Clinical trials: Primary
Muscle Weakness
Controlled Trial of 3,4-Diaminopyridine (3-4DAP) in Lambert-Eaton Myasthenic Syndrome (LEMS)
The main purpose for this study is to provide access to 3,4 DAP, a drug which has demonstrated to be effective in treating weakness associated with Lambert-Eaton Myasthenic Syndrome.
- Trial name
- 3-4DAP (NCT02090725)
- Testing
- 3-4 Diaminopyridine
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeffrey A. Cohen, MD
Movement Disorders, Heathly Subjects
Changes in the Posterior Parietal Cortex - Primary Motor Cortex Pathway Induced by Motor Training
Objective When learning to tap to a rhythm the brain has to coordinate information from different senses (eyes, ears, touch). This information has to be integrated into a movement plan to allow a smooth, continuous performance.
- Trial name
- NCT00904332
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cystic Fibrosis, Pulmonary Fibrosis
Role of Genetic Factors in the Development of Lung Disease
This study is designed to evaluate the genetics involved in the development of lung disease by surveying genes involved in the process of breathing and examining the genes in lung cells of patients with lung disease.
- Conditions
- Cystic Fibrosis, Pulmonary Fibrosis, Tuberous Sclerosis, Asthma
- Trial name
- NCT00001532
- Where
- 2 sites in United States
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Colorectal Cancer, Chemotherapy
Supportive Cancer Care Networkers (SCAN)
Aim of the study is to increase the proportion of indicated patients with colorectal cancer undergoing adjuvant chemotherapy following surgical resection through an optimized symptom management and logistical support.
- Trial name
- SCAN (NCT01651832)
- Testing
- SCAN
- Where
- 9 sites in Germany
- Volunteers
- 261 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Cirrhosis, Liver, Portal Hypertension
Beta-blockers or Placebo for Primary Prophylaxis (BOPPP) of Oesophageal Varices Trial.
Research has proven that large varices can be treated with beta-blockers (a type of anti-hypertensive medication) to reduce the pressure in the veins. The management of small varices is still uncertain.
- Conditions
- Cirrhosis, Liver, Portal Hypertension, Variceal Hemorrhage, Varices, Esophageal
- Trial name
- BOPPP (NCT05872698)
- Testing
- Carvedilol
- Where
- United Kingdom
- Volunteers
- 763 people
- Sponsor
- King's College Hospital NHS Trust
Myelofibrosis, Primary, Myelofibrosis, Post PV
Defining the Molecular Risk in Israeli Patients With Secondary Compared to Primary Myelofibrosis
The aim of the study is to determine the rate of HMR mutations in PMF and secondary MF (post PV/ET) subjects, and correlate the rate of mutations with clinical features as known prognostic scores.
- Conditions
- Myelofibrosis, Primary, Myelofibrosis, Post PV, Myelofibrosis, Post ET
- Trial name
- MRMF01 (NCT03402399)
- Testing
- Molecular analysis
- Where
- Israel
- Volunteers
- 222 people
- Sponsor
- Assaf-Harofeh Medical Center
Breast Cancer
TRIal evalUating the Menstrual and Ovarian Function of Young Breast Cancer Patients Treated With a cycloPHosphamide-free Regimen
Recently, there has been a rising trend of delaying childbearing and hence more women are diagnosed with breast cancer before completing their families.
- Trial name
- TRIUMPH (NCT02053597)
- Testing
- Doxorubicin, paclitaxel
- Where
- 4 sites in Belgium
- Sponsor
- Jules Bordet Institute
Relationship Problems Specific to Childhood and Adolescence
Mitigating Adverse Sexual and Reproductive Health Outcomes Among Young Adolescents
This study evaluates the effectiveness of comprehensive sexuality education (CSE) among young adolescents (10-14 years) in schools.
- Trial name
- NCT03669913
- Testing
- Lessons on comprehensive sexuality education
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Mbarara University of Science and Technology
FIGO Stage III and IV Ovarian Cancer, FIGO Stage III and IV Fallopian Tube Cancer
IP ALT-803 Followed by SQ ALT-803 for Ovarian Cancer
This is a single center, randomized phase II study of an IL-15Rα-Fc super-agonist complex (ALT-803) given as maintenance therapy after the completion of 1st line IV/IP chemotherapy for the treatment of advanced ovarian, fallopian…
- Conditions
- FIGO Stage III and IV Ovarian Cancer, FIGO Stage III and IV Fallopian Tube Cancer, FIGO Stage III Primary Peritoneal Cancer
- Trial name
- NCT03054909
- Testing
- ALT-803 Subcutaneous, ALT-803 Intraperitoneal
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Strep Throat, Pneumonia
Integrated Clinical Prediction Rules: Bringing Evidence to Diverse Primary Care Settings
The study is a randomized controlled trial, with an Intervention Group and a Control Group at the University of Utah (U of U) and University of Wisconsin (UW). BU serves as the primary award and coordinating institution.
