Clinical trials: Primary
Idiopathic Parkinson Disease, Primary Parkinsonism
Evaluation of Safety and Tolerability of Fetal Mesencephalic Dopamine Neuronal Precursor Cells for Parkinson's Disease
The purpose of clinical trials is to evaluate safety and tolerability of Fetal Mesencephalic Dopamine Neuronal Precursor Cells as a treatment for Patients with Parkinson's disease.
- Trial name
- NCT01860794
- Testing
- Mesencephalic Neuronal Precursor Cells
- Where
- South Korea
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Bundang CHA Hospital
Preterm
Alliance for Family Integrated Care Implementation in Neonatal Intensive Care Units
International, multi-centre, pluri-cultural, stepped wedge cluster controlled trial, to demonstrate superiority of site tailored 'Family integrated care model'(FICare), that promotes the active participation of the parents as…
- Trial name
- RISEinFAMILY (NCT06087666)
- Testing
- FICare
- Where
- 2 sites in Spain, Turkey (Türkiye)
- Volunteers
- 12 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Substance Use Disorders
Recovery Management Checkups for Primary Care Experiment
National data show that only 8% of people with past-year substance use disorders (SUD) received any treatment for these disorders in the past year, resulting in high costs, both in terms of their own health and functioning and…
- Trial name
- RMC-PC (NCT03746756)
- Testing
- SBIRT, SBIRT+RMC-PC
- Where
- 4 sites in United States
- Volunteers
- 266 people
- Sponsor
- Chestnut Health Systems
Type 2 Diabetes Mellitus, Primary Prevention
The Impact of a Diabetes Risk Prediction Model in Primary Care.
Little evidence exists on the impact of diabetes risk scores, e.g. on physicians and patient's behavior, perceived risk of persons, shared-decision making and particularly on patient´s health.
- Trial name
- NCT03234322
- Testing
- external validated risk prediction model
- Where
- Germany
- Volunteers
- 315 people, healthy volunteers welcome
- Sponsor
- German Diabetes Center
STEMI - ST Elevation Myocardial Infarction
Reperfusion Approach in Predicted In-hospital Delay for Primary PCI in STEMI
This study aims at evaluating of the effectiveness of in-hospital thrombolysis for ST-segment elevation myocardial infarction in PCI centers under conditions of predicted in-hospital delay (>60 min after admission in PCI-center)…
- Trial name
- RAPID-STEMI (NCT07641231)
- Testing
- Single, weight-adjusted i.v. bolus of tenecteplase, catheterisation
- Where
- Russia
- Volunteers
- 240 people
- Sponsor
- National Medical Research Center for Cardiology, Ministry of Health of Russian Federation
Primary Sjögren Syndrome
Pilot Trial of Ustekinumab for Primary Sjögren's Syndrome
This pilot study will make a preliminary determination of the safety of ustekinumab in patients with Primary Sjogren's Syndrome (PSS) and assess the response of systemic measures of inflammation (biomarkers).
- Trial name
- NCT04093531
- Testing
- Ustekinumab
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Rochester
Multiple Primary Lung Cancer
ENB Guided MWA Combined With VATS Versus Sequential Surgery for Synchronous Bilateral Multiple Primary Lung Nodules
The goal of this clinical trial is to evaluate the safety and efficacy of ENB guided MWA combined with VATS versus sequential surgery for synchronous bilateral multiple primary lung nodules.
- Trial name
- NCT05662553
- Testing
- ENB guided MWA combined with VATS, sequential surgery
- Where
- China
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Depression, Adolescent Behavior
Adolescent Depression Screening and Treatment in Mozambican Primary Care
This is a cluster-randomized pilot trial of depression screening and treatment implementation at four Youth-friendly Health Services (YFHS) in primary care clinics, two in Maputo City and two in Maputo Province.
- Trial name
- NCT05476237
- Testing
- Group Interpersonal Therapy for Adolescents (IPT-AG), Treatment as Usual (TAU)
- Where
- 4 sites in Mozambique
- Volunteers
- 95 people
- Sponsor
- Columbia University
Primary Ciliary Dyskinesia (PCD)
Study of Inhaled RCT1100 in Adults With PCD Caused by Pathogenic Mutations in the DNAI1 Gene to Measure Mucociliary Clearance
This is a multi-dose study with RCT1100 and is designed to provide safety, tolerability and preliminary efficacy data for future clinical studies.
- Trial name
- NCT06633757
- Testing
- RCT1100
- Where
- 3 sites in United States, Denmark and 1 more
- Volunteers
- 14 people
- Sponsor
- ReCode Therapeutics
Liver Cancer
Yttrium Y 90 Radiolabeled Glass Beads in Treating Patients With Liver Cancer That Cannot Be Removed by Surgery
RATIONALE: Internal radiation therapy uses radioactive material placed directly into or near a tumor to kill tumor cells. Using radiolabeled glass beads to kill tumor cells may be effective treatment for liver cancer that cannot…
- Trial name
- NCT00589030
- Testing
- brachytherapy, yttrium Y 90 glass microspheres
- Where
- United States
- Sponsor
- City of Hope Medical Center
Primary Brain Tumor
Neurocognitive Function After Proton Therapy in Children and Adolescents
Brain tumors are the second most frequent malignant diseases in children and adolescents. In the study the short and medium term consequences of proton therapy on cognitive processes in particular on executive functions in…
- Trial name
- ELBE-ProKids (NCT04066465)
- Where
- 3 sites in Germany
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Technische Universität Dresden
Inflammatory Breast Carcinoma, Invasive Breast Carcinoma
Biospecimen and Medical Data Collection and Tumor Biopsy in Creating Research Tissue Registry in Patients With Inflammatory or Invasive Breast Cancer
This trial studies the biospecimen and medical data collection in creating a research tissue registry in patients with inflammatory or invasive breast cancer.
