Clinical trials: Primary Osteoarthritis
Osteoarthritis of Knee
Clinical Study of Non-inferiority With Participants Diagnosed With Primary Knee OA (GLACIAL)
This phase III clinical study will be conducted in Brazilian research sites. It will be included in the study 314 participants diagnosed with primary knee OA according to the classification criteria of the ACR.
- Trial name
- GLACIAL (NCT02830919)
- Testing
- Glucosamine and chondroitin sulfate combination (Eurofarma), Glucosamine and chondroitin sulfate combination (Zodic)
- Where
- 4 sites in Brazil
- Volunteers
- 627 people
- Sponsor
- Eurofarma Laboratorios S.A.
Osteoarthritis
Efficacy and Safety of Lumiracoxib in Patients With Primary Knee Osteoarthritis (OA)
This 39-week, active controlled, study is designed to assess long-term efficacy, safety and tolerability of lumiracoxib 100mg od in patients with osteoarthritis (OA) of the knee who participated in the 13-week core CCOX189A2361…
- Trial name
- NCT00476034
- Testing
- lumiracoxib
- Where
- 15 sites in Australia, Austria and 13 more
- Volunteers
- 1,312 people
- Sponsor
- Novartis
Osteoarthritis of the Shoulder
TITAN™ Reverse Shoulder System
The Integra® TITAN™ Reverse Shoulder System (TRS) is a semi-constrained total shoulder construct. When used under the conditions and purposes intended the TRS will relieve pain and restore some functional joint motion to the…
- Trial name
- NCT02204228
- Testing
- TITAN™ Reverse Shoulder System (TRS)
- Where
- 10 sites in United States, France and 2 more
- Volunteers
- 151 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Post-traumatic Arthritis
A Randomised Single Centre Study to Compare the Long-term Performance of 4 Designs of the DePuy Ultima LX Stem in Primary Total Hip Replacement
The purpose of this study is to compare the performance of 4 designs of the DePuy Ultima LX hip stem in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Collagen Disorder, Avascular Necrosis
- Trial name
- NCT00208351
- Testing
- Ultima LX Collared Stem - Non-Polished/Blasted Finished, Ultima LX Collared Stem - Polished Finished, Ultima LX Collarless Stem - Non-Polished/Blasted Finished
- Where
- United Kingdom
- Volunteers
- 164 people
- Sponsor
- DePuy International
Arthroplasty, Replacement, Hip
Tritanium® Primary Acetabular Shell Study
This study will be a prospective, non-randomized evaluation of the Tritanium® Acetabular Shell for primary total hip replacement (THR) with a cementless application in a consecutive series of patients who meet the eligibility…
- Trial name
- NCT01063751
- Testing
- Tritanium® Primary Acetabular Shell
- Where
- 7 sites in United States
- Volunteers
- 275 people
- Sponsor
- Stryker Orthopaedics
Osteoarthritis, Post-traumatic Arthritis
China ATTUNE® Study
The study was designed as prospective, single-arm, multi-center which was intended to broadly capture all patients as the technology is adopted.
- Trial name
- NCT03542045
- Testing
- Cemented ATTUNE® Knee System
- Where
- China
- Volunteers
- 120 people
- Sponsor
- DePuy Orthopaedics
Osteoarthritis
Study to Assess the Stability, Efficacy and Safety of the Silent™ Hip Prosthesis in Primary Total Hip Replacement
The purpose of this study is to determine if the Silent™ hip, when used as part of an artificial hip joint, is stable and effective in treatment of patients with joint disease requiring a total hip replacement.
- Trial name
- NCT00894140
- Testing
- DePuy Silent™ Hip femoral prosthesis
- Where
- 2 sites in Australia, Germany
- Volunteers
- 44 people
- Sponsor
- DePuy International
Osteoarthritis
Multi-centre Study to Assess Long-term Safety and Efficacy of the Silent™ Hip Prosthesis in Primary THR
The purpose of this study is to determine if the Silent™ hip is effective in the treatment of patients with hip joint disease requiring a total hip replacement.
- Trial name
- NCT00878046
- Testing
- DePuy Silent™ Hip femoral prosthesis
- Where
- 7 sites in Australia, France and 3 more
- Volunteers
- 108 people
- Sponsor
- DePuy International
Osteoarthritis
Gait and Functional Improvement in Total Knee Arthroplasty With the Use of Verasense for Soft Tissue Balancing
The primary objectives of this study are to understand the effects of soft-tissue balancing on Gait, function and rehabilitation potential after sensor-assisted Total Knee Arthroplasty and correlate Intra-operative subjective…
- Trial name
- NCT02290119
- Testing
- Sensor-assisted TKR (Verasense), Control - Without the use of Verasense
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orthosensor, Inc.
Osteoarthritis
10003 PRO Current Products
This post-marketing investigation will evaluate the functional knee performance of Subjects who have undergone primary total knee arthroplasty (TKA).
