Clinical trials: Primary Osteoarthritis
Osteoarthritis, Knee, Osteoarthritis Hand
The Halland Osteoarthritis Cohort
Osteoarthritis is the most common musculoskeletal disease and is characterized by cartilage destruction, osteophyte formation, subchondral bone sclerosis and cysts.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis Hand, Osteoarthritis Generalized
- Trial name
- HALLOA (NCT04928170)
- Where
- Sweden
- Volunteers
- 312 people
- Sponsor
- FoU Center Spenshult
Osteoarthritis, Post-traumatic Arthritis
China ATTUNE® Study
The study was designed as prospective, single-arm, multi-center which was intended to broadly capture all patients as the technology is adopted.
- Trial name
- NCT03542045
- Testing
- Cemented ATTUNE® Knee System
- Where
- China
- Volunteers
- 120 people
- Sponsor
- DePuy Orthopaedics
Primary Osteoarthritis, Secondary Osteoarthritis
Prospective Study for the Evaluation of the Cementless Anatomic Femoral Stem Minimax -Launay
This is a post-marketing surveillance on MiniMAX Stem
- Conditions
- Primary Osteoarthritis, Secondary Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis
- Trial name
- NCT06012656
- Testing
- MiniMAX
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Medacta International SA
Osteoarthritis, Knee, Osteoarthritis
Evaluation of CYT-108, A Recombinant Protease Inhibitor, for Treatment of Mild To Moderate Primary Osteoarthritis Of The Knee
The goal of this Phase 1 study is to investigate the safety of CYT-108, our experimental recombinant protease inhibitor drug candidate for osteoarthritis, in a population of patients suffering from osteoarthritis of the knee.
- Trial name
- NCT06263270
- Testing
- CYT-108, a recombinant protease inhibitor, Phosphate Buffered Saline (PBS)
- Where
- 3 sites in Australia
- Volunteers
- 19 people
- Sponsor
- Cytonics Corporation
Osteoarthritis, Arthritis
Bipolar Sealer Aquamantys Use in Total Knee Replacement
This study will compare the clinical outcomes for patients undergoing a total knee replacement using a bipolar sealer, the Aquamantys® System, as compared to standard electrocautery.
- Conditions
- Osteoarthritis, Arthritis, Surgery, Infection
- Trial name
- NCT01736644
- Testing
- Electrocautery, Bipolar sealer Aquamantys
- Where
- 2 sites in United Kingdom
- Volunteers
- 97 people
- Sponsor
- Medtronic Surgical Technologies
Osteoarthritis, Knee Replacement
Disability and Self-rated Health Following Primary Knee Replacement
Knee replacement is an effective treatment in late-stage osteoarthritis. It reduces pain and improves quality of life. There is, however, limited data concerning its results in older people and on its effect on how patients…
- Trial name
- NCT01236729
- Where
- Finland
- Volunteers
- 460 people
- Sponsor
- Coxa, Hospital for Joint Replacement
Osteoarthritis
Medico-economic Study of Patient Matched Cutting Blocks (Ancillary) MyKnee ® LBS During Knee Arthroplasty GMK ®.
Total knee arthroplasty represents over 70 000 surgical procedures per year in France, increasing about 10% each year since the early 1990s.
- Trial name
- NCT01814384
- Testing
- prosthesis GMK ® without the ancillary MyKnee ® LBS, Matched patient cutting blocks MyKnee ® LBS
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Nantes University Hospital
Osteoarthritis
A Multicentre Trial to Compare Two Articulating Bearing Surfaces as Used in Cementless Primary Hip Arthroplasty
The aim of this study is to demonstrate the non-inferiority of the ceramic-on-metal articulation using large diameter bearings (38mm to 60mm) compared to the metal on metal articulation using the same cup in regards to the…
- Trial name
- MagnumCRCT (NCT01247038)
- Testing
- Metal on ceramic articulation, Metal-on-Metal
- Where
- 2 sites in Bosnia and Herzegovina, South Africa
- Volunteers
- 130 people
- Sponsor
- Zimmer Biomet
Knee Replacement Surgery, Osteoarthritis, Knee
Cannabidiol for Postoperative Opioid Reduction in Primary Total Knee Arthroplasty
The goal of this study is to better understand how daily treatment with cannabidiol (CBD) affects the need for opioid pain medication, as well as pain, inflammation and other related symptoms, after knee replacement surgery.
