Clinical trials: Primary Open - Angle Glaucoma (POAG)
Glaucoma Open-Angle Primary, Hypertension
The Acute Effect of Exercise Type And Timing on Ambulatory Blood Pressure and Intra-Ocular Pressure in Individuals With Glaucoma (The ACHIEVE-project).
ACHIEVE aims to determine whether exercise can be a safe and effective non-drug approach to improve blood pressure control in patients with primary open-angle glaucoma (POAG).
- Conditions
- Glaucoma Open-Angle Primary, Hypertension, Elevated Blood Pressure
- Trial name
- ACHIEVE (NCT07413614)
- Testing
- Exercise
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- KU Leuven
Open Angle Glaucoma, Primary Open Angle Glaucoma
IOP and Medication Reduction in MIGS Procedures
The primary objective of this research is to compare the efficacy of trabecular minimally invasive glaucoma surgery (MIGS) devices (iStent vs iStent Inject vs Hydrus) for intra ocular pressure (IOP) and anti-glaucoma medication…
- Conditions
- Open Angle Glaucoma, Primary Open Angle Glaucoma, Pigmentary Glaucoma, Pseudoexfoliation Glaucoma in Both Eyes
- Trial name
- NCT04202510
- Testing
- Glaucoma and Cataract Surgery
- Where
- United States
- Sponsor
- Wills Eye
Glaucoma, Open-Angle
Choroidal Thickness and Its Correlations With Ocular Parameters in Primary Open-angle Glaucoma
Glaucoma is one of the leading causes of blindness worldwide that is a chronic public health problem. Unfortunately, glaucoma can be diagnosed when the disease reaches a certain level in today's conditions.
- Trial name
- NCT03966560
- Testing
- Brimonidine Tartrate, Dorzolamide (as Dorzolamide Hydrochloride) 20 Mg/mL and Timolol (as Timolol Maleate) 5 Mg/mL Eye Drops, Brinzolamide/Timolol 10 MG/1 ML-5 MG/1 ML Ophthalmic Suspension
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Afyon Kocatepe University Hospital
Morbidity of Primary Open Angle Glaucoma
Matching Glaucoma With Impaired Cognition
Glaucoma is the leading cause of irreversible blindness in the world. The current study is designed to find the underlying relationship between impairment of topological perception and incidence of glaucoma.
- Trial name
- MAGIC (NCT03695224)
- Testing
- Topological perception test
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Primary Open Angle Glaucoma, Ocular Hypertension
Study of the Intraocular Pressure (IOP)-Lowering Efficacy of Azopt 1.0% Compared to Timolol 0.5% in Patients With Glaucoma or Ocular Hypertension
This is a multiple-dose study of the IOP-lowering efficacy of Azopt (brinzolamide) 1.0% compared to timolol 0.5% when added to a prostaglandin analogue (PGA) as adjunctive therapy over a 24 hour period in patients with glaucoma…
- Trial name
- NCT00300079
- Testing
- brinzolamide 1.0%
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Alcon Research
Primary Open Angle Glaucoma, Primary Open-Angle Glaucoma, Unspecified Eye
Glaucoma Screening Using Dynamic Analysis of Computerized Pupillary Light Reflex Assessment Device
To explore an effective diagnostic tool of glaucoma through the dynamic analysis of computerized pupillary light reflex assessment device (CPLRAD) pupillography based on iris recognition techniques and investigate its feasibility…
- Conditions
- Primary Open Angle Glaucoma, Primary Open-Angle Glaucoma, Unspecified Eye, Primary Open Angle Glaucoma of Both Eyes, Suspect Glaucoma
- Trial name
- NCT04595227
- Testing
- Computerized pupillary light reflex assessment device
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peking University
Primary Open Angle Glaucoma, Ocular Hypertension
Comparison of Brimonidine Purite, Dorzolamide, and Brinzolamide as Adjunctive Therapy to Prostaglandin Analogs
The purpose of this study is to compare the efficacy of brimonidine Purite, dorzolamide, and brinzolamide in reducing intraocular pressure when added to prostaglandin analog therapy (bimatoprost, latanoprost, or travoprost) in…
- Trial name
- NCT00675207
- Testing
- Brimonidine purite 0.15%, Dorzolamide 2%, Brinzolamide 1%
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Northwestern Ophthalmic Institute S.C.
