Clinical trials: Primary
Open-angle Glaucoma
Single-dose Study of ANX007 in Participants With Primary Open-angle Glaucoma
This is a multi center, open-label, single dose, safety study. Approximately 9 to 15 participants with open-angle glaucoma are assigned into 3 sequential dose-levels and will receive ANX007 administered as single, IVT injections.
- Trial name
- NCT03488550
- Testing
- ANX007
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Annexon, Inc.
ST-segment Elevation Myocardial Infarction (STEMI)
Impact of Stent Length and Diameter on Patients Undergoing Primary PCI
The goal of the study is to evaluate the Impact of coronary stent length and/or diameter in patients with ST segment myocardial infarction undergoing primary PCI, on Short term clinical outcomes.
- Trial name
- NCT04110691
- Volunteers
- 200 people
- Sponsor
- Assiut University
Healthy
Comparison of Intramuscular Distribution of Different Injection Volumes Via Diffusion Tensor Imaging (DTI)
The purpose of this experimental pilot study is to assess a positive effect of higher injection volumes of fluid (physiological sodium) in the elbow-flection-muscle (M.
- Trial name
- NCT01162291
- Where
- Austria
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Kirsten Elwischger
Myeloproliferative Neoplasms
A Study to Evaluate INCA035784 in Participants With Myeloproliferative Neoplasms
This study is being conducted to evaluate the safety and tolerability of INCA035784 in participants with myeloproliferative neoplasms.
- Trial name
- NCT07008118
- Testing
- INCA035784
- Where
- 26 sites in United States, Australia and 3 more
- Volunteers
- 120 people
- Sponsor
- Incyte Corporation
Emotional Disorder
Cost-effectiveness of a Transdiagnostic Psychological Treatment for Emotional Disorders in Primary Care
The aim of this study is to test the cost-effectiveness and cost-utility of adding a transdiagnostic group cognitive-behavioural therapy (TD-CBT) to treatment as usual (TAU) for emotional disorders in primary care .
- Trial name
- PsicAP-Costs2 (NCT05314920)
- Testing
- Transdiagnostic cognitive-behavioral therapy (TD-CBT), Bernstein and Borkovec progressive muscle relaxation (PMR)
- Where
- 4 sites in Spain
- Volunteers
- 300 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Stroke
SURA'A Campaign for Stroke Awareness in Primary Health Care Centers
This study aims to evaluate the effectiveness of a one-week multifaceted Stroke Urgency Recognition, and Action Awareness (SURA'A) consultation-based campaign in increasing stroke awareness and the intention to seek emergency…
- Trial name
- SURA'A (NCT07578259)
- Testing
- SURA'A Consultation-Based Campaign
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis
Long-term Safety and Efficacy of Momelotinib in Subjects With Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis, Polycythemia Vera or Essential Thrombocythemia
This open-label study is to determine the long-term safety and tolerability of momelotinib in previously enrolled study participants with primary myelofibrosis (PMF), post-polycythemia vera myelofibrosis (post-PV MF)…
- Conditions
- Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, Post-Essential Thrombocythemia Myelofibrosis, Polycythemia Vera
- Trial name
- NCT02124746
- Testing
- Momelotinib
- Where
- 22 sites in United States, Australia and 3 more
- Volunteers
- 87 people
- Sponsor
- Sierra Oncology LLC - a GSK company
Primary Open Angle Glaucoma
A Study of AMDX-2011P in Participants With Primary Open Angle Glaucoma
The purpose of this research study is to assess the ability of AMDX- 2011P to identify amyloid deposits in the retina of participants with Primary Open Angle Glaucoma (POAG).
- Trial name
- NCT06223048
- Testing
- AMDX-2011P
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Amydis Inc.
Contrast-induced Nephropathy
Predictive Value of CHA2DS2-VASC Score and Contrast Volume to Creatinine Clearance Ratio in Relation to Mehran Score for Contrast-Induced Nephropathy In ST- Elevation Myocardial Infarction Patients Undergoing Primary Percutaneous Coronary Intervention
all patient presented with ST elevated myocardial infarction and underwent PPCI will be calculated with CHA2DS2-VASC score and contrast volume / creatinine clearance as apredictive value for Contrast induced nephropathy and the…
- Trial name
- NCT03266458
- Testing
- Primary percutaneous coronary intervention
- Where
- Egypt
- Volunteers
- 210 people
- Sponsor
- Assiut University
Esophageal Squamous Cell Carcinoma
Standardized MRI and Structured Reporting for Esophageal Squamous Cell Carcinoma
This prospective, multicenter diagnostic accuracy study will develop and validate a standardized 3.0-T magnetic resonance imaging (MRI) acquisition protocol and structured reporting system for primary esophageal squamous cell…
- Trial name
- ESCC-MRI-TRG (NCT07769658)
- Testing
- Standardized 3.0-T Esophageal Magnetic Resonance Imaging
- Where
- 7 sites in China
- Volunteers
- 500 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Stroke
The Stroke Box: a Patient-centered eHealth Approach for Improving Post-stroke Care.
Although there have been major advances in (personalized) stroke treatment in the last decade, the need for prevention of stroke remains critical.
