Clinical trials: Primary Headache Disorders
Migraine, Headache Disorders
MIGRAFIT: Evaluating a Group Therapy Program Combining Physical Activity, Progressive Muscle Relaxation and Psychoeducation for Adolescents With Migraine
Background: Migraine is a headache disorder highly prevalent in children and adolescents. It significantly affects academic performance and quality of life.
- Conditions
- Migraine, Headache Disorders, Pediatric Migraine
- Trial name
- NCT07419607
- Testing
- Weekly group training
- Where
- Austria
- Volunteers
- 6 people
- Sponsor
- Medical University Innsbruck
Migraine
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden.
- Trial name
- MechSens_Migra (NCT07559565)
- Testing
- pressure pain algometry
- Where
- Austria
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bernhard Taxer
Headache, Headache Disorders
Cross-cultural Adaptation, Reliability and Validity of the Turkish Version of the Headache Disability Questionnaire
The purpose of this study was to investigate cultural adaptation, reliability and validity of the Turkish version of the Headache Disability Questionnaire (HDQ).
- Conditions
- Headache, Headache Disorders, Headache, Migraine, Headache, Tension
- Trial name
- NCT04736654
- Testing
- Survey study
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Gazi University
Migraine Disorders
Non-steroidal Anti-inflammatory Drugs Alone or With a Triptan and Reports of Transition From Episodic to Chronic Migraine
Chronic Migraine (CM), or 15 or more migraine headaches per month, is common in tertiary headache care and is associated with a number of deleterious outcomes, especially higher disability and poorer quality of life, relative to…
- Trial name
- NCT01435941
- Testing
- Non-steroidal anti-inflammatory drug (NSAID), Triptan
- Volunteers
- 11,249 people
- Sponsor
- GlaxoSmithKline
Migraine, Headache Disorders
High-Intensity Interval Training and Progressive Muscle Relaxation as a Movement-Based Group Intervention for the Non-Pharmacological Prevention of Adolescent Migraine
Background: The prevalence of migraine during adolescence is 7.7%, affecting 9.7% of girls and 6.0% of boys. Despite its high prevalence, treatment options remain limited.
- Conditions
- Migraine, Headache Disorders, Pediatric Migraine
- Trial name
- MigraFit (NCT07850622)
- Testing
- Weekly group training
- Where
- Austria
- Volunteers
- 27 people
- Sponsor
- Medical University Innsbruck
Headache
Prednisolone in the Treatment of Withdrawal Headache in Probable Medication Overuse Headache
The purpose of this study is to determine whether prednisolone is more effective than placebo in the first six days after initiation of medication withdrawal therapy for a medication overuse headache.
- Trial name
- NCT00135122
- Testing
- prednisolone
- Where
- Norway
- Volunteers
- 100 people
- Sponsor
- Sorlandet Hospital HF
Migraine
Safety and Efficacy Study of MK0974 in the Acute Migraine (0974-016)
The purpose of this study is to investigate the efficacy and safety of MK0974 compared to a placebo for acute migraine.
- Trial name
- NCT00432237
- Testing
- MK0974 50 mg, MK0974 150 mg, MK0974 300 mg
- Volunteers
- 1,703 people
- Sponsor
- Merck Sharp & Dohme LLC
Cluster Headache
High Dose Vitamin D Plus Multivitamin in the Prevention of Cluster Headache
This study intends to investigate the use of high-dose Vitamin D3 plus a multivitamin in the prevention of cluster headache attacks.
- Trial name
- NCT04570475
- Testing
- Vitamin D, multivitamin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- The University of Texas Health Science Center, Houston
Migraine
Bilateral DLPC tDCS in Drug-resistant Migraine
The goal of this clinical trial is to study and describe the effects of bilateral tDCS applied to dorso-lateral-prefrontal cortex (DLPC) in patients with drug-resistant migraine in terms of reduction in frequency of pain, impact…
- Trial name
- NCT06079801
- Testing
- Transcranial direct current stimulation (tDCS), anti-CGRP-mAbs
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Clínica de Intervención en Neurociencias
Acute Headache, Migraine
High- vs Standard-Dose Intravenous Magnesium for Acute Headache
Headache is one of the most common reasons for consultation in emergency departments and represents a significant cause of disability, particularly in patients with migraine and other primary headache disorders.