Open Angle Glaucoma
Comparative Effectiveness of Treatment Strategies for Primary Open-Angle Glaucoma
The primary objectives of the study are: 1. To compare the proportion of patients who achieve a successful response to treatment (reduction in Intraocular Pressure (IOP) of >15%) between patients treated with laser surgery…
- Trial name
- RiGOR (NCT01645319)
- Where
- United States
- Volunteers
- 2,597 people
- Sponsor
- Agency for Healthcare Research and Quality (AHRQ)
Glaucoma
Optic Nerve Perfusion Following Treatment with Latanoprost Versus Brimionidin Tartrate
This study aimed to evaluate the effects of topical Latanoprost 0.005 % versus Brimionidin tartrate 0.2% on perfusion of optic nerve head This prospective interventional randomized study included 56 naive patients recently…
- Trial name
- NCT06730516
- Testing
- Latanoprost (Xalatan), Brimonidine 0.2 %
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Glaucoma, Open-Angle, Ocular Hypertension
Safety and Efficacy of Triple Combination Therapy in Patients With Primary Open-Angle Glaucoma or Ocular Hypertension
This study will evaluate the safety and efficacy of Triple Combination Therapy compared with Fixed Combination brimonidine tartrate/timolol ophthalmic solution in patients with primary open-angle glaucoma or ocular hypertension.
- Trial name
- NCT01241240
- Testing
- bimatoprost/brimonidine tartrate/timolol ophthalmic solution (Triple Combination Therapy), Fixed Combination 0.2% brimonidine tartrate/0.5% timolol ophthalmic solution
- Where
- 2 sites in Colombia, Mexico
- Volunteers
- 192 people
- Sponsor
- Allergan
Glaucoma, Open-Angle, Glaucoma, Primary Open Angle
Following Patients After Selective and Pascal Laser Trabeculoplasty for Treatment of Chronic Open-Angle Glaucoma
The purpose of this study is to follow and describe the outcomes of patients after selective and pascal laser trabeculoplasty treatment for chronic open-angle glaucoma.
- Conditions
- Glaucoma, Open-Angle, Glaucoma, Primary Open Angle, Exfoliation Glaucoma, Glaucoma, Pigmentary
- Trial name
- FPSPLTTCOAG (NCT02679482)
- Where
- Colombia
- Volunteers
- 36 people
- Sponsor
- Fundación Oftalmológica Nacional
Glaucoma, Primary Open Angle, Ocular Hypertension
Generic Travoprost Versus Brand Name Travoprost in Patients With Primary Open Angle Glaucoma or Ocular Hypertension
The purpose of this study is to compare the efficacy and tolerance of generic travoprost with its brand name formulation. In this open label, randomized, crossover study, the primary outcome will be intraocular pressure and the…
- Trial name
- NCT02796560
- Testing
- Brand name travoprost, Generic travoprost
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Université de Sherbrooke
Open Angle Glaucoma, Ocular Hypertension
DE-111 Against Tafluprost Ophthalmic Solution 0.0015% Alone and Concomitant Use of Tafluprost Ophthalmic Solution 0.0015% Plus Timolol Ophthalmic Solution 0.5%
DE-111 ophthalmic solution will be evaluated for superiority in comparison with Tafluprost 0.0015% ophthalmic solution, or for non-inferiority in comparison with Tafluprost 0.0015% and Timolol ophthalmic solution 0.5% used…
- Trial name
- NCT01342081
- Testing
- DE-111 ophthalmic solution, Tafluprost ophthalmic solution 0.0015%, Concomitant use of tafluprost ophthalmic solution 0.0015% plus timolol ophthalmic solution 0.5%
- Where
- Japan
- Volunteers
- 489 people
- Sponsor
- Santen Pharmaceutical Co., Ltd.
