Clinical trials: Primary
Migraine
Feasibility of Using a Mobile Device Controlled Micro-pressure Pulse Insufflator for Acute Migraine Relief
Evaluate the feasibility of using a mobile interface to control the insufflator device administering treatment for aborting (stopping) an acute episode of migraine.
- Trial name
- NCT03263897
- Testing
- insufflation
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- Caps Research Network
IGF1 Deficiency
Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).
The Increlex® Global Registry is a descriptive, multicenter, observational, prospective, open-ended, non interventional, post-authorisation surveillance registry.
- Trial name
- NCT00903110
- Testing
- Increlex®
- Where
- 58 sites in United States, Austria and 9 more
- Volunteers
- 500 people
- Sponsor
- Esteve Pharmaceuticals, S.A.
Osteoarthritis
A Study Comparing Ceramic-on-metal Articulation to Metal-on-metal Articulation in Cementless Primary Hip Arthroplasty
The aim of this study is to demonstrate the non-inferiority of the ceramic on metal articulation using M2a-38™ mm cup compared to the metal on metal articulation using the same cup.
- Trial name
- NCT00754520
- Testing
- Ceramic On Metal, Metal on Metal
- Where
- 3 sites in Finland, United Kingdom
- Volunteers
- 213 people
- Sponsor
- Zimmer Biomet
Primary Peritoneal Carcinoma, Recurrent Ovarian Carcinoma
CT-2103 in Treating Patients With Recurrent or Persistent Ovarian Epithelial Cancer or Primary Peritoneal Cancer
Phase II trial to study the effectiveness of CT-2103 in treating patients who have recurrent or persistent ovarian epithelial cancer or primary peritoneal cancer.
- Trial name
- NCT00045682
- Testing
- Paclitaxel Poliglumex
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- Gynecologic Oncology Group
Primary Immune Thrombocytopenia
Effect of DNMT SNPs on DNA Methylation in Primary ITP
To compare global DNA methylation status between ITP patients and healthy subjects . To determine the effect of DNMT3A -448 G/A SNP variant A allele and DNMT3B -149C/T SNP variant T-allele on global DNA methylation in both ITP…
- Trial name
- NCT04100876
- Testing
- Global DNA methylation will be quantified in the DNA samples by colorimetry
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assiut University
Migraine Without Aura
Ibuprofen in Migraine Patients
In this study, the investigators planned to compare the effectiveness of an intravenous ibuprofen against an intravenous dexketoprofen among patients (18-65 years) who were admitted to the emergency department (ED) with acute…
- Trial name
- NCT04533568
- Testing
- Ibuprofen 400 mg, Dexketoprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 160 people
- Sponsor
- Kecioren Education and Training Hospital
Choroidal Melanoma, Indeterminate Lesions
A Phase 3 Randomized, Masked, Controlled Trial to Evaluate Efficacy and Safety of Belzupacap Sarotalocan (AU-011) Treatment Compared to Sham Control in Subjects With Primary Indeterminate Lesions or Small Choroidal Melanoma
The primary objective is to determine the safety and efficacy of belzupacap sarotalocan (bel-sar) compared to sham control in patients with primary indeterminate lesions (IL) or small choroidal melanoma (CM).
- Conditions
- Choroidal Melanoma, Indeterminate Lesions, Uveal Melanoma, Ocular Melanoma
- Trial name
- CoMpass (NCT06007690)
- Testing
- Bel-sar, Suprachoroidal Microinjector, Infrared Laser
- Where
- 53 sites in United States, Australia and 12 more
- Volunteers
- 108 people
- Sponsor
- Aura Biosciences
Diet Modification
Therapeutic Nutrition With Technology in Primary Care
Low-carbohydrate diets (less than approximately 130 grams per day) are emerging as an efficacious treatment option with several studies supporting weight loss and remission of type 2 diabetes.
- Trial name
- NCT04616482
- Testing
- Digital therapeutic carbohydrate restriction (TCR) program
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University of British Columbia
Menstrual Pain
Effectiveness of Additional Self-care Acupressure for Women With Menstrual Pain Compared to Usual Care Alone
The aim of the study is to evaluate the effectiveness of additional self-care acupressure in women with menstrual pain compared to usual care alone.
- Trial name
- AKUD (NCT01582724)
- Testing
- Self-care acupressure at three predefined points
- Where
- Germany
- Volunteers
- 220 people
- Sponsor
- Charite University, Berlin, Germany
Anastomosis, Leaking
THE ROLE OF C-REACTIVE PROTEIN (CRP) IN THE EARLY DIAGNOSIS OF ANASTOMOTIC LEAKAGE FOLLOWING PRIMARY REPAIR IN GASTROINTESTINAL SURGERY
Despite advancements in surgical procedures, Anastomotic leakage (AL) remains a common complication following gastrointestinal surgery.
