Clinical trials: Primary Headache Disorders
Patent Foramen Ovale
Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches
The foramen ovale, a kind of physiologic channel in the interatrial septum in the heart at embryonic stage, is closed normally at 5-7 months after birth.
- Trial name
- NCT02777359
- Testing
- the transcatheter closure of PFO
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Migraine
Comparison of Patient-reported Outcomes for Rimegepant and Triptans in the 2023 US National Health and Wellness Survey
This is a cross-sectional study using the cross-sectional 2023 National Health and Wellness Survey (NHWS) data from the US, with a large and nationally representative population (N=75,007).
- Trial name
- NCT06680206
- Testing
- Rimegepant, Triptans
- Where
- United States
- Volunteers
- 1,395 people
- Sponsor
- Pfizer
Postural; Defect, Tension-Type Headache
Fascial Distortion Model in Tension Type Headache
Tension-type headache is a headache that starts from the cervical and suboccipital regions, spreads from the back of the head to the parietal, frontal and temporal regions, and is felt in the form of compression, pressure and…
- Conditions
- Postural; Defect, Tension-Type Headache, Pain, Neck, Craniovertebral; Syndrome
- Trial name
- NCT05964517
- Testing
- Fascial Distortion Model
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- University of Gaziantep
Migraine
Comparative Bioavailability Study of Omexa Sumatriptan vs. Imitrex® in Healthy Volunteers
the trial is a randomized, open label, crossover, single-administration bioavailability study to compare the pharmacokinetic parameters of Omexa sumatriptan transmucosal sublingual tablet versus commercial Imitrex® sumatriptan…
- Trial name
- NCT02954276
- Testing
- Omexa Sublingual Sumatriptan tablet, Imitrex Oral Product
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Targia Pharmaceuticals Ltd.
Chronic Cluster Headache
Sphenopalatine Ganglion Stimulation for the Acute Treatment of Cluster Headache
The purpose of the proposed clinical study is to evaluate the use of an implanted Neurostimulator to provide Sphenopalatine Ganglion (SPG) stimulation for the management of the pain associated with cluster headaches.
- Trial name
- NCT01255813
- Testing
- Stimulation (Sub-perception), Stimulation (Full), Control
- Where
- 5 sites in Belgium, Denmark and 2 more
- Volunteers
- 43 people
- Sponsor
- Autonomic Technologies, Inc.
Migraine Aura, Migraine With Aura
Induction of Migraine Attacks With Aura Using Calcitonin Gene-Related Peptide
Calcitonin gene-related peptide (CGRP) is a key neuropeptide in migraine pathophysiology and treatment. This study investigates whether CGRP administration can trigger aura in individuals with a diagnosis of migraine with aura.
- Trial name
- NCT07021859
- Testing
- Calcitonin-gene related peptide (CGRP)
- Where
- Denmark
- Volunteers
- 21 people
- Sponsor
- Danish Headache Center
Migraine
Physiopathology, Diagnosis and Therapy of Primary Cephalalgia and Adaptive Disorders
The main aim of the present pilot study is to prove the possibility to use the Nitroglycerin (NTG) model to describe the pathophysiology of headache using task-free advanced Magnetic Resonance Imaging (MRI) techniques, in order…
- Trial name
- NCT04696510
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine Headache
Greater Occipital Nerve Block for Migraine Prophylaxis
Migraine is a common neurological condition that can be disabling, particularly if chronic. Greater occipital nerve (GON) block has been utilized for decades for the treatment of migraine in the absence of a single randomized…
- Trial name
- NCT00915473
- Testing
- bupivicaine, normal saline, methylprednisolone
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Mayo Clinic
Migraine
Abortive Effect of an Ear Insufflator on Migraine
Evaluate the effectiveness of air insufflation in aborting (stopping) an acute episode of migraine and compare it with a placebo effect of using the same procedure but without active insufflation.
