Clinical trials: Primary Parkinsonism
Parkinson Disease
Evaluation of the Efficacy and Safety of Fecal Microbiota Transplantation for Constipation in Parkinson's Disease
Participants will be allocated to FMT group or placebo group at a 1:1 ratio. For interventional group, patients will be given six FMT capsules twice a week for 24 weeks.
- Trial name
- NCT06388863
- Testing
- Healthy donor-derived FMT capsule
- Where
- China
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Shanghai Zhongshan Hospital
Parkinson's Disease
NAD Supplementation in Parkinson's Disease
The goal of this clinical trial is to learn whether Nicotinamide Riboside, a form of Vitamin B3 also known as NR, can improve blood vessel health in the brain, memory, and physical function in eligible study participants.
- Trial name
- NCT07703137
- Testing
- Nicotinamide Riboside (NR)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Oklahoma
Parkinson Disease
Programmes de Marche Active et qualité de Vie Dans la Maladie de Parkinson
The aim of this randomized controlled pilot trial is to assess the impact of different gait rehabilitation programs on the level of physical activity and gait in daily life in patients with Parkinson's disease (PD).
- Trial name
- ACTI-PARK (NCT05685095)
- Testing
- Physical training
- Where
- France
- Sponsor
- University Hospital, Grenoble
Basal Ganglia Diseases
Basal Ganglia Local Field Potentials in Gait and Speech
Electrid activity of the basal ganglia will be recorded with an implantable deep brain stimulation device (supplied by Medtronic Inc). Study hypothesis is that these activities differ according to what the patient does, i.e.
- Trial name
- NCT01905995
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- Kai Bötzel
Parkinson Disease
Study to Evaluate DNL201 in Subjects With Parkinson's Disease
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple oral doses of DNL201 in subjects with Parkinson's disease.
- Trial name
- NCT03710707
- Testing
- DNL201
- Where
- 7 sites in United States
- Volunteers
- 29 people
- Sponsor
- Denali Therapeutics Inc.
Parkinson Disease
rTMS in Facilitation of Working Memory in PD
Ten sessions of repetitive transcranial magnetic stimulation yield ability to upregulate the function of primary motor cortex and prefrontal cortex that play key roles in motor and frontal memory processing.
- Trial name
- NCT03059212
- Testing
- rTMS, Cognitive training program
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Parkinson's Disease
Expectation and Response to Levodopa and Acupuncture in Parkinson's Disease
To investigate how levodopa and acupuncture affect fatigue and muscle function in people who suffer from Parkinson's disease. Subjects may choose to participate in levodopa or acupuncture part, or both.
- Trial name
- NCT00692328
- Testing
- Levodopa or acupuncture
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- Oregon Health and Science University
Parkinson's Disease (PD)
Prevention-in-PD-Study
The goal of this clinical trial (feasibility study) is to learn if a multimodal lifestyle program can improve adherence to recommended lifestyle changes in people with REM Sleep Behavior Disroder (RBD) or Parkinson's disease…
- Trial name
- NCT07297407
- Testing
- Multidomain lifestyle intervention
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- University Hospital Schleswig-Holstein
Parkinson Disease
10,000 Step Club: Community Walking Program for People with Parkinson's Disease
The 10,000 Step Club (10KSTC) is a 6-month community walking program for people with Parkinson's disease (PwP) and their caregivers in Las Vegas, Nevada (LV).
- Trial name
- (10KSC) (NCT06605183)
- Testing
- Community walking program using Nordic walking poles
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Nevada, Las Vegas
Parkinson Disease
A Late Phase II Clinical Trial of KDT-3594 in Patients With Parkinson's Disease
This trial is a late phase II, multicenter, randomized, double-blind, placebo-controlled, parallel group trial to evaluate the efficacy, safety, and pharmacokinetics of KDT-3594 administered at escalating doses ranging from 0.25…
- Trial name
- NCT06722729
- Testing
- KDT-3594
- Where
- Japan
- Volunteers
- 178 people
- Sponsor
- Kissei Pharmaceutical Co., Ltd.
Parkinson's Disease
Evaluation of Long-term Effect of Resonator Therapy on Parkinson's Disease (PD)
An extension study for subjects with prior participation in previous resonator studies using low level magnetic fields to treat some of the symptoms of idiopathic Parkinson's Disease.
