Clinical trials: Primary Hyperaldosteronism
Primary Hyperaldosteronism
Proof-of-concept for the Aldosterone Synthase Inhibitor LCI699 in Patients With Primary Hyperaldosteronism
The purpose of this study is to determine if LCI699, thorough reductions in aldosterone, can lower BP in patients with Primary hyperaldosteronism.
- Trial name
- NCT00732771
- Testing
- LCI699
- Where
- France
- Volunteers
- 12 people
- Sponsor
- Novartis
Hyperaldosteronism
Kallikrein-kinin (KKS) and Renin-angiotensin-aldosterone System (RAAS) in Primary Aldosteronism
The tissue kallikrein-kinin (KKS) and renin-angiotension-aldosterone system (RAAS) had been implicated in regulating blood pressure and electrolyte homeostasis.
- Trial name
- NCT00155064
- Testing
- captopril, Losartan (drug)
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Subclinical Primary Aldosteronism
Early Aldo Blockade in Subclinical PA
This trial aims to evaluate the preventive effect of early intervention with eplerenone, a highly selective nonsteroidal mineralocorticoid receptor antagonist, against new-onset hypertension in normotensive patients with…
- Trial name
- EARLY-PA (NCT07727252)
- Testing
- Eplerenone
- Volunteers
- 880 people
- Sponsor
- Xinjiang Medical University
Primary Aldosteronism, Hypertension
The Diagnostic Performance of 24-hour Urinary Aldosterone for Primary Aldosteronism
This is an observational study to define the cut-off value of 24-hour urinary aldosterone for diagnosing primary aldosteronism in hypertensive patients in our center.
- Trial name
- NCT06236698
- Testing
- 24-hour urinary aldosterone measurement
- Where
- China
- Volunteers
- 999 people
- Sponsor
- Zhiming Zhu
Resistant Hypertension, Secondary Hypertension
Comparison of Catecholamine Concentrations in Venous Blood During Selective Adrenal Artery Embolization
To explore the relationship between perioperative blood pressure and catecholamine concentrations in adrenal venous blood and peripheral venous blood in hypertensive patients with primary aldosteronism (PA) who underwent…
- Conditions
- Resistant Hypertension, Secondary Hypertension, Secondary Hypertension to Endocrine Disorders, Primary Aldosteronism
- Trial name
- NCT06228677
- Testing
- Selective adrenal artery embolization
- Where
- China
- Volunteers
- 196 people
- Sponsor
- First Affiliated Hospital of Chengdu Medical College
Primary Aldosteronism
Corticotropin Stimulation in Adrenal Venous Sampling for Patients With Primary Aldosteronism(ADOPA)
To compare the effect of different procedures of AVS(with or without ACTH stimulation) on the long-term outcomes of patients with PA
- Trial name
- NCT04461535
- Testing
- Adrenocorticotropic hormone
- Where
- China
- Volunteers
- 228 people
- Sponsor
- Chongqing Medical University
Hypertension, Hypertension Resistant to Conventional Therapy
High Prevalence of Secondary Arterial Hypertension (HIPRESH) with Prospective Systematic Screening in a Cohort of Consecutive Hypertensive Patients Referring to Regional Specialized Center
Hypertensive Patients referring to our center will undergo a systematic diagnostic workup aimed at finding the cause(s) of their high blood pressure.
- Conditions
- Hypertension, Hypertension Resistant to Conventional Therapy, Secondary Hypertension to Endocrine Disorders, Secondary Hypertension
- Trial name
- HIPRESH (NCT06664255)
- Volunteers
- 1,400 people
- Sponsor
- University Hospital Padova
Primary Aldosteronism
Optimizing Diagnosis Of Primary Aldosteronism
To optimize the confirmatory tests for primary aldosteronism.
- Trial name
- ODPA (NCT02755519)
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Chongqing Medical University
Adrenal Tumor, Pheochromocytoma
Randomized Clinical Trial of Posterior Retroperitoneoscopic Adrenalectomy Versus Lateral Laparoscopic Adrenalectomy
Laparoscopic adrenalectomy has become the gold standard operation for non-malignant adrenal tumors replacing open adrenalectomy.
- Conditions
- Adrenal Tumor, Pheochromocytoma, Conn's Syndrome, Cushing's Syndrome
- Trial name
- NCT01959711
- Testing
- Posterior RA, Lateral transperitoneal LA
- Where
- Poland
- Volunteers
- 65 people
- Sponsor
- Jagiellonian University
Primary Aldosteronism
Study of QLS1410 in the Treatment of Primary Aldosteronism.
This is a Phase II, multicenter, randomized, double-blind, placebo-controlled, parallel-group study to evaluate the safety, tolerability, and efficacy of QLS1410 versus placebo, on the reduction of Seated Blood Pressure (SBP) in…
- Trial name
- NCT07550465
- Testing
- QLS1410
- Volunteers
- 60 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Aldosteronism
Postoperative Cardiovascular Index Change of Primary Aldosteronism
Primary aldosteronism (PA), characterized by an inappropriate production of aldosterone, is far more common than is usually perceived.
