Clinical trials: Primary Headache Disorders
Headache, Migraine
Erenumab (AMG 334) Plus Combined Oral Contraceptive Drug Interaction Study in Healthy Females
A pharmacokinetic drug interaction study of erenumab and an oral contraceptive containing progestin and estrogen.
- Trial name
- NCT02792517
- Testing
- Erenumab, Ethynil Estradiol/Norgestimate Oral Contraceptive
- Where
- 4 sites in United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Amgen
Migraine Without Aura, Migraine With Aura
Anisodine Hydrobromide For The Preventive Treatment Of Episodic Migraine
In this study,288 adult migraine patients aged 18-65 years (diagnosed with migraine without aura and/or migraine with aura, with at least a 1-year history)will be collected to evaluate the efficacy, safety and tolerability of…
- Trial name
- ATEM (NCT05416476)
- Testing
- Anisodine Hydrobromide
- Where
- 19 sites in China
- Volunteers
- 288 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Primary Headaches (Includes Migraines, Tension, Cluster Headaches)
Droperidol Versus Metoclopramide + Diphenhydramine for the Treatment of Primary Headaches
The purpose of this study is to determine if droperidol is equally as effective as metoclopramide for treatment of primary headaches in the Emergency Department.
- Trial name
- NCT01406860
- Testing
- Droperidol, Metoclopramide + diphenhydramine
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Migraine Headache
Intravenous Fluid Therapy for the Treatment of Emergency Department Patients With Migraine Headache
The purpose of this study is to determine whether patients in the emergency department with migraine headache who are administered an intravenous fluid bolus will report greater improvement in pain scores than control patients.
- Trial name
- NCT02933060
- Testing
- Normal saline (1000 mL), Control
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Cooper Norcross Health
Episodic Migraine
Prophylactic Treatment With Atorvastatin for Episodic Migraine.
The main objective of this study is to see whether the favorable preventative effect of Atorvastatin 40mg per day in episodic migraine, that was found previously in three smaller randomized controlled cross-over studies, can be…
- Trial name
- EStatinMig (NCT06248671)
- Testing
- Atorvastatin 40mg, Atorvastatin 20mg
- Where
- 6 sites in Norway
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- St. Olavs Hospital
Migraine Disorders, Patent Foramen Ovale
Effects of PFO Closure on Glymphatic Function and Clinical Symptoms in Patients With Migraine
Patent Foramen Ovale (PFO) is a common congenital heart defect. Recent studies have suggested a potential association between PFO and migraines, particularly migraine with aura.
- Conditions
- Migraine Disorders, Patent Foramen Ovale, Right-to-Left Shunt, Cardiac
- Trial name
- NCT07170176
- Testing
- Percutaneous Patent Foramen Ovale Closure, No Intervention
- Where
- 2 sites in China
- Volunteers
- 150 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Migraine, Primary Headache Disorders
Digital-technology Based Interventions on Treatment of Migraine.
The main aim of the research: To develop an interdisciplinary treatment platform based on digital technology and test the operation and effectiveness of digital interventions in comparison with conventional multidisciplinary…
- Trial name
- Migrevention (NCT05458817)
- Testing
- digital platform
- Where
- Estonia
- Volunteers
- 600 people
- Sponsor
- Tartu University Hospital
Migraine
A Study to Learn About Zavegepant as the Acute Treatment of Migraine in Asian Adults
The purpose of this study is to learn how safe and effective zavegepant is compared to placebo in the acute treatment of migraine in Asian adults.
- Trial name
- NCT05989048
- Testing
- Zavegepant
- Where
- 61 sites in China, South Korea and 1 more
- Volunteers
- 1,414 people
- Sponsor
- Pfizer
Migraine
Plasma Levels of CGRP and Expression of Specific microRNAs in Blood Cells of Episodic and Chronic Migraine Subjects
Migraine can manifest with an episodic or chronic pattern in a continuum of disease severity. Multiple factors are associated to the transformation of the pattern form episodic to chronic.
- Trial name
- CGRP-RNA (NCT04473976)
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Headache, Migraine
RELAXaHEAD for Headache Patients (Phase I)
The goal of this research is to assess the utility of smartphone-based progressive muscle relaxation (PMR) for the treatment of headaches.
- Conditions
- Headache, Migraine, Multiple Sclerosis
- Trial name
- NCT03183791
- Testing
- RELAXaHEAD app, Monitored Usual Care (MUC)
- Where
- United States
- Volunteers
- 402 people
- Sponsor
- NYU Langone Health
Cluster Headache
The Efficacy and Safety of Sphenopalatine Ganglion Pulsed Radiofrequency Treatment for Cluster Headache
The investigators aim to investigate the effectiveness and safety of sphenopalatine ganglion pulsed radiofrequency on cluster headache.
