Clinical trials: Primary Parkinsonism
Parkinson's Disease
Study to Assess Participant/Caregiver/Investigator Satisfaction of Video-Assisted Telenursing in Adult Participants With Parkinson's Disease Treated With Levodopa-Carbidopa Intestinal Gel
Parkinson's disease (PD) is a neurological condition, which affects the brain. PD gets worse over time, but how quickly it progresses varies a lot from person to person.
- Trial name
- FACILITATECARE (NCT04500106)
- Where
- 13 sites in Australia, Israel and 2 more
- Volunteers
- 41 people
- Sponsor
- AbbVie
Parkinson's Disease
Open-label Investigation of the Safety and Clinical Effects of NTCELL in Patients With Parkinson's Disease
To assess the safety of xenotransplantation of NTCELL [immunoprotected (alginate-encapsulated) choroid plexus cells] in patients with Parkinson's disease, assessed over the duration of the study, by monitoring the occurrence of…
- Trial name
- NCT01734733
- Testing
- NTCELL
- Where
- New Zealand
- Volunteers
- 4 people
- Sponsor
- Living Cell Technologies
Parkinson''s Disease
Pilot Study of Safety and Efficacy of Spheramine
Tolerability and Efficacy of Spheramine will be evaluated after operative implantation (Stereotactic Intrastriatal Implantation) in patients with advanced Parkinson's Disease
- Trial name
- NCT00761436
- Testing
- Spheramine (BAY86-5280)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Bayer
Parkinson's Disease
Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease
Balance problems and falls are among the most common complaints in Veterans with Parkinson's Disease (PD), but there are no effective treatments and the ability to measure balance and falls remains quite poor.
- Trial name
- NCT06405334
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Convection Enhanced Delivery of CSF in DBS for Parkinson's
This study will evaluate safety foremost but also the distribution and initial effectiveness of infusion-enhanced, MRI-guided DBS for patients with medication-refractory, Parkinson's disease
- Trial name
- NCT03540134
- Testing
- Intracerebral Infusion of Autologous Cerebral Spinal Fluid
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeff Elias, MD
Parkinson's Disease
A Study of Istradefylline (KW-6002) for the Treatment of Parkinson's Disease
To establish the efficacy of 40 mg/day doses of istradefylline for the change in Unified Parkinson's Disease Rating Scale (UPDRS) part-III (Motor examination) score in patients with Parkinson's disease (PD).
- Trial name
- NCT00250393
- Testing
- Istradefylline (KW-6002)
- Where
- Japan
- Volunteers
- 64 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Idiopathic Parkinsonism
Fall Risk Assessment in Parkinson's Disease Using Kinetikos Health
This is a single-center, prospective observational study aiming to validate the Kinetikos Health App for fall risk assessment in PD patients undergoing dopaminergic medication adjustments.
- Trial name
- PD_FALLRISK (NCT07257393)
- Testing
- No Intervention: Observational Cohort
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Parkinson's Disease (PD)
Observational Study Evaluating Robotic Spinal Mobilization in 16 Parkinson's Disease Participants. The Study Recorded Changes in Mobility, Sit-to-stand Performance, and Pain Scores After a 2-week Intervention With the BackHug Device.
The goal of this completed observational pilot study was to evaluate the immediate and short-term clinical effects of robotic spinal mobilization on motor and non-motor symptoms in community-dwelling adults with Parkinson's…
- Trial name
- NCT07384364
- Where
- United Kingdom
- Volunteers
- 19 people
- Sponsor
- Pacla Medical Limited
Parkinson Disease (PD)
Robotic Apparel to Prevent Freezing of Gait in Parkinson Disease
Freezing-of-gait (FoG) in Parkinson Disease (PD) is one of the most vivid and disturbing gait phenomena in neurology. Often described by patients as a feeling of "feet getting glued to the floor," FoG is formally defined as a…
- Trial name
- XF (NCT06602544)
- Testing
- Robotic Apparel
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Harvard Medical School (HMS and HSDM)
Parkinson Disease
Telehealth Allied Health Care With People Who Have Parkinson's Disease Living in Rural Nevada and Wyoming
The investigators have developed a three-part allied health care intervention to be delivered via telehealth. These interventions are usually provided face-to-face.
