Clinical trials: Primary Malignant Brain Tumor
Brain Metastases, Adult, Primary Brain Tumor
Survivorship Study of Cancer Patients Who Received Cranial Radiation Therapy
This study represents a survivorship protocol that focuses on cognition and health-related quality of life (HRQoL) in cancer patients that have received prior brain irradiation.
- Conditions
- Brain Metastases, Adult, Primary Brain Tumor, Lung Cancer
- Trial name
- SPiRiT (NCT04567251)
- Testing
- Noona® application
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Duke University
Malignant Neoplasm of Breast, Malignant Neoplasms of Digestive Organs
Pembrolizumab With Intratumoral Injection of Clostridium Novyi-NT
Some tumors are difficult to treat with chemotherapy or radiation. One of the reasons is that areas of the tumor do not have many blood vessels, which makes it difficult for drugs to reach those areas.
- Conditions
- Malignant Neoplasm of Breast, Malignant Neoplasms of Digestive Organs, Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System, Malignant Neoplasms of Female Genital Organs
- Trial name
- NCT03435952
- Testing
- Pembrolizumab, Clostridium Novyi-NT, Doxycycline
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Brain Tumor, Primary, Cognitive Impairment
Cognitive Rehabilitation in Brain Tumor Patients After Neurosurgery
Many patients with primary brain tumors experience cognitive deficits and cognitive rehabilitation programs aim to alleviate these deficits.The cognitive rehabilitation program developed by the investigators proved effective in a…
- Trial name
- NCT03373487
- Testing
- The cognitive rehabilitation program ReMind
- Where
- 3 sites in Netherlands
- Volunteers
- 115 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
Primary Brain Tumor
Impact of the Development of Pediatric Palliative Care
Despite medical advances, cancer remains the leading cause of death by disease in children. Brain tumors are the second most common cause of cancer in children after leukemia, representing 25% of pediatric cancers.
- Trial name
- PTB (NCT05660499)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Glioma, Glioma Intracranial
A Study Using Brain Stimulation and Behavioral Therapy to Increase Extent of Resection in Low-Grade Gliomas
This study uses a cranial implant to deliver cortical stimulation that, when paired with physiotherapy, will remap the brain so that critical brain functions can be protected during brain tumor surgery.
- Conditions
- Glioma, Glioma Intracranial, Gliomas Benign, Brain Tumor
- Trial name
- NCT04745156
- Testing
- RNS System Implantation
- Volunteers
- 3 people
- Sponsor
- Medical College of Wisconsin
Brain and Central Nervous System Tumors
Procarbazine and Isotretinoin in Treating Patients With Recurrent Primary Malignant Gliomas
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining more than one drug may kill more tumor cells.
- Trial name
- NCT00003564
- Testing
- Isotretinoin, Procarbazine Hydrochloride
- Sponsor
- M.D. Anderson Cancer Center
Brain Tumor, Primary, Brain Tumor, Recurrent
Two-Part Study to Evaluate the Safety and Efficacy of Image Guided Surgery Using Indocyanine Green for Intramolecular Imaging of Nervous System Tumors Compared to Standard of Care, (TumorGlow)
Primary malignant and non-malignant brain tumors account for an estimated 21.42 cases per 100,000 for a total count of 343,175 incident tumors based on worldwide population estimates [1].
- Trial name
- TumorGlow(TM) (NCT03262636)
- Testing
- Indocyanine Green
- Volunteers
- 363 people
- Sponsor
- University of Pennsylvania
Brain Tumor, Primary
Intra-operative Variation in Size of Brain Tumors After Craniotomy
We planned to evaluate the change in tumor dimensions of intraaxial parenchymal tumors after craniotomy by comparing the tumor size on intraoperative ultrasonography (IOUSG) with pre-operative CECT and CEMRI brain.
- Trial name
- NCT04365647
- Where
- India
- Volunteers
- 51 people
- Sponsor
- Sheri Kashmir Institute of Medical Sciences
Ependymomas, Gliomas
A Pilot Study of Inpatient Hospice With Procurement of Brain Tumor Tissue on Expiration for Research Purposes
Background: An important new area of brain tumor research is the development of tumor and brain stem cell lines. Successful growth of these cell lines requires obtaining large volumes of fresh tumor and brain tissue, which is…
- Conditions
- Ependymomas, Gliomas, PNET, Pineal Tumors
- Trial name
- NCT01251913
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Cancer Institute (NCI)
Primary Malignant Brain Tumors
A Taiwanese Oncogenetic Panel and Integrated Clinical Data Registry Study for Diffuse Glioma
Glioma is a major histological subtype of primary malignant brain tumors in Taiwan, with distinct epidemiological, clinical, and pathological features comparing to the other common cancer diseases.
