Clinical trials: Primary Headache Disorders
Migraine, Tension-Type Headache
Carotid Sinus Massage in Trendelenburg Position for Headache Relief
Headaches significantly impact patients' quality of life, with tension-type headaches and migraines being among the most prevalent types.
- Trial name
- NCT06745648
- Testing
- Arm A - Carotid Sinus Massage + Trendelenburg (CSM+T)
- Where
- Argentina
- Volunteers
- 18 people
- Sponsor
- Hospital Municipal Pedro T. Orellana
Migraine
Bronx MBCT-Migraine
This randomized clinical trial aims to examine the effect of a standardized 8-week course of Mindfulness Based Cognitive Therapy for Migraine on migraine-related disability in people with migraine.
- Trial name
- BMBCT-M (NCT02443519)
- Testing
- MBCT for Migraine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Albert Einstein College of Medicine
Migraine
Bioequivalence of Two Tablet Forms of MK0974 (0974-045)
This study will evaluate the bioequivalence of two solid dose formulations of MK0974.
- Trial name
- NCT00965887
- Testing
- MK0974 Ethanolate formulation, Comparator: MK0974 Hydrate formulation
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Migraine
A Study of Gastrointestinal Emptying Time in Adult Participants With Migraine Before and After Start of a mAb CGRP Antagonist
The purpose of this study is to measure the gastrointestinal emptying time using the wireless motility capsule (WMC) technology (FDA approved SmartPill™) in adult participants with migraine who are taking a monoclonal antibody…
- Trial name
- NCT04294147
- Testing
- Galcanezumab, Erenumab
- Where
- 3 sites in United States
- Volunteers
- 65 people
- Sponsor
- Eli Lilly and Company
Migraine, Episodic Migraine
Study of Two Digital Therapeutics for the Prevention of Episodic Migraine
Randomized study of two digital therapeutics for the prevention of episodic migraine
- Conditions
- Migraine, Episodic Migraine, Headache, Headache, Migraine
- Trial name
- ReMMi-D (NCT05853900)
- Testing
- ReMMi-D Digital Therapeutic
- Where
- United States
- Volunteers
- 568 people
- Sponsor
- Click Therapeutics, Inc.
Migraine
Clinical Effectiveness of Osteopathic Manipulative Treatment in Chronic Migraine
The aim of the present study is to determine the extend to which OMT is effective on a sample of subjects affected by migraine evaluated using the headache impact test (HIT-6) questionnaire.
- Trial name
- NCT01851148
- Testing
- osteopathic manipulative treatment, triptans
- Where
- Italy
- Volunteers
- 105 people
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Migraine
Improving Health Outcomes of Migraine Patients Who Present to the Emergency Department
This is a pilot feasibility acceptability study to examine the impact of smartphone-based progressive muscle relaxation (PMR) on migraine quality of life, frequency, intensity, and disability.
- Trial name
- NCT04281030
- Testing
- PMR (Progressive muscle relaxation therapy), Monitored Usual Care (MUC)
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- NYU Langone Health
Cervicogenic Headache, Tension-Type Headache
Chiropractic Spinal Manipulation for Headache
This is a pilot and feasibility randomized controlled trial to assess the efficacy of chiropractic spinal manipulative therapy in patients with tension-type and cervicogenic headache.
- Trial name
- NCT05240547
- Testing
- Spinal Manipulation
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Real Centro Universitario Maria Cristina
Migraine
A Clinical Study Examining the Safety and Effectiveness of a New Medication (Keppra®) for the Prevention of Migraine Headaches
The study drug levetiracetam is FDA approved as an add-on medication in the treatment of partial onset seizures in adults with epilepsy. The trade name is Keppra®.
- Trial name
- NCT00203216
- Testing
- levetiracetam, Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Thomas Jefferson University
Migraine, Greater Occipital Nerve Pulsed Radiofrequency, Headache Disorders
Comparing Unilateral and Bilateral Proximal GONPRF in Migraine Treatment
This study is designed to compare the clinical effectiveness of unilateral and bilateral Greater Occipital Nerve Pulsed Radiofrequency (GON-PRF) treatment at the C2 level in patients with migraine.
- Conditions
- Migraine, Greater Occipital Nerve Pulsed Radiofrequency, Headache Disorders, Ultrasound Guided Nerve Block
- Trial name
- (UBGON-PRF) (NCT06894121)
- Testing
- Greater Occipital Nerve Pulsed Radiofrequency (Unilateral), Bilateral GON PRF Treatment:
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people
- Sponsor
- Ankara City Hospital Bilkent
Migraine
Efficacy and Safety Study of Rimegepant for the Preventative Treatment of Migraine in Pediatric Subjects
The purpose of this study is to compare the efficacy and safety of rimegepant to placebo as a preventative treatment for migraine in children and adolescents ≥ 6 to <18 years with episodic migraine.
