Clinical trials: Preventive Measures
Infection Control, Antibiotic Prophylaxis
The Effect of Antibiotic Prophylaxis Associated With Dental Implant Surgery
The overall aim of the study is to investigate whether routine administration of antibiotic prophylaxis 1 hour prior to implant surgery may prevent postoperative infection and implant loss in healthy or substantially healthy…
- Trial name
- NCT03412305
- Testing
- Amoxicillin
- Where
- Sweden
- Volunteers
- 474 people
- Sponsor
- Malmö University
Chronic Migraine
Evaluation of Galcanezumab in the Prevention of Chronic Migraine
The main purpose of this study is to evaluate the efficacy of the study drug known as galcanezumab in participants with chronic migraine.
- Trial name
- REGAIN (NCT02614261)
- Testing
- Galcanezumab
- Where
- 117 sites in United States, Argentina and 11 more
- Volunteers
- 1,117 people
- Sponsor
- Eli Lilly and Company
HIV Prevention, Pre-exposure Prophylaxis
Hybrid Evaluation of a Home-based HIV Pre-exposure Prophylaxis Program
The study's aim is to implement a home-based PrEP (HB-PrEP) monitoring system (self-collected blood and extragenital specimens at home and telehealth follow-up) into a large, urban sexual health clinic while also evaluating the…
- Conditions
- HIV Prevention, Pre-exposure Prophylaxis, STI
- Trial name
- HOT4PrEP (NCT05856942)
- Testing
- Health service - home-based PrEP monitoring
- Where
- United States
- Volunteers
- 458 people, healthy volunteers welcome
- Sponsor
- University of Washington
GBS
The Implementation of Real-time PCR - Intrapartum GBS (Group B Streptococcus) Colonization to Reduce Antibiotic Prophylaxis
The implementation of real-time PCR for detection of intrapartum GBS (group B Streptococcus) colonization as a way to reduce antibiotic prophylaxis usage.
- Trial name
- NCT03936816
- Testing
- GBS vaginal double swab
- Where
- Israel
- Volunteers
- 303 people
- Sponsor
- Carmel Medical Center
Allogeneic Stem Cell Transplant, Viral Infection
Donor-Derived Viral Specific T-cells (VSTs) for Prophylaxis Against Viral Infections After Allogeneic Stem Cell Transplant
The purpose of this research study is to learn more about the use of viral specific T-lymphocytes (VSTs) to prevent viral infections that may happen after allogeneic stem cell transplant.
- Trial name
- NCT03883906
- Testing
- Viral Specific T-cells (VSTs)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
HIV, PrEP
Behavioral Intervention for PrEP Service Utilization Among Chinese MSM: A HAPA and CEI Integrated Model
The goal of this clinical trial is to evaluate the effectiveness of a novel, intelligent intervention platform in bridging the "intention-behavior gap" for pre-exposure prophylaxis (PrEP) uptake among men who have sex with men…
- Conditions
- HIV, PrEP, MSM, Behavior Changes
- Trial name
- NCT06931106
- Testing
- HAPA and CEI behavioral intervention, HAPA-based intervention
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Peking University
HIV/AIDS
Body Compartment Pharmacokinetics of Anti-retroviral Agents That May be Considered for Future On-demand Peri-exposure HIV Prophylaxis Regimens
This study is being conducted to determine if the uptake of anti-HIV medication, called Genvoya®, at different time-frames, is different at several body sites, including mucosal tissues.
- Trial name
- NCT03976752
- Testing
- Genvoya
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Emory University
Covid19, SARS-CoV Infection
COVID-19 Prophylaxis South Africa (COVER HCW)
This is a randomised, multi-center, open label, adaptive, exploratory trial to assess the efficacy of two different drug regimens in terms of preventing symptomatic COVID-19 disease in healthcare workers at high risk of exposure…
- Trial name
- COVER (NCT04561063)
- Testing
- Nitazoxanide, Sofosbuvir/Daclatasvir
- Where
- 2 sites in South Africa
- Volunteers
- 1,950 people, healthy volunteers welcome
- Sponsor
- University of Witwatersrand, South Africa
Impacted Mandibular Third Molar, Impacted Mandibular Third Molar Extraction
Preoperative Versus Postoperative Amoxicillin in Impacted Third Molar Surgery
This prospective observational cohort study evaluated the effects of the timing of amoxicillin use on postoperative recovery and oral health-related quality of life following impacted mandibular third molar surgery.
- Trial name
- NCT07857863
- Testing
- Amoxicillin
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Recep Tayyip Erdogan University
HIV
Likely Use of PrEP for African American YMSM
HIV Pre-Exposure Prophylaxis (PrEP), in the form of the anti-retroviral pill Truvada©, has been approved by the FDA as a method for reducing HIV transmission rates in the population, particularly young men who have sex with men…
- Trial name
- NCT02810249
- Testing
- No intervention used
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Duke University
Pain, Postoperative
Postoperative Pain After Orthopedic Surgery: Does it Help to Give Fentanyl Before Start of Remifentanil Based Anesthesia?
