Clinical trials: Primary Parkinsonism
Parkinson Disease
The Alouette Test in Parkinson Disease
Reading disorders in Parkinson's Disease (PD) are poorly evaluated due to the lack of validated tests to screen for them. They are often attributed to hand tremors associated with the disease.
- Trial name
- REPEAT (NCT03958175)
- Testing
- Alouette test (reading test)
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Parkinson's Disease
Study of KW-6002 (Istradefylline) in Parkinson's Disease in Patients With Motor Response Complications on Levodopa
The purpose of this study is to confirm the long term tolerability and safety of oral 20 or 40 mg/d doses of Istradefylline.
- Trial name
- NCT00203957
- Testing
- Istradefylline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Chicago
Parkinson's Disease
Comparison of Constant Current to Constant Voltage Stimulation in Subthalamic Deep Brain Stimulation for Parkinson's Disease
HYPOTHESIS: Constant current stimulation for STN DBS will allow better and more stable control of Parkinson's disease symptoms than constant voltage stimulation.
- Trial name
- NCT01423565
- Testing
- Deep Brain Stimulation (Medtronic, Activa PC)
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Hadassah Medical Organization
Parkinson Disease
Assessing the Polygenic Burden of Rare Disruptive Mutations in Parkinson's Disease
The project intends to assess the polygenic burden of rare disruptive mutations in Parkinson's disease (PD) and how they influence the phenotype/pathological heterogeneity of disease.
- Trial name
- NCT04620980
- Testing
- targeted resequencing
- Where
- Italy
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
Parkinson Disease, Gait Disorders, Neurologic
Automated Mechanical Peripheral Stimulation to Treat Freezing of Gait in Patients With Parkinson's Disease and STN-DBS
The objective is to investigate whether AMPS (Automated Mechanical Peripheral Stimulation) is effective in reduction of FOG measured via the FOG-AC (Freezing Of Gait Assessment Course) in people with Parkinson Disease and STN-DBS…
- Trial name
- AMBITION (NCT04831879)
- Testing
- GONDOLA AMPS
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Gondola Medical Technologies SA
Parkinson Disease
Application of LLM Care and Related Affective Computing Systems on People With Parkinson's Disease
The study is an adaptation of the Long Lasting Memories (LLM) (NCT02267499) and the subsequent LLM Care (NCT02313935) projects in patients with Parkinson's Disease (PD).
- Trial name
- pdLLM (NCT04426903)
- Testing
- webFitForAll, BrainHQ
- Where
- Greece
- Volunteers
- 23 people
- Sponsor
- Aristotle University Of Thessaloniki
Parkinson's Disease, Levodopa Induced Dyskinesia (LID)
Efficacy and Safety of JM-010 in PD With Levodopa-Induced Dyskinesia
The purpose of a randomized, double-blind, placebo-controlled, 2-way crossover study is to evaluate the efficacy, safety/tolerability and pharmacokinetics of JM-010 for the treatment of subjects with Parkinson's Disease (PD) with…
- Trial name
- LID (NCT02439203)
- Testing
- JM-010
- Where
- South Africa
- Volunteers
- 30 people
- Sponsor
- Bukwang Pharmaceutical
Parkinson, Posture
The Relationship of Spine Posture and Mobility With Upper Extremity Functions in Parkinson's Patients
The aim of this study is to investigate whether spinal alignment and spinal mobility have an effect on upper extremity functions in Parkinson's patients.
- Conditions
- Parkinson, Posture, Upper Extremity, Quality of Life
- Trial name
- NCT05119803
- Testing
- Spinal Mouse (IDIAG M360 ), Nine Hole Peg Test
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Parkinson's Disease
Sequence Effect in Parkinson's Disease
This study will explore sequence effect, a fatigue or tiredness commonly seen in patients with Parkinson's disease after they have been doing the same thing for a while.
- Trial name
- NCT00431366
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Freezing of Gait, Parkinson Disease
Usability of a Novel Cueing Device for Patients With Parkinson's Disease
Hypokinetic gait disorder and Freezing of Gait (FOG) are frequent symptoms in the advanced stage of Parkinson's disease (PD). These impair quality of life and significantly increase the risk of falls.
- Trial name
- TCP (NCT04459559)
- Testing
- Tactile Cueing Device
- Where
- Switzerland
- Volunteers
- 16 people
- Sponsor
- Swiss Federal Institute of Technology
Parkinson Disease
Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease
An Open-Label Phase 3 Study to Examine the Long-Term Safety, Tolerability and Efficacy of APL-130277 for the Acute Treatment of "OFF" Episodes in Patients With Parkinson's Disease
- Trial name
- NCT02542696
- Testing
- APL-130277
- Where
- 70 sites in United States, Austria and 6 more
- Volunteers
- 496 people
- Sponsor
- Sumitomo Pharma America, Inc.