- Trial name
- NCT03381898
- Testing
- Telehealth Exercise, speech therapy, medication management
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Wyoming
Parkinson Disease
Study to Evaluate DNL201 in Subjects With Parkinson's Disease
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple oral doses of DNL201 in subjects with Parkinson's disease.
- Trial name
- NCT03710707
- Testing
- DNL201
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- Denali Therapeutics Inc.
Parkinson Disease, REM Sleep Behavior Disorder
Ultra High Field Magnetic Resonance Imaging as a Biomarker for Premotor Parkinson's Disease
This is a prospective observational study investigating the utility of 7 Tesla MRI to quantify nigrosome1 signal in a cohort of individuals with recent onset Parkinson's disease and in at-risk cohorts at a premotor state of…
- Trial name
- NCT03288909
- Testing
- MRI
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Parkinson Disease, Anxiety
Yoga for Anxiety in Adults
The purpose of this study is to investigate the effect of a telerehabilitation-yoga intervention delivered remotely via videoconferencing on adults with Parkinson's Disease and anxiety symptoms.
- Trial name
- NCT04240899
- Testing
- Tele-yoga
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Rutgers, The State University of New Jersey
Parkinson Disease
Effects of Aerobic Exercise in Parkinson's Disease
Motivated by reported improvements in aerobic fitness and executive functions after a 6-month aerobic walking intervention in normal sedentary elderly, we conducted a Phase I/II study to investigate effects of aerobic exercise on…
- Trial name
- NCT00784563
- Testing
- Continuous training, Interval training
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- US Department of Veterans Affairs
PARKINSON DISEASE (Disorder)
A 12-Week Study of Flexilev With the OraFID Device and App in Parkinson's Patients
Flexilev is a Parkinson's disease medicine made of small, dissolvable tablets containing low doses of levodopa and carbidopa, allowing doses to be adjusted in small, precise steps.
- Trial name
- FLORA (NCT07839793)
- Testing
- OraFID dosing device, Levodopa/Carbidopa minitablets delivered via OraFID dosing device
- Where
- 5 sites in Sweden
- Volunteers
- 58 people
- Sponsor
- Navamedic AB
Parkinson Disease
TEND Study:Telemedicine Nurse DBS for Parkinson's Disease
The central hypothesis is that home health nurses can improve access and provide high quality care when guided by a sophisticated platform that integrates bioinformatics, patient-specific computational modeling, and continuous…
- Trial name
- NCT04677621
- Testing
- Nurse Telehealth, STANDARD DBS
- Sponsor
- University of Florida
Idiopathic Parkinson's Disease
Randomized Safety Study of CVT-301 Compared to an Observational Control Group
This study is a 12-month, open-label, randomized, multicenter study which will evaluate the safety and efficacy of CVT-301 for the treatment of up to 5 OFF episodes per day in Parkinson's Disease (PD) patients experiencing motor…
- Trial name
- NCT02352363
- Testing
- CVT-301, Observational cohort
- Where
- 76 sites in United States, Austria and 12 more
- Volunteers
- 408 people
- Sponsor
- Acorda Therapeutics
Parkinson's Disease
Transplantation of Neural Stem Cell-Derived Neurons for Parkinson's Disease
This is a prospective study to demonstrate the safety and efficacy of differentiated neurons-derived from adult CNS progenitors cells transplanted in selected patients with Parkinson's disease.
- Trial name
- NCT03309514
- Testing
- Intracerebral microinjections
- Sponsor
- NeuroGeneration
Parkinson's Disease
Noninterventional Study Evaluating Parkinson's Disease Diary Use
This study aims to evaluate the impact of the frequency of assessments on the variability over time, reliability, and compliance for the Parkinson's disease (PD) diary in patients with PD in whom medications do not provide…
- Trial name
- NCT05363046
- Where
- 34 sites in United States, Canada and 3 more
- Volunteers
- 194 people
- Sponsor
- BlueRock Therapeutics
Parkinson Disease
Open Label Sumanirole Study of Safety, Tolerability, and Therapeutic Response In Patients With Parkinson's Disease
The primary objective is to assess the long term safety and tolerability of sumanirole as measured by safety labs, ECG monitoring, vital signs, and adverse event reports in subjects with Parkinson's Disease who participated in…
- Trial name
- NCT00036205
- Testing
- sumanirole
- Where
- 110 sites in United States, Argentina and 2 more
- Volunteers
- 984 people
- Sponsor
- Pfizer
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.