- Trial name
- NCT05156398
- Testing
- Rimegepant
- Where
- 93 sites in United States, Canada and 5 more
- Volunteers
- 640 people
- Sponsor
- Pfizer
Migraine
STOP PAIN: Septal Closure of PFO - Does it Prevent Migraine?
The primary objective of this Study is to compare the effect of transcatheter device closure of atrial shunting to a non-closure control group over a period from cessation of procedure related medication at 3 months until 9…
- Trial name
- NCT00369499
- Testing
- PFO Closure
- Where
- Germany
- Volunteers
- 656 people
- Sponsor
- Abbott Medical Devices
Migraine, Exercises
Effect of a Home-based Versus Supervised Exercise Program in Patients With Migraine
Migraine is a common primary headache with documented impacts on the patient, the economy, and society. A growing number of studies have reported that people with migraines are more likely to experience neck pain and neck…
- Trial name
- NCT05292599
- Testing
- Experimental, Control
- Where
- Argentina
- Volunteers
- 40 people
- Sponsor
- University of Gran Rosario
Migraine, Migraine Disorder
Tai Chi and Acupuncture on Migraine Attack Prevention and Brain White Matter Changes
The goal of this clinical trial is to determine the effectiveness of Tai Chi training and acupuncture on the migraine attacks and structural brain changes in women with episodic migraine.
- Trial name
- NCT06967909
- Testing
- Tai Chi training, Acupuncture
- Where
- Hong Kong
- Volunteers
- 132 people
- Sponsor
- The Hong Kong Polytechnic University
Migraine Disorders, Headache Migraine Chronic
Proximal and Distal Approach GON RFT in Migraine
Greater occipital nerve pulsed radiofrequency therapy is used in the treatment of migraine. This method is applied at the level of the proximal c2 vertebra and by approaching the nerve from the distal 1/3 medial of the occipital…
- Trial name
- NCT05888298
- Testing
- Greater occipital nerve radiofrequency
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Diskapi Teaching and Research Hospital
Migraine, Chronic Migraine
Eptinezumab as an Adjunct to Standard of Care for Migraine in an Acute Emergency Context
The purpose of the study is to investigate how a medication called eptinezumab (Vyepti) given to patients in the Emergency Department (ED) might help prevent migraines from happening again.
- Trial name
- NCT06428838
- Testing
- Eptinezumab, Standard of Care
- Where
- 2 sites in Canada
- Volunteers
- 102 people
- Sponsor
- Dr George Medvedev
Migraine Headache
Autonomic Dysfunction in Patients With Migraine: Cardiovascular and Neurophysiology Assessment
Autonomic dysfunction in patients with migraine: cardiovascular and neurophysiology assessment.
- Trial name
- NCT06798259
- Where
- Egypt
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Migraine
Inhaled IAV vs Inhaled Eucalyptus for the Treatment of Nausea With Acute Migraine
The goal of this study is to compare the efficacy and adverse events of inhaled isopropyl alcohol vapor (IAV) versus placebo (inhaled eucalyptus scent (IES) (1:20 dilution in mineral oil) for treating nausea associated with acute…
- Trial name
- NCT05175521
- Testing
- Eucalyptus Oil Scent, Isopropyl Alcohol Vapors
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- HonorHealth Research Institute
Migraine
Efficacy and Safety of Eletriptan for the Treatment of Migraine in Patients Not Satisfied With Rizatriptan Therapy
To assess the efficacy and safety of eletriptan for migraine headaches in subjects who were not satisfied with rizatriptan therapy
- Trial name
- NCT00632385
- Testing
- Eletriptan
- Where
- 16 sites in United States
- Volunteers
- 127 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Migraine, Irritable Bowel Syndrome
Effects of a Multispecies Probiotic on Migraine
The prevalence of migraine is higher in female patients with various intestinal diseases. An explanation could be that migraine is caused by a leaky gut, defined by increased intestinal permeability that permits particles to pass…
- Conditions
- Migraine, Irritable Bowel Syndrome, Headache, Migraine
- Trial name
- NCT04696458
- Testing
- Lactobacillus plantarum (CECT7484 and CECT7485)/ Pediococcus acidilactici (CECT7483)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Scripps Health
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