- Trial name
- NCT05622409
- Where
- 8 sites in Taiwan
- Volunteers
- 250 people
- Sponsor
- National Health Research Institutes, Taiwan
Brain Tumor
Cell Culture of Glioma Specimens for in Vitro Preclinical Studies
The purpose of this study is to culture primary human brain tumor cells with the specific aims of: 1. Develop primary cultures from human brain tumor surgical specimens 2.
- Trial name
- NCT01125826
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Albany Medical College
Amyotrophic Lateral Sclerosis, Brainstem Stroke
Optimizing BCI-FIT: Brain Computer Interface - Functional Implementation Toolkit
This project adds to non-invasive BCIs for communication for adults with severe speech and physical impairments due to neurodegenerative diseases.
- Conditions
- Amyotrophic Lateral Sclerosis, Brainstem Stroke, Muscular Dystrophies, Parkinson's Disease and Parkinsonism
- Trial name
- BCI-FIT (NCT04468919)
- Testing
- BCI-FIT multi-modal access, BCI-FIT adaptive signal modeling, BCI-FIT active querying
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Glioma, Primary Brain Tumor
MRI-based Computer Aided Diagnosis Software (V1) for Glioma
The goal of this multi-center clinical trial is to evaluate the effectiveness of MRI-based computer-aided diagnosis software (V1) for glioma segmentation, gene prediction, and tumor grading.
- Trial name
- NCT05739500
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Mingge LLC
Recurrent Glioblastoma, Brain Tumor
Phase I : Cediranib in Combination With Lomustine Chemotherapy in Recurrent Malignant Brain Tumour
This is a Phase I, open-label, multi-centre study designed to assess the safety and tolerability of Cediranib in combination with lomustine in patients with primary recurrent malignant brain tumour.
- Trial name
- NCT00503204
- Testing
- Cediranib, Lomustine
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 20 people
- Sponsor
- AstraZeneca
Brain Tumor, Central Nervous System Tumor
Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. Drugs used in chemotherapy work in different ways to stop tumor cells from dividing so they stop growing or die.
- Trial name
- NCT00085098
- Testing
- filgrastim, carboplatin, cisplatin
- Where
- 107 sites in United States, Australia and 2 more
- Volunteers
- 24 people
- Sponsor
- Children's Oncology Group
Lung Cancer, Brain Tumor
The Effects of Using Different Anesthetics on the Prognosis of Primary Tumors and Its Mechanism of Action
1. Eligible participants were assessed prior to anesthesia. After the patient is admitted to the hospital, the subject's consent form is explained, and the consent form must be signed before the operation. 2.
- Conditions
- Lung Cancer, Brain Tumor, Liver Cancer, Ovarian Cancer
- Trial name
- NCT05926336
- Testing
- Propofol, Sevoflurane
- Where
- Taiwan
- Volunteers
- 1,316 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Bladder Cancer, Brain and Central Nervous System Tumors
Study of Genes and Environment in Patients With Cancer in East Anglia, Trent, or West Midlands Regions of the United Kingdom
RATIONALE: Studying samples of blood from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Conditions
- Bladder Cancer, Brain and Central Nervous System Tumors, Esophageal Cancer, Intraocular Melanoma
- Trial name
- NCT00757614
- Testing
- DNA analysis, polymorphism analysis, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 14,000 people
- Sponsor
- Cancer Research UK
Brain Cancer
Assessment of Primary and Metastatic Brain Tumor Hypoxia With Fluoromisonidazole, FDG and Water
Purpose of Study This exploratory clinical study will investigate FMISO (fluoromisonidazole) in patients with (1) newly diagnosed primary malignant brain tumors (WHO [World Health Organization] Grade III or IV glial-based tumors)…
- Trial name
- NCT01246869
- Testing
- [18F]fluoro-2-deoxy-D-glucose (FDG), 1H-1-(3-[18F]-fluoro-2-hydroxy-propyl)-2-nitro-imidazole [18F]-fluoromisonidazole, [15O]water
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Utah
Brain Tumor, Primary
Perampanel in Seizure Patients With Primary Glial Brain Tumors
This is a Phase 2 single-arm study to assess the efficacy of perampanel as an adjunctive anti-epileptic drug (AED) in patients with primary glioma that are presenting refractory partial onset seizure activity (defined as 3 or…
- Trial name
- NCT02363933
- Testing
- Perampanel
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Duke University
Primary Brain Tumor, Epilepsy
Trial of Levetiracetam in Patients With Primary Brain Tumors and Symptomatic Seizures Who Undergo Surgery
The purpose of this study is to determine the feasibility, efficacy and safety of intravenous and oral antiepileptic treatment with levetiracetam in patients with primary brain tumors and symptomatic epilepsy in the period of…
- Trial name
- NCT00571155
- Testing
- levetiracetam
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Hospital Tuebingen