- Trial name
- TAIPAI (NCT00746070)
- Testing
- with the clinical treatment ( ex adrenalectomy or spironolactone
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma
Ipsilateral and Contralateral Index for the Interpretation of Adrenal Vein Sampling (AVS) in Primary Aldosteronism
Adrenal vein sampling (AVS) is currently considered the gold standard for subtype diagnosis of primary aldosteronism (PA). However, the percentage of unsuitable procedures due to the unsuccessful cannulation of one of the two…
- Conditions
- Primary Aldosteronism, Primary Aldosteronism Due to Aldosterone Producing Adenoma, Primary Aldosteronism Due to Adrenal Hyperplasia (Bilateral)
- Trial name
- NCT04378387
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Turin, Italy
Primary Aldosteronism
Prognosis of Primary Aldosteronism: A Prospective Cohort Study
Primary aldosteronism (PA) is the most common cause of secondary hypertension, and patients with PA have a significantly higher risk of developing cardiovascular and renal complications compared with those with essential…
- Trial name
- PA-PROG (NCT07378176)
- Where
- 2 sites in China
- Volunteers
- 5,000 people
- Sponsor
- Xinjiang Medical University
Primary Aldosteronism
Intensive vs. Standard Blood Pressure Control in Primary Aldosteronism
The goal of this clinical trial is to evaluate whether an intensive blood pressure control strategy (systolic blood pressure target <120 mmHg) is more effective than a standard strategy (systolic blood pressure target <140 mmHg)…
- Trial name
- Intensia-Aldo (NCT07673445)
- Testing
- Intensive BP control, Standard BP control
- Where
- China
- Volunteers
- 3,830 people
- Sponsor
- Chongqing Medical University
Cushing Syndrome, Primary Aldosteronism
Continuous Steroid Monitoring in Interstitial Fluid With Wearable and Nanoparticle-enhanced Biosensors for Improved Management of Adrenal Disorders
The goal of this project is to provide novel technology that will pave the way from the present single-point (analogue) endocrinology towards continuous cortisol and aldosterone monitoring with full time resolution.
- Conditions
- Cushing Syndrome, Primary Aldosteronism, Adrenal Insufficiency
- Trial name
- NCT06980753
- Testing
- Participants will use the biossensor for 48 h
- Where
- Brazil
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Hypertension
The Role of Aldosterone on Augmented Exercise Pressor Reflex in Hypertension
Hypertensive patients often show an exaggerated rise in blood pressure during exercise through overactivity of the exercise pressor reflex.
- Trial name
- NCT01996449
- Testing
- Eplerenone, Amlodipine, Microneurography
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Primary Aldosteronism, Hyperaldosteronism
A Study of CIN-107 in Adults With Primary Aldosteronism
This is a multicenter, open-label study in adult patients with PA to evaluate the effectiveness and safety of CIN-107 after up to 12 weeks of treatment (Part 1), and then for eligible, consenting patients follow patients in Part…
- Trial name
- NCT04605549
- Testing
- CIN-107 2 mg dosing, CIN-107 4 mg dosing, CIN-107 8 mg dosing
- Where
- 10 sites in United States
- Volunteers
- 15 people
- Sponsor
- AstraZeneca
Hypertension
SPIRO-First: A Pragmatic Primary Care-Embedded Pilot Trial of Renin-Guided First-Line Antihypertensive Therapy
The goal of this clinical trial is to determine whether a renin-guided antihypertensive treatment strategy is feasible to implement in community primary care clinics and to explore whether spironolactone improves blood pressure…
- Trial name
- SPIRO-First (NCT07687160)
- Testing
- Spironolactone (drug), Candesartan 8mg, Hydrochlorothiazide (HCTZ) 25 milligrams.
- Where
- 4 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Ottawa Hospital Research Institute
Primary Aldosteronism, Primary Hyperaldosteronism
Primary Aldosteronism in General Practice: Organ Damage, Epidemiology and Treatment
Primary aldosteronism (PA) is the most frequent form of secondary hypertension. It is caused by autonomous secretion of aldosterone, encompassing a group of disorders which is for 99% predominated by unilateral…
- Trial name
- PAGODE (NCT01728493)
- Where
- Netherlands
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
Accuracy of 68Ga-Pentixafor PET/CT for Subtypting Diagnosis in Patients With Primary Aldosteronism Concurrent With Autonomous Cortisol Secretion
To evaluate the accuracy of 68Ga-Pentixafor PET-CT in the classification diagnosis of primary aldosteronism concurrent with autonomous cortisol secretion patient, using AVS and/or postoperative remission as the reference standard…
- Trial name
- ABOARD (NCT06635993)
- Testing
- 68Ga-Pentixafor PET/CT
- Where
- China
- Volunteers
- 97 people
- Sponsor
- Qifu Li