Clinical trials: Primary PCI
Reperfusion Injury, Myocardial
Effects of Melatonin on Reperfusion Injury
Acute myocardial infarction is a major cause of mortality and morbidity. Primary percutaneous coronary intervention (pPCI) is currently the most effective treatment strategy in acute myocardial infarction.
- Trial name
- NCT03303378
- Testing
- melatonin (Helsinn Chemical Co, Biasca, Switzerland)
- Where
- China
- Volunteers
- 190 people
- Sponsor
- Chinese PLA General Hospital
ST-elevation Myocardial Infarction
Evaluation of Myocardial Reperfusion After Primary PCI in Patients With High Platelet Reactivity Treated by Cangrelor or Not
This study aims to evaluate the impact on myocardial reperfusion and residual thrombotic burden of adding Cangrelor -a potent and immediate P2Y12 inhibitor- to ticagrelor in primary PCI patients with high on ticagrelor platelet…
- Trial name
- ERMIT (NCT04927949)
- Testing
- cangrelor perfusion during PCI, standard PCI
- Where
- France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Caen
ST Segment Elevation Myocardial Infarction (STEMI), Coenzyme Q10
Effect Supplementation of COenzyme Q10 in Acute STEMI Underwent PPCI
Left ventricular remodeling can still occur after primary percutaneous coronary intervention (PCI). Global longitudinal strain (GLS) assessment has been used as a predictor of left ventricular remodeling.
- Trial name
- ESCOMI (NCT06661018)
- Testing
- Coenzyme Q 10
- Where
- 2 sites in Indonesia
- Volunteers
- 46 people
- Sponsor
- Universitas Diponegoro
Patients With a First Acute Myocardial Infarction to be Treated With Primary Percutaneous Coronary Intervention (PCI).
Effect of Additional Treatment With EXenatide in Patients With an Acute Myocardial Infarction (the EXAMI Trial)
Myocardial infarction (MI) causes loss of myocytes and may lead to loss of ventricular function, morbidity and mortality. The most effective therapy is early reperfusion of the ischemic myocardium by percutaneous coronary…
- Trial name
- EXAMI (NCT01254123)
- Testing
- Exenatide infusion
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- Amsterdam UMC, location VUmc
Cardiovascular Diseases
Time-trend Analysis of Clinical Characteristic and Outcomes in Patients With Unprotected Left Main Coronary Artery Disease Treated With PCI Over a 10-year Period
Surgical coronary bypass surgery (CABG) has been demonstrated to confer significant survival benefit over medical therapies patients with LMCA in earlier clinical trials1,2,3 and therefore was the revascularization modality of…
- Trial name
- NCT05548023
- Testing
- The AngioliteTM Durable Fluoroacrylate Polymer-based Sirolimus-Eluting Stent
- Where
- Hong Kong
- Volunteers
- 500 people
- Sponsor
- Chinese University of Hong Kong
Myocardial Infarction
STREAM-Strategic Reperfusion (With Tenecteplase and Antithrombotic Treatment) Early After Myocardial Infarction
This study aims at evaluating, in a proof of concept approach, the outcome of patients presenting with acute ST-elevation myocardial infarction within 3 hours of symptom onset in either a pre-hospital setting or community…
- Trial name
- NCT00623623
- Testing
- primary PCI, enoxaparin, catheterisation
- Where
- 201 sites in Austria, Belgium and 14 more
- Volunteers
- 1,899 people
- Sponsor
- Boehringer Ingelheim
ST Elevation Myocardial Infarction
Early Discharge After Primary Percutaneous Coronary Intervention
When Primary percutaneous coronary intervention (PPCI) is performed expeditiously and at a high-volume centre, it is the optimal approach for ST elevation myocardial infarction (STEMI) .
- Trial name
- EDAPPCI (NCT01860079)
- Testing
- early discharge
- Where
- 3 sites in Turkey (Türkiye)
- Volunteers
- 900 people
- Sponsor
- Acibadem University
ST-elevation Myocardial Infarction (STEMI)
The Impact of Post Stenting Balloon Dilatation on Coronary Microcirculation in STEMI Patients Undergoing PPCI
This study aims to assess the impact of NC balloon post-dilatation on coronary microcirculation in patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI).
- Trial name
- POSTDILSTEMI (NCT02788396)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Mid and South Essex NHS Foundation Trust