Clinical trials: Primary Parkinsonism
Anxiety Disorders, Parkinson Disease
Anxiety in Parkinson's: Use of Quantitative Methods to Guide Rational Treatment
This study will evaluate the effectiveness of the rotigotine transdermal patch in reducing anxiety in people with Parkinson's disease.
- Trial name
- ANXPD (NCT02365870)
- Testing
- rotigotine transdermal patch
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Johns Hopkins University
White Matter Lesions, Postural Instability Gait Disorders
White Matter Pathology in Parkinson's Disease (PD)
The relationship between WM lesions (WM) and Postural Instability Gait Disorders (PIGD-PD)in Parkinson's disease patients is largely unknown.
- Trial name
- NCT01039831
- Where
- Israel
- Volunteers
- 120 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinsonian Disorders
Post-prandial Hypotension and Sleepiness in Parkinson's Disease and Other Synucleinopathies
Excessive daytime sleepiness (EDS) is observed in 30 to 50 % of patients with Parkinson's disease (PD) patients, Dementia with Lewy Bodies (DLB) and Multiple System Atrophy (MSA).
- Trial name
- HYPOSOMNPARK (NCT02021903)
- Where
- 2 sites in France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Toulouse
Parkinson Disease, PARK8, Parkinson Disease
Molecular Pathology and Neuronal Networks in LRRK2 Parkinson's Disease
Parkinson's Disease (PD) is a progressive neurodegenerative disease characterized clinically by bradykinesia, resting tremor, rigidity, and postural instability.
- Conditions
- Parkinson Disease, PARK8, Parkinson Disease, Idiopathic Parkinson Disease
- Trial name
- NCT03782753
- Where
- United Kingdom
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- King's College London
Parkinson Disease, Freezing of Gait
Provocation of Freezing of Gait in Parkinson's Disease
Sample Size N= 10 Parkinson's disease patients with self-reported freezing of gait and 10 without self-reported freezing of gait (in total, 20 Parkinson's disease patients) Accrual Period Single visit for 2 hours Study Design…
- Trial name
- NCT04799613
- Testing
- walking speed, visual loading, dual task
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Toronto
Parkinson Disease
Efficacy and Tolerability of IRL790 in Parkinson's Disease Dyskinesia
Mesdopetam (IRL790) is an experimental small molecule compound with psychomotor stabilizing properties. The primary target is the dopamine D3 receptor, a target implicated in the generation of levodopa-induced dyskinesia, a…
- Trial name
- NCT03368170
- Testing
- Mesdopetam (IRL790)
- Where
- 20 sites in Sweden, United Kingdom
- Volunteers
- 75 people
- Sponsor
- Integrative Research Laboratories AB
Parkinson Disease, Parkinson's Disease and Parkinsonism
Complex Eye Movements in Parkinson's Disease and Related Movement Disorders
Diagnosing Parkinson's disease (PD) depends on the clinical history of the patient and the patient's response to specific treatments such as levodopa.
- Conditions
- Parkinson Disease, Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Corticobasal Degeneration
- Trial name
- NCT04925622
- Testing
- Complex eye movement exam
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Saccadous, Inc.
Depressive Disorder, Parkinson Disease
Effectiveness of Antidepressant Treatment for Depression in People With Parkinson's Disease
This study will evaluate the effectiveness of atomoxetine in reducing symptoms of depression in people with Parkinson's disease.
- Trial name
- NCT00304161
- Testing
- Atomoxetine
- Where
- 2 sites in United States
- Volunteers
- 55 people
- Sponsor
- University of Pennsylvania
Parkinson's Disease
Concurrent Transcranial Direct Current Stimulation and Gait Training in Parkinson's Disease
To investigate the effect of concurrent transcranial direct current stimulation and gait training on gait performance when doing the cognitive dual-task in people with Parkinson's Disease.
- Trial name
- NCT04041661
- Testing
- Active tDCS plus gait training
- Volunteers
- 30 people
- Sponsor
- National Yang Ming Chiao Tung University
Parkinson Disease
Acute Effects of Whole Body Vibration for Individuals With Parkinson Disease
This is an exploratory study to assess the impact of whole body vibration on backward walking speed in people with Parkinson disease.
- Trial name
- NCT06352905
- Testing
- Whole body vibration (WBV), Control
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Baylor University
Dyskinesia, Levodopa-Induced Dyskinesia (LID)
Efficacy and Safety Study of ADS-5102 in PD Patients With Levodopa-Induced Dyskinesia
This is a multi-center, randomized, double-blind, placebo-controlled, 2-arm, parallel group study to evaluate the efficacy and safety of ADS-5102 extended release (ER) capsules, an investigational formulation of amantadine, dosed…
- Conditions
- Dyskinesia, Levodopa-Induced Dyskinesia (LID), Parkinson's Disease (PD)
- Trial name
- EASE LID 3 (NCT02274766)
- Testing
- ADS-5102
- Where
- 51 sites in United States, Austria and 3 more
- Volunteers
- 77 people
- Sponsor
- Adamas Pharmaceuticals, Inc.
