Clinical trials: Primary Parkinsonism
Parkinson Disease
Phosphorylation of ERK1/2 in Patients With Parkinson's Disease
Levodopa-induced dyskinesia severely limits the use of levodopa in Parkinson's disease and constitutes a debilitating complication of dopaminergic treatment in late stage.
- Trial name
- BIODYS (1) (NCT01142739)
- Testing
- Clinical variables
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Parkinson Disease Psychosis
Hallucinations in Parkinson's Disease
Investigation on how robotically mediated sensorimotor stimulation induces and triggers presence hallucinations in different clinical groups of parkinsonian patients, and in aged-matched controls
- Trial name
- NCT04592965
- Testing
- Clinical and neuropsychological assessments, Induction of PH and associated bodily states, Resting-state fMRI acquisition
- Where
- 6 sites in Spain, Switzerland
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Olaf Blanke
Idiopathic Parkinson's Disease
Investigation of Gait, Foot Pressure Distribution and Balance in Parkinson's Patients With Motor Freezing
Parkinson's disease is characterized by cardinal motor signs such as bradykinesia, tremor, rigidity and postural instability. In addition to these findings, motor freezing, gait disorders, posture disorders, decreased arm swings…
- Trial name
- NCT05107531
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Parkinson's Disease
The Effects of Mindfulness-based Cognitive Therapy in People With Parkinson's Disease
Parkinson's disease (PD) is a debilitating neurodegenerative disorder occurring in 7 million patients worldwide. PD is caused by progressive loss of nigro-striatal dopamine cells, which causes motor symptoms such as slowness of…
- Trial name
- MIND-PD (NCT05779137)
- Testing
- MBCT
- Where
- Netherlands
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Parkinson's Disease, Multiple System Atrophy
Individualized Transcranial Magnetic Stimulation in Parkinsonian Disorders
This clinical trial aims to evaluate whether individualized targeted repetitive transcranial magnetic stimulation (rTMS) can improve motor and non-motor symptoms in patients with parkinsonian disorders.
- Conditions
- Parkinson's Disease, Multiple System Atrophy, Progressive Supranuclear Palsy
- Trial name
- NCT07570212
- Testing
- TMS
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University First Hospital
PARKINSON DISEASE (Disorder), Mild Cognitive Impairment (MCI)
Dual-task Cognitive-motor Telerehabilitation in Persons With PD-MCI
Telerehabilitation is a promising tool for treating and preventing further disease progression in Parkinson's disease (PD) [1, 2].
- Trial name
- HomeFitPD (NCT07411365)
- Testing
- Dual-task Cognitive Motor Training, Cognitive Motor Training
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- University Hospital Tuebingen
Parkinson Disease
Spectroscopy in Parkinson Disease
The primary objective of the study is to determine the utility of blood plasma infrared spectroscopy (biospectroscopy) in distinguishing subjects with idiopathic Parkinson's disease from healthy controls.
- Trial name
- SPIN-PD (NCT01005030)
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Molecular Biometrics, Inc.
Parkinson's Disease, Dysphagia
Study of the Link Between Freezing of Gait and Oropharyngeal Freezing in Parkinson's Patients
Parkinson's Disease: Study of the Link Between Gait Freezing and Oropharyngeal Freezing Parkinson's disease is the second most common neurodegenerative disorder worldwide.
- Conditions
- Parkinson's Disease, Dysphagia, Swallowing Disorder, Freezing of Gait
- Trial name
- Freez in park (NCT06713265)
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Hopital La Musse
Parkinson's Disease
The Effects of a High Intensity Exercise Training Program in Patients With Parkinson's Disease
The purpose of this randomized, controlled interventional study is to determine the effects of a high intensity exercise training program on objective sleep measures, daytime sleepiness, mobility, and brain health/functional…
- Trial name
- NCT02593955
- Testing
- PD exercise, Sleep Hygiene
- Where
- United States
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease
Quasi-experimental Study With a Control Group to Evaluate a Psychoeducational Intervention in Parkinson's Disease Patients and Carers
The aim of this study is to evaluate the effects of a psychoeducational multidisciplinary intervention focusing on improving coping skills, the psychosocial adaptation to Parkinson's disease and the quality of life in patents and…
- Trial name
- ReNACE-PD01 (NCT03129425)
- Testing
- ReNACE Psychoeducational Intervention, General Educational Program
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Cognitive Impairment, Parkinson Disease
Impact of Individual Cognitive Remediation for Parkinson's Disease
This is an interventional clinical trial that will be conducted as a pilot project. Investigators hope to conduct the study to obtain at least 10 study completers.
