Clinical trials: Primary Parkinsonism
Parkinson Disease (PD)
Clinical Study to Evaluate XS411 in Treatment of Early-onset Parkinson's Disease
This study is a Phase I/II clinical study to evaluate the safety, tolerability, and efficacy of XS411 in the treatment of EOPD. The study consists of two phases: Phase I and Phase II.
- Trial name
- NCT07166757
- Testing
- human allogeneic induced pluripotent stem cell (iPSC)-derived dopaminergic neural progenitor cell injection
- Where
- China
- Volunteers
- 90 people
- Sponsor
- XellSmart Bio-Pharmaceutical (Suzhou) Co., Ltd.
Parkinson Disease
Post Market (Brio™ System) Deep Brain Stimulation (DBS) PD Study
The objective of this study is to evaluate the effectiveness of a rechargeable Deep Brain Stimulation as an adjunctive treatment for reducing some of the symptoms of advanced, levodopa-responsive Parkinson's disease that are not…
- Trial name
- NCT01218919
- Sponsor
- Abbott Medical Devices
Parkinson Disease
Acute Effects of Cycling Dual-task in Parkinson´s Disease.
Taking into account the process of functional and cognitive evolution that patients with Parkinson's disease experience throughout the pathology, the objective of this study is to evaluate the acute effects of aerobic exercise in…
- Trial name
- NCT05375032
- Testing
- Cycling combined with cognitive tasks, Cycling
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Vigo
Parkinson Disease, Urinary Disease Other
Cognitive Therapy for Urinary Dysfunction in Parkinson´s Disease
Idiopathic Parkinson's syndrome (IPS) is one of the most common neurodegenerative diseases. The prevalence and significance of this disease is continuously increasing in the course of demographic change.
- Trial name
- PD-UD (NCT03917732)
- Testing
- cognitive training, pelvic floor training
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University Hospital Schleswig-Holstein
Parkinson's Disease and Parkinsonism
Voice-activated Intelligent Personal Assistant (VIPA) Intervention for People With Parkinson's Disease
This pilot randomized control trial (RCT) aims to develop a Voice-activated Intelligent Personal Assistance (VIPA) user protocol and study its feasibility and preliminary efficacy among 48 People with Parkinson's disease (PWP).
- Trial name
- NCT06036771
- Testing
- Voice-activated Intelligent Personal Assistant (VIPA)
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- The Hong Kong Polytechnic University
Parkinson Disease
A Study on the Treatment of Parkinson's Disease With Autologous Neural Stem Cells
This is a single center, single arm and open-label study to investigate the safety and efficacy of iPS-NCS with Parkinson's Disease
- Trial name
- NCT03815071
- Testing
- Ips-nsc cells
- Volunteers
- 10 people
- Sponsor
- Allife Medical Science and Technology Co., Ltd.
Parkinson Disease
Etoricoxib in Patients With Parkinsonian Disease
Neuroinflammation is considered one of the most important factors contributing critically to pathophysiology of PD . Recently, high mobility group box-1 (HMGB1) protein has been encoded as a potential inflammatory biomarker in…
- Trial name
- NCT07370532
- Testing
- L-dopa, Etoricoxib
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ihab Elsayed Hassan
Parkinson's Disease
The Association of Neurotoxin Exposure With Parkinson's Disease and Parkinsonism in World War II Veterans and Other Men
This program aims to investigate factors associated with development of parkinsonism or idiopathic Parkinson's Disease in an ongoing cohort of patients established in 1965 who are currently undergoing their sixth examination.
- Trial name
- NCT00018577
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Parkinson Disease
Multi-limb Dual-task Control in Parkinson's Disease
People with Parkinson disease commonly experience difficulty driving, which requires the arms and legs to do different tasks simultaneously.
- Trial name
- NCT03662009
- Testing
- multilimb dual task
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- A.T. Still University of Health Sciences
Parkinson Disease
Cycling Deep Brain Stimulation on Parkinson's Disease Gait
Our hypothesis is that cycling DBS stimulation would be superior or non-inferior to regular DBS stimulation in Parkinson's disease patients with gait impairment.