- Trial name
- iCPR2 (NCT02534987)
- Testing
- iCPR2
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- NYU Langone Health
Knee Osteoarthritis
Intrawound Administration of Vancomycin in TKA
The purpose of this study is to determine the intra-articular and serum levels of vancomycin over the first 24 hours postoperatively after intra-articular administration of a standard dose of vancomycin in primary total knee…
- Trial name
- NCT05338021
- Testing
- Intrawound administration of vancomycin after closure of the arthrotomy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Affiliated Hospital of Qingdao University
Infertility
Optimal Balloon Catheter Placement During Sonohysterography
Saline infusion sonohysterography and other intrauterine investigations methods may cause uterine cramping, pain and vasovagal reactions.
- Trial name
- NCT01936116
- Testing
- sonohysterography with inflated catheter in uterine cavity, sonohysterography with inflated catheter in cervical cavity
- Where
- Iran
- Volunteers
- 300 people
- Sponsor
- Royan Institute
Wound Healing
Basement Membrane Regeneration for Wound Repair
This study is a prospective, multicenter, real-world observational study. It aims to evaluate the effectiveness and safety of autologous basement membrane regeneration technology (epidermal basal cell suspension prepared using a…
- Trial name
- NCT07551284
- Testing
- Autologous Epidermal Basal Cell Suspension
- Volunteers
- 1,000 people
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Mitral Valve Prolapse, Left Ventricular Fibrosis
PRIMARY Ancillary Substudy
The PRIMARY trial (NCT05051033), which compares mitral valve repair (MVr) to transcatheter-edge-to-edge-repair (TEER), offers a platform for conducting mechanistic studies to develop early insights into the pathophysiological…
- Conditions
- Mitral Valve Prolapse, Left Ventricular Fibrosis, Ventricular Arrhythmias
- Trial name
- NCT07103733
- Testing
- Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring, Myocardial Tissue Biopsy
- Where
- 25 sites in United States, Germany and 1 more
- Volunteers
- 250 people
- Sponsor
- Annetine Gelijns
Infections, Streptococcal
Primary and Booster Vaccination Study With Pneumococcal Vaccine GSK1024850A and Prophylactic Antipyretic Treatment
The aim of the current study is to determine whether ibuprofen, given as immediate or delayed prophylactic antipyretic treatment in a standardized manner, significantly impacts the immune response in children receiving primary…
- Trial name
- NCT01235949
- Testing
- GSK1024850A (SynflorixTM), Infanrix hexa, Infanrix-IPV/Hib
- Where
- 23 sites in Romania
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Myocardial Infarction
Prolonged Enoxaparin in Primary Percutaneous Coronary Intervention
This is a feasibility study aiming to generate pilot data on safety and efficacy of a novel anticoagulant regimen (enoxaparin bolus and prolonged infusion) compared to the local standard-of-care in opiate-treated patients…
- Trial name
- PENNYWISE (NCT03568838)
- Testing
- Enoxaparin
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Health Services, Comorbidity
Ambulatory ICU Study for Medically and Socially Complex Patients
This is a prospective randomized wait-list control study to determine whether a stand-alone, co-located team of physician, mental health behaviorist, and care coordinators with decreased panel size (aka "intensive primary care")…
- Conditions
- Health Services, Comorbidity, Primary Health Care
- Trial name
- SUMMIT (NCT03224858)
- Testing
- SUMMIT intervention, Enhanced usual care
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Cirrhoses, Liver, Oesophageal Varices
Beta-blockers for Oesophageal Varices
To determine if carvedilol reduces the rate of variceal haemorrhage in patients with cirrhosis and small oesophageal varices
- Trial name
- BOPPP (NCT03776955)
- Testing
- Carvedilol
- Where
- 4 sites in United Kingdom
- Volunteers
- 1,200 people
- Sponsor
- King's College Hospital NHS Trust
Fibromyalgia
Effect of Transcranial Static Magnetic Field Stimulation in Fibromyalgia Syndrome
The main objective is to know if the transcranial static magnetic field stimulation (tSMS) reduces the perception of pain in patients with fibromyalgia and its effect on health-related quality of life.
- Trial name
- TSMFS-FMS (NCT04836325)
- Testing
- transcranial static magnetic field stimulation (tSMS)
- Where
- Spain
- Volunteers
- 16 people
- Sponsor
- University of Seville
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