Clinical trials: Preventive Intervention
Breast Cancer, Colon Cancer
Partnership for Healthy Seniors
The Centers for Medicare and Medicaid Services (CMS) has awarded cooperative agreements to 6 sites from across the country (Salt Lake City, UT, Molokai, HI, Houston, TX, Newark, NJ, Detroit, MI, and Baltimore City) to participate…
- Conditions
- Breast Cancer, Colon Cancer, Rectum Cancer, Cervix Cancer
- Trial name
- NCT00379743
- Testing
- Health coordinator (or patient navigator), Educational materials only
- Where
- United States
- Volunteers
- 2,593 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Single Leg Hop Sand Surface, Single Leg Hop Grass Surface
Effect of Sand on Knee Load and Muscle Activity During a Single Leg Landing Task
This study evaluates the effect of different surfaces on the load experienced by the knee when landing from a single leg hop. A sand, pliable grass and firm (hard floor) surface will be compared when hopping from a 30 cm height.
- Conditions
- Single Leg Hop Sand Surface, Single Leg Hop Grass Surface, Single Leg Hop Firm Surface
- Trial name
- NCT04502615
- Testing
- Sand, artificial grass, firm ground
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Teesside University
Localized Prostate Carcinoma, Prostate Adenocarcinoma
Diet and Physical Activity Intervention for the Prevention of ADT-Induced Metabolic Changes in Patients With Prostate Cancer, TRIPLE-A PILOT Study
This clinical trial studies the effects of a diet and physical activity intervention on blood measures of lipids and insulin resistance in patients with prostate cancer undergoing radiation therapy (RT) and androgen deprivation…
- Trial name
- NCT04870515
- Testing
- Best Practice, Dietary Intervention, Exercise Intervention
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Fred Hutchinson Cancer Center
Palatal Wound
Effects of Topical Hyaluronic Acid Gel on Postoperative Pain and Wound Healing
This clinical study aims to investigate the impact of a topical hyaluronic acid (HA) gel on postoperative pain and wound healing at palatal donor sites in patients undergoing mucogingival procedures involving a de-epithelialized…
- Trial name
- NCT05821725
- Testing
- Hyaluronic acid, Control
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
ART Adherence, PMTCT
HIV Self Testing of Male Partners of Women in PMTCT
The investigators will conduct a randomized trial to evaluate whether provision of oral HIV self-test kits (HIVST) to HIV-positive pregnant women to provide to their male partner, increases the proportion of male partners who…
- Conditions
- ART Adherence, PMTCT, Linkage to Care, HIV
- Trial name
- NCT03484533
- Testing
- HIV self-test kit, Standard of Care (invitation letters for fast-track HIV testing in the clinic)
- Where
- Uganda
- Volunteers
- 736 people, healthy volunteers welcome
- Sponsor
- University of Washington
Refractory Multiple Myeloma, Stage I Multiple Myeloma
Lenalidomide After Donor Stem Cell Transplant and Bortezomib in Treating Patients With High Risk Multiple Myeloma
This phase I trial studies the side effects and best dose of lenalidomide after donor stem cell transplant and bortezomib in treating patients with high-risk multiple myeloma.
- Conditions
- Refractory Multiple Myeloma, Stage I Multiple Myeloma, Stage II Multiple Myeloma, Stage III Multiple Myeloma
- Trial name
- NCT01954784
- Testing
- fludarabine phosphate, total-body irradiation, nonmyeloablative allogeneic hematopoietic stem cell transplantation
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Case Comprehensive Cancer Center
Evaluation of Primary Prevention ICD in Real Life
Primary Prevention ICD French Registry
The indication of implantable cardioverter defibrillator (ICD) therapy for primary prevention of sudden cardiac death has been introduced later in France than in other parts of the World.
- Trial name
- DAI-PP (NCT01992458)
- Where
- France
- Volunteers
- 5,576 people
- Sponsor
- Clinique Pasteur
Postoperative Sore Throat
Efficacy of K-Y Jelly in Prevention of Postoperative Sore Throat After Nasal Surgery
Postoperative sore throat (POST) is a fairly common side effect of general anesthesia which is caused by the mucosal injury and nerve compression associated with tracheal intubation or laryngeal mask airway device insertion.
- Trial name
- NCT05436743
- Testing
- K-Y Jelly, Topical Gel soaked packs, Water soaked packs
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Alaa Gamal
Radial Artery Spasm, Angina
Topical Nitroglycerine Treatment for Radial Artery Spasm Prevention
The primary objective of the study is to determine the role of transdermal vasodilators as an adjunct to parenteral vasodilators in reducing radial artery spasm, improving patient comfort, and post procedure radial artery patency…
- Conditions
- Radial Artery Spasm, Angina, Coronary Artery Disease
- Trial name
- TNT-RASP (NCT02832115)
- Testing
- Topical Nitroglycerine, Topical Lidocaine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Aultman Health Foundation
Actinic Keratoses
Aminolevulinic Acid-photodynamic Therapy for Facial Actinic Keratosis Treatment and Prevention
Background Actinic keratoses (AKs) are often treated separately, lesion by lesion. However, in the past years, AKs have been described as a field disease and not limited to single clinically apparent lesions.
