Clinical trials: Primary
Osteoarthritis, Hip
Outcomes Following Anterior Approach to Total Hip Arthroplasty
Osteoarthritis disables approximately 10% of people who are 60 years or older and compromises the quality of life of more than 20 million Americans every year.
- Trial name
- AAP (NCT01353885)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Headache, Migraine
New-onset Severe Headache After Covid-19 Vaccine
Hypotheses: 1. Severe new-onset headache after Covid-19 vaccine occur in a minor subset of vaccinated individuals. 2. Immunological reactivity with activation of trigeminal nociceptors can be among the mechanisms in severe…
- Conditions
- Headache, Migraine, COVID-19
- Trial name
- CovaxHEAD (NCT05235776)
- Testing
- observation
- Where
- 10 sites in Norway
- Volunteers
- 63 people
- Sponsor
- Oslo University Hospital
Alcohol Drinking, Sex Behavior
Alcohol and Implicit Process in Sexual Risk Behavior in MSM
The current study is the first empirical investigation that directly addresses the correspondence between responses regarding indicators of risky sexual behavior while under the influence of alcohol in the laboratory and the…
- Conditions
- Alcohol Drinking, Sex Behavior, Men
- Trial name
- NCT03361384
- Testing
- Alcohol
- Where
- 3 sites in United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Syracuse University
Primary Insomnia
The Effects of Modafinil on Waking Function and on Sleep in Individuals With Primary Insomnia
This study examines how treatment with the drug modafinil, by itself or in combination with cognitive behavioral treatment for insomnia (CBT-I), may improve daytime functioning and/or diminish the severity of insomnia.
- Trial name
- NCT00124384
- Testing
- CBT-I, modafinil
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Primary IgA Nephropathy
Replication of the NefIgArd Trial of TRF-budesonide in Primary IgAN
This replication of the NefIgArd trial of TRF-budesonide aims to use real-world data to evaluate the efficiency and safety of TRF-budesonide in the treatment of IgA nephropathy, from completing real-world research to providing…
- Trial name
- NCT06589752
- Testing
- TARPEYO 4 MG Delayed Release Oral Capsule, RAS inhibitor
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Ruijin Hospital
Ocular Hypertension, Glaucoma
Safety and Efficacy of AGN 210669 Ophthalmic Solution in Patients With Ocular Hypertension or Primary Open-Angle Glaucoma
The study will evaluate the safety and efficacy of AGN-210669 ophthalmic solution in comparison with AGN-210669 vehicle and bimatoprost ophthalmic solution dosed once-daily each morning, in subjects with ocular hypertension or…
- Trial name
- NCT00809848
- Testing
- AGN-210669 ophthalmic solution, 0.075%, AGN-210669 ophthalmic solution, 0.05%, AGN-210669 ophthalmic solution, 0.025%
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Allergan
Cerebellar Ataxia
Motor Learning After Cerebellar Damage: The Role of the Primary Motor Cortex
This study will determine (1) whether baseline inhibitory activity in the primary motor cortex can predict motor learning ability in individuals with cerebellar degeneration, and (2) whether modulating primary motor cortex…
- Trial name
- NCT05351255
- Testing
- Transcranial Magnetic Stimulation (TMS)
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Albert Einstein Healthcare Network
Dysmenorrhea Primary
A Study of Diclofenac Gel in Women With Primary Dysmenorrhea
The goal of this clinical trial is to compare 1% and 3% diclofenac gel (DARE-PDM1) to placebo in women with symptomatic primary dysmenorrhea.
- Trial name
- DARE-PDM1 (NCT05752526)
- Testing
- Diclofenac 1%, Diclofenac 3%
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Daré Bioscience, Inc.
Liver Metastasis Colon Cancer, Synchronous Neoplasm
Surgery Outcome Treated by Neo-adjuvant Combination of Oxaliplatin, Irinotecan, Folinic Acid and Fluorouracil (FOLFOXIRI) Regimen in Synchronous Liver Limited Metastasis Colorectal Cancer
This single arm study aims to evaluate the rate of conversion therapy in patients with unresectable liver-limited metastatic colorectal cancer (mCRC) using FOLFOXIRI neoadjuvant regimen and to assess the other outcome including…
- Trial name
- NCT05362825
- Testing
- Neo-adjuvant Chemotherapy FOLFOXIRI Regimen, synchronous resection surgery
- Where
- Vietnam
- Volunteers
- 89 people
- Sponsor
- Cho Ray Hospital
Hypertension, Left Ventricular Diastolic Dysfunction
Sacubitril/Valsartan Versus Valsartan Alone on Left Atrial Volume Index in Hypertensive Patients
Hypertension is a leading global risk factor for cardiovascular disease and is frequently associated with left atrial and ventricular remodeling, leading to subclinical diastolic dysfunction[cite: 2].