- Trial name
- 10003 (NCT01497730)
- Testing
- Total Knee Replacement
- Where
- 22 sites in United States, Australia and 2 more
- Volunteers
- 842 people
- Sponsor
- DePuy Orthopaedics
Low Back Pain, Migraine
Evaluating the Safety and Tolerability of OraVescent Fentanyl for Opioid Tolerant Patients With Noncancer Related Breakthrough Pain
The purpose of this study is to evaluate the safety and tolerability of OraVescent fentanyl for the potential treatment of breakthrough pain episodes in patients who have chronic noncancer pain.
- Conditions
- Low Back Pain, Migraine, Diabetic Neuropathies, Osteoarthritis
- Trial name
- NCT00228605
- Testing
- OraVescent Fentanyl
- Where
- 38 sites in United States
- Volunteers
- 500 people
- Sponsor
- Cephalon
Rheumatoid Arthritis, Osteoarthritis
A Single Centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery
The purpose of this study is to monitor the performance and determine the metal ion release of the DePuy ASR™ System in the treatment of patients with hip joint disease requiring hip resurfacing surgery.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872794
- Testing
- DePuy ASR™ Hip System
- Where
- South Africa
- Volunteers
- 50 people
- Sponsor
- DePuy International
Osteoarthritis, Arthritis
AMIStem Primary Hip System Prospective Post-marketing Multi-centre Surveillance Study
This is a multicentre post-marketing prospective study to evaluate performance and clinical outcomes of AMIIStem primary hip system.
- Conditions
- Osteoarthritis, Arthritis, Avascular Necrosis, Fracture of the Femoral Neck or Head
- Trial name
- NCT01107340
- Testing
- AMIStem Hip System
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 500 people
- Sponsor
- Medacta International SA
Osteoarthritis, Post-traumatic Arthritis
A Randomised Multi-centre Study to Compare the Long-term Performance of the Future Hip to 3 Other Implants in Primary Total Hip Replacement
This post-market clinical follow-up study was designed to compare hip replacement outcomes of the European Hip against 3 controls (Omniflex, Zweymuller, and Spotorno), however Omniflex did not end up being used.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders, Avascular Necrosis
- Trial name
- NCT00208468
- Testing
- European Hip, Zweymüller, CLS Spotorno
- Where
- 3 sites in Austria, Germany and 1 more
- Volunteers
- 317 people
- Sponsor
- DePuy International
Degenerative Osteoarthritis, Rheumatoid Arthritis
All Polyethylene Tibia-VEGA Kiel
Obligatory Post-Marketing Clinical Follow-up (PMCF) as part of the post marketing surveillance plan for the product under investigation For this PMCF only CE-marked medical devices will be used within their intended purpose and…
- Conditions
- Degenerative Osteoarthritis, Rheumatoid Arthritis, Post-traumatic; Arthrosis, Other Instability, Knee
- Trial name
- APT-VEGA_KI (NCT02756702)
- Testing
- All-Poly
- Where
- Germany
- Volunteers
- 70 people
- Sponsor
- Aesculap AG
Knee Osteoarthritis, Pain Management
Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty
The purpose of the study is to compare magnitude of postsurgical analgesic effect in different groups following a single dose of study drug when administered via adductor canal block in subjects undergoing primary unilateral…
- Trial name
- NCT05139030
- Testing
- bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
- Where
- 6 sites in United States
- Volunteers
- 167 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Primary Osteoarthritis, Post-Traumatic Arthritis
AVANTAGE® RELOAD Double Mobility Acetabular Cup -Clinical Study
This is a Post Marketing Clinical Follow Up study (PMCF) on the AVANTAGE RELOAD dual mobility system cup.
- Conditions
- Primary Osteoarthritis, Post-Traumatic Arthritis, Inflammatory Joint Disease, Femoral Neck Fracture
- Trial name
- NCT03357445
- Testing
- Avantage Reload cup
- Where
- 4 sites in France, Slovenia
- Volunteers
- 500 people
- Sponsor
- Zimmer Biomet
Rheumatoid Arthritis, Osteoarthritis
A Multi-centre Study to Assess the Long-term Performance of the DePuy PROXIMA™ Hip in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the DePuy PROXIMA™ hip in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT00208455
- Testing
- DePuy Proxima™ Hip
- Where
- 4 sites in Germany, Italy and 2 more
- Volunteers
- 184 people
- Sponsor
- DePuy International
Primary Knee Osteoarthritis Grade 3 - 4
LIKEST Study: Lipocet® in Adults With Primary Knee Osteoarthritis Grade 3-4
The purpose of this study is to assess the safety, tolerability and efficacy of Lipocet® (food supplement) in patients with primary knee osteoarthritis grade 3 - 4
- Trial name
- NCT06134115
- Testing
- Lipocet® (food supplement)
- Where
- 3 sites in Georgia
- Volunteers
- 60 people
- Sponsor
- Pharmanutra S.p.a.
Osteoarthritis
ARTEBONE Bone Void Filler in Arthrodesis Procedure of the Ankle
The purpose of this investigation is to assess safety and performance of ARTEBONE Bone Void Filler in the single arthrodesis procedure.
- Trial name
- NCT02480868
- Testing
- ARTEBONE
- Where
- 5 sites in Finland, Poland
- Volunteers
- 34 people
- Sponsor
- BBS-Bioactive Bone Substitutes Oy