Macular Degeneration, Dry, Primary Open-angle Glaucoma
Retinal Photoreceptor Outer Segment Length Before and After Light Stimulation - a Pilot Study
It has been shown that reactions of human retinal photoreceptors to a light stimulus can be measured with custom-made, research prototype optical coherence tomography (OCT) systems.
- Trial name
- NCT03921931
- Testing
- White light stimulation
- Where
- Austria
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Vitamin D Deficiency, Primary Open-angle Glaucoma
Comparison of Vitamin D Status and Vitamin D Receptor Polymorphisms in Patients With High Myopia and Primary Open-angle Glaucoma
Vitamin D deficiency is known to be significantly associated with high myopia. This study investigated the vitamin D status in patients with high myopia and primary open-angle glaucoma, in order to understand the relationship…
- Conditions
- Vitamin D Deficiency, Primary Open-angle Glaucoma, High Myopia, Vitamin D Receptor Polymorphisms
- Trial name
- NCT03021629
- Testing
- Serum levels of 1a, 25-Dihydroxyvitamin D3 were measured by an enzyme-linked immuno-absorbent assay
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Lv Yingjuan
Primary Open Angle Glaucoma
African Descent and Glaucoma Evaluation Study
According to the National Eye Institute, Glaucoma affects about three million Americans. Among Blacks in the United States, open- angle glaucoma is the leading cause of irreversible visual loss.
- Trial name
- ADAGES (NCT00221923)
- Where
- 3 sites in United States
- Volunteers
- 1,540 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Primary Open Angle Glaucoma (POAG), Istent Inject W
Trabecular Microbypass IStent in Patients with Glaucoma
The goal of this clinical trial is to assess the safety and efficacy of phacoemulsification combined with one trabecular micro-bypass stent implantation (phaco-iStent) versus phacoemulsification alone in a Taiwanese population…
- Conditions
- Primary Open Angle Glaucoma (POAG), Istent Inject W, Normal Tension Glaucoma (NTG)
- Trial name
- NCT06630546
- Testing
- first generation iStent (Glaukos, San Clemente, CA, USA) insertion, phacoemulsification
- Where
- Taiwan
- Volunteers
- 71 people
- Sponsor
- Yu-Ting Tsao
Primary Open Angle Glaucoma, Ocular Hypertension
Ph2 Placebo-Controlled Study for Safety & Ocular Efficacy of SBI-100 Ophthalmic Emulsion in Pts w/ Elevated Eye Pressure
The goal of this clinical trial is to test in patients with glaucoma and elevated pressure in the eye. The main questions it aims to answer are: • ability to lower pressure in the eye • safety in the eye and the body of patients…
- Trial name
- NCT06144918
- Testing
- SBI-100 Ophthalmic Emulsion, 0.5%, SBI-100 Ophthalmic Emulsion, 1.0%
- Where
- 3 sites in United States
- Volunteers
- 56 people
- Sponsor
- Skye Bioscience, Inc.
Glaucoma
Glaukos® iStent Infinite Trabecular Micro-Bypass System in Subjects With Mild to Moderate Primary Open-angle Glaucoma
Prospective, multicenter, single-arm study of the iStent infinite in adult pseudophakic or phakic subjects with mild to moderate primary open angle glaucoma who have not failed conventional medical and surgical treatment
- Trial name
- NCT06057051
- Testing
- iStent Infinite
- Where
- United States
- Volunteers
- 245 people
- Sponsor
- Glaukos Corporation
Glaucoma, Primary Open Angle, Ocular Hypertension
Safety and IOP-Lowering Effects of WB007
The study evaluated the safety and IOP-lowering effects of WB007 in adults with primary open-angle glaucoma or ocular hypertension in both eyes. This was a 2-part study.
- Trial name
- NCT04149899
- Testing
- WB007 0.05%, WB007 0.15%, WB007 0.4%
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Bausch & Lomb Incorporated