Clinical trials: Primary
Hypercholesterolemia, Medication Adherence
Effectiveness of a Combined Strategy to Improve Therapeutic Compliance and Degree of Control Among Patients With Hypercholesterolaemia
Background In subjects with hypercholesterolaemia, cholesterol values remain above guideline levels. One of the limiting factors to the achievement of goals in such patients is therapeutic non-adherence.
- Conditions
- Hypercholesterolemia, Medication Adherence, Primary Health Care
- Trial name
- EFESCOM (NCT02314663)
- Testing
- "COMBINED STRATEGY"
- Volunteers
- 358 people
- Sponsor
- Gerencia de Atención Primaria, Albacete
Post Partum Hemorrhage
Mansoura-VV Uterine Compression Suture for Primary Atonic Postpartum Hemorrhage
Postpartum hemorrhage is the leading cause of maternal, uterine atony accounts for 75-90% of primary postpartum hemorrhage. The efficacy of the Uterine compression suture in the treatment of atonic postpartum hemorrhage is…
- Trial name
- NCT03117647
- Testing
- Mansoura-VV compression suture
- Volunteers
- 108 people
- Sponsor
- Mansoura University
Main Focus: Gluten and Starch Digestibility
GlutDigest - Pilot Study
This is a pilot, feasibility study to evaluate, test and optimize sample analysis procedures and protocols before the full-scale, crossover study is conducted.
- Trial name
- GlutDigestP (NCT04489836)
- Testing
- Glutalytic®, DE111®, Meal A
- Where
- Ireland
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Deerland Enzymes
Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma
Bevacizumab and Anetumab Ravtansine or Paclitaxel in Treating Patients With Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer
This phase II trial studies the side effects of bevacizumab and anetumab ravtansine or paclitaxel in treating patients with ovarian, fallopian tube, or primary peritoneal cancer that does not respond to treatment (refractory).
- Conditions
- Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube High Grade Serous Adenocarcinoma, Ovarian Endometrioid Adenocarcinoma, Ovarian High Grade Serous Adenocarcinoma
- Trial name
- NCT03587311
- Testing
- Anetumab Ravtansine, Bevacizumab, Paclitaxel
- Where
- 23 sites in United States, Canada
- Volunteers
- 96 people
- Sponsor
- National Cancer Institute (NCI)
Adult Patients, Immune Primary Thrombocytopenia
TPO-mimetics Before Splenectomy in Adult Primary Immune Thrombocytopenia Patients.
This study aims at analyzing the therapeutic activity of TPO-mimetics Eltrombopag and Romiplostim as bridge therapy for splenectomy in adult patients with primary immune thrombocytopenia.
- Conditions
- Adult Patients, Immune Primary Thrombocytopenia, Splenectomy, TPO-mimetics
- Trial name
- ITP0614 (NCT02063763)
- Where
- 14 sites in Italy
- Volunteers
- 31 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
HIV, AIDS
Effectiveness of a Smoking Cessation Algorithm Integrated Into HIV Primary Care
To determine the efficacy of an algorithm designed to recommend smoking cessation-related pharmacotherapy options to the primary care providers of smokers living with HIV/AIDS.
- Conditions
- HIV, AIDS, Smoking Cessation
- Trial name
- NCT03670316
- Testing
- Algorithm Treatment, Quitline only
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- University of Alabama at Birmingham
Adenosine Deaminase Deficiency, Severe Combined Immunodeficiency (SCID)
An Observational LTFU Study for Patients Previously Treated With Autologous ex Vivo Gene Therapy for ADA-SCID
This observational long-term follow-up study is designed to collect safety and efficacy data from ADA-SCID patients previously treated with autologous ex vivo gene therapy products based on the EFS-ADA LV encoding for human…
- Trial name
- NCT04049084
- Testing
- autologous ex vivo gene therapy products based on the EFS LV encoding for the human adenosine deaminase (ADA) gene (EFS-ADA LV)
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 70 people
- Sponsor
- University of California, Los Angeles
Primary Aldosteronism
Primary Aldosteronism LC-MS/MS-specific Cutoffs
Aims to evaluation the LC-MS/MS-specific cutoffs of PA screening and CCT test.
- Trial name
- PM (NCT05959863)
- Testing
- Captopril Challenge Test
- Where
- 2 sites in China
- Volunteers
- 396 people
- Sponsor
- Chongqing Medical University
Primary Anatomic or Reverse Total Shoulder Arthroplasty
Hydrogen Peroxide to the Wound Following Surgical Incision Affecting Cultures in Primary Shoulder Arthroplast
Cutibacterium acnes has been the focus of much recent shoulder literature, as it has been found to be both a common cause of periprosthetic joint infection as well as a common contaminant in shoulder surgery.
- Trial name
- NCT04609306
- Testing
- H2O2 application to incision
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Florida
Delirium, Dementia, Amnestic, Cognitive Disorders, Arthroplasty, Hip Replacement
Cerebral Regional Oxygen Saturation and Markers of Brain Damage During Primary Hip Arthroplasty
Postoperative Cognitive Disorders (POCD) are common in hospitalized people > 60 year old, especially in orthopedic patients. Etiology of POCD is complex, and in some aspects still remains unclear.