- Trial name
- NCT07763379
- Testing
- c-reactive protein
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Dental Caries
3D-Printed Resin Crowns vs Stainless Steel Crowns in Pulpotomized Primary Molars.
The goal of this clinical trial is to learn whether 3D-printed resin-based crowns are an effective alternative to stainless steel crowns for restoring pulpotomized primary mandibular molars in children.
- Trial name
- 3DRSCVSSSC (NCT07648979)
- Testing
- 3D printed resin based crowns, Prefabricated stainless steel crowns
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University
Stroke
Stroke COunseling for Risk REduction
The purpose of this study is to test the efficacy of the Stroke Counseling for Risk Reduction (SCORRE) intervention in increasing accuracy of perceived stroke risk and promoting lifestyle behavior change to reduce stroke risk in…
- Trial name
- SCORRE (NCT03076125)
- Testing
- SCORRE, Attention-Control Activity
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Georgia State University
Primary Insomnia
Study of the Insomnia in Patients With Low Back Pain
The purpose of this study is to examine whether insomnia due to chronic low back pain can improve with use of eszopiclone.
- Trial name
- NCT00365976
- Testing
- Eszopiclone
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- Duke University
Cancer
Cancer Prevention Among Individuals with Mental Ill-health: Patient Navigation for Primary Cancer Prevention
Prevention is essential for reducing cancer-related mortality. However, people with mental ill-health often face difficulties in accessing cancer prevention services.
- Trial name
- CO-CAPTAIN (NCT06435117)
- Testing
- Patient Navigation
- Where
- 9 sites in Austria, Greece and 2 more
- Volunteers
- 1,240 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Unipolar Depression
RCT of Psychoeducational Program of Depression
The purpose of the study is to test the efficacy of a psychoeducational group program on unipolar depression
- Trial name
- NCT00319540
- Testing
- Control with depression course (CWD)
- Where
- Norway
- Volunteers
- 155 people
- Sponsor
- Norwegian Institute of Public Health
Severe Combined Immunodeficiency Syndrome
Gene Transfer Therapy for Severe Combined Immunodeficieny Disease (SCID) Due to Adenosine Deaminase (ADA) Deficiency
This study will evaluate a new method for delivering gene transfer therapy to patients with severe combined immunodeficiency disease (SCID) due to a defective adenosine deaminase (ADA) gene.
- Trial name
- NCT00018018
- Testing
- CD34+ cells transduced with ADA retrovir
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Human Genome Research Institute (NHGRI)
Radiation Caries
Nano-Silver Versus Bioactive Glass for Primary Teeth Exposed to Therapeutic Radiation
This study aims to evaluate and compare the remineralizing and antimicrobial effects of nano silver fluoride and bioactive glass gel on primary teeth exposed to therapeutic radiation.
- Trial name
- NCT07866482
- Testing
- Nano Silver Fluoride, Bioactive Glass Gel
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Faculty of Dental Medicine for Girls
Chronic Pain
Impact of QoLibri Medical Device on the Consequences of Chronic Pain: a Randomized Controlled Trial
A superiority study evaluating the impact of the QoLibri Software as Medical Device on functional and psychological consequences of chronic pain in primary care patients.
- Trial name
- QoLiDoc (NCT06841276)
- Testing
- QoLibri Digital Therapy
- Where
- France
- Volunteers
- 410 people
- Sponsor
- Novesia
Hypertension,Essential, White Coat Hypertension
Implementing Hypertension Screening Guidelines in Primary Care
The goal of this study is to use a cluster-randomized design (1:1 ratio) among 8 primary care clinics affiliated with New York-Presbyterian Hospital to test the effectiveness of a theory-informed multifaceted implementation…
- Trial name
- EMBRACE (NCT03480217)
- Testing
- Multifaceted Implementation Strategy, Usual care
- Where
- 2 sites in United States
- Volunteers
- 1,186 people
- Sponsor
- Columbia University
Menopause, Migraine
The Functional Magnetic Resonance Imaging Study on the Processing of Acute Pain and Cognition Among Perimenopause Women
There lacks effective early screen system for the migraine-susceptible women during the peri-menopause period. The processing of acute pain and cognition as well as the underling functional magnetic resonance imaging (fMRI)…
- Trial name
- NCT02820974
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
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