- Trial name
- NCT03642535
- Testing
- ALA
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Shanghai Dermatology Hospital
Rabies
Phone Text Message Reminders on Compliance With Human Rabies Post Exposure Prophylaxis Project
Every year, rabies, a disease transmitted to humans by rabid dogs, is estimated to kill 59,000 people globally, mostly children 15 years and below in Africa and Asia.
- Trial name
- NCT05350735
- Testing
- Intervention arm: SMS text reminders and medical card
- Where
- Kenya
- Volunteers
- 180 people
- Sponsor
- Washington State University
Hypercholesterolemia, Atherosclerotic Cardiovascular Disease (ASCVD)
Dual PCSK9 Inhibition With Inclisiran and Alirocumab in Secondary Prevention
This study will evaluate the effectiveness and safety of combining two different types of PCSK9 inhibitors, inclisiran and alirocumab, in patients with high cardiovascular risk who are unable to tolerate statins.
- Trial name
- PCSK9-DUO (NCT07581808)
- Testing
- Inclisiran, Alirocumab
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Eating Disorders in Adolescence, Body Dissatisfaction
Young Athlete Body Project - Prevention of Body Dissatisfaction and Eating Disorders Among Adolescent Athletes
Body dissatisfaction is common among adolescents and is a well-established risk factor for the development of eating disorders. Young athletes may be particularly vulnerable because they are exposed to appearance-related…
- Conditions
- Eating Disorders in Adolescence, Body Dissatisfaction, Mental Health
- Trial name
- YABP (NCT07795333)
- Testing
- Young Athlete Body Project
- Where
- 2 sites in Norway
- Volunteers
- 1,740 people, healthy volunteers welcome
- Sponsor
- Norwegian School of Sport Sciences
Obesity
Pediatric Behavioral Informatics to Prevent Cancer
The goal of this study is to do formative research which will lead ultimately to the development of a computer-based system called Tailored Information for Diet and Exercise or TIDE for short.
- Trial name
- TIDE (NCT01768533)
- Where
- United States
- Volunteers
- 305 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Boston
Thrombosis, Venous, Cancer
Evaluate the Efficacy and Safety of Edoxaban on Prevention of Catheter-related Thrombosis (CRT) in Cancer Patients
To evaluate the efficacy and safety of edoxaban in the prevention of tumor catheter-related thrombosis (CVC/PICC) in high-risk patients
- Conditions
- Thrombosis, Venous, Cancer, Catheter Complications
- Trial name
- Thrombosis (NCT06149533)
- Testing
- Edoxaban
- Where
- China
- Volunteers
- 366 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Conjunctival Bacterial Flora
Effectiveness of Topical 0.5% Levofloxacin to Reduce the Conjunctival Bacterial Flora Before Intraocular Surgery
The purpose of this study is to determine whether additional topical application of 0.5% levofloxacin is more effective in reducing the load of the conjunctival bacterial flora in patients scheduled for intraocular surgery than…
- Trial name
- NCT00491049
- Testing
- 0.5% levofloxacin eye drops
- Where
- Germany
- Volunteers
- 140 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Vaccine-Preventable Diseases, Herpes Zoster
Safety and Immunogenicity of CVI-VZV-001 for Prevention of Herpes Zoster in Healthy Adults Age 50 Years and Above
The purpose of this study is to evaluate the safety and immunogenicity of the investigational medicinal product, CVI-VZV-001.
- Trial name
- NCT06137755
- Testing
- CVI-VZV-001, Shingrix
- Where
- 2 sites in South Korea
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Aribio Lab Co., Ltd.
Obesity, Weight Gain
Role of Dairy Products in Weight Maintenance
The goal of the current study is to determine the role of dairy in similarly preventing weight and fat re-gain in obese adults who have successfully completed a weight loss diet program.240 obese subjects will undergo a…
- Trial name
- NCT00686426
- Testing
- Dairy Foods
- Where
- 2 sites in United States
- Volunteers
- 338 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Accidental Overdose of Opiate
Remote Intervention to Prevent Overdose
This Type 1 hybrid effectiveness-implementation randomized controlled trial, A Remote Intervention to Prevent Overdose among People who Use Stimulants and/or Opioids, aims to address the United States opioid crisis driven by…
- Trial name
- NCT07128485
- Testing
- Overdose prevention resources, Overdose prevention education
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Alabama at Birmingham
Healthy
Improving Survey Procedures for Young Men Who Have Sex With Men in Web-based HIV Prevention: Retention Study
The purpose of this study is to test the efficacy of alternative methods to improve survey completion.
- Trial name
- NCT02424643
- Testing
- Monetary Incentive, Altruistic Incentive, Dashboard Incentive
- Where
- United States
- Volunteers
- 1,131 people, healthy volunteers welcome
- Sponsor
- Emory University
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