Clinical trials: Primary Parkinsonism
Parkinson Disease
Study to Assess Pharmacokinetics of Accordion Pill Carbidopa-Levodopa Compared to Immediate Release Carbidopa-Levodopa in Parkinson's Disease Patients
The purpose of this study is to assess the PK of AP-CD/LD given at dose of 50/500mg three times daily compared to CD/LD immediate release (Sinemet) 1.5 tablets of dose of 25/100 given 5 times per day in Parkinson's Disease…
- Trial name
- NCT03576638
- Testing
- Accordion Pill Carbidopa/Levodopa, Sinemet CR 25Mg-100Mg Extended-Release Tablet
- Volunteers
- 12 people
- Sponsor
- Intec Pharma Ltd.
Parkinson's Disease
Single-Centre Study of VR040(Inhaled Apomorphine) in Idiopathic Parkinson's Disease
In this first study of inhaled apomorphine in Parkinson's disease patients, the primary objective is to find the minimum efficacious dose of apomorphine that is useful in rescuing patients during 'off' periods.
- Trial name
- NCT01683292
- Testing
- Inhaled VR040
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- South Glasgow University Hospitals NHS Trust
Freezing of Gait, Parkinson Disease
DBS and Levodopa for Treating Freezing of Gait in Parkinson's Disease
Freezing of gait (FoG) is a complex symptom of Parkinson's disease (PD) that cause falls and disability in PD patients, heavily affect patients' autonomy and quality of life.
- Trial name
- NCT06316232
- Testing
- STIM ON plus, MED ON plus
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS Istituto delle Scienze Neurologiche di Bologna
Parkinson's Disease
A Drug Interaction Study of KW-6356 With Midazolam, Caffeine, or Rosuvastatin
The purpose of this study is to evaluate the influence of repeated oral doses of KW-6356 on the pharmacokinetics of index substrates for CYP3A4/5, CYP1A2 and BCRP.
- Trial name
- NCT03970798
- Testing
- Midazolam, Caffeine, Rosuvastatin
- Where
- Japan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Multiple System Atrophy, Parkinson Variant (Disorder), Parkinson Disease
Mobility in Atypical Parkinsonism: a Trial of Physiotherapy
Patients with atypical parkinsonism often show gait and mobility impairment manifesting in early disease stages. In order to maintain mobility and physical autonomy as long as possible for these patients, we will examine the…
- Conditions
- Multiple System Atrophy, Parkinson Variant (Disorder), Parkinson Disease, Progressive Supranuclear Palsy
- Trial name
- Mobility_APP (NCT04608604)
- Testing
- Physiotherapy
- Where
- Austria
- Volunteers
- 180 people
- Sponsor
- Victoria Sidoroff
Parkinson's Disease, Psychotic Disorders
Melperone (an Anti-Psychotic) in Patients With Psychosis Associated With Parkinson's Disease
The purpose of this study is to evaluate the safety and efficacy of three target doses of melperone compared to placebo in the treatment of psychosis associated with Parkinson's disease.
- Trial name
- NCT00125138
- Testing
- Melperone HCl
- Where
- 21 sites in United States, India and 1 more
- Volunteers
- 90 people
- Sponsor
- Lundbeck LLC
Parkinson Disease(PD)
Objective Mobility Assessment Using Wearable Technology for Clinical Application in Parkinson's Disease: From Validation to Fall Prediction
The main objective of this observational trial is to explore the validity and reliability of DANU smart socks when used for mobility assessments in people with Parkinson's.
- Trial name
- NCT07281755
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Northumbria University
Parkinson's Disease (PD)
Study To Assess Adverse Events and Change in Disease Activity Of 24-hour Continuous Subcutaneous Infusion Of ABBV-951 In Adult Participants With Advanced Parkinson's Disease
Parkinson's disease (PD) is a neurological condition, which affects the brain. PD gets worse over time, but how quickly it progresses varies a lot from person to person.
- Trial name
- NCT04750226
- Testing
- ABBV-951
- Where
- 52 sites in United States, Australia
- Volunteers
- 118 people
- Sponsor
- AbbVie
Parkinson Disease
Effects of Inspiratory Muscle Training in Patients With Parkinson's Disease
Parkinson's patients usually have a significant decrease in respiratory muscle strength and respiratory function, which may increase in proportion to the severity of the disease.
