Clinical trials: Primary
Breast Cancer, Lung Cancer
18F-ASIS PET/CT Imaging of Tissue Factor Expression In Patients With Primary and Metastastic Cancer
The primary objective of the trial is to test the new radio tracer 18F-ASIS for PET imaging of tissue factor (TF) expression. The tracer has the potential of identifying tumors with high levels of TF expression, which is expected…
- Conditions
- Breast Cancer, Lung Cancer, Pancreatic Cancer, Ovarian Cancer
- Trial name
- NCT03790423
- Testing
- Injection of 18F-ASIS, PET/CT scan
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Primary Biliary Cirrhosis
Fenofibrate in Combination With Ursodeoxycholic Acid (UDCA) in Primary Biliary Cirrhosis
The purpose of this study is to determine if the combination of ursodeoxycholic acid (UDCA) and fenofibrate is more effective than UDCA alone in the treatment of primary biliary cirrhosis.
- Trial name
- NCT01141296
- Testing
- fenofibrate
- Where
- 2 sites in United States
- Sponsor
- University of Miami
Primary Liver Cancer
Chinese Liver Cancer Clinical Survey
In order to make better use of clinical resources of the real world, strengthen the standardization of PLC diagnosis and treatment, and constantly improve the academic level of liver cancer in China, we intends to launch "Chinese…
- Trial name
- CLCS (NCT03161925)
- Volunteers
- 5,000 people
- Sponsor
- Beijing Insight Science & Technology Co. Ltd.
Ovarian Cancer, Primary Peritoneal Cavity Cancer
Paclitaxel and Cisplatin in Treating Patients With Stage III or Stage IV Ovarian Cancer or Primary Peritoneal Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00002717
- Testing
- cisplatin, paclitaxel
- Where
- 52 sites in United States
- Volunteers
- 324 people
- Sponsor
- Gynecologic Oncology Group
Aneurysm
Thoracic Endoprosthesis for Treatment of Aneurysm of the Descending Thoracic Aortic
To assess the safety and efficacy of the GORE Conformable TAG® Thoracic Endoprosthesis in the primary treatment of aneurysm of the descending thoracic aorta (DTA) > Primary Hypothesis: The proportion of subjects free from a major…
- Trial name
- NCT00874250
- Testing
- GORE CTAG Device
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- W.L.Gore & Associates
Fibromyalgia, Primary
An Eight Week, Double-Blind Efficacy Study of Armodafinil Augmentation to Alleviate Fibromyalgia Fatigue
Armodafinil (NuvigilTM) is an isomer of a drug currently approved by the FDA for the treatment of fatigue secondary to narcolepsy, sleep apnea, and shift work sleep disorder called modafinil (ProvigilTM).
- Trial name
- NCT00678691
- Testing
- armodafinil
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- State University of New York - Upstate Medical University
Obesity, Overweight
PACE-PC: Primary Care Management of Adolescent Obesity
This 12-month randomized controlled trial, sponsored by NIH/NCI, aims to reduce BMI in obese adolescents (ages 11 -13) by intervening on physical activity and nutrition behaviors within primary care settings.
- Conditions
- Obesity, Overweight, Weight Loss
- Trial name
- NCT00415974
- Testing
- Physician Counseling, Health Educator, Phone Counseling
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- University of California, San Diego
Bile Duct Obstruction, Extrahepatic
Ultrasound-guided Percutaneous Biliary Drainage With Primary Metal Implantation by Endoscopic Luminal Guidance
In a recently published meta-analysis (Sharaiha, Gastrointestinal Endoscopy, 2017), it is reported that percutaneous transhepatic biliary drainage (PTBD) is less clinical successful, causes more adverse events and needs more…
- Trial name
- NCT03541590
- Testing
- Percutaneous transhepatic biliary drainage
- Where
- Germany
- Volunteers
- 66 people
- Sponsor
- Theresienkrankenhaus und St. Hedwig-Klinik GmbH
Deep Vein Thrombosis
Rheolytic Thrombectomy For Acute Deep Vein Thrombosis Of Whole Lower Limb
Ipsilateral popliteal venous the most common access for pharmacomechanical thrombectomy (PMT) in the treatment of acute deep venous thrombosis (DVT), but the result was not satisfactory.
- Trial name
- NCT05286710
- Testing
- pharmacomechanical thrombectomy (PMT)
- Where
- China
- Volunteers
- 160 people
- Sponsor
- RenJi Hospital
Non-severe Aplastic Anemia
Safety and Effectiveness of Trappa Ethanolamine Tablets Combined With Ciclosporin in the Treatment of Primary Treatment of Non-severe Aplastic Anemia
This is a multicenter, randomized, double-blind, and open-label, placebo-controlled phase II clinical study. In order to evaluate the effectiveness and safety of trappa ethanolamine tablets combined with ciclosporin in the…
- Trial name
- NCT05797623
- Testing
- Trappa ethanolamine tablets ; ciclosporin
- Where
- China
- Volunteers
- 78 people
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Obesity (Disorder)
AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR OBESITY AND CARDIOVASCULAR DISEASE PRIMARY PREVENTION IN YOUTH
The goal of this clinical trial is to learn if an AI-based peer-mentoring works to prevent obesity in adolescents and young adults.
