Clinical trials: Primary Parkinsonism
Parkinson Disease
BUrst vs. Spaced Physical Therapy for Parkinson's Disease: The BUS PT Timing Trial
Many patients with Parkinson's Disease (PD) will encounter difficulties with balance, posture, and gait for which physical therapy (PT) has been shown to be beneficial.
- Trial name
- NCT05180747
- Testing
- Frequency of physical therapy sessions
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
Parkinson Disease
Study to Assess Pharmacokinetics of Accordion Pill Carbidopa-Levodopa Compared to Immediate Release Carbidopa-Levodopa in Parkinson's Disease Patients
The purpose of this study is to assess the PK of AP-CD/LD given at dose of 50/500mg three times daily compared to CD/LD immediate release (Sinemet) 1.5 tablets of dose of 25/100 given 5 times per day in Parkinson's Disease…
- Trial name
- NCT03576638
- Testing
- Accordion Pill Carbidopa/Levodopa, Sinemet CR 25Mg-100Mg Extended-Release Tablet
- Volunteers
- 12 people
- Sponsor
- Intec Pharma Ltd.
Parkinson Disease
The Effect and Mechanism of Transcutaneous Auricular Vagus Nerve Stimulation on Gait Impairments in PD
This study is a double blind comparative study examining the effectiveness of the transcutaneous auricular vagus nerve stimulation treatment on Parkinson's disease patients .
- Trial name
- NCT05561348
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Parkinson's Disease, Nocturia
Melatonin for Nocturia in Parkinson's Disease
This is an an open label clinical trial of sustained-release Melatonin 2mg once daily for 12 weeks in patients with Parkinsons's Disease reporting nocturia, defined as getting up regularly at night > twice to pass urine.
- Trial name
- NCT02359448
- Testing
- Melatonin
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- University College, London
Parkinson Disease
DB RCT for Specialized Phototherapy in Parkinson's Disease.
This is a pivotal study to determine whether light therapy can improve non-motor and motor function in Parkinson's disease, on top of current best medical treatment.
- Trial name
- LIGHT-PD (NCT04453033)
- Testing
- Celeste Specialized Phototherapy Device
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- PhotoPharmics, Inc.
Parkinson Disease, Medication
Behavioural Profiling of Disease-related Cognitive and Motor Impairment in PD
In this project, patients with Parkinson's Disease (PD) will be characterized by measuring cognitive and motor function and relation to effect of Levodopa.
- Conditions
- Parkinson Disease, Medication, UPDRS, Motor Function
- Trial name
- NCT06275633
- Testing
- Levodopa
- Where
- Denmark
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Parkinson Disease
Evaluation of a Speech-to-noise Feedback Device for Treatment of Hypophonia in Parkinson's Disease
This study will evaluate the effectiveness of a speech-to-noise feedback procedure for the treatment of hypophonia in Parkinson's disease.
- Trial name
- NCT03648749
- Testing
- Speech-to-noise feedback
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Parkinson's Disease
Clinical Trial of Apomorphine Subcutaneous Infusion in Patients With Advanced Parkinson's Disease
The primary objective of the trial was to investigate the efficacy of apomorphine continuous subcutaneous infusion compared to placebo in Parkinson's Disease patients with motor fluctuations not well controlled on medical…
- Trial name
- TOLEDO (NCT02006121)
- Testing
- Apomorphine hydrochloride
- Where
- 20 sites in Austria, Denmark and 5 more
- Volunteers
- 107 people
- Sponsor
- Britannia Pharmaceuticals Ltd.
Parkinson Disease
Help-seeking for Health Problems in People With Parkinson's
Non-motor symptoms (NMS) are common in Parkinson's disease (PD) and cause significant distress and decreased quality of life. A high rate of non-declaration of NMS by patients means that many NMS remain unrecognized and…
- Trial name
- PDHelp (NCT03275649)
- Testing
- Help-seeking for non-motor symptoms
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- City, University of London
SCI - Spinal Cord Injury, PD - Parkinson's Disease
Differential Assessment of Hypertonia
Spasticity and rigidity are common symptoms of central nervous system injuries, such as spinal cord injury and Parkinson's disease, and result in distinct patterns of increased resistance during passive joint movements.