- Trial name
- DBS (NCT04408573)
- Testing
- Cycling deep brain stimulation
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Sao Paulo General Hospital
Parkinson's Disease
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06649751 in Parkinson's Disease
This study will be an open label, dose escalation study to investigate the safety, tolerability, pharmacokinetics and pharmacodynamics of repeated daily quaque die (QD) doses given over 21 days (Day 3 to Day 23) to sequential…
- Trial name
- NCT02224664
- Testing
- PF-06649751
- Where
- 17 sites in United States, Belgium
- Volunteers
- 50 people
- Sponsor
- Pfizer
Parkinson Disease
French Parkinson's Disease Cohort - NS-PARK
The aim of NS-PARK cohort are to describe the natural history of Parkinson's disease (PD), and to propose patients stratification models based on PD pathophysiological mechanisms.
- Trial name
- NS-PARK (NCT04888364)
- Where
- France
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease
Effect of Scalp Nerve Block on the Recovery Quality of Parkinson's Patients After Deep Brain Stimulation
Patients diagnosed with Parkinson's disease (PD) undergoing deep Brain Stimulation (DBS) have a higher risk of perioperative complications and postoperative pain will affect quality of recovery (QoR) resulting in longer…
- Trial name
- NCT05353764
- Testing
- scalp nerve block combined with intercostal nerve block using 0.5% ropivacaine
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Changhai Hospital
Parkinson Disease
Feasibility and Effectiveness of Virtual Reality & Use of Body Weight Support Treadmill Training in Parkinson's Disease
The primary hypothesis of the investigators is that a virtual reality system combined with physical activity provided on a body weight support treadmill training would change clinical parameters of balance and mobility in people…
- Trial name
- NCT02516644
- Testing
- Virtual Reality, Conventional Therapy
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University Hospital of Ferrara
Parkinson's Disease (PD), Functional Capacity
Validity and Reliability of the Six-Minute Pegboard Ring Test in Individuals With Parkinson's Disease
Parkinson's patients who volunteer to participate in the study will be included. Parkinson's patients participating in the study will be referred from the SANKO University Hospital Neurology Outpatient Clinic.
- Conditions
- Parkinson's Disease (PD), Functional Capacity, Upper Extremity Function, Validity and Safety
- Trial name
- NCT07422064
- Where
- Turkey (Türkiye)
- Volunteers
- 47 people
- Sponsor
- Sanko University
Parkinson's Disease, Dysarthria
Improve Speech Using an In-the-ear Device in Parkinson's Disease
This project will systematically examine the therapeutic effect of altered auditory feedback provided by the in-the-ear device on the speech impairments in patients with Parkinson's disease.
- Trial name
- MJFFSpeech (NCT00488657)
- Testing
- SpeechEasy Model ITC
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Rush University Medical Center
Parkinson's Disease
A Study of AAV-hAADC-2 in Subjects With Parkinson's Disease
Safety Study in subjects with Parkinson's Disease
- Trial name
- NCT00229736
- Testing
- AAV-hAADC-2
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Genzyme, a Sanofi Company
Parkinson Disease
Safety and Efficacy of Adaptive DBS Vs Conventional DBS in Patients With Parkinson's Disease
This is an exploratory study to preliminary assess safety and efficacy of an adaptive Deep Brain Stimulation (DBS) closed-loop method in patients with PD.
- Trial name
- NCT03422757
- Testing
- adaptive Deep Brain Stimulation, conventional Deep Brain Stimulation
- Where
- 4 sites in Italy
- Volunteers
- 6 people
- Sponsor
- Newronika
Parkinson Disease
The University of Alabama at Birmingham (UAB) Neuroinflammation in Parkinson's Disease-TSPO- Positron Emission Tomography (PET) Substudy
The primary objective of this substudy is to measure the concentration and the regional brain distribution of activated brain microglia/macrophages using the PET ligand [18F]DPA-714 in participants enrolled in the UAB Innate and…
- Trial name
- NCT03457493
- Testing
- DPA-714-PET/MRI, 5-year Follow-up DPA-714-PET/MRI, DPA-714 Metabolite Analysis
- Where
- United States
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Stroke, Parkinson' s Disease, Neurological Impairments, Tele-rehabilitation
Challenges Faced By Neurophysiotherapist While Consultation Through Tele-rehabilitation
Being the most important stakeholder of such a vulnerable population, the neuro physiotherapist faced a lot of difficulties while consulting and assessing patients with neurological impairments.
- Trial name
- NCT04988763
- Testing
- Opinions about tele-rehabilitation for consulting a clients with neurological impairments
- Where
- India
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Mahatma Gandhi Institute of Medical Sciences
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