- Trial name
- PeerMentorOBCV (NCT07505459)
- Testing
- AI-informed behavioral intervention, Standard behavioral intervention, Health Education
- Where
- 3 sites in Greece, Italy and 1 more
- Volunteers
- 840 people, healthy volunteers welcome
- Sponsor
- Aikaterini Karaivazoglou
Patent Foramen Ovale
PFx Closure System in Subjects With Cryptogenic Stroke,Transient Ischemic Attack,Migraine or Decompression Illness(PFO)
The primary objective of this study is to demonstrate the safety and performance of the PFx Closure System when utilized for patients with PFOs suffering from cryptogenic stroke, transient ischemic attack, migraine or…
- Trial name
- NCT00335296
- Testing
- PFx catheter
- Where
- 4 sites in Belgium, France and 1 more
- Volunteers
- 100 people
- Sponsor
- Cierra
Primary Immunodeficiency
An Open-label, Multicenter Study to Assess the Pharmacokinetics (PK), Safety, and Tolerability of Subcutaneous IgPro20 in Immunoglobulin (IG) Treatment-naïve Participants With Primary Immunodeficiency (PID)
This is an open-label, multicenter, phase 4 study in IG treatment-naïve participants with PID, conducted in the United States (US), to assess the PK, safety, and tolerability of IgPro20.
- Trial name
- NCT07076446
- Testing
- IgPro
- Where
- 8 sites in United States
- Volunteers
- 8 people
- Sponsor
- CSL Behring
B Acute Lymphoblastic Leukemia With t(v;11q23.3); KMT2A Rearranged, Recurrent B Acute Lymphoblastic Leukemia
CD19-Specific T Cells Post AlloSCT
This phase I trial investigates the side effects and best dose of CD19 positive (+) specific CAR-T cells in treating patients with CD19+ lymphoid malignancies, such as acute lymphoblastic leukemia, non-Hodgkin lymphoma, small…
- Conditions
- B Acute Lymphoblastic Leukemia With t(v;11q23.3); KMT2A Rearranged, Recurrent B Acute Lymphoblastic Leukemia, Recurrent Chronic Lymphocytic Leukemia, Recurrent Diffuse Large B-Cell Lymphoma, Not Otherwise Specified
- Trial name
- NCT03579888
- Testing
- Autologous CD19-CD8-CD28-CD3zeta-CAR-mbIL15-HER1t T Cells, Cyclophosphamide, Fludarabine
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Hypertension
Observational Study That Will Evaluate Treatment Patterns in the Management of Hypertension in the Public Primary Care System
This is a retrospective observational cohort study based on secondary use of routinely collected electronic health data. The design was selected to enable population-level characterisation of treatment patterns and clinical…
- Trial name
- CLEAR-HTN (NCT07361276)
- Where
- Brazil
- Volunteers
- 15,000 people
- Sponsor
- AstraZeneca
Hodgkin Lymphoma
Pembrolizumab and Involved Site Radiation Therapy for Early Stage Relapsed or Primary Refractory Hodgkin Lymphoma
This study is being done to test the safety and effectiveness of pembrolizumab followed by radiation therapy in Hodgkin lymphoma.
- Trial name
- NCT03179917
- Testing
- Pembrolizumab, Involved Site Radiation Therapy
- Where
- 9 sites in United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pediatric Hypertension
Boosting Primary Care Awareness and Treatment of Childhood Hypertension
The proposed research, building on an ongoing AHRQ-funded research project to prevent pediatric diagnostic errors in primary care (R01HS023608) and using a prospective, cluster-randomized, stepped wedge design, will investigate…
- Trial name
- BP-CATCH (NCT03783650)
- Testing
- Control condition, QIC with PCP and without subspecialist, QIC with Subspecialist
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Infections, Pneumonia
Natural History, Management, and Genetics of the Hyperimmunoglobulin E Recurrent Infection Syndrome (HIES)
The Hyper IgE Syndromes (HIES) are primary immunodeficiencies resulting in eczema and recurrent skin and lung infections. Autosomal dominant Hyper IgE syndrome (AD-HIIES; Job's syndrome) is caused by STAT3 mutations, and is a…
- Conditions
- Infections, Pneumonia, Immune System Diseases, STAT3 Transcription Factor
- Trial name
- NCT00006150
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Parkinsonism, Transcranial Magnetic Stimilation
Clinical Efficacy of Intermittent Theta Burst Transcranial Magnetic Stimulation With Different Modes on Parkinson's Disease
TMS regulates cortical excitability through electromagnetic induction, with low-frequency stimulation suppressing and high-frequency stimulation enhancing excitability.
- Conditions
- Parkinsonism, Transcranial Magnetic Stimilation, Intermittent Theta Burst Stimulation, Primary Motor Cortex
- Trial name
- NCT07176091
- Testing
- High-dose iTBS treatment group, Low-dose iTBS treatment group
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Second Affiliated Hospital of Soochow University
Glaucoma Open-Angle Primary, Ocular Hypertension
Open-Label Study of Safety of H1337 in Healthy Volunteers
The trial will evaluate the safety of one dose regimen of H-1337 [1% twice daily (b.i.d.)] in both eyes in healthy volunteers.
- Trial name
- NCT06572397
- Testing
- H-1337 1.0%
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- D. Western Therapeutics Institute, Inc.
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