- Conditions
- Hypertension, Left Ventricular Diastolic Dysfunction, Essential (Primary) Hypertension
- Trial name
- NCT07853625
- Testing
- Sacubitril / Valsartan, Valsartan
- Volunteers
- 102 people
- Sponsor
- University of Health Sciences Lahore
Primary Sclerosing Cholangitis
Short-term Stenting Versus Balloon Dilatation for Dominant Strictures in Primary Sclerosing Cholangitis
Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of the biliary tract of unknown origin. Around 50% of patients develop during their disease course narrowing of the main bile duct with corresponding increase…
- Trial name
- NCT01398917
- Testing
- plastic endoprosthesis, balloon dilatation
- Where
- 4 sites in Belgium, Netherlands and 2 more
- Volunteers
- 100 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Migraine
Effects Of Dry Needling On Sternocleidomastoid Muscle For Pain And Disability In Migraine
To determine the effects, sequel of dry needling in migraine by resolving MTrPs in sternocleidomastoid muscle. To determine the possession of dry needling technique to mitigate the frequency, intensity and duration of headache.
- Trial name
- NCT05285852
- Testing
- Dry Needling
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Herombopag
A Clinical Study on the Efficacy and Safety of Herombopag in the Treatment of Senile Primary ITP
The objective of this study was to evaluate the efficacy and safety of Herombopag in the treatment of elderly patients with ITP.
- Trial name
- NCT06838949
- Testing
- herombopag olamine tablets
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Institute of Hematology & Blood Diseases Hospital, China
Breast Cancer, Leukemia
High-Dose Chemotherapy, Total-Body Irradiation, and Autologous Stem Cell Transplantation or Bone Marrow Transplantation in Treating Patients With Hematologic Cancer or Solid Tumors
RATIONALE: Radiation therapy uses high-energy x-rays to damage cancer cells. Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.
- Conditions
- Breast Cancer, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00060255
- Testing
- busulfan, carboplatin, carmustine
- Where
- United States
- Volunteers
- 451 people
- Sponsor
- Roswell Park Cancer Institute
Pulmonary Fibrosis of Any Cause, Primary Supporters/Caretakers of Patients With Pulmonary Fibrosis
Pulmonary Fibrosis Contact Registry
As the name states, contact registries securely store contact information from groups of reasonably well-characterized patients (or primary supporters/caregivers) who are interested in being informed about ongoing or future…
- Trial name
- NCT01935726
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Jewish Health
Digital Nerve Injuries
Sensory Recovery of Digital Nerves After Microsurgical Epineural Neurorrhaphy Alone or in Combination With Tisseel - RET
Evaluation of sensitivity after primary surgical treatment of digital nerve injuries with microsurgical epineural end-to-end neurorrhaphy alone or in combination with the fibrin glue Tisseel®
- Trial name
- RET (NCT05490940)
- Testing
- Tisseel®
- Where
- Switzerland
- Volunteers
- 74 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Primary Adrenal Insufficiency
Screening and Stimulation Testing for Residual Secretion of Adrenal Steroid Hormones in Autoimmune Addison's Disease
In autoimmune adrenal insufficiency, or Addison's disease (AD), the immune system attacks the adrenal cortex. As a result, the adrenal cells producing hormones such as cortisol and aldosterone are destroyed, leaving the body with…
- Trial name
- NCT03793114
- Testing
- Cosyntropin stimulation test, Baseline blood tests, 30-hour ambulatory sampling of intestinal fluid
- Where
- 3 sites in Germany, Norway and 1 more
- Volunteers
- 200 people
- Sponsor
- University of Bergen
Psychosocial, Narrative
Psychosocial Wellbeing Following Stroke
The purpose of this feasibility study is to develop and initially test a dialogue-based psychosocial intervention aimed at promoting coping and psychosocial wellbeing following an acute stroke.
- Conditions
- Psychosocial, Narrative, Coping, Quality of Life
- Trial name
- NCT01912014
- Testing
- Psychosocial support and counselling
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- University of Oslo
Ovarian Cancer, Fallopian Tube Cancers
Targeting Immune Modulation in High Grade Serous Carcinoma: Combined Effects of Chemotherapy and Atorvastatin
The goal of this clinical trial is to learn how atorvastatin in patients with advanced high grade serous cancer of the ovary, fallopian tube, or peritoneum changes the tumor immune environment.
- Conditions
- Ovarian Cancer, Fallopian Tube Cancers, Primary Peritoneal Cancer, High Grade Serous Adenocarcinoma of Ovary
- Trial name
- NCT07815704
- Testing
- Standard of Care + atorvastatin, Standard of Care (SOC)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Metabolic Disorders in Children
Early Detection of Metabolic Syndrome and Obesity Comorbidities
To assess : Compare predictive value of waist to-height ratio and bio-electrical impedance analysis versus BMI in early detection of metabolic syndrome parameters and complication of obesity.
- Trial name
- NCT05681104
- Testing
- Waist-height ratio, body mass index, Bio-electrical impedance analysis
- Volunteers
- 275 people
- Sponsor
- Assiut University
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