Clinical trials: Primary Parkinsonism
Parkinson's Disease Psychosis
Pimavanserin vs. Quetiapine for Treatment of Parkinson's Psychosis
Patients with Parkinson's disease (PD) sometimes experience symptoms affecting their movement, such as slowness, tremor, stiffness, and balance or walking problems.
- Trial name
- C-SAPP (NCT04373317)
- Testing
- Pimavanserin, Quetiapine
- Where
- 24 sites in United States
- Volunteers
- 358 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Psychological Adaptation, Parkinson's Disease
Stress-Busting Program for Caregivers of Patients With Neruological Diseases
Although family caregivers perform an incredibly valuable service for their relatives and the formal health care system, they do so at a considerable cost to themselves both emotionally and physically.
- Conditions
- Psychological Adaptation, Parkinson's Disease, Neurological Disorders
- Trial name
- NCT00122174
- Testing
- Stress Busting Program for family caregivers
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Parkinson Disease, Deep Brain Stimulation
Effect of Mediterranean Diet on Nutrition in Parkinson's Disease Patients With Bilateral Subthalamic Deep Brain Stimulation
The goal of this clinical trial is to evaluate whether Mediterranean diet can help manage body weight and improve body composition in adult Parkinson's disease patients who have undergone bilateral subthalamic nucleus deep brain…
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Deep Brain Stimulation Surgery
- Trial name
- NCT07187739
- Testing
- Mediterranean diet
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Ankara University
PARKINSON DISEASE (Disorder)
Feasibility of a Community-Based Multimodal Exercise Programme in Parkinson's Disease
This study aims to evaluate the feasibility and preliminary effectiveness of a multimodal, group-based but individualised therapeutic exercise programme for people with Parkinson's disease delivered within a real-world…
- Trial name
- NCT07618728
- Testing
- Exercise Group
- Where
- Spain
- Volunteers
- 64 people
- Sponsor
- Universidad Rey Juan Carlos
Parkinson Disease
Interactive POWER Rehabilitation System on Rehabilitation Training for Patients With Parkinson's Disease
In the previous studies, progressive resistance training (PRT) has significantly improved the muscle strength and disease severity of Parkinson's disease.
- Trial name
- NCT05046236
- Testing
- Interactive POWER rehabilitation, Conventical physical training
- Where
- 2 sites in Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Parkinson Disease, Parkinson's Disease and Parkinsonism
Complex Eye Movements in Parkinson's Disease and Related Movement Disorders
Diagnosing Parkinson's disease (PD) depends on the clinical history of the patient and the patient's response to specific treatments such as levodopa.
- Conditions
- Parkinson Disease, Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Corticobasal Degeneration
- Trial name
- NCT04925622
- Testing
- Complex eye movement exam
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Saccadous, Inc.
Parkinson's Disease, Validity
The Validity and Reliability of an Improved Paper Grasping Test for Parkinson's Disease
The study will include volunteer patients diagnosed with Parkinson's disease who applied to the Neurology Outpatient Clinic at SANKO University Sani Konukoğlu Application and Research Hospital.
- Conditions
- Parkinson's Disease, Validity, Reability
- Trial name
- NCT07772622
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Sanko University
Parkinson's Disease
Levodopa Concentration Profile With Stalevo 75/125 mg
The purpose of this study is to confirm that the dose levels and dosing frequency utilising the new Stalevo strengths would result into more stable levodopa plasma levels.
- Trial name
- NEWSTA (NCT01070628)
- Testing
- Stalevo (levodopa/ carbidopa/ entacapone), Sinemet (levodopa/carbidopa)
- Where
- Finland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Orion Corporation, Orion Pharma
Parkinson's Disease
Parcopa Versus Carbidopa-levodopa in a Single Dose Cross-over Comparison Study
To find out if a single dose of Parcopa®, a form of levodopa that dissolves in your mouth, works faster than regular oral levodopa which is swallowed, in fluctuating PD patients.
- Trial name
- NCT00590122
- Testing
- Parcopa, carbidopa-levodopa (Sinemet)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Parkinson Disease
A Clinical Study of NLY01 in Patient's With Early Parkinson's Disease
This is a phase 2 study designed to assess the safety, tolerability and efficacy of NLY01 in subjects with early untreated Parkinson's disease (PD).
- Trial name
- NCT04154072
- Testing
- NLY01, Vehicle
- Where
- 61 sites in United States, Canada
- Volunteers
- 255 people
- Sponsor
- Neuraly, Inc.