- Trial name
- NCT05388578
- Testing
- Blood pressure monitor, Weighting scale, Activity tracker
- Where
- Netherlands
- Volunteers
- 55 people
- Sponsor
- Leiden University Medical Center
Primary Non-operated Squamous Cell Carcinoma of Oral Cavity, Primary Non-operated Squamous Cell Carcinoma of Oropharynx
Comparison of Adaptive Dose Painting by Numbers With Standard Radiotherapy for Head and Neck Cancer.
The investigators hypothesize that treatment adaptation to biological and anatomical changes, occurring during treatment, can increase the chance of cure at minimized or equal radiation-induced toxicity in head and neck cancer…
- Conditions
- Primary Non-operated Squamous Cell Carcinoma of Oral Cavity, Primary Non-operated Squamous Cell Carcinoma of Oropharynx, Primary Non-operated Squamous Cell Carcinoma of Hypopharynx, Primary Non-operated Squamous Cell Carcinoma of Larynx
- Trial name
- C-ART-2 (NCT01341535)
- Testing
- Adaptive dose-painting-by-numbers, standard intensity-modulated radiotherapy (IMRT)
- Where
- 2 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- University Hospital, Ghent
Primary Central Nervous System Lymphoma
R2-MTX With Lenalidomide Maintenance in Newly-diagnosed PCNSL：a Multicenter Phase Ib/II Stuty
This is a multicenter prospective single arm phase Ib/II study, and the purpose of this study is to evaluate the safety and efficiency of R2-MTX regimen (rituximab \& lenalidomide \& methotrexate) combined with lenalidomide…
- Trial name
- REMLA (NCT04120350)
- Testing
- Methotrexate, Rituximab, Lenalidomide
- Where
- China
- Volunteers
- 47 people
- Sponsor
- Peking Union Medical College Hospital
Migraine
Ictal and Interictal Inflammatory Markers in Migraine
The purpose of this study is to evaluate blood levels of several proteins that may be altered in the inflammation associated with migraine headaches.
- Trial name
- NCT01138150
- Testing
- Treximet
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Johns Hopkins University
Vasovagal Syncope (VVS), Presyncope
A Warning Red Flag Classification System to Predict Risk of Vasovagal Event During Office Hysteroscopy
The goal of this pilot cross sectional study is to identify participants at risk of vasovagal reaction/syncope(VVR/VVS) during office hysteroscopy.
- Trial name
- FLAG-VS (NCT07030218)
- Testing
- Office hysteroscopy
- Where
- India
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tanvir Hospital
Temporomandibular Disorder (TMD)
Marine Lipids Ease Painful TMD
The ADAPT study is a single-site, Phase 2b, randomized, quadruple-masked, placebo-controlled trial evaluating an omega-3 dietary supplement enriched with specialized pro-resolving mediator (SPM) precursors in adults with chronic…
- Trial name
- ADAPT (NCT07437313)
- Testing
- SPM Precursor-Enriched Marine Lipid Supplement, Medium-Chain Triglyceride Supplement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of North Carolina, Chapel Hill
Primary Hypercholesterolemia
Efficacy and Safety of HS-25 or in Combination With Atorvastatin in Chinese Adults With Primary Hypercholesterolemia
To determine the efficacy of the HS-25 (10mg or 20mg) or in combination with Atorvastatin (10mg)in reducing low density lipoprotein-cholesterol (LDL-C) levels after a 12-week period of treatment in adults with primary…
- Trial name
- HS-25-C-01 (NCT03464682)
- Testing
- HS-25 10mg, HS-25 10mg combination with Atorvastatin, HS-25 20mg combination with Atorvastatin
- Volunteers
- 720 people
- Sponsor
- Zhejiang Hisun Pharmaceutical Co. Ltd.
Membranous Nephropathy, Nephrotic Syndrome
Belimumab With Rituximab for Primary Membranous Nephropathy
The primary objective of this study is to evaluate the effectiveness of belimumab and intravenous rituximab co-administration at inducing a complete or partial remission (CR or PR) compared to rituximab alone in participants with…
- Trial name
- REBOOT (NCT03949855)
- Testing
- Belimumab, Rituximab
- Where
- 20 sites in United States
- Volunteers
- 58 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Type 2 Diabetes Mellitus
Value-based Emotion-focused Educational Programme to Reduce Diabetes-related Distress
The purpose of the clinical trial is to evaluate the effectiveness of a relatively simple and short value-based emotion-focused educational programme in adults with type 2 diabetes (VEMOFIT) on diabetes-related distress…
- Trial name
- VEMOFIT (NCT02730078)
- Testing
- VEMOFIT, Attention-meetings (AG)
- Volunteers
- 124 people
- Sponsor
- Universiti Putra Malaysia
Primary Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer
3-AP and Cisplatin in Treating Patients With Recurrent or Persistent Platinum-Resistant Ovarian Epithelial or Primary Peritoneal Cancer
Drugs used in chemotherapy, such as 3-AP and cisplatin, work in different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Conditions
- Primary Peritoneal Cavity Cancer, Recurrent Ovarian Epithelial Cancer, Stage III Ovarian Epithelial Cancer, Stage IV Ovarian Epithelial Cancer
- Trial name
- NCT00081276
- Testing
- triapine, cisplatin, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- National Cancer Institute (NCI)
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