- Trial name
- NCT06017336
- Testing
- Inspiratory Muscle Training Group, Control Group (breathing exercises)
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gazi University
Parkinson Disease
The UPbeating GReek Application of DancE in Parkinson's Disease Clinical Trial
Dance for Parkinson's Disease® (DfPD®) is a specially designed dance program for individuals with PD. This study assesses the efficacy, safety and feasibility of a culturally adapted DfPD® program offered both live and online in…
- Trial name
- UPGRADE-PD (NCT06220084)
- Testing
- Dance for PD®
- Where
- Greece
- Volunteers
- 40 people
- Sponsor
- University of West Attica
Parkinson Disease, Parkinsonism
Cross-System Effects of Acute Intermittent Hypercapnia-Based Interventions in PD
Parkinsonism impairs upper airway and axial motor control, leading to disordered breathing, reduced speech volume, and ineffective cough. Symptoms are poorly addressed by current therapies.
- Trial name
- NCT07674264
- Testing
- Acute intermittent hypercapnic hypoxia (AIHH), Acute intermittent hypercapnic normoxia (AIHN)
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- University of Florida
Parkinson Disease
Staccato Apomorphine Single and Multi Dose PK
This study will be conducted in 3 parts. A) compare the pharmacokinetics (PK) of a single dose of AZ-009 with that of a therapeutically-relevant dose of a commercially available apomorphine injector in healthy volunteers; B)…
- Trial name
- NCT03822364
- Testing
- 009-1, active comparator, 009-0
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Alexza Pharmaceuticals, Inc.
Parkinson Disease
Video Game-based Exercise for Persons With Parkinson's Disease
This study assessed the effects of interactive video game-based exercise (IVGB) on balance in persons with Parkinson's disease . Twenty-four patients were randomly allocated to two groups (12 participants per group).
- Trial name
- NCT03689764
- Testing
- interactive video game-based exercise, no intervention
- Where
- Taiwan
- Volunteers
- 24 people
- Sponsor
- Taipei Medical University Hospital
Parkinson Disease
LRRK2 G2385R Leucocyte and Urine Biomarker Study
Given the emerging evidence on LRRK2-related biomarkers, this project will focus on identifying leucocyte and urine biomarkers that are altered by the LRRK2 G2385R variant, and investigating the effects of LRRK2 kinase inhibitor…
- Trial name
- LRRK2 G2385R (NCT04436848)
- Testing
- This is a non-interventional study
- Where
- Malaysia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Parkinson Disease
Transcranial Low Voltage Pulsed Electromagnetic Fields (T-PEMF) in Patients With Parkinson's Disease
The aim of this study, is to determine whether treatment using transcranial low voltage pulsed electromagnetic fields (T-PEMF) can reduce the symptoms patients with Parkinson's Disease (PD) experience.
- Trial name
- NCT02125032
- Testing
- Transcranial low voltage pulsed electromagnetic fields (T-PEMF)
- Where
- Denmark
- Volunteers
- 98 people
- Sponsor
- Odense University Hospital
Parkinson's Disease
Relaxation Guided Imagery for Treatment of Parkinson's Disease
Parkinson's disease patients may have pronounced ON-OFF motor fluctuations. These motor fluctuations are currently treated with medication and surgery, which are limited by their efficacy and side effects.
- Trial name
- NCT01151111
- Testing
- Relaxation guided imagery
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Sialorrhea, Parkinson's Disease
Study of Glycopyrrolate for Moderate-to-severe Sialorrhea in Parkinson's Disease
Sialorrhea is a frequently occurring problem with detrimental effect on quality of life in 25% of PD patients. Currently, there is no intervention approved for sialorrhea in Parkinsons and evidence is only available for a 30-day…
- Trial name
- GLYCOPAR (NCT02382198)
- Testing
- Glycopyrrolate
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Ottawa Hospital Research Institute
Parkinson's Disease
D-serine Adjuvant Treatment for Parkinson's Disease
The proposed experiment will evaluate the effects of the NMDA receptor full agonist D-serine (~2g/day) on persistent symptoms of Parkinson's Disease and on antiparkinsonian drugs-induced dyskinesias.
- Trial name
- NCT00215904
- Testing
- D-serine (~2g/day)
- Where
- Israel
- Volunteers
- 13 people
- Sponsor
- Herzog Hospital
Dystonia Disorder, Parkinson Disease
Botulinum Toxin Type A for Foot Dystonia-associated Pain in Parkinson's Disease
To study the effects of Botulinum toxin type A (BTXA) in the treatment of foot dystonia-associated pain in Parkinson's disease
- Trial name
- NCT04277247
- Testing
- Botulinum toxin type A
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Calgary
Parkinson Disease
Modulation of Cognitive Control Via Transcranial Continuous Electrical Stimulation of Additional Motor Areas in Parkinson's Patients
In Parkinson's disease (PD), recent work has shown that dopaminergic treatments alter one of the two aspects of impulsivity: they do not alter the propensity to produce "automatic" responses, but deteriorate the ability to…
- Trial name
- STAR-PARK (NCT04897633)
- Testing
- transcranial electric stimulation
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
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