Parkinson Disease, Parkinsonian Disorders
The Personalized Parkinson Project De Novo Cohort
Currently, the Movement Disorders Society (MDS)-UPDRS scale remains the gold standard to document the outcomes in clinical trials for Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Parkinsonian Disorders, Basal Ganglia Diseases, Brain Diseases
- Trial name
- PPP-novo (NCT04985539)
- Testing
- Verily Study Watch
- Where
- Netherlands
- Volunteers
- 103 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
The Effect of Whole Body Vibration in Individuals With Parkinson's Disease
Previous studies reported that whole body vibration has the potential impact on balance and walking abilities in individuals with Parkinson's disease; however, the inconsistent treatment protocols and different experimental…
- Trial name
- NCT03777501
- Testing
- non-random whole body vibration, occupational therapy
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Chang Gung University
Parkinson's Disease
A Trial of MitoQ for the Treatment of People With Parkinson's Disease
In Parkinson's Disease, the mitochondrial membranes in cells that produce dopamine become damaged by oxidants, leading to the death of these cells and progressive tremor, slowness of movement and the loss of neurons in the…
- Trial name
- NCT00329056
- Testing
- MitoQ
- Where
- 13 sites in Australia, New Zealand
- Volunteers
- 128 people
- Sponsor
- Antipodean Pharmaceuticals, Inc.
Parkinson Disease
The Effects of Tele-rehabilitation Interventions in Parkinson's Patients
Parkinson's Disease (PD) is the most common neurodegenerative movement disorder. The main motor symptoms of PD are tremor, rigidity, bradykinesia, and postural instability.
- Trial name
- NCT05187195
- Testing
- Home-based telerehabilitation with exercise videos, Exercise brochure
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Istanbul University - Cerrahpasa
Parkinson Disease
Kick Out Parkinson's Disease- Karate Intervention
The benefits of exercise for general health and wellbeing in older adults are well-established. Balance exercises such as tai chi and yoga, along with resistance training, can improve or maintain physical function in older adults…
- Trial name
- NCT03555695
- Testing
- Karate Classes, Pre-Intervention Focus Group, Post-Intervention Focus Group
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Rush University Medical Center
Idiopathic Parkinson's Disease
Long Term Study of Istradefylline in Subjects With Moderate to Severe Parkinson's Disease
This is a Phase 3, 52-week, open-label, flexible-dose, multinational, multicenter study to evaluate the safety and tolerability of istradefylline 20 or 40 mg/d in subjects with moderate to severe PD with motor fluctuations and…
- Trial name
- NCT02610231
- Testing
- Istradefylline 20 mg or 40 mg
- Where
- 55 sites in United States, Canada and 6 more
- Volunteers
- 239 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Parkinson Disease
Deep Brain Stimulation for Parkinson's Disease: Probabilistic STN Targeting Under General Anaesthesia Without Micro-electrode Recordings vs Current Targeting Procedure
Deep brain stimulation (DBS) of the sub-thalamic nucleus (STN) has evolved over the past decades as a mainstream therapy for advanced Parkinson's disease (PD).
- Trial name
- PARKEO2 (NCT04884412)
- Testing
- Surgery under general anesthesia with experimental targeting, Usual Surgery
- Where
- 8 sites in France
- Volunteers
- 128 people
- Sponsor
- University Hospital, Bordeaux
Regenerative Medicine
PRP and PBD-VSEL Stem Cell Therapy for Parkinson's Disease
An experimental study will be conducted at Iffat Anwar medical complex conducted to evaluate the effectiveness of PRP and stem Cell therapy in the treatment of PD.
- Trial name
- NCT06142981
- Testing
- PRP and PBD-VSEL Stem Cell therapy
- Where
- Pakistan
- Volunteers
- 30 people
- Sponsor
- Fatima Jinnah Medical University
Parkinson Disease
A Study of AB-1005 Gene Therapy in Japanese Adults With Moderate Parkinson's Disease (J-REGENERATE-PD)
The objective of this Phase 2, open-label, single group, one-time, fixed-dose study is to assess the safety and efficacy of bilateral intraputaminal infusion of AB-1005 (AAV2-GDNF gene therapy) in Japanese patients with moderate…
- Trial name
- NCT07566429
- Testing
- AB-1005
- Where
- 6 sites in Japan
- Volunteers
- 8 people
- Sponsor
- Bayer
Alzheimer's Disease, Lewy Body Dementia
Distinguishing Between Alzheimer's Disease, Lewy Body Dementia, and Parkinson's Disease
The study is designed to characterize the clinical, neuropsychological, polysomnographic, and neuroimaging findings among subjects with Alzheimer's disease, Lewy Body dementia, and Parkinsons' Disease.
- Conditions
- Alzheimer's Disease, Lewy Body Dementia, Parkinson's Disease
- Trial name
- NCT03019757
- Testing
- DaTscan, F18-AV-45, FDG-PET
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Douglas Scharre
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