Parkinson Disease
The Effectiveness of Mixed Reality as Interventional Tool for the Improvement on Quality of Life for People With Parkinson´s Disease.
Parkinson's disease is a chronic, neurodegenerative disease of unknown cause, affecting elderly people over the age of 60. It is the second most common neurodegenerative disease, presenting psychomotor signs and symptoms that…
- Trial name
- NCT06459154
- Testing
- Mixed Reality, Traditional Physiotherapy
- Where
- Cyprus
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Nicosia
Parkinson Disease
Exploring Brain Molecular Imaging and Blood Biomarkers in Subjects With Glucocerebrosidase Mutations: Toward a Precision Medicine Approach to Characterize Parkinson's Disease Clinical Trajectories
Glucocerebrosidase (GBA) mutations are the most common risk factor for Parkinson's Disease (PD). GBA-related PD(GBA-PD) exhibits a more malignant phenotype as compared to no-carriers.
- Trial name
- NCT06167603
- Testing
- FDG-PET, Blood test and clinical examination.
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- IRCCS San Raffaele
Essential Tremor, Parkinson Disease
RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease
To determine the efficacy of frameless Virtual Cone Radiosurgical Thalamotomy for medically refractory tremor resulting from either Essential Tremor or Tremor-Dominant Parkinson's Disease with the Fahn-Tolosa-Marin Tremor Rating…
- Trial name
- NCT03305588
- Testing
- Unframed Virtual Cone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease, Chronic Pain
Efficacy of Ericksonian Hypnosis in the Management of Chronic Pain Related to Parkinson's Disease
This study evaluates the efficacity of Erickson hypnosis in the treatment of chronic pain in patients with Parkinson's disease. Half of participants will follow a 2-month Erickson hypnosis protocole, while the other half will…
- Trial name
- DOLHYP-PARK-1 (NCT04259203)
- Testing
- Erickson hypnosis
- Where
- 4 sites in France
- Volunteers
- 33 people
- Sponsor
- University Hospital, Lille
Parkinson Disease (PD), PARKINSON DISEASE (Disorder)
GBPDC: Gut-Brain in PD Consortium Master Protocol
The purpose of this research study is to identify the role that the gut-brain axis, the group of nerves that connect the brain and gut, plays in Parkinson's disease (PD).
- Conditions
- Parkinson Disease (PD), PARKINSON DISEASE (Disorder), Gut Microbiome, Gut Microbiota
- Trial name
- GBPDC (NCT07567794)
- Where
- 7 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Duke University
Parkinson Disease
The Efficacy and Safety of Transcutaneous Auricular Vagus Nerve Stimulation for Depression in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients with depression.
- Trial name
- PD-D-taVNS (NCT07679529)
- Testing
- Active Transcutaneous auricular vagus nerve stimulation
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson Disease
Gait Re-education Program in Subjects With Parkinson´s Disease
Randomized controlled study that will include participants diagnosed with Parkinson's disease in mild or moderate stage with altered gait pattern who will be randomized following a simple randomization procedure in which one…
- Trial name
- NCT05131880
- Testing
- Gait Re-education Program Using the Fisior® Mat Sequential Training System in Subjects with Parkinson's Disease
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Universidad Europea de Madrid
Parkinson Disease
Study of (Mirapex) Pramipexole for the Early Treatment of Parkinsons Disease (PD)
This is a double blind, placebo-controlled clinical trial of 15 months duration designed to examine early Mirapex (pramipexole) treatment vs. delayed Mirapex (pramipexole) treatment in patients with new onset Parkinsons disease
- Trial name
- NCT00321854
- Testing
- pramipexole
- Where
- 99 sites in United States, Austria and 8 more
- Volunteers
- 535 people
- Sponsor
- Boehringer Ingelheim
Parkinson' Disease
Blood Flow Restriction and Exercise in Parkinson's Disease
The goal of this clinical trial is to learn whether training with blood flow restriction (BFR), combined with aerobic exercise (performing stepping on a Nu-Step exercise machine), can help improve mobility and other outcomes in…
- Trial name
- BFR-PD (NCT07221994)
- Testing
- Blood flow restriction (BFR) and aerobic exercise via recumbent stepping (Nu-Step)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of California, San Francisco
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