- Conditions
- Inflammatory Breast Carcinoma, Invasive Breast Carcinoma, Second Primary Malignant Neoplasm
- Trial name
- NCT00477100
- Testing
- Biospecimen Collection, Interview, Medical Chart Review
- Where
- 10 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- M.D. Anderson Cancer Center
Primary Central Nervous System Diffuse Large B Cell Lymphoma (PCNS-DLBCL)
Characterization of Primary Central Nervous System Diffuse Large B Cell Lymphoma (PCNS-DLBCL) by Multiomic Approach
PCNS-DLBCL is a rare extranodal non-Hodgkin lymphoma that primarily affects the brain, spine, or vitreoretinal space. The prognosis for PCNS-DLBCL is significantly worse than that for its systemic counterpart.
- Trial name
- NCT07147751
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 100 people
- Sponsor
- International Extranodal Lymphoma Study Group (IELSG)
Primary Dysmenorrhea
Effect of Massage and Progressive Relaxation Exercises on Primary Dysmenorrhea
A total of 97 female students, 50 in the intervention group and 47 in the control group, were included in this pretest-posttest design randomized controlled study.
- Trial name
- NCT04356131
- Testing
- progressive relaxation exercises and massage
- Where
- Turkey (Türkiye)
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Mersin University
Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia
Shorter Course Tacro After NMA, Related Donor PBSCT With High-dose Posttransplant Cy for Hard-to-Engraft Malignancies
To see if it is possible to use short-duration tacrolimus after a peripheral blood stem cell transplant in certain malignancies that are considered difficult to engraft.
- Conditions
- Myelodysplastic Syndrome, Chronic Myelomonocytic Leukemia, Small Lymphocytic Lymphoma, Chronic Lymphocytic Leukemia
- Trial name
- NCT02556931
- Testing
- Fludarabine, Cyclophosphamide, Total body irradiation
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive
An Observational Biomarker Study in Multiple Sclerosis (MS) Patients
All males and females between 18-70 years of age regardless of their race and ethnicity with a confirmed diagnosis of Primary Progressive Multiple Sclerosis (PPMS), Secondary Progressive Multiple Sclerosis (SPMS), and Relapse…
- Conditions
- Multiple Sclerosis, Relapsing-Remitting, Multiple Sclerosis, Primary Progressive, Multiple Sclerosis, Secondary Progressive
- Trial name
- NCT05663853
- Where
- 4 sites in United States
- Volunteers
- 137 people
- Sponsor
- LAPIX Therapeutics Inc.
Deprescriptions, Polypharmacy
Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug Dispensing Systems
Overuse is common in frail older people with polypharmacy, especially in frail older users of multidose drug dispensing (MDD) systems.
- Conditions
- Deprescriptions, Polypharmacy, Primary Health Care, Community Pharmacy Services
- Trial name
- NCT05609981
- Testing
- Clinical medication review focused on deprescribing
- Where
- Netherlands
- Volunteers
- 318 people
- Sponsor
- SIR Institute for Pharmacy Practice and Policy
Parathyroid Carcinoma, Hypercalcemia
An Intra-individual Titration Study of KRN1493 for the Treatment of Hypercalcemia in Patients With Parathyroid Carcinoma or Intractable Primary Hyperparathyroidism
This is an intra-individual titration study of KRN1493 to evaluate the safety and efficacy of KRN1493 for the treatment of hypercalcemia in patients with parathyroid carcinoma or intractable primary hyperparathyroidism (PHPT).
- Conditions
- Parathyroid Carcinoma, Hypercalcemia, Primary Hyperparathyroidism
- Trial name
- NCT01460030
- Testing
- Cinacalcet HCl
- Where
- Japan
- Sponsor
- Kyowa Kirin Co., Ltd.
MELAS Syndrome, Lebers Hereditory Optic Neuropathy With Extra Ocular Symptoms (LHON-Plus)
A Basket Clinical Study to Assess Glycerol Tributyrate in Patients With Mitochondrial Encephalopathy, Lactic Acidosis, Stroke-like Episodes (MELAS) or Leber's Hereditary Optic Neuropathy-Plus (LHON-Plus)
This is a parallel arm non-randomized dose-escalation, open-label basket exploratory phase 1 clinical trial where Mitochondrial encephalopathy, lactic acidosis, stroke-like episodes (MELAS) and Leber's hereditary optic…
- Trial name
- NCT06792500
- Testing
- Glycerol Tributyrate
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- George Washington University
Central Nervous System Tumors
Study of BLZ-100 in Pediatric Subjects With CNS Tumors
Many types of cancer are primarily treated with surgery and patient survival is directly related to the extent to which the tumor is able to be removed.
- Trial name
- NCT02462629
- Testing
- BLZ-100
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Blaze Bioscience Inc.
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