- Trial name
- NCT03622840
- Testing
- Cognitive Remediation
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- New York Institute of Technology
Parkinson's Disease
A Study to Compare Pharmacokinetics and Pharmacodynamics of IPX066 to Standard Carbidopa-Levodopa
This study evaluated the pharmacokinetics, motor effects, and assessed the safety of IPX066 compared with an immediate-release cabridopa-levodopa formulation in subjects with advanced Parkinson's disease.
- Trial name
- NCT00869791
- Testing
- IPX066, IR CD-LD
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Impax Laboratories, LLC
Multiple System Atrophy (MSA), Healthy Adult
Evaluation of [¹⁸F]MODAG-009 PET Imaging in Synucleinopathies
This is a single-center, open-label clinical study designed to evaluate the imaging characteristics and safety of [¹⁸F]MODAG-009 in participants with Parkinson's disease (PD), Multiple system atrophy (MSA), and Healthy controls…
- Conditions
- Multiple System Atrophy (MSA), Healthy Adult, Parkinson Disease
- Trial name
- MODAG-009-P1-0 (NCT07640555)
- Testing
- [¹⁸F]MODAG-009 PET imaging
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- MODAG GmbH
Parkinson Disease
PPMI Tau PET Imaging
The Assessment of Brain Tau Burden in Participants with Parkinson's Disease in the PPMI Study (PPMI Tau PET Imaging) will evaluate if [18F] PI-2620 facilitates better understanding of Tau deposition in the brain in Parkinson's…
- Trial name
- NCT04906590
- Testing
- [18F] PI-2620
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Parkinson Disease, COPD
The ADAPT-study: Measuring Physical Performance Using Wearable Sensors in Parkinson's Disease and COPD (ADAPT)
The aim of this study is to investigate whether a smartwatch can measure the physical capacity of patients with Parkinson's Disease and COPD in the physiotherapy practice and at home.
- Trial name
- ADAPT (NCT05756075)
- Testing
- Aerobic exercise training
- Where
- 28 sites in Netherlands
- Volunteers
- 154 people
- Sponsor
- Radboud University Medical Center
Idiopathic Parkinson's Disease, Parkinson Disease
Exploring Mechanisms for Neuropsychiatric Symptoms of Parkinson Disease Using Transcranial Direct Current Stimulation
This study evaluates the effect of transcranial direct current stimulation (tDCS) on non-motor symptoms of Parkinson's disease, including depression and cognitive symptoms.
- Conditions
- Idiopathic Parkinson's Disease, Parkinson Disease, Depression
- Trial name
- NCT03074812
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Johns Hopkins University
Parkinson Disease, Vestibular Disorder
Visual Perturbation Training to Reduce Fall Risk in People with Parkinson's Disease
Falls during walking are common in people with Parkinson's Disease (PD). Fall risk can be attributed in part to the loss of automaticity in walking and an increased reliance on sensory cues, such as the input from the balance…
- Conditions
- Parkinson Disease, Vestibular Disorder, Gait, Falling
- Trial name
- Vesti-PD (NCT05690308)
- Testing
- Visual perturbation treadmill training, Regular treadmill training
- Where
- Belgium
- Volunteers
- 35 people
- Sponsor
- University Hospital, Ghent
Parkinson Disease, Healthy Aging
Functional Neuroimaging in Parkinson's Disease
The study uses magnetic resonance imaging (MRI) to better understand changes in the brain underlying motor symptoms affecting upper and lower limbs in Parkinson's disease.
- Trial name
- NCT04904068
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Delaware
PARKINSON DISEASE (Disorder)
Treatment of Cognitive and Sensorimotor Deficits in Parkinson's Disease With High Definition Transcranial Direct Current Stimulation
The purpose of this research study is to examine the effects of transcranial Direct Current Stimulation (tDCS) on verbal retrieval and cognition and sensorimotor control and to determine if tDCS can be used as a way to improve…
- Trial name
- NCT07534397
- Testing
- transcranial direct current stimulation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- The University of Texas at Dallas
Advanced Parkinson's Disease
Effect of Rotigotine on Motor Symptoms in Patients With Advanced Parkinson's Disease (PD) With Motor Fluctuations and Symptoms of Gastrointestinal Dysfunction
The primary purpose is to demonstrate superiority of Rotigotine over Placebo on motor symptoms when used in subjects with symptoms of Gastrointestinal Dysfunction. Hypothesis: Rotigotine will decrease OFF time compared to Placebo.
- Trial name
- ROADMAP (NCT01536015)
- Testing
- Rotigotine
- Where
- 26 sites in United States
- Volunteers
- 25 people
- Sponsor
- UCB Pharma
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