Clinical trials: Primary Parkinsonism
Parkinson, Cerebellar Tumor
Detecting the Rest Tremor Associated With Parkinson's Disease Using Analysis of the Muscle Contractions Rhythmicity
Resting tremors associated with Parkinson's disease (PD) remains difficult to quantify and track during disease progression. This study propose to explore the rhythmicity of distal muscle contractions in the upper limb to…
- Conditions
- Parkinson, Cerebellar Tumor, Rest Tremor, Diagnoses Disease
- Trial name
- TREMORHYTHM (NCT05998486)
- Testing
- EMG in wrist flexor-pronators and extensor-supinators
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Henri Mondor University Hospital
Parkinson Disease, Dyskinesias
Different Dyskinesias in Parkinson's Disease and Their Relation to Levodopa Pharmacokinetics
The purpose of this study is to study different kinds of dyskinesias in advanced Parkinson's disease appearing at different levels of levodopa infusion dose.
- Trial name
- DYSK-PD-2007 (NCT00888186)
- Testing
- levodopa/carbidopa
- Where
- Sweden
- Volunteers
- 5 people
- Sponsor
- Uppsala University
Oral Health, Parkinson Disease
Preliminary Study of the Quality of the Oral Flora in Parkinson's Patients
This is a prospective interventional clinical study whose main objective is to determine the impact of oral hygiene guidance on the oral health status of patients with Parkinson disease
- Trial name
- PARKIDENT (NCT03827551)
- Testing
- Delivery of oral hygiene advices
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Parkinson's Disease
12-Week, Double-Blind, Placebo-Controlled, Randomized Study of the Efficacy of 40 mg/Day KW-6002 in Parkinson's Disease Patients on Levodopa/Carbidopa
12-week, double-blind, placebo-controlled, multicenter, randomized study designed to evaluate the safety and efficacy of 40 mg/day istradefylline compared with placebo in subjects with OFF phenomena advanced PD who were treated…
- Trial name
- NCT00456586
- Testing
- KW-6002 (istradefylline)
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- Kyowa Kirin, Inc.
Parkinson Disease, Deep Brain Stimulation
Understanding Motivation in Parkinson's Patients Through Neurophysiology
The study aims to better understand motivation and value-based decision-making in Parkinson's patients through neurophysiology using Medtronic's Percept DBS device.
- Conditions
- Parkinson Disease, Deep Brain Stimulation, Motivation
- Trial name
- MPPN (NCT05065151)
- Testing
- Stimulation on, Stimulation off, Decision Making Task
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of California, San Francisco
Advanced Parkinson's Disease
Levodopa-Carbidopa Intestinal Gel Open-Label Study in Advanced Parkinson's Disease
The primary objective of this study will be to provide further evidence of the long-term safety and tolerability of levodopa-carbidopa intestinal gel (Duodopa®) over 12-months in participants with advanced Parkinson's disease…
- Trial name
- NCT00335153
- Testing
- Levodopa-carbidopa intestinal gel, CADD-Legacy® 1400 ambulatory infusion pump, PEG tube
- Where
- 83 sites in United States, Australia and 14 more
- Volunteers
- 354 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Idiopathic Parkinson's Disease (PD)
Study on the Incidence of Malignant Neoplasms in Patients With Parkinson's Disease and Heterozygous Mutation of the GBA Gene
This multicenter retrospective observational study investigates the incidence of malignant neoplasms in Parkinson's disease (PD) patients carrying heterozygous pathogenic variants in the GBA1 gene.
- Trial name
- ONCOGBA (NCT06814431)
- Where
- 4 sites in Italy
- Volunteers
- 3,000 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Parkinson's Disease
Impulsivity and Parkinson's Disease : a Neuropsychology With Magnetic Resonance Imaging Study
This study aims to characterize the nature of impulsivity in Parkinson's Disease (PD).
- Trial name
- NCT02463617
- Testing
- magnetic resonance imaging
- Where
- 3 sites in France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Poitiers University Hospital
Parkinson's Disease, Mild Cognitive Impairment
Longitudinal Study of Mild Cognitive Impairment in Parkinson's Disease
Parkinson's disease (PD) is known for its motor symptoms and affects more than 100,000 Canadians. However, PD patients also show cognitive deficits and neuropsychiatric problems that significantly impair their quality of life.
- Trial name
- PD-MCI (NCT02637089)
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Healthy, Neurodegenerative Disease
Brain Health Registry: An Online Registry to Identify and Assess Subjects for Brain Research
The overall goal of this project is to identify, assess and longitudinally monitor subjects who are interested in participating in brain research.