- Trial name
- NCT06596187
- Testing
- Continuous passive motion device (CPM) of ankle - fast, Continuous passive motion device (CPM) of ankle - slow
- Where
- Taiwan
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Gait Disorders, Neurologic
Biomechanical Parameters of Gait in Patients With Parkinson's Disease and Parkinsonian Syndromes
Gait disorders and falls are frequent in patients with parkinsonian syndromes. In patients with Parkinson's disease (PD), these signs occurred later during the course of the disease in comparison to patients with other…
- Trial name
- NCT00139321
- Testing
- Force platform and electromyography
- Where
- France
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
Parkinson Disease
Randomized Single-blind Placebo Controlled Comparative Trial of Pramipexole and Bromocriptine in Parkinson's Disease
The objective of this study was to investigate the efficacy and safety of Pramipexole Tablets in patients with Parkinson's disease (who can be treated with L-DOPA concomitantly) in a single blind, comparative method using…
- Trial name
- NCT00240409
- Testing
- Pramipexole, Bromocriptine
- Where
- 7 sites in China
- Volunteers
- 208 people
- Sponsor
- Boehringer Ingelheim
PARKINSON DISEASE (Disorder), Cell Therapy
A Phase 1 Study of NCR201 in Parkinson's Disease Patients With Prior DBS
This is a Phase 1 clinical trial to evaluate the safety and tolerability of a new cell therapy called NCR201. The study will enroll adults with moderate-to-advanced primary Parkinson's disease who have previously undergone deep…
- Conditions
- PARKINSON DISEASE (Disorder), Cell Therapy, Human Induced Pluripotent Stem Cells, Deep Brain Stimulation
- Trial name
- NCR201-2004 (NCT07896187)
- Testing
- NCR201
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Nuwacell Biotechnologies Co., Ltd.
Parkinson's Disease
Role of Dopamine on Loss Aversion Behaviour: Study on Parkinsonian Patients
Use lay language. Many decisions involve the possibility of gaining or losing relative to the status quo. The loss aversion behaviour is a cognitive concept explaining that people are more sensitive to the possibility of losing…
- Trial name
- NCT01780467
- Testing
- Role of dopamine
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Parkinson Disease
Evaluation of Using Vibrotactile Coordinated Reset for Management of Parkinson's Disease
This is a study to evaluate peripheral vibrotactile coordinated reset stimulation for Parkinson's disease seeks to explore the safety and efficacy of an experimental non-invasive method to aid in the symptoms of Parkinson's…
- Trial name
- NCT03857867
- Testing
- Tactile Stimulation Glove
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Peter Tass, MD, PhD
Parkinson's Disease
Circadian & Homeostatic Synchronization Effect on Waking Mobility in Parkinson's Disease
Sleep benefit (SB) consists of a spontaneous, transient and inconsistent improvement of the mobility occurring on morning awakening in approximately 40% of Parkinson's disease (PD) patients, before taking the first morning dose…
- Trial name
- Synch Fit (NCT04467632)
- Testing
- Validation of the mobility assessment by IMU wearable sensors, Testing in real-life conditions at patients' home in a small group of subjects
- Where
- France
- Sponsor
- University Hospital Center of Martinique
Parkinson Disease, Parkinsonian Syndrome
Study of the Effects of Dopaminergic Medications on Dopamine Transporter Density in Subjects With Parkinson's Disease
This study investigates whether there is a change in 123iodine-2ß- carbomethoxy-3ß-(4-iodophenyl) tropane ([123I]ß-CIT) uptake after short-term treatment with levodopa compared to either dopamine agonist or placebo.
- Trial name
- NCT00129181
- Testing
- cabergoline, carbidopa/levodopa, DATscan and SPECT imaging
- Where
- 9 sites in Austria, Germany and 2 more
- Volunteers
- 30 people
- Sponsor
- Institute for Neurodegenerative Disorders
Parkinson's Disease
A Study to Evaluate the Efficacy and Safety of Monosialotetrahexosylganglioside Sodium Injection in Parkinson's Disease Participants With Motor Fluctuations
This is a multicenter, randomized, double-blind, placebo-controlled, parallel-group, phase 2 study. A total of 276 eligible Parkinson's disease participants with motor fluctuations will be enrolled and assigned to one of three…
- Trial name
- NCT07585565
- Testing
- GM1
- Volunteers
- 276 people
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Parkinson Disease
A Study to Evaluate the Effectiveness and Safety of LY03003 in Patients With Early Primary PD
This study is to evaluate the effictiveness and safety of Ly03003 following intramuscular injections
- Trial name
- NCT04571164
- Testing
- LY03003(Rotigotine,extended-release microspheres)
- Where
- China
- Volunteers
- 294 people
- Sponsor
- Luye Pharma Group Ltd.
Healthy Volunteers
A Study to Assess the Safety, Tolerability and PK of NPT520-34 in Healthy Subjects
To evaluate the PK, safety and tolerability of orally administered NPT520-34 in healthy subjects at single and multiple doses that may be therapeutically relevant.
- Trial name
- NCT03954600
- Testing
- NPT520-34 (125 mg)
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Neuropore Therapies Inc.
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