Clinical trials: Preventive Measures
Hemophilia B
Study of Next-Generation Recombinant Factor IX Variant in Adult Subjects With Hemophilia B
Phase 2b, single-center, open-label study designed to evaluate the pharmacokinetics, pharmacodynamics, efficacy and safety of subcutaneous (SC) prophylaxis treatment regimens with CB2679d in 6 adult, male subjects with severe…
- Trial name
- NCT03995784
- Testing
- Coagulation Factor IX variant
- Where
- South Africa
- Volunteers
- 6 people
- Sponsor
- Catalyst Biosciences
HIV Infections, Malaria
The Effect of Malaria on Disease Progression of HIV/AIDS
The purpose of this study is to find out whether malaria affects how HIV/AIDS disease progresses in an infected patient, and to determine the effect of reducing malaria infection on HIV disease progression in Kumasi
- Trial name
- NCT00499876
- Testing
- mefloquine
- Where
- Ghana
- Volunteers
- 197 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Haemophilia A
BAY81-8973 Pediatric Safety and Efficacy Trial
The primary objective was to evaluate the safety and efficacy of the treatment with BAY81-8973 for prophylaxis and treatment of breakthrough bleeds in children with severe hemophilia A.
- Trial name
- NCT01311648
- Testing
- Recombinant Factor VIII (Kovaltry, BAY81-8973)
- Where
- 43 sites in United States, Argentina and 15 more
- Volunteers
- 94 people
- Sponsor
- Bayer
GVHD, Chronic, Acute Leukemia
Electronic Database for the Follow up of the ATG_FamilyStudy
Allogeneic hematopoietic stem cell transplantation (HSCT) is capable of definitive cure of acute leukemias. The most important post-transplant complication is graft vs host disease (GVHD) which can be substantially decreased by…
- Conditions
- GVHD, Chronic, Acute Leukemia, Stem Cell Transplant Complications
- Trial name
- AFF (NCT03042676)
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Hematologic Malignancy, Myeloproliferative Disorder
Fungal Prophylaxis With Isavuconazole for Patients Undergoing Allogeneic Hematopoietic Stem Cell Transplant (HCT)
The purpose of this study is to study the effects of isavuconazole in preventing fungal infections in patients who have had a hematopoietic stem cell transplant (HCT).
- Trial name
- NCT03149055
- Testing
- Isavuconazole
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Symptomatic Venous Thromboembolism (VTE)
REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
This study is researching an experimental drug called REGN7508 (called "study drug") and how it compares against another treatment called Acetylsalicylic Acid (ASA).
- Trial name
- ROXI-ASPEN (NCT07213778)
- Testing
- REGN7508, Acetylsalicylic Acid (ASA)
- Where
- 51 sites in United States, Greece and 3 more
- Volunteers
- 2,000 people
- Sponsor
- Regeneron Pharmaceuticals
Fungal Infection
Vfend Special Investigation For Prophylaxis
Examine the safety and effectiveness of Vfend [voriconazole] for prophylaxix use under general clinical practices.
- Trial name
- NCT02674685
- Volunteers
- 241 people
- Sponsor
- Pfizer
Endophthalmitis, Prophylaxy of Post Traumatic Endophthalmitis
Prophylaxis of Acute Post-Traumatic Bacterial Endophthalmitis
Purpose: To evaluate the efficacy of combined intraocular injection of gentamycin and clindamycin in prevention of acute posttraumatic bacterial endophthalmitis (APBE) following penetrating eye injuries.
- Conditions
- Endophthalmitis, Prophylaxy of Post Traumatic Endophthalmitis, Bacterial Endophthalmitis
- Trial name
- NCT00398658
- Testing
- gentamycin and clindamycin
- Where
- Iran
- Sponsor
- Shahid Beheshti University of Medical Sciences
Pneumonitis, Coronavirus Infection
Proflaxis Using Hydroxychloroquine Plus Vitamins-Zinc During COVID-19 Pandemia
Healthcare professionals mainly doctors, nurses and their first degree relatives (spouse, father, mother, sister, brother, child) who have been started hydroxychloroquine(plaquenil) 200mg single dose repeated every three weeks…
- Trial name
- NCT04326725
- Testing
- Plaquenil 200Mg Tablet
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istinye University
HIV, Violence, Gender-Based
Development and Evaluation of a PrEP Decision Aid for Women Seeking Domestic Violence Services in Baltimore
This study is designed to develop and test an individual decision aid for pre-exposure prophylaxis (PrEP) tailored to Black women who have been exposed to intimate partner violence and are working with a domestic violence service…
- Conditions
- HIV, Violence, Gender-Based, Pre-Exposure Prophylaxis
- Trial name
- NCT05614492
- Testing
- Individual PrEP Decision Aid, CDC PrEP Video, Shared PrEP Decision Aid
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Thromboembolism, Arthroplasty Replacement, Knee
Safety Study of Stopping Thromboprophylaxis Based on Ultrasound Results After Total Knee Replacement
The purpose of this study is to determine whether stopping Low Molecular Weight Heparin (LMWH) thromboprophylaxis is safe after total knee joint replacement.
- Trial name
- NCT00362492
- Testing
- Bilateral ultrasound examination 7+/- 2 after surgery
- Where
- 17 sites in France
- Volunteers
- 850 people
- Sponsor
- University Hospital, Caen
HIV
Implementation of the Pre-Exposure Prophylaxis (PrEP) to HIV: A Demonstrative Project.