- Trial name
- NCT03567590
- Testing
- Pulsed Radiofrequency treatment, Nerve Block treatment
- Where
- 3 sites in China
- Volunteers
- 80 people
- Sponsor
- Beijing Tiantan Hospital
Migraine
BrainCool-Migraine Intranasal Cooling Trial
This study will be a randomised placebo controlled trial examining the effectiveness of using an intranasal evaporative cooling device (the RhinoChill intransal device) in providing relief of pain and symptoms of acute…
- Trial name
- NCT03167060
- Testing
- Active RhinoChill, Control Rhinochill
- Where
- 4 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Cumbria Partnership NHS Foundation Trust
Migraine
Combined Occipital and Trigeminal Nerve Stimulation (eCOT-NS) for Preventive Treatment of Migraine
The PERL Study will evaluate the safety and efficacy of a self-administered preventive treatment for migraine headache using combined occipital and trigeminal nerve stimulation (Relivion®).
- Trial name
- NCT05804396
- Testing
- Relivion®
- Sponsor
- Neurolief Ltd.
Migraine Disorders, Heart Disease
Telcagepant (MK-0974) Treatment of Migraine in Participants With Stable Vascular Disease (MK-0974-034)
The purpose of this study is to evaluate the safety and efficacy of telcagepant in the treatment of acute migraine in participants with stable vascular disease.
- Conditions
- Migraine Disorders, Heart Disease, Cerebrovascular Accident, TIA (Transient Ischemic Attack)
- Trial name
- NCT00662818
- Testing
- Telcagepant, Acetaminophen/Paracetamol
- Volunteers
- 165 people
- Sponsor
- Merck Sharp & Dohme LLC
Migraine
Efficacy and Tolerability of Rimegepant for the Prevention of Migraine in Adults With History of Inadequate Response to Oral Preventive Medications
This study is being conducted to evaluate the efficacy and tolerability of rimegepant for migraine prophylaxis in adults with a history of inadequate response to oral preventive medications
- Trial name
- NCT05518123
- Testing
- Rimegepant
- Where
- 111 sites in United States, Australia and 12 more
- Volunteers
- 962 people
- Sponsor
- Pfizer
Migraine
A Randomized, Double-blind Clinical Investigation to Evaluate the Use of the Relievion™ Device in Treating Migraine.
This study will evaluate the clinical performance and safety of a self-administered abortive treatment for migraine headache using combined occipital and supraorbital transcutaneous nerve stimulator (Neurolief device, Relievion™).
- Trial name
- NCT03185559
- Testing
- Relievion Device- Treatment Stimulation
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Neurolief Ltd.
Migraine
Rizatriptan 10 MG RPD in the Treatment of Acute Migraine
This is a multicentre, open label, prospective, randomized, two-attack study with active comparator in patients reporting inadequate response to analgesics and/or triptans to examine the efficacy of Rizatriptan 10 mg RPD in this…
- Trial name
- Rinotama (NCT01057160)
- Testing
- Rizatriptan
- Where
- Germany
- Volunteers
- 195 people
- Sponsor
- Universität Duisburg-Essen
Patent Foramen Ovale
Anticoagulants for PFO Patients
Patients who underwent both bubble transcranial Doppler (bubble-TCD) and transoesophageal echocardiography (TEE) at our institution were consecutively enrolled in this real-world case-control study from August 2016 through August…
- Trial name
- NCT06375070
- Testing
- PFO closure, anticoagulant
- Volunteers
- 277 people
- Sponsor
- Xuanwu Hospital, Beijing
Migraine
A Pharmacokinetic Study of MK-1602 in the Treatment of Acute Migraine (MK-1602-007)
The purpose of this study is to characterize the pharmacokinetics of MK-1602 in the treatment of acute migraine, including the influence of demographic and other variables on MK-1602 pharmacokinetics, and to evaluate the…
- Trial name
- NCT01657370
- Testing
- MK-1602, Rescue medication
- Volunteers
- 195 people
- Sponsor
- Allergan
Headache, Migraine
Intravenous Paracetamol, Dexketoprofen and Ibuprofen in the Treatment of Acute Migraine Attack Headache
Currently, paracetamol and nonsteroidal antiinflammatory drugs are widely used by emergency physicians in Turkey for the treatment of patients with Acute Migraine Attack Headache The objective of the study is compare the efficacy…
- Trial name
- NCT04372264
- Testing
- Paracetamol, Dexketoprofen, Ibuprofen
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people
- Sponsor
- Pamukkale University
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