- Conditions
- Acute Headache, Migraine, Tension-type Headache, Cluster Headache
- Trial name
- MAGHEAD (NCT07779486)
- Testing
- Magnesium Sulfate 2 grams, Magnesium Sulfate 4 G, Paracetamol 1 g
- Where
- Tunisia
- Volunteers
- 300 people
- Sponsor
- University of Monastir
Migraine Disorders
Buccal Prochlorperazine Versus Intravenous Prochlorperazine for Migraine Headaches, a RCT
Headache is a common presenting complaint to the emergency department accounting for 1-2% of patient visits. Of these headaches, approximately 90% are migraine, tension headache, or combined presentations.
- Trial name
- NCT02779959
- Testing
- Prochlorperazine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center
Headache, Migraine, Aura
Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura
To investigate the migraine inducing effect of levcromakalim in patients with migraine with aura.
- Trial name
- NCT04905654
- Testing
- Levcromakalim, Saline
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Danish Headache Center
Headache Disorders, Tension-Type Headache
Jaw Muscle Function in Patients With Tension-type Headache
Patients with tension-type headache (TTH) and migraine often experience musculoskeletal complaints, like neck pain and/or jaw pain.
- Trial name
- NCT04196127
- Testing
- Bite force testing
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Familial and Environmental Factors Behind Migraine
Migraine is a chronic neurological disease characterized by recurrent moderate to severe headaches often in association with a number of autonomic nervous system symptoms.
- Trial name
- NCT04356079
- Testing
- International Headache Society Test
- Volunteers
- 80 people
- Sponsor
- Assiut University
Migraine
Single-Ascending Dose Study of AMG 333 in Healthy Subjects and Subjects With Migraines
The primary purpose of this study is to determine whether AMG 333 is safe and well tolerated in healthy subjects and subjects with migraines.
- Trial name
- NCT01953341
- Testing
- AMG 333
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Amgen
Migraine
A Study to Compare the Blood Levels of Two Dosage Formulations of the Study Medicine in Healthy Adults
The purpose of this study is to assess the bioequivalence of an alternative ODT formulation (ODT2) versus the approved ODT formulation of a CGRP receptor antagonist in healthy adult participants under fasting conditions.
- Trial name
- NCT07594769
- Testing
- ODT2 Test formulation, ODT Reference formulation
- Where
- Belgium
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Pfizer
Migraine Disorders, Post-Traumatic Headache
The Role of Osteopathic Manipulation in the the Management of Post-traumatic Migraine
This study evaluates the use of osteopathic manipulation (manual medicine) for migraine headache following traumatic head injury.
- Trial name
- OMT/mTBI (NCT03588364)
- Testing
- Osteopathic Manipulation
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of California, San Diego
Migraine, Migraine With Aura
Oxygenation and Perfusion in Patients With Acute Migraine Attacks
The aim of the study is to retrospectively evaluate brain perfusion and oxygenation in acute migraine attacks. Magnetic resonance perfusion and susceptibility weighted imaging are the technics to measure perfusion and oxygenation…
- Conditions
- Migraine, Migraine With Aura, Migraine; Status
- Trial name
- OPAMA (NCT03536936)
- Volunteers
- 1,000 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Episodic Migraine Headache
Craniocervical Flexion Training for Reducing Migraine Headaches and Disability
Migraine, a leading cause of disability globally, necessitates effective interventions beyond pharmacotherapy due to the associated risks.
- Trial name
- NCT06751732
- Testing
- Craniocervical Flexion Training (CCFT), Diaphragm Respiratory Training, Cervical Mobilization and Traction
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Migraine
A Phase III Trial of e-TNS for the Acute Treatment of Migraine
The main objective of this study is to have Phase III evidences of the efficacy of the Cefaly® Abortive Program device used at home for 2 hours to treat a migraine attack.
- Trial name
- TEAM (NCT03465904)
- Testing
- Verum Cefaly® Abortive Program device
- Where
- 10 sites in United States
- Volunteers
- 607 people
- Sponsor
- Cefaly Technology
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