Clinical trials: Primary Parkinsonism
Parkinson Disease
Data-Driven Characterization of Neuronal Markers During Deep Brain Stimulation for Patients With Parkinson's Disease
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) has developed into a standard therapy in the refractory stage of Parkinson's disease (PD).
- Trial name
- NCT03079960
- Testing
- Electrophysiological recording and measurement devices
- Where
- Germany
- Volunteers
- 120 people
- Sponsor
- Prof. Dr. Volker Arnd Coenen
Parkinson Disease, Dyskinesia, Drug-Induced
Dipraglurant (ADX48621) for the Treatment of Patients With Parkinson's Disease Receiving Levodopa-based Therapy
This study is designed to evaluate the safety and efficacy of dipraglurant in PD patients with dyskinesia (randomized 1:1 to receive active or placebo) for 12 weeks (1 week at 150 mg per day and 11 weeks at 300 mg per day).
- Conditions
- Parkinson Disease, Dyskinesia, Drug-Induced, Dyskinesias
- Trial name
- NCT04857359
- Testing
- Dipraglurant
- Where
- 41 sites in United States
- Volunteers
- 25 people
- Sponsor
- Addex Pharma S.A.
Parkinson's Disease
Managing Changes in Life After Deep Brain Stimulation for Parkinson's Disease
Parkinson's disease is a chronic progressive neurological disorder. Symptoms are tremor, slowness in movement, rigidity and postural instability.
- Trial name
- NCT01681641
- Testing
- A psycho-social intervention
- Where
- 3 sites in Denmark
- Volunteers
- 32 people
- Sponsor
- University of Aarhus
Parkinson's Disease
Multi-disciplinary Rehabilitation Program for Advanced Parkinson's Patients in the Community
The present study examines the effectiveness of the rehabilitation program in the framework of the "Ezra LeMarpeh" project for Parkinson's patients. The Ezra LeMarpeh Association, founded by Rabbi A. E.
- Trial name
- NCT03406754
- Testing
- rehabilitation programs
- Where
- 2 sites in Israel
- Volunteers
- 60 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson's Disease
Topiramate as a Treatment for Levodopa-Induced Dyskinesia in Parkinson's Disease
A phase II double blind trial to evaluate the effects of the AMPA, glutamte antagonist, topiramate on levodopa-induced dyskinesia in Parkinson's disease
- Trial name
- NCT00296959
- Testing
- topiramate (drug)
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
Parkinson's Disease
A Multiple-Dose Study of Sinemet® CR (Carbidopa/Levodopa) in Healthy Subjects
The purpose of this clinical research study is to determine if different dosage regimens of Sinemet® CR (Carbidopa/levodopa) are dose proportional
- Trial name
- NCT00460954
- Testing
- Sinemet® controlled release (Carbidopa/levodopa)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Parkinson
Prism Adaptation Treatment of Parkinson's Disease
Subjects diagnosed with Idiopathic Parkinson's Disease, between ages of 40-85 inclusive, who have been referred for gait training.
- Trial name
- NCT02380859
- Testing
- Prism adaptation
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Parkinson's Disease
Study to Compare Adhesiveness of Two Different Rotigotine Patch Formulations
The primary objective of the study is to compare the adhesiveness of two different patch formulations of rotigotine using patch size 40 cm2, under the assumption that both patch formulations show similar adhesiveness properties.
- Trial name
- NCT01338896
- Testing
- Rotigotine transdermal patch
- Where
- 16 sites in Austria, Germany and 1 more
- Volunteers
- 56 people
- Sponsor
- UCB Pharma
Parkinson Disease
Non-motor Symptoms (Depressive Symptoms) of Parkinson's Disease and Their Course Under Pramipexole Treatment
The objective of this PMS study is the evaluation of depressive symptoms measured with Unified Parkinson's Disease Rating Scale (UPDRS) Part I (mentation, behavior and mood) and with Hospital Anxiety and Depression Scale…
- Trial name
- NCT00651183
- Testing
- Pramipexole immediate release
- Where
- 57 sites in Austria
- Volunteers
- 286 people
- Sponsor
- Boehringer Ingelheim
Parkinson's Disease, Essential Tremor
Local Fields Potentials Recorded From Deep Brain Stimulating Electrodes
Deep Brain Stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's Disease (PD), Essential Tremor (ET) and Dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- LFP DBS (NCT02071446)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Transcranial Magnetic Stimulation, Freezing of Gait
Dual-target, High-dose TMS for PD Patients With FOG
The aim of the current study was to verify whether high-dose TMS treatment of the motor and cognitive cortices is more effective in alleviating FOG than conventional-dose TMS of the motor cortex only.