- Trial name
- BHR (NCT02402426)
- Where
- United States
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Parkinson's Disease
Early Parkinson's Disease Monotherapy With CVN424
This is a multicenter, 12-week, placebo-controlled clinical trial of CVN424 150 milligrams (mg) tablets in early, untreated Parkinson's Disease (PD).
- Trial name
- NCT06006247
- Testing
- CVN424 150 mg
- Where
- 42 sites in United States
- Volunteers
- 64 people
- Sponsor
- Cerevance Beta, Inc.
Parkinson Disease, Parkinson
State-dependent Pathophysiological Oscillations in Parkinson's Disease and Treatment With DBS Using the Medtronic RC+S
Primary objectives. The ability of the RC+S to record Local Field Potentials (LFP's) is novel in Deep Brain Stimulation (DBS) technology. The primary goals of this project are to use this function of the RC+S to characterize: 1.
- Trial name
- NCT04011449
- Testing
- Medtronic RC+S DBS system
- Where
- United States
- Sponsor
- University of Minnesota
PARKINSON DISEASE (Disorder)
Description of the Reasons for Hospitalization of Patients With Parkinson's Disease Following Admission Through the Adult Emergency Department
The goal of this observational study is to investigate the causes of hospitalisation via emergency services in patients with degenerative parkinsonian syndromes.
- Trial name
- Emerge Park (NCT07439926)
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 2,580 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease, Other Neurological Disorders
Prevalence of Visual Dysfunction in Neurological Disorders
The objective is to determine the prevalence of visual dysfunction in People with Parkinson's Disease (PwP). The investigators will administer the: Visual Impairment in Parkinson's Disease Screen and Revised-Self-Report…
- Conditions
- Parkinson Disease, Other Neurological Disorders, Healthy
- Trial name
- NCT04836715
- Where
- 2 sites in United States
- Volunteers
- 92 people
- Sponsor
- University of Florida
Parkinson's Disease
Deep Brain Stimulation for Parkinson's Disease Trial
The purpose of this trial is to evaluate the effect of deep brain stimulation in the the globus pallidus (Gpi) and the subthalamic nucleus (STN) on motor, neuropsychological and psychiatric function, and quality of life in…
- Trial name
- NCT00053625
- Testing
- deep brain stimulation
- Where
- 2 sites in United States
- Volunteers
- 123 people
- Sponsor
- University of Minnesota
Parkinson Disease
Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease
Observational, prospective, monocentric study to assess clinical features, imaging and biologic biomarkers in Parkinson disease (PD) patients and rate of progression compared to healthy controls (HC) and subjects at risk to…
- Trial name
- ICEBERG (NCT02305147)
- Testing
- Clinical, biological and imaging followup
- Where
- France
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease, Apathy
Non Motors Aspects in De Novo Parkinson's Disease
Clinical description and pathophysiological study of recently diagnosed untreated patients with Parkinson's Disease. Effect of a dopamine agonist (rotigotine) on apathy in de novo patients with Parkinson disease: A controlled…
- Trial name
- Honeymoon (NCT02786667)
- Testing
- Rotigotine
- Where
- France
- Volunteers
- 199 people
- Sponsor
- University Hospital, Grenoble
Parkinson Disease
Monocentric, Prospective Study to Assess the Pharmacokinetic Profile of Continuous and Diurnal Subcutaneous Apomorphine Infusion in Patients With Parkinson's Disease
This monocentric and prospective trial aims firstly to assess the pharmacokinetic profile of continuous and diurnal subcutaneous apomorphine infusion in patients with Parkinson's disease under stabilized treatment and, secondly…
- Trial name
- PHARM-APO (NCT04887467)
- Testing
- Apomorphine
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Rennes University Hospital
Parkinson's Disease
Long-term Extension of RECOVER- Long-term Effect of the 24h Transdermal Delivery of Rotigotine in Subjects With Idiopathic Parkinson's Disease
The objective of this open-label extension is to assess the long-term effect of the 24-hour transdermal delivery of rotigotine on motor function, sleep quality, and nocturnal and non-motor symptoms of Parkinson's disease.
- Trial name
- NCT00519532
- Testing
- Rotigotine
- Where
- 21 sites in United States, Australia and 9 more
- Volunteers
- 84 people
- Sponsor
- UCB Pharma
Parkinson's Disease (PD), REM Sleep Behavior Disorder
IMPACT 360 for Parkinson's Disease
The IMPACT 360 study will evaluate the effects of a combined intervention of exercise, mindfulness, and nutrition on 8 key indicators of health and the mechanisms that drive these changes.
- Trial name
- NCT07443293
- Testing
- Exercise, Meditation, Diet
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
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