Clinical trials: Primary
Modified Fixed Bridge
3D Printed vs CAD/CAM Rehabilitation of Primary Anterior Teeth Loss
compare 3D Printed versus CAD/CAM fabricated modified fixed appliance for rehabilitation of premature loss of anterior teeth in preschool children
- Trial name
- NCT07752147
- Testing
- 3D Printed modified fixed bridge, CAD/CAM fabricated modified fixed bridge
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Tanta University
Primary Open Angle Glaucoma (POAG)
Direct Selective Laser Trabeculoplasty (DSLT) for Reducing Eye Pressure in Non-Caucasian Patients With Open Angle Glaucoma
The goal of this clinical trial is to to evaluate how well Direct Selective Laser Trabeculoplasty (DSLT) lowers eye pressure in eyes of adult, non-Caucasian participants with primary open angle glaucoma.
- Trial name
- NCT07147647
- Testing
- Direct Selective Laser Trabeculoplasty
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Select Eye Care
Primary Open-angle Glaucoma
Safety and Effectiveness of VISULAS Green Selective Laser Trabeculoplasty (SLT)
An interventional, open, prospective, multi-center pre-market clinical investigation according to §§20-23a Medizinproduktegesetz (MPG, medical devices act), in which a total of 40 eyes of 40 consecutive patients at up to five (5)…
- Trial name
- NCT04519814
- Testing
- selective laser trabeculoplasty (SLT)
- Where
- 5 sites in Germany
- Volunteers
- 37 people
- Sponsor
- Carl Zeiss Meditec AG
Myelofibrosis
To Evaluate the Effect of Food on the Pharmacokinetics of TQ05105 Tablets in Healthy Adult Subjects
TQ05105 is a class 1 new drug with a new chemical structure developed by Chia Tai Tianqing Pharmaceutical Group Co., Ltd. It is a Janus Kinase 2 （JAK2）inhibitor and can be used to treat JAK2 target-related diseases.
- Trial name
- NCT05982106
- Testing
- TQ05105 Tablets
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Leukemia, Lung Cancer
Vaccine Therapy and GM-CSF in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndromes, Non-Small Cell Lung Cancer, or Mesothelioma
RATIONALE: Vaccines made from peptides may help the body build an effective immune response to kill cancer cells. Biological therapies, such as GM-CSF, may stimulate the immune system in different ways and stop cancer cells from…
- Conditions
- Leukemia, Lung Cancer, Malignant Mesothelioma, Myelodysplastic Syndromes
- Trial name
- NCT00398138
- Testing
- WT-1 analog peptide vaccine, incomplete Freund's adjuvant, sargramostim
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Uterine Sarcoma
IRCI Gynae Sarcomas, High Grade Uterine Sarcoma
This study aims to investigate a drug called Cabozantinib which belongs to a family of drugs that have effects on tumour growth, blood supply, invasion and spread.
- Trial name
- NCT01979393
- Testing
- Cabozantinib
- Where
- 15 sites in France, Italy and 3 more
- Volunteers
- 58 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Ulcer
PRP ULCERAS: Clinical Trial Phase III
INTRODUCTION: Vascular ulcers are an important pathology in the daily medical practice in all the assistance levels, and they have big repercussion referring to individual, social and labour levels, supposing a big consumption of…
- Trial name
- PRPULCERAS (NCT02213952)
- Testing
- Platelet-Rich Plasma, Usual treatment
- Where
- 2 sites in Spain
- Sponsor
- Basque Health Service
Papillary Thyroid Cancer
Percutaneous Ethanol Injection for Primary Papillary Thyroid Microcarcinoma
We assess the effectiveness of percutaneous ethanol ablation for the treatment of thyroid cancer.
- Trial name
- NCT01974284
- Testing
- percutaneous ethanol ablation
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Yale University
Postural Tachycardia Syndrome, Orthostatic Tachycardia
Acute Salt Handling in Orthostatic Intolerance
The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control…
- Conditions
- Postural Tachycardia Syndrome, Orthostatic Tachycardia, Orthostatic Intolerance
- Trial name
- NCT00581633
- Testing
- normal saline (0.9%)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Psychosis, Psychotic Disorders
Acceptability, Feasibility and Preliminary Outcomes of the Kiso Mind App for Outpatients With Schizophrenia Spectrum Disorders
The Kiso pilot study is a randomized controlled trial to test the acceptability and feasibility of a novel digital intervention, namely the Kiso Mind smartphone app. A parallel-group design is utilized.