- Trial name
- NCT05625386
- Testing
- transcranial magnetic stimulation
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Anhui Medical University
Parkinson Disease
Therapeutic Education in Parkinson's Disease: What Impact on Drug Representations of Patients? (ETPARK-REMED)
Dopaminergic drug can have adverse effects leading to potential serious consequences. Therapeutic patient education must promote the understanding of drugs to improve its management.
- Trial name
- ETPARK-REMED (NCT04228523)
- Testing
- Therapeutic education workshop, Speaking Therapy
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Parkinson's Disease, Restless Leg Syndrome
A Single Dose, 2-Period, 2-Treatment, 2-Way Crossover Bioequivalency Study of Ropinirole 0.25 mg Tablets Und Fasted Conditions
The objective of this study was to assess the single dose bioequivalence of Roxane's Ropinirole Tablets, 0.25 mg to ReQuip Tablets, 0.25 mg (GlaxoSmithKline) under fasting conditions using a single-dose, randomized, 2-treatment…
- Trial name
- NCT00673088
- Testing
- Ropinirole Hydrochloride
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Parkinson Disease
Feasibility of Whole-body Drumming Classes for People With Parkinson's Disease
People with Parkinson's disease (PD) experience difficulty with gait, postural instability, and lack of movement coordination and rhythmic timing.
- Trial name
- NCT04982003
- Testing
- exercise
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- A.T. Still University of Health Sciences
Parkinson's Disease
Cont. of a Study to Evaluate Implanting Peripheral Nerve Grafts Into Subjects With Parkinson's Disease (PD) During DBS
This pilot study is designed to follow up on a previous, preliminary study and test the long-term safety and feasibility of the implantation of autologous peripheral nerve grafts into the substantia nigra, basal forebrain…
- Trial name
- CAPNG (NCT02369003)
- Testing
- Autologous Peripheral Nerve Graft
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Craig van Horne, MD, PhD
Parkinson Disease
Idiopathic Parkinson's Progression and Dopamine Transporter SPECT
DaTscanTM Ioflupane I123, a radiopharmaceutical will be used as an adjunct diagnostic tool in combination with single photon emission computed tomography (SPECT) to evaluate striatal dopamine transporter (DAT) distribution in…
- Trial name
- NCT03531086
- Testing
- Ioflupane I 123
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Julie Gurwell
Excessive Sleepiness, Parkinson Disease
A 4-Week Study of the Safety, Efficacy, and Pharmacokinetics of JZP-110 [(R)-2-amino-3-phenylpropylcarbamate Hydrochloride] in Subjects With Parkinson's Disease and Excessive Sleepiness
This study is a 4-week, multicenter, randomized, double-blind, placebo-controlled, ascending dose, 4-period crossover study designed to evaluate the safety, tolerability, efficacy, and PK of JZP-110 (75, 150, and 300 mg) in the…
- Trial name
- NCT03037203
- Testing
- JZP-110
- Where
- 25 sites in United States
- Volunteers
- 66 people
- Sponsor
- Jazz Pharmaceuticals
Parkinson's Disease
A Rehabilitative Approach in Patients With Parkinson's Disease
The purpose of the study is to evaluate the effectiveness of a rehabilitative approach using breathing and relaxation techniques, and specifically the elongation of the latissimus dorsi muscle according to the Mézières Method to…
- Trial name
- NCT02891473
- Testing
- Mézières Method, Home based exercise program
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- University of Roma La Sapienza
Idiopathic Parkinson's Disease (PD)
MER Versus MRI Guidance DBS in Parkinson's Disease
Most leading academic centers including Baylor College of Medicine (BCM) perform deep brain stimulation surgery in the awake patient using microelectrode recording to guide final electrode placement.
- Trial name
- NCT01883973
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Baylor College of Medicine
Parkinson's Disease
Shanghai Parkinson's Study
Background: Parkinson disease (PD) is the second most prevalent neurodegenerative disease, affecting more than 1 percent of the elderly population in the United States and other Western countries.
- Trial name
- NCT00999388
- Where
- 2 sites in China
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
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