- Trial name
- NCT00862537
- Testing
- Resonator Device
- Volunteers
- 18 people
- Sponsor
- pico-tesla Magnetic Therapies, LLC
Healthy Elderly, Parkinson Disease
A Study to Assess Single and Multiple Doses of IkT-148009 in Healthy Elderly Participants and Parkinson's Patients
This study investigates the safety and tolerability of drug IkT-148009 in healthy elderly volunteers (55 to 70 years old). This first-in-human study is designed in 3 parts.
- Trial name
- NCT04350177
- Testing
- IkT-148009
- Where
- 4 sites in United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- ABLi Therapeutics, Inc.
Parkinson Disease
GM1 Ganglioside Effects on Parkinson's Disease
The purpose of this trial is to examine the short term effects (24 Weeks) of GM1 on Parkinson's disease (PD) symptoms, as well as the effects of long-term treatment (120 Weeks) with GM1 on disease progression, and to examine the…
- Trial name
- NCT00037830
- Testing
- GM1 ganglioside
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- Thomas Jefferson University
Parkinson's Disease
Gait Characteristics and Cognitive Evolution in Parkinson Disease
Parkinson's disease (PD) is a chronic progressive nervous system disease with gradual motor impairment. Cognitive dysfunction is common in PD, even in the early stages, and it is characterized by impairments in executive…
- Trial name
- GECO-PD (NCT04297800)
- Where
- 3 sites in Italy
- Volunteers
- 60 people
- Sponsor
- FROM- Fondazione per la Ricerca Ospedale di Bergamo- ETS
Parkinson's Disease
Study of Tai Chi Exercise and Balance in Persons With Parkinson's Disease
Patients practicing Tai Chi will exhibit significant improvements in primary outcome measures of balance, and secondary outcomes of gait, physical performance, Unified Parkinson's Disease Rating Scale, Falls, muscle strength.
- Trial name
- NCT00611481
- Testing
- Tai Chi, Strength training, Low-Impact Exercise Control
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Oregon Research Institute
Parkinson Disease
Convection Enhanced Delivery of CSF in DBS for Parkinson's
This study will evaluate safety foremost but also the distribution and initial effectiveness of infusion-enhanced, MRI-guided DBS for patients with medication-refractory, Parkinson's disease
- Trial name
- NCT03540134
- Testing
- Intracerebral Infusion of Autologous Cerebral Spinal Fluid
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Jeff Elias, MD
Parkinson Disease, Urinary Disease Other
Cognitive Therapy for Urinary Dysfunction in Parkinson´s Disease
Idiopathic Parkinson's syndrome (IPS) is one of the most common neurodegenerative diseases. The prevalence and significance of this disease is continuously increasing in the course of demographic change.
- Trial name
- PD-UD (NCT03917732)
- Testing
- cognitive training, pelvic floor training
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University Hospital Schleswig-Holstein
Parkinson Disease
Effects of Cycling Dual-task in Parkinson's Disease.
Taking into account the process of functional and cognitive evolution that patients with Parkinson's disease experience throughout the evolution of the pathology, the objective of this study is to evaluate the effect of a…
- Trial name
- NCT05565300
- Testing
- Cycling exercise, Cognitive tasks
- Where
- Spain
- Volunteers
- 44 people
- Sponsor
- University of Vigo
Parkinson's Disease
Real-time fMRI Neurofeedback for Treatment of Parkinson's Disease
The aim of the study is to train patients with Parkinson's Disease to increase activity in a brain area that is involved in the control of motor functions with the use of a technique called real-time fMRI neurofeedback (NF) along…
- Trial name
- NCT01867827
- Testing
- Neurofeedback and Physical Exercise, Physical Exercise
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cardiff University
Parkinson Disease
Function-based Accelerated Stimulation Therapy (FAST-therapy) for Freezing of Gait (FOG) After Parkinson's Disease (PD)
Parkinson disease (PD) is a common disorder in which reduced speed of movement results from inadequate brain production of the chemical dopamine.
- Trial name
- NCT05509842
- Testing
- rTMS
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Michigan
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