The aim of this trial is to examine the possibility that fentanyl 1,5 µgr/kg given intravenously (i.v.) before the start of remifentanil infusion for anesthesia gives less development of tolerance/hyperalgesia postoperative than…
- Trial name
- NCT00241332
- Testing
- fentanyl
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Ullevaal University Hospital
Kidney Transplantation, Cytomegalovirus Infections, EBV Infection
Is Valacyclovir Non-inferior to Valganciclovir as CMV and EBV Prophylaxis in Kidney Transplant Recipients? A Single-Center Prospective Randomized Pilot Study
Opportunistic CMV viremia (primary infection or reactivation) is usually managed by taking prophylactic medication for both adult and pediatric kidney transplant patients.
- Conditions
- Kidney Transplantation, Cytomegalovirus Infections, EBV Infection, Antiviral Prophylaxis
- Trial name
- NCT07294547
- Testing
- Valacyclovir (Valtrex), Valganciclovir (Valcyte)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
Surgical Site Infection
The Use of Ceftaroline as Surgical Prophylaxis in Surgery With Risk of MRSA Infection
The study is a randomized double-blinded study comparing ceftaroline to standard of care therapy with cefazolin and vancomycin as surgical prophylaxis for high risk orthopedic and cardiac surgeries.
- Trial name
- PREVTAROLINE (NCT02307006)
- Testing
- Ceftaroline, Cefazolin / Vancomycin
- Where
- 2 sites in United States
- Volunteers
- 500 people
- Sponsor
- University of Cincinnati
Leukemia, Myelocytic, Acute, Infusions, Intravenous
Study Evaluating the Effect of Corticosteroids on Mylotarg® Infusion-Related Adverse Events in Patients With Leukemia
The purpose of this study is to evaluate the effect of corticosteroids on the frequency and severity of Mylotarg® infusion-related adverse events, to evaluate the effect of corticosteroids on the efficacy of Mylotarg® induced…
- Trial name
- NCT00304447
- Testing
- Mylotarg
- Volunteers
- 30 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Leukemia, Myelocytic, Acute, Leukemia, Lymphocytic, Acute
Sirolimus/Tacrolimus Versus Tacrolimus/Methotrexate for Preventing Graft-Versus-Host Disease (GVHD) (BMT CTN 0402)
The study is designed as a phase III, randomized, open label, multicenter, prospective, comparative trial of sirolimus and tacrolimus versus tacrolimus and methotrexate as graft-versus-host disease (GVHD) prophylaxis after human…
- Conditions
- Leukemia, Myelocytic, Acute, Leukemia, Lymphocytic, Acute, Leukemia, Myeloid, Chronic, Myelodysplastic Syndromes
- Trial name
- NCT00406393
- Testing
- Tacrolimus, Methotrexate, Sirolimus
- Where
- 24 sites in United States, France
- Volunteers
- 304 people
- Sponsor
- Medical College of Wisconsin
Pressure Ulcer
Olive Oil's Cream Effectiveness in Prevention of Pressure Ulcers in Immobilized Patients in Primary Care
Pressure ulcers (UPP) represent an important sanitary problem affecting mostly elderly immobilized persons, increasing the burden of care to professionals in the health system, as well as pharmaceutical spending.
- Trial name
- PrevenUP (NCT01595347)
- Testing
- Hyper-oxigenated fatty acid, Olive oil's cream
- Where
- Spain
- Volunteers
- 410 people
- Sponsor
- Andaluz Health Service
Rabies
Rabies Immunization Concomitant With JEV in Children
Background. The World Health Organization recommends pre-exposure vaccination (PreP) to protect children living in canine rabies endemic countries.
- Trial name
- NCT00703521
- Testing
- Rabies vaccine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Candidiasis
Pharmacokinetics of Fluconazole IV as Prophylaxis or Therapy to ICU Patients
The pharmacokinetics of fluconazole are expected to be different in ICU patients compared to non-ICU patients. The investigators will determine fluconazole and free fluconazole concentrations in 20 ICU patients, who will get…
- Trial name
- PACIFIC (NCT02666716)
- Testing
- fluconazole
- Where
- 3 sites in Netherlands
- Volunteers
- 20 people
- Sponsor
- Radboud University Medical Center
Bradyarrhythmia, Cardiac Arrest
Glycopyrrolate Prophylaxis for Prevention of Bradyarrhythmia During Laparoscopic Cholecystectomy
The goal of this clinical trial is to evaluate the incidence of bradycardia during laparoscopic cholecystectomy. The main question[s] it aims to answer are: Does bradycardia really occurs during pneumoperitoneum/laparoscopic…
- Conditions
- Bradyarrhythmia, Cardiac Arrest, Tachycardia, Asystole
- Trial name
- NCT05997004
- Testing
- Normal Saline, Glycopyrrolate
- Where
- Nepal
- Volunteers
- 62 people
- Sponsor
- National Academy of Medical Sciences, Nepal
HIV Infections, Pre-exposure Prophylaxis
PrEP Readiness Interventions for Supporting Motivation
The overarching goal of this formative research is to examine whether, and in what combination, contingency management (CM) and motivational interviewing (MI) can facilitate entry of stimulant-using men who have sex with men…
- Conditions
- HIV Infections, Pre-exposure Prophylaxis, Substance Use Disorders
- Trial name
- PRISM (NCT04205487)
- Testing
- Motivational Interviewing (MI), Contingency Management (CM)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida International University
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