- Trial name
- NCT02614378
- Testing
- air insufflation
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Carrick Institute for Graduate Studies
Migraine, Menstrual Migraine
Fremanezumab Treatment of Migraine in Women With Menstrual Migraine Ages 18-45
The goal of this clinical trial is to learn about how a migraine prevention medicine works for people who have migraines/headaches with their menstrual period.
- Conditions
- Migraine, Menstrual Migraine, Menstrually Related Migraine
- Trial name
- NCT06173661
- Testing
- Fremanezumab
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Brigham and Women's Hospital
Osteoarthritis, Migraine
Migraine and Neuropathic Pain in Osteoarthritis
The goal of this observational study is to estimate the frequency of neuropathic pain and migraines in a group of patients with osteoarthritis of the knees, hips, hands, spine or other joints.
- Conditions
- Osteoarthritis, Migraine, Neuropathic Pain
- Trial name
- MEDUSA (NCT06224959)
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Migraine With Aura
Study of NXN 188 for the Treatment of Migraine With Aura
NXN-188 Dihydrochloride is being developed as an immediate release oral product for the treatment of acute migraine. This study is being conducted to evaluate NXN-188 in subjects with a migraine history of aura.
- Trial name
- NCT00920686
- Testing
- NXN-188, sumatriptan succinate
- Where
- 16 sites in United States
- Volunteers
- 239 people
- Sponsor
- NeurAxon Inc.
Migraine Headache, Migraine
Neuro-Complex & Multi Supplements for Migraine Prevention
The goal of this prospective, monocentric, open-label, non-randomized and single arm study is to evaluate a reduction of migraine days per months (MDM) by 25% by using the combined supplementation with Neuro-Complex \& Multi…
- Conditions
- Migraine Headache, Migraine, Migraine in Adults
- Trial name
- NeuroCare (NCT07015411)
- Testing
- Neuro-Complex and Multi
- Where
- Belgium
- Volunteers
- 120 people
- Sponsor
- Benfida, a department of Handi-Move
Migraine
Long-Term Extension Study With Eptinezumab as Preventive Treatment in Participants With Migraine in Japan
This study is an open label extension study, which means that the participants from the Lead-in Study 19140A (NCT04921384) can join this study, if they meet the study Eligibility Criteria, and continue to receive the study drug…
- Trial name
- NCT05064371
- Testing
- Eptinezumab
- Where
- 17 sites in Japan
- Volunteers
- 160 people
- Sponsor
- H. Lundbeck A/S
Migraine Disorders
Caffeine/Propranolol Intervention for Acute Migraine
This is a research study to assess the safety of caffeine/propranolol at different dose levels. We want to find out what effects, good and/or bad, it has on patients and their migraines.
- Trial name
- NCT01080677
- Testing
- caffeine/propranolol combination tablet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Migraine
Psychological and Biological Markers of Refractory Migraine
The term "refractory" migraine describes a particularly aggressive form of the disease in which the patient does not benefit from any of the preventive therapies with the various classes of drugs available, including treatment…
- Trial name
- NCT05046119
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Headache, Migraine
Psychological Assessment and Treatment of Chronic Benign Headache
Subjects with chronic migraine or tension headaches will receive 12 sessions of biofeedback or relaxation training after fulfilling screening, intake interviews, \& psychological testing requirements.
- Conditions
- Headache, Migraine, Tension Headache, Stress Headache
- Trial name
- NCT00018811
- Testing
- Relaxation training & thermal biofeedback, Surface EMG biofeedback
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Familial Hemiplegic Migraine
Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2.
The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to Calcitonin Gene Related Peptide (CGRP)infusion.
- Trial name
- NCT00358839
- Testing
- CGRP
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
A Study to Test if Fremanezumab is Effective in Preventing Episodic Migraine in Patients 6 to 17 Years of Age
The primary objective of the study is to evaluate the efficacy of fremanezumab as compared to placebo for the preventive treatment of episodic migraine (EM).
- Trial name
- NCT04458857
- Testing
- Fremanezumab
- Where
- 89 sites in United States, Canada and 7 more
- Volunteers
- 235 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Migraine Headaches
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Trial name
- NCT04211454
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
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