Clinical trials: Primary
Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis
Non-inferiority Study of Ocrelizumab and Rituximab in Active Multiple Sclerosis
The DanNORMS study is a phase 3, non-inferiority clinical trial examining whether treatment of active multiple sclerosis with rituximab is non-inferior to ocrelizumab regarding efficacy and safety.
- Conditions
- Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis
- Trial name
- DanNORMS (NCT04688788)
- Testing
- Rituximab, Ocrelizumab, Fexofenadine
- Where
- 11 sites in Denmark
- Volunteers
- 600 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Primary Inguinal Hernia
Rives Technique Versus Lichtenstein Repair for Primary Inguinal Hernia
Lichtenstein technique, inserting a mesh over the inguinal cord in the neurological plane, is considered the standard of inguinal hernia repair, but it has 4% recurrence and 12% chronic postoperative pain.
- Trial name
- NCT03488342
- Testing
- Repair for primary inguinal hernia
- Where
- Spain
- Volunteers
- 600 people
- Sponsor
- Hospital Siberia-Serena
Overweight and Obesity
Implementation and Validation of the "5As Framework of Obesity Management" in Primary Care. "5AsT"
The main goal of this project is to develop, implement and evaluate the 5As Team intervention (5AsT)for healthcare practitioners to improve their weight management patient encounters and improve patient health outcomes.
- Trial name
- 5AsT (NCT01967797)
- Testing
- 5As Team Intervention
- Where
- Canada
- Volunteers
- 255 people
- Sponsor
- University of Alberta
Hereditary Angioedema
OASIS-HAE: A Study to Evaluate the Safety and Efficacy of Donidalorsen (ISIS 721744 or IONIS-PKK-LRx) in Participants With Hereditary Angioedema (HAE)
The purpose of this study was to evaluate the safety and efficacy of donidalorsen in participants with HAE and effect of donidalorsen on the quality and pattern of HAE attacks and their impact on quality of life (QoL).
- Trial name
- NCT05139810
- Testing
- Donidalorsen
- Where
- 51 sites in United States, Belgium and 12 more
- Volunteers
- 91 people
- Sponsor
- Ionis Pharmaceuticals, Inc.
Dystonia
Efficacy and Safety of DBS of the GPi in Patients With Primary Generalized and Segmental Dystonia
The purpose of this study is to evaluate the efficacy and safety of bilateral deep brain stimulation of the internal globus pallidus for treating idiopathic generalized or severe segmental dystonia.
- Trial name
- NCT00142259
- Testing
- Deep brain stimulation of the internal globus pallidus
- Where
- 8 sites in Austria, Germany
- Volunteers
- 40 people
- Sponsor
- German Parkinson Study Group (GPS)
Primary Inguinal Hernia
Freedom Inguinal Hernia Repair System Study
The primary objective of this study is to evaluate patient quality-of-life (QOL) after inguinal hernia repair. "Carolinas Comfort Scale" (CCS) assessments will be held at regular intervals.
- Trial name
- NCT01984996
- Testing
- Freedom ProFlor Inguinal Hernia Implant
- Where
- 8 sites in United States, Austria and 1 more
- Volunteers
- 100 people
- Sponsor
- Insightra Medical, Inc.
Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer
Erlotinib in Treating Patients With Unresectable Liver Cancer and Liver Dysfunction
Phase I trial to study the effectiveness of erlotinib in treating patients who have unresectable liver cancer and liver dysfunction.
- Conditions
- Adult Primary Hepatocellular Carcinoma, Advanced Adult Primary Liver Cancer, Localized Unresectable Adult Primary Liver Cancer, Recurrent Adult Primary Liver Cancer
- Trial name
- NCT00047346
- Testing
- erlotinib hydrochloride, pharmacological study, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Cancer Institute (NCI)
Small Cell Lung Carcinoma, Large Cell Neuroendocrine Carcinoma of the Lung
Phase I Study of [225Ac]Ac-ETN029 in Patients With Advanced DLL3-expressing Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, dosimetry and preliminary efficacy of [225Ac]Ac-ETN029 and the safety and imaging properties of [111In]In-ETN029 in patients aged ≥ 18 years with locally advanced…
- Conditions
- Small Cell Lung Carcinoma, Large Cell Neuroendocrine Carcinoma of the Lung, Neuroendocrine Prostate Cancer, Gastroenteropancreatic Neuroendocrine Carcinoma
- Trial name
- NCT07006727
- Testing
- 225Ac-ETN029, 111In-ETN029
- Where
- 8 sites in United States, Canada and 2 more
- Volunteers
- 116 people
- Sponsor
- Novartis Pharmaceuticals
Multiple Sclerosis (MS)
Assessment of the Quality of Life of Multiple Sclerosis Patients Treated With Ofatumumab in Real-life in France
SEPROS is a non-interventional study, based on primary data collection of MS adult patients who initiated ofatumumab as per neurologist practice and regardless of the study protocol.