Parkinson Disease
Recording and Modulation of Brain Activity Through Chronically Implanted Stimulation Electrodes
For decades, deep brain stimulation (DBS) therapies have been employed very successfully to alleviate segmental motor symptoms (tremor, brady-kinesia or rigidity) in patients with Parkinson's disease (PD).
- Trial name
- PDNeuroGAIT (NCT04703556)
- Testing
- Devices for deep brain stimulation
- Where
- Switzerland
- Volunteers
- 8 people
- Sponsor
- Jocelyne Bloch
Parkinson Disease, Parkinson Disease, Mild Cognitive Impairment
Electrophysiological Signature of Mild Cognitive Impairment and Its Relationship with Parkinson's Disease: a High-density EEG Investigation
The study aims to investigate neural correlate of Mild Cognitive Impairment (MCI) in Parkinson's disease (PD) and to identify a link between functional impairment (in both cognitive and motor domains) and electrophysiological…
- Conditions
- Parkinson Disease, Parkinson Disease, Mild Cognitive Impairment, Healthy
- Trial name
- MMCI (NCT06640673)
- Testing
- Hd-EEG
- Where
- Italy
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Parkinson's Disease
The Differential Diagnosis of Parkinson's Disease and Parkinsonism by Positron-emission Tomography
The objective of this protocol is to analyze the sensitivity and specificity of 18F-DTBZ PET to the differential diagnosis of Parkinson's disease (PD) and other parkinsonism disorders, including multiple system atrophy (MSA)…
- Trial name
- NCT01824056
- Testing
- 18F-FDG
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Parkinson's Disease Aggravated
Microbiota Modification for the Treatment of Motor Complication of Parkinson´s Disease
In recent years, abnormalities in gut microbiota have been identified in patients with Parkinson´s disease having a possible role in motor manifestations.
- Trial name
- NCT04730245
- Testing
- sodium phosphate enema, oral rifaximin and polyethylene glycol
- Where
- Mexico
- Volunteers
- 14 people
- Sponsor
- Torre Médica Santé
Parkinson's Disease
Impact of Non-traditional Guitar Group Instruction on Functional Movement and Well-being in Parkinson's Disease Patients
This controlled prospective cohort study is designed to assess the feasibility and effect of twice-weekly 60 minute non-traditional guitar classes on PD patient's self-reported and measurable outcomes including upper extremity…
- Trial name
- PD/Guitar (NCT02925065)
- Testing
- Non-traditional group guitar instruction
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Johns Hopkins University
Early Stage Parkinson Disease
SLV 308 and Pramipexole for Treatment of Patients With Early Parkinson Disease
This is a multicenter, randomized, double blind, parallel group study of 6 months' treatment with SLV308 as monotherapy in patients with early stage PD.
- Trial name
- NCT00335166
- Testing
- Pardaprunox, pramipexole
- Where
- 89 sites in United States, Australia and 16 more
- Volunteers
- 330 people
- Sponsor
- Solvay Pharmaceuticals
Parkinson's Disease
Ascending Dose Tolerability/Safety of SLV308 for the Treatment of Parkinson's Disease
This study is a multicenter, randomized, double-blind, placebo controlled, parallel group study of a seven-week ascending dose period of SLV308 adjunctive to L-dopa treatment in patients with advanced stage Parkinson's disease…
- Trial name
- NCT00134251
- Testing
- SLV308
- Where
- 10 sites in Bulgaria, Malta and 1 more
- Sponsor
- Solvay Pharmaceuticals
Parkinson Disease
Circuit-Based Deep Brain Stimulation for Parkinson's Disease; Udall Clinical Core
The goal of this project is to provide comprehensive longitudinal assessments of a cohort of PD patients before, during, and after DBS surgery, including neurological, neurophysiological, and neuropsychological data.
- Trial name
- NCT03021031
- Testing
- Observational
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Minnesota
Traumatic Brain Injury, Parkinson's Disease
Imaging Biomarkers of Delayed Sequelae in Trauma Brain Injury
The purpose of this study is to learn if a new brain imaging technology called DaTscan can detect subtle changes in the brain that are similar to those seen in early Parkinson's disease (PD).
- Trial name
- NCT01516281
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
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