- Trial name
- NCT02342236
- Testing
- cemented or cementless type of hip prothesis
- Where
- Poland
- Volunteers
- 18 people
- Sponsor
- Military Institute od Medicine National Research Institute
Myelofibrosis
Clonal Architecture of ASXL1-mutated Myelofibrosis
Prospective study to decipher the clonal architecture of ASXL1-mutated primary and secondary myelofibrosis and its impact on prognosis
- Trial name
- CLONEMF (NCT05710211)
- Testing
- Clonal architecture determination
- Where
- 13 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Angers
Head and Neck Cancer, Oral Complications
Sargramostim in Decreasing Mucositis in Patients Receiving Radiation Therapy for Head and Neck Cancer
RATIONALE: Sargramostim may lessen symptoms of mucositis in patients receiving radiation therapy for head and neck cancer. It is not yet known if sargramostim is more effective than no treatment in reducing mucositis caused by…
- Conditions
- Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00008398
- Testing
- sargramostim, quality-of-life assessment, radiation therapy
- Where
- 236 sites in United States, Canada
- Sponsor
- Radiation Therapy Oncology Group
HIV
HIV Clinic-Based Intervention to Improve ART Adherence and Prevent HIV Transmission
This research, co-sponsored by the Centers for Disease Control and Prevention and the National Institute of Mental health, is conducted at six HIV clinics in the U.S.
- Trial name
- APTcare (NCT02044484)
- Testing
- Multi-component intervention
- Where
- 6 sites in United States
- Volunteers
- 2,794 people
- Sponsor
- Centers for Disease Control and Prevention
HIV Prevention, Primary Care
Clinic-based HIV Identification and Prevention Project Using Electronic Resources
Hybrid Type II effectiveness-implementation trial to investigate whether electronic medical and sexual history data collection with HIV risk categorization/scoring will increase pre-exposure prophylaxis (PrEP) uptake among…
- Conditions
- HIV Prevention, Primary Care, PrEP
- Trial name
- CHIPPER (NCT05412433)
- Testing
- Patient Level, Multilevel, Control
- Where
- United States
- Volunteers
- 1,170 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Carious Primary Molars
Comparison of ZOE vs ZON in Primary Mandibular Molars Pulpectomy of 5-7-Year-Olds
The goal of this clinical trial is to evaluation of Zinc oxide-eugenol compared to Zinc oxide with Neem as obturating materials in primary mandibular molars pulpectomy for 5-7 Year-Old Children.The main question(s)it aim to…
- Trial name
- NCT07090252
- Testing
- Group I zinc oxide Neem, Group II zinc oxide eugenol
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Fallopian Tube Cancer, Ovarian Cancer
TLK286 in Treating Patients With Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effectiveness of TLK286 in treating patients who have advanced ovarian…
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00022347
- Testing
- canfosfamide hydrochloride
- Where
- United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Primary Dental Caries
Evaluation of Hall Technique and Atraumatic Restorative Treatment for Management of Caries in the Primary Dentition
The aim of the present study is to evaluate both Hall technique and atraumatic restorative technique in comparison to the conventional restorative technique in the management of carious lesions in primary molars.
- Trial name
- NCT04367649
- Testing
- Hall technique, Atraumatic restorative treatment, Conventional Stainless Steel Crown Restoration
- Where
- Egypt
- Volunteers
- 155 people
- Sponsor
- Nourhan M.Aly
Rotator Cuff-related Shoulder Pain, Shoulder Pain
Personalised Education Versus Usual Physiotherapy for Acute Rotator Cuff-Related Shoulder Pain
Rotator cuff-related shoulder pain (RCRSP) is one of the most common musculoskeletal disorders presenting in primary care. It is frequently associated with persistent pain, disability, healthcare utilisation and work absenteeism.
- Conditions
- Rotator Cuff-related Shoulder Pain, Shoulder Pain, Shoulder Disability
- Trial name
- SHOULD-ER (NCT07859891)
- Testing
- Personalised, Multimodal Educational Intervention, Usual Physiotherapy Care
- Where
- France
- Volunteers
- 118 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Hyperparathyroidism, Primary, Parathyroid Neoplasms
WHITE CAP: Intra-operative Parathyroid Tissue Sensor (PTS)-Guided Assessment of Parathyroid Viability and Surgical Decision-Making
Primary hyperparathyroidism is usually cured by removing the single over-active parathyroid adenoma. During surgery, however, surgeons often see a thin rim of normal parathyroid tissue that still "glows" under a near-infrared…
- Conditions
- Hyperparathyroidism, Primary, Parathyroid Neoplasms, Parathyroid Adenoma, Hypocalcemia
- Trial name
- WHITE CAP-PTS (NCT07043010)
- Testing
- Near-Infrared Parathyroid Tissue Sensor Imaging (PTS), Rim-Preservation Technique, En-bloc Resection Technique
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fujian Medical University
Colorectal Cancer, Esophageal Cancer
Combination Chemotherapy in Treating Patients With Recurrent, Refractory, or Metastatic Solid Tumors or Lymphomas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Colorectal Cancer, Esophageal Cancer, Extrahepatic Bile Duct Cancer, Gallbladder Cancer
- Trial name
- NCT00019513
- Testing
- fluorouracil, gemcitabine hydrochloride, leucovorin calcium
- Where
- United States
- Volunteers
- 108 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
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