A prospective, open, multicenter,demonstrative of PrEP, which aims to assess the acceptability, feasibility and safety from chemoprophylaxis co-formulated emtricitabine / tenofovir disoproxil fumarate (FTC / TDF) administered…
- Trial name
- PrEPBrasil (NCT01989611)
- Testing
- emtricitabine / tenofovir 200/300 mg
- Where
- 3 sites in Brazil
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Oswaldo Cruz Foundation
Cytomegalovirus Infections, Cytomegalovirus Viremia
HCMV Breakthrough Infections During Letermovir Prophylaxis
The goal of this clinical trial is to compare two strategies to monitor human cytomegalovirus (HCMV) infections in transplanted patients receiving letermovir (LTV) as anti-HCMV prophylaxis.
- Conditions
- Cytomegalovirus Infections, Cytomegalovirus Viremia, Hematopoietic Stem Cell Transplantation
- Trial name
- CMVbreak (NCT06339892)
- Testing
- Determination of HCMV DNA in plasma after DNAse digestion., Determination of HCMV DNA in blood or plasma.
- Where
- 8 sites in Italy
- Volunteers
- 140 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
HIV Infections, Opioid Use
Trauma Intervention to Optimize PrEP Among Women Who Inject Drugs
The goal of this randomized controlled trial is to test the effectiveness of "TIARAS," a trauma intervention designed to reduce HIV acquisition risk among women who inject drugs (WWID).
- Conditions
- HIV Infections, Opioid Use, Trauma, Psychological
- Trial name
- TIARAS (NCT05192434)
- Testing
- Expressive Writing, Contingency Management
- Where
- United States
- Volunteers
- 219 people
- Sponsor
- Drexel University
Covid-19, Nosocomial Infection
COG-UK Project Hospital-Onset COVID-19 Infections Study
Hospitals are recognised to be a major risk for the spread of infections despite the availability of protective measures. Under normal circumstances, staff may acquire and transmit infections, but the health impact of within…
- Conditions
- Covid-19, Nosocomial Infection, Coronavirus, Coronavirus Infection
- Trial name
- COG-UK HOCI (NCT04405934)
- Testing
- Use of virus (Covid-19) genome sequence report to inform infection prevention control procedures
- Where
- United Kingdom
- Volunteers
- 2,170 people
- Sponsor
- University College, London
Diabetes, Obesity
Tu Salud Si Cuenta: UT Community Outreach Program for Community-based Diabetes Prevention and Control.
Building from existing intervention strategies designed for the Mexican American population entitled Tu Salud Si Cuenta(TSSC) or Your Health Matters.
- Trial name
- UTCO (NCT01168765)
- Testing
- Tu Salud Si Cuenta Behavioral Intervention
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Rectal Adenocarcinoma
Prestoma-Trial for Parastomal Hernia Prevention
Prestoma Trial is designed to compare the safety and efficiency of three different meshes and techniques to prevent parastomal hernia after laparoscopic or robotic-assisted abdominoperineal resection for rectal adenocarcinoma.
- Trial name
- NCT03527784
- Testing
- Parietene Macro, Parietex Parastomal, Dynamesh IPST
- Where
- 6 sites in Finland
- Volunteers
- 14 people
- Sponsor
- University of Oulu
Hand Hygiene Training, Infection Prevention and Control
Effectiveness of an Edge AI-based Augmented Reality System for Hand Hygiene Training: a Multi-centre, Mixed-methods Cluster Randomised Controlled Trial
This multi-centre, mixed-methods cluster randomised controlled trial (cRCT) aims to evaluate the effectiveness of an edge artificial intelligence (AI)-based augmented reality (AR) training and assessment system for improving hand…
- Conditions
- Hand Hygiene Training, Infection Prevention and Control, Healthcare-Associated Infections (HAIs), Health Education
- Trial name
- HANDHEART (NCT07280026)
- Testing
- Instructional Video + Scanner Feedback, Edge AI-based AR Hand Hygiene Training System
- Where
- 3 sites in China, Hong Kong
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Pneumonia, Pneumocystis Carinii, HIV Infections
A Study of Pentamidine Plus Dapsone in the Prevention of Pneumocystis Carinii Pneumonia (PCP) in HIV-Infected Patients Who Cannot Take Trimethoprim or Sulfonamides
To compare the safety and efficacy of aerosolized pentamidine and dapsone in the prevention of Pneumocystis carinii pneumonia (PCP) in high-risk HIV-infected patients who are intolerant to trimethoprim and/or sulfonamides.
- Trial name
- NCT00001028
- Testing
- Pentamidine isethionate, Dapsone
- Where
- 14 sites in United States
- Volunteers
- 400 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Non-Interventional Study
Home Administration of NivestimTM in the Primary Prophylaxis of Chemotherapy-Induced Febrile Neutropenia
Non-interventional, non-comparative, national, multi-site, single-arm prospective observational study to investigate home administration of Nivestim in the primary prophylaxis of chemotherapy-Induced febrile neutropenia
- Trial name
- NCT02956967
- Testing
- Overall satisfaction questionnaires of home use of Nivestim
- Where
- 28 sites in Germany
- Volunteers
- 171 people
- Sponsor
- Pfizer
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