- Trial name
- SEPROS (NCT06157086)
- Testing
- ofatumumab
- Where
- 49 sites in France
- Volunteers
- 302 people
- Sponsor
- Novartis Pharmaceuticals
Diffuse Large B-cell-lymphoma
High-dose Chemotherapy and ASCT or Consolidating Conventional Chemotherapy in Primary CNS Lymphoma
In the presently planned multicentre Phase III trial the two therapies will be compared: Patients will be randomized after intensified induction treatment with 4 cycles rituximab, methotrexate, cytarabine and thiotepa (MATRix)…
- Trial name
- MATRix (NCT02531841)
- Testing
- Arm A (Fortecortin®-ETOPOPHOS®-IFO-cell®-CARBO-cell®), Arm B (TEPADINA®-CARMUBRIS®-Busilvex®)
- Where
- 2 sites in Germany
- Volunteers
- 250 people
- Sponsor
- University Hospital Freiburg
ELDRELY
Nutritional Status in Patients Over 65 Years of Age and Meal Presentation
The prevalence of undernutrition in hospitals is estimated between 30 and 40% and up to 50% in the elderly. The consequences of undernutrition are significant: complications, delayed healing, higher risk of infections, pressure…
- Trial name
- NUPOBA (NCT04696068)
- Testing
- Porcelain plates
- Volunteers
- 300 people
- Sponsor
- University Hospital, Caen
Postpartum Hemorrhage (Primary)
Effect of Extracellular Calcium on Carbetocin Mediated Contractility in Human Myometrium
Postpartum hemorrhage (PPH) continues to be an increasing problem globally. Uterotonics play an essential role in the pharmacological management of uterine atony.
- Trial name
- NCT06930391
- Testing
- Oxytocin, Carbetocin, Calcium
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Cystic Fibrosis
Primary Nasal Cell Culture as a Tool for Personalized Therapy in Cystic Fibrosis
characterization of CFTR function and expression in nasal primary cells collected from patients with cystic fibrosis in comparison to their parents, healthy heterozygotes and healthy controls
- Trial name
- Epiithelix (NCT03652090)
- Testing
- cell sampling
- Volunteers
- 112 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Chronic Limb-Threatening Ischemia
IVUS Guidance in BTK Interventions
Chronic limb-threatening ischemia (CLTI) is a severe form of peripheral artery disease in which very poor blood flow in the arteries below the knee can cause rest pain, non-healing wounds, and even loss of the limb.
- Trial name
- IMAGE-BTK (NCT07731997)
- Testing
- Intravascular ultrasound-guided EVT, Angiography-guided EVT
- Where
- 4 sites in Taiwan
- Volunteers
- 212 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Hygiene
Dermacyd PH_DETINBACK Tangerine Mix (Lactic Acid)- Compatibility
The purpose of this study is to demonstrate the absence of irritation potential (primary dermic irritability and cumulated dermic irritability) and allergy (sensibilization) of the product Dermacyd PHDETINBACK Tangerine Mix…
- Trial name
- NCT00784160
- Testing
- Lactic Acid (Dermacyd PH_DETINBACK Tangerine Mix)
- Where
- Brazil
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Sanofi
Coronary Stenosis, Stent Stenosis
Culotte Versus DK-CRUSH Technique in Non-left Main Coronary Bifurcation Lesions
Randomised comparison of Culotte technique versus "Double Kissing" - Crush technique (DK-Crush) for the percutaneous treatment of de novo non-left main coronary bifurcation lesions with modern everolimus-eluting stents (DES) …
- Trial name
- BBK-3 (NCT04192760)
- Testing
- Stenting
- Where
- 13 sites in Germany
- Volunteers
- 400 people
- Sponsor
- University Heart Center Freiburg - Bad Krozingen
Primary Dysmenorrhea
Auriculotherapy in the Treatment of Dysmenorrhea
This study aims to determine if auriculotherapy is effective in the treatment of dysmenorrhoea. This intervention consists of fixation of yellow mustard seeds at specific points of the auricular pavilion (or area), with opaque…
- Trial name
- NCT03148223
- Testing
- auriculotherapy
- Where
- Brazil
- Volunteers
- 74 people
- Sponsor
- University of Sorocaba
Gastrointestinal Stromal Tumors
Preoperative and Postoperative Imatinib Mesylate Study in Patients With c-Kit Positive GIST
Primary objectives 1. To determine whether induction of apoptosis or inhibition of angiogenesis are involved in the antitumor activity of (Gleevec, Formerly STI-571) in patients with gastrointestinal stromal tumors (GIST) as…
- Trial name
- NCT00500188
- Testing
- Imatinib Mesylate (Gleevec)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- M.D. Anderson Cancer Center
Problematic Behavior in Children
Prevention and Intervention of Externalizing Problem Behavior in School: Development and Evaluation of a Teacher Coaching.
Children with externalizing problem behaviour are at risk of developing educational impairment, because of their problems in rule following, social behaviour and attention. This behaviour represents a great challenge for teacher.
- Trial name
- NCT02116088
- Testing
- Teacher Coaching
- Where
- Germany
- Volunteers
- 53 people
- Sponsor
- University of Cologne
Pain, Cesarean Section
Intrathecal Hydromorphone for Pain Control After Cesarean Section
The use of intrathecal opioids for analgesia in the setting of cesarean section has become standard obstetric anesthesia practice. Currently, two opioids are commonly used. These opioids are fentanyl and morphine (Duramorph).
- Trial name
- NCT02096003
- Testing
- Intrathecal morphine, Intrathecal hydromorphone
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
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