- Conditions
- Psychosis, Psychotic Disorders, Primary Psychotic Disorders, Schizophrenia Spectrum Disorders
- Trial name
- KISO (NCT07395206)
- Testing
- Digital: Kiso Mind App
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Lymphoma, B Cell, Lymphoma Non-Hodgkin
A Phase 1/2 Study of UB-VV400 With Rapamycin in Relapsed/Refractory B-cell Malignancies
This study is a Phase 1/2 dose-finding and dose-confirmation study to evaluate the safety and antitumor activity of UB-VV400. The study will enroll patients with relapsed/refractory B-cell malignancies, including large B-cell…
- Conditions
- Lymphoma, B Cell, Lymphoma Non-Hodgkin, High Grade B Cell Lymphoma, Richter Transformation Lymphoma
- Trial name
- NCT07735533
- Testing
- UB-VV400, Rapamycin (sirolimus)
- Where
- United States
- Volunteers
- 274 people
- Sponsor
- Umoja Biopharma
Primary Gout
Immune Molecular and Inflammatory Cytokines Dysfunction Analysis in Gout Patients With Different Urate Levels
The aim of study was to assess the efficiency and safety of oral IL-1βinhibitor in combination with urate lowering therapy on joint pain intensity,urate control, global assessments of disease activity, self-monitored gouty acute…
- Trial name
- NCT02060552
- Testing
- Diacerein, Colchicine, Febuxostat
- Where
- China
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Tongji Hospital
Primary Insomnia
A High Density EEG Comparison of Sleep Patterns in Insomnia
Insomnia, defined as a subjective report of difficulty initiating sleep, maintaining sleep, and/or non-restorative sleep, leads to significant daytime dysfunction and increased health risks.
- Trial name
- NCT01960452
- Testing
- Serial awakenings
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Migraine
Effect of Manual Therapy on Migraine in Postmenopausal Women
The purpose of the study is to determine the effect of manual therapy on migraine in postmenopausal women.
- Trial name
- NCT07127107
- Testing
- Non-steroidal anti-inflammatory drugs (NSAIDs), Manual therapy techniques
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Accidental Fall
Evaluating the Cost Effectiveness of STEADI
Stopping Elderly Accidents, Deaths, and Injuries (STEADI) is an intervention to prevent falls among older adults developed by the Centers for Disease Control \& Prevention (CDC).
- Trial name
- STEADI (NCT05390736)
- Testing
- Gait and balance assessment, Medication review, Comorbidity review
- Where
- United States
- Volunteers
- 780 people
- Sponsor
- National Opinion Research Center
Gastrointestinal Dysmotility
Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal Function
Post-operative administration of ipamorelin is expected to reduce time to recovery of Gastrointestinal (GI) function in patients who have undergone partial small and/or large bowel resection.
- Trial name
- NCT01280344
- Testing
- Saline Solution for Injection, Ipamorelin
- Where
- 45 sites in United States
- Volunteers
- 320 people
- Sponsor
- Helsinn Therapeutics (U.S.), Inc
Brain Tumor Adult, Brain Metastases From Solid Tumors
Evaluating Biomarkers of Cognitive Dysfunction in Patients With Cancer
This study investigates the effects of brain radiotherapy on cognitive function by evaluating plasma biomarkers and apolipoprotein E (APOE) genotype in patients with primary or metastatic brain tumors.
- Conditions
- Brain Tumor Adult, Brain Metastases From Solid Tumors, Brain Tumor, Primary, Brain Tumor
- Trial name
- NCT07226466
- Testing
- Blood sample, Brain magnetic resonance imaging (MRI), Brain Health Assessment
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Francisco
Moderate to Severe Traumatic Brain Injury
Continuous Hyperosomolar Therapy for Traumatic Brain-injured Patients
Traumatic brain injury (TBI) is a major cause of death and severe prolonged disability. Intracranial hypertension (ICH) is a critical risk factor of bad outcomes after TBI.
- Trial name
- COBI (NCT03143751)
- Testing
- NaCl20% (Continuous hyperosmolar therapy)
- Where
- 10 sites in France
- Volunteers
- 370 people
- Sponsor
- Nantes University Hospital
Migraine
CHOCOlate MeLatonin for AdolescenT MigrainE
Existing treatments for acute migraine are not effective for all children and adolescents, and can cause side effects. Investigator propose a dose-finding study of melatonin for acute migraine treatment in children and…
- Trial name
- CHOCOLATE (NCT03597529)
- Testing
- Melatonin
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Amy Gelfand
Caries, Dental, Caries; Dentin
3D-printed Ceromer Crowns Versus Stainless Steel in Posterior Primary Molars
The aim of the study is to compare preformed metal crowns and 3D-printed ceromer crowns in primary molars of 4-9 years old children.
- Conditions
- Caries, Dental, Caries; Dentin, Dental Caries in Children
- Trial name
- NCT07091331
- Testing
- Personalized 3D-printed pediatric ceromer crown, Prefabricated stainless steel crown group
- Where
- Mexico
- Volunteers
- 40 people
- Sponsor
- Universidad Autonoma de Baja California
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