
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Soroka University Medical Center
Pressure Ulcers
Evaluate the Efficacy of a Silk-Like Fabric for the Prevention of Pressure Sores in a Long Term Care Setting
The primary purpose of this research study is to evaluate if DermaTherapy® bedding will significantly reduce pressure ulcer incidence by decreasing maceration, friction, and shearing among residents of Nursing Homes.
- Trial name
- NCT01403272
- Testing
- DermaTherapy® Linen and underpads.
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Precision Fabrics Group, Inc.
Erythroplakia, Hyperplasia
Metformin Hydrochloride in Preventing Oral Cancer in Patients With an Oral Premalignant Lesion
This phase IIa trial studies how well metformin hydrochloride works in preventing oral cancer in patients with an oral premalignant lesion (oral leukoplakia or erythroplakia).
- Conditions
- Erythroplakia, Hyperplasia, Oral Cavity Carcinoma, Oral Leukoplakia
- Trial name
- NCT02581137
- Testing
- Laboratory Biomarker Analysis, Metformin Hydrochloride
- Where
- 4 sites in United States, Canada
- Volunteers
- 26 people
- Sponsor
- National Cancer Institute (NCI)
Diabetes Mellitus, Type II, Overweight and Obesity
Microclinic Social Induction Pilot Intervention for Diabetes and Obesity Management in Qatar
The purpose of the study is to pilot-phase test the effectiveness of the microclinic social induction model and its effects on behavioral and metabolic outcomes in different levels of social and familial relationships in Qatar.
- Conditions
- Diabetes Mellitus, Type II, Overweight and Obesity, Hypertension, Behavioral Lifestyle Change
- Trial name
- NCT02175537
- Testing
- Microclinic Social Induction Diabetes and Obesity Program
- Where
- Qatar
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Microclinic International
Young Football Players, Ankle Sprain Prevention
Comparison Interventions on Kinetic and Kinematic Parameters
Currently, it is difficult to find studies in the literature comparing proprioception exercises with the effect of manual therapy on improving balance, and in the long run it may translate into improved activity, functionality…
- Trial name
- Balance (NCT07326475)
- Testing
- Manual therapy, Exercise
- Where
- Poland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
HIV Infections, Circumcision
Infant Male Circumcision in Gaborone, Botswana, and Surrounding Areas: Feasibility, Safety and Acceptability
Background: Novel HIV prevention approaches are urgently needed in Botswana and elsewhere in sub-Saharan Africa. Although adult male circumcision (MC) has been shown to reduce the heterosexual acquisition of HIV by men by about…
- Trial name
- NCT00971958
- Testing
- Circumcision, Mogen Clamp, Plastibell
- Where
- Botswana
- Volunteers
- 1,235 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Stress
Efficacy of Healing Touch in Stressed Neonates
The purpose of this project is to evaluate whether or not Healing Touch therapy (HT) helps to treat the stress of babies in the Neonatal Intensive Care Unit (NICU).
- Trial name
- NCT00034008
- Testing
- Healing Touch
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- National Center for Complementary and Integrative Health (NCCIH)
Atrial Fibrillation, Rheumatic Heart Disease
Surgical Prevention of Atrial Fibrillation in Patients With Rheumatic Mitral Valve Lesion and Left Atrium Enlargement
This study evaluates the safety and efficiency of surgical prevention of atrial fibrillation in patients with valvular heart disease and left atrium enlargement
- Trial name
- NCT02474108
- Testing
- surgical prevention of atrial fibrillation, cardiomonitor
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Papillomavirus Infections
Efficacy Against Oral Persistent Infection, Immunogenicity and Safety of the 9-valent Human Papillomavirus Vaccine (9vHPV) in Men Aged 20-45 Years (V503-049)
The purpose of this study is to evaluate the efficacy, immunogenicity and safety of the 9vHPV vaccine in men 20 to 45 years of age.
- Trial name
- NCT04199689
- Testing
- 9vHPV Vaccine
- Where
- 103 sites in United States, Belgium and 14 more
- Volunteers
- 6,033 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Antibiotic Associated Diarrhea, Clostridium Difficile Infection
Probiotic Lactobacillus Reuteri to Prevent Antibiotic-associated Diarrhea and Clostridium Difficile-related Infections in Hospitalized Children
The purpose of this study is to determine if the daily intake of the probiotic Lactobacillus reuteri prevents antibiotic-associated diarrhoea and related Clostridium difficile infections in children and adolescents.
- Conditions
- Antibiotic Associated Diarrhea, Clostridium Difficile Infection, Gastroenteritis
- Trial name
- AADreuter (NCT01295918)
- Testing
- L reuteri in children on antibiotics
- Where
- 2 sites in Bulgaria
- Volunteers
- 100 people
- Sponsor
- St Marina University Hospital, Varna, Bulgaria
Insomnia, Depression
Perinatal Research on Improving Sleep and Mental Health
The goal of this clinical trial is to compare two sleep programs in pregnant people with insomnia. The main questions it aims to answer are: 1.
- Trial name
- PRISM (NCT05596318)
- Testing
- Digital CBT-I, Digital SHE
- Where
- United States
- Volunteers
- 456 people
- Sponsor
- University of California, San Francisco
Postoperative Cognitive Dysfunction, Postoperative Delirium
Study of Prevention of Postoperative Delirum to Reduce Incidence of Postoperative Cognitive Dysfunction
Postoperative cognitive dysfunction describes a condition where cognitive functions such as attention, perception, concentration, learning, abstract thinking and problem solving are impaired postoperatively.
- Trial name
- DelPOCD (NCT03060174)
- Testing
- monitoring and non-medical prophylaxis of delirium
- Where
- Germany
- Volunteers
- 638 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Surgical Site Infection
Antibiotic Prophylaxis in Clean Surgery. Impact on Surgical Site Infection
This is a randomized control study of antibiotic uses in clean non prosthetic surgeries. One group will be given antibiotic prophylaxis, other will receive a placebo.
- Trial name
- NCT03595852
- Testing
- Cefazolin
- Where
- Rwanda
- Volunteers
- 138 people
- Sponsor
- University of Rwanda
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