Clinical trials: Preventive Measures
Hemophilia A
A Trial to Compare Prophylaxis Therapy to On-demand Therapy With a New Full Length Recombinant FVIII in Patients With Severe Hemophilia A
The objective of the trial is to demonstrate that 2-3 times per week prophylaxis therapy with BAY81-8973 is superior to on-demand therapy with BAY81-8973 in patients with severe Hemophilia A.
- Trial name
- Leopold II (NCT01233258)
- Testing
- rFVIII (BAY81-8973) on demand, rFVIII (BAY81-8973) prophylaxis low-dose, rFVIII (BAY81-8973) prophylaxis high-dose
- Where
- 47 sites in United States, Argentina and 16 more
- Volunteers
- 80 people
- Sponsor
- Bayer
Hepatitis B Virus, Allograft
Risk of Hepatitis B Virus Reactivation in Patients Undergoing Allografting
The purpose of this study is to evaluate the risk of hepatitis B reactivation in patients undergoing allografting.
- Conditions
- Hepatitis B Virus, Allograft, Hematological Malignancies
- Trial name
- NCT00876148
- Where
- Italy
- Sponsor
- Azienda Ospedaliera San Giovanni Battista
Gastric Varix, Sepsis
Antibiotic Prophylaxis in Patients Undergoing GVO
We design a randomized trial to clarify the necessity of antibiotic prophylaxis for the patients chronic liver disease with gastric varices treated by elective GVO.
- Conditions
- Gastric Varix, Sepsis, Liver Cirrhoses, Fever
- Trial name
- ABX-GV (NCT04140578)
- Testing
- Ertapenem
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Critical Illness
Cytomegalovirus Control in Critical Care
The purpose of this study is to determine whether reactivation of latent cytomegalovirus infection in critically ill patients looked after in the intensive care unit can be successfully and safely prevented using antiviral…
- Trial name
- CCCC (NCT01503918)
- Testing
- Valaciclovir/Aciclovir, Valganciclovir/Ganciclovir
- Where
- United Kingdom
- Volunteers
- 124 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Surgical Wound Infection
Prevention of Surgical Site Infections
The primary research question is whether interventions to prevent caregiver and system errors will increase the proportion of laparotomy patients who receive recommended measures to prevent surgical site infections.
- Trial name
- NCT00353613
- Testing
- Package of targeted interventions to reduce error
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- The University of Texas Health Science Center, Houston
Graft Versus Host Disease, Hematopoietic Cell Transplantation Recipient
Gluten Free Diet in Preventing Graft Versus Host Disease in Patients Undergoing Donor Stem Cell Transplant
This pilot clinical trial studies how well a gluten free diet works in preventing graft versus host disease in patients who are undergoing a donor stem cell transplant.
- Trial name
- NCT03102060
- Testing
- Dietary Intervention, Laboratory Biomarker Analysis
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Rutgers, The State University of New Jersey
Multiple Myeloma, Hypogammaglobulinemia
Study of IgPro20 to Prevent Infection in People With Multiple Myeloma and Hypogammaglobulinemia
The main purpose of this study is to see if IgPro20 can prevent infection in people with multiple myeloma (MM) who have hypogammaglobulinemia from receiving bispecific monoclonal antibodies (BsAbs).
- Conditions
- Multiple Myeloma, Hypogammaglobulinemia, Hypogammaglobulinemia, Acquired
- Trial name
- NCT06976476
- Testing
- IgPro20
- Where
- 9 sites in United States
- Volunteers
- 100 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Nosocomial Infection
The Prophylactic Effect of Garlic Tablets to Prevent Nosocomial Infections in Intensive Care Unit Patients.
The goal of this clinical trial is to learn if garlic tablets works to prevent nosocomial infections in hospitalized patients in ICU.
- Trial name
- NCT06833125
- Testing
- Garlic powder standardized to allicin
- Where
- Egypt
- Volunteers
- 62 people
- Sponsor
- Alexandria University
Infection
PReclude Infection EVEnts With No Prophylaxis Transperineal Biopsy 2
Approximately one million transrectal prostate biopsies are performed annually in the U.S., and the risk of post- biopsy infection is increasing due to greater antibiotic resistance of rectal flora.
- Trial name
- PREVENT2 (NCT04815876)
- Testing
- Transperineal MRI-guided prostate biopsy, Transrectal MRI-guided prostate biopsy, Antibiotic (prophylaxis)
- Where
- 16 sites in United States
- Volunteers
- 1,040 people
- Sponsor
- Weill Medical College of Cornell University
Gender-Based Violence
Tu'Washindi na PrEP: Adolescent Girls in Kenya Taking Control of Their Health
This study is nested within the ongoing DREAMS (Determined, Resilient, Empowered, AIDS-free, and Safe) initiative in Siaya County, Kenya.