- Trial name
- CORK (NCT06234631)
- Testing
- Epidiolex oral solution
- Where
- 2 sites in United States
- Volunteers
- 380 people
- Sponsor
- Chad Brummett
Knee Osteoarthritis
ROM Outcomes in Patients Undergoing a Primary TKA
The goal of this prospective, randomized study is to compare the outcomes of patients undergoing primary TKA after photographing final knee range of motion immediately post-operatively and sharing these photographs with patients…
- Trial name
- NCT04217486
- Testing
- Patient will be shown a photograph of their knee at 2 weeks postop, Patient will not be shown a photograph of their knee at 2 weeks postop
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- University of Louisville
Osteoarthritis, Knee
A Study of Siriraj Home Exercises Protocol for Primary Osteoarthritis of the Knee
The purpose of this study is to compare the exercise protocol called "Siriraj home base exercise program for OA knee" to usual care and physical modalities for conservative treatment in patients with 1st OA knee.
- Trial name
- NCT02600702
- Testing
- Siriraj knee exercise, Physical modalities
- Where
- Thailand
- Volunteers
- 135 people
- Sponsor
- Mahidol University
Osteoarthritis, Knee
Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA)
This prospective randomized controlled trial evaluates whether a modified J-shaped skin incision can reduce peri-incisional numbness after primary total knee arthroplasty (TKA) compared with the conventional midline skin…
- Trial name
- NCT07514598
- Testing
- Conventional Midline Incision, J-shaped Incision
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Hip Osteoarthritis, Osteoarthritis, Hip
Gluteal Sling Release on Gluteal Dysfunction After in Primary Total Hip Arthroplasty
This study investigates the effects of gluteal sling release during total hip arthroplasty (THA) on gluteal muscle function and hip joint performance.
- Conditions
- Hip Osteoarthritis, Osteoarthritis, Hip, Gluteus Maximus Muscle Atrophy, Muscle Weakness Condition
- Trial name
- NCT06850155
- Testing
- Sling release, Sling release and repair
- Where
- Turkey (Türkiye)
- Volunteers
- 144 people
- Sponsor
- Ankara City Hospital Bilkent
Total Hip Arthroplasty, Osteoarthritis, Hip
Dual-mobility Cups Compared to Unipolar Cups on Dislocation and Cost-effectiveness After Primary Total Hip Arthroplasty.
Objective: The primary objective is to investigate whether there is a difference in the number of hip dislocations following primary total hip arthroplasty (THA), using the posterolateral approach, with a DM cup compared to a…
- Trial name
- REDEP (NCT04031820)
- Testing
- Unipolar cup, Dual mobility cup
- Where
- Netherlands
- Volunteers
- 1,100 people
- Sponsor
- JointResearch
Osteoarthritis
A Comparison of Fixation Method in Total Knee Arthroplasty - Low Viscosity Versus High Viscosity Bone Cement
The purpose of this study is to compare the early migration and periprosthetic bone changes of two total knee arthroplasties fixated with two different type bone cement.
- Trial name
- NCT00175162
- Testing
- Osteopal G vs. Refobacin-Palacos R bone cement
- Where
- Denmark
- Sponsor
- University of Aarhus
Osteoarthritis, Knee
Oral Steroid Taper After Total Knee Arthroplasty
This study aims to evaluate the effectiveness of an oral methylprednisolone taper in reducing postoperative pain, opioid consumption, and nausea following primary total knee arthroplasty (TKA).
- Trial name
- NCT07070882
- Testing
- Methylprednisolone
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- Columbia University
Knee Osteoarthritis, Gonarthrosis; Primary
Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty
This prospective observational cohort study aims to evaluate the association between perioperative dexamethasone administration and early postoperative recovery following primary total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Gonarthrosis; Primary, Total Knee Arthroplasty
- Trial name
- TKA (NCT07442812)
- Testing
- Routine perioperative management
- Where
- Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Haseki Training and Research Hospital
Osteoarthritis, Hip
Outcomes Following Anterior Approach to Total Hip Arthroplasty
Osteoarthritis disables approximately 10% of people who are 60 years or older and compromises the quality of life of more than 20 million Americans every year.
- Trial name
- AAP (NCT01353885)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- McMaster University
Chronic Low Back Pain, Hip Ostearthritis
Making Better Lives: Patient-Focused Care for Low Back Pain (LBP)
Back pain is a huge problem for millions of Americans, including nearly 11 million Veterans. Our older Veterans suffer the most. Citizens spend billions of dollars, yet consistently get poor results.
- Conditions
- Chronic Low Back Pain, Hip Ostearthritis, Myofascial Pain Syndrome, Fibromyalgia
- Trial name
- NCT02697435
- Testing
- Patient-Centered Care, Imaging-Directed Care
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- VA Office of Research and Development
Hip Arthritis, Osteoarthritis, Hip
Observational Study to Collect Safety Data and PROMs on Primary THA
This observational study is designed to collect safety data and PROMs on retrospective primary total hipa arthroplasty surgeries with Trinity cup and Meije Duo cementless hip system
- Conditions
- Hip Arthritis, Osteoarthritis, Hip, Coxitis, Femoral Head Necrosis
- Trial name
- NCT06518993
- Testing
- Total hip arthroplasty with a Trinity cup and a Meije Duo cementless stem
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Corin