- Trial name
- NCT03938818
- Testing
- Tu'Washindi intervention, Control
- Where
- Kenya
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- RTI International
Oral Health, Oral Hygiene
Effectiveness of Personalized Oral Hygiene Education in Medical and Dental Students Over Two Years
This prospective cohort study is designed to evaluate the long-term effects of individualized oral hygiene education, known as Individually Trained Oral Prophylaxis (iTOP), on oral health outcomes in medical and dental students…
- Conditions
- Oral Health, Oral Hygiene, Periodontal Health, Dental Plaque
- Trial name
- iTOP (NCT07085013)
- Testing
- Individually Trained Oral Prophylaxis (iTOP)
- Where
- Bosnia and Herzegovina
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- University of Mostar
Intensive Critical Unit, Pneumonia
Evaluation of the Effectiveness and Safety of Supratube Device
Purpose of the trial: Trial design: Two-parallel arm, double-blind, individually randomized controlled trial. Primary endpoint: Clinical evaluation of sinus, oropharyngeal, tracheal, bronchial or pulmonary infections during…
- Conditions
- Intensive Critical Unit, Pneumonia, Aspiration, Prevention and Control
- Trial name
- SUPRANAV (NCT03573609)
- Testing
- Supranav
- Where
- Colombia
- Volunteers
- 108 people
- Sponsor
- Fundación Cardiovascular de Colombia
HIV Infection
Botswana Tenofovir Oral HIV Prophylaxis Trial
This study will test whether taking a pill of tenofovir (an antiretroviral medicine) is safe for sexually-active young adults in Botswana without HIV infection and whether it will reduce their risk of getting an HIV infection.
- Trial name
- NCT00111150
- Testing
- Tenofovir Disoproxil Fumarate 300 mg daily
- Where
- 2 sites in United States, Botswana
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Secondary Immune Deficiency Disorder
Humoral Immunodeficiency in CLL and Therapy With Subcutaneous Ig
Patients with chronic lymphocytic leukemia (CLL) are at increased risk of infections as compared to age matched controls, with infections being a major cause of morbidity and mortality.
- Trial name
- NCT03730129
- Testing
- Hizentra
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rochester General Hospital
Incidence of Infectious Diseases
Enhanced Molecular Microbiological Surveillance Versus Ceftriaxone Prophylaxis in Hematopoietic Cell Transplant Patients
The goal of this clinical trial is to learn whether close microbiological monitoring without preventive antibiotics works as well as preventive treatment with ceftriaxone in adults receiving stem cell transplants.
- Trial name
- CRONOS (NCT07308457)
- Testing
- Ceftriaxone 1000 MG
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Pomeranian Medical University Szczecin
Alveolar Ridge Augmentation, Bone Grafting
Antibiotic Prophylaxis Versus Placebo in Alveolar Bone Grafting: A Randomized Controlled Trial
Tooth extraction sites often require alveolar bone grafting to preserve ridge dimensions and improve conditions for future implant placement.
- Conditions
- Alveolar Ridge Augmentation, Bone Grafting, Antibiotic Prophylaxis
- Trial name
- ABXGRAFT (NCT07296302)
- Testing
- Amoxicillin 500 mg (prophylactic regimen)
- Where
- Brazil
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Agnaldo Rocha de Souza Junior
Migraine Disorders
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches
This is a 60 week study including a double-blind phase followed by an open-label phase.
- Trial name
- NCT00168428
- Testing
- Botulinum Toxin Type A
- Where
- 6 sites in United States, Canada and 4 more
- Volunteers
- 705 people
- Sponsor
- Allergan
HIV Infection
Partners Demonstration Project of PrEP and ART
The purpose of this protocol is to determine user preferences for antiretroviral therapy (ART) for HIV-1 infected partners and pre-exposure prophylaxis (PrEP) HIV-1 un-infected partners and to optimize targeted delivery and…
- Trial name
- NCT02775929
- Testing
- FTC-TDF PrEP, ART
- Where
- 4 sites in Kenya, Uganda
- Volunteers
- 1,013 people
- Sponsor
- University of Washington
Athletes With Previous Lateral Ankle Sprain(s)
The Spraino Pilot Trial
This pilot study will establish the preliminary effect and safety of using Spraino® to prevent lateral ankle sprains amongst athletes competing in indoor sports at sub-elite level, with a one-year follow-up.
- Trial name
- NCT03311490
- Testing
- Spraino
- Where
- 2 sites in Denmark
- Volunteers
- 510 people, healthy volunteers welcome
- Sponsor
- Spraino
Ventilator Acquired Pneumonia, Catheter Related Blood Stream Infections
Ontario ICU Clinical Best Practices Demonstration Project
The pragmatic issue at hand how to get physicians and nurses to use best practices… and how to measure consequences of their implementation.
- Conditions
- Ventilator Acquired Pneumonia, Catheter Related Blood Stream Infections, Pressure Ulcer Prophylaxis, DVT Prophylaxis
- Trial name
- NCT00332982
- Testing
- Focused knowledge translation strategies
- Where
- Canada
- Sponsor
- Sunnybrook Health Sciences Centre
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