Clinical trials: Primary Parkinsonism
Parkinson's Disease
A Study to Evaluate the Safety, Tolerability, PK and PD of HNC364 Injectable Suspension
This is a non-randomized, dose-escalation first-in-human study to evaluate the safety, tolerability, PK, and PD of HNC364 following intramuscular administration of single ascending doses.
- Trial name
- NCT05523570
- Testing
- HNC364
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Guangzhou Henovcom Bioscience Co. Ltd.
Early Stage Parkinson Disease
SLV 308 and Pramipexole for Treatment of Patients With Early Parkinson Disease
This is a multicenter, randomized, double blind, parallel group study of 6 months' treatment with SLV308 as monotherapy in patients with early stage PD.
- Trial name
- NCT00335166
- Testing
- Pardaprunox, pramipexole
- Where
- 89 sites in United States, Australia and 16 more
- Volunteers
- 330 people
- Sponsor
- Solvay Pharmaceuticals
Parkinson Disease
Use of Low-dose Zolpidem in Parkinson's Disease
This study will evaluate the motor and cognitive benefits of low-dose zolpidem in Parkinson's.
- Trial name
- NCT03621046
- Testing
- Zolpidem
- Where
- United Kingdom
- Volunteers
- 28 people
- Sponsor
- Aston University
Gait Disorders, Neurologic
Study to Assess Droxidopa in the Treatment of Freezing Of Gait Symptoms in Patients With Parkinson's Disease
Freezing of Gait (FoG) is a class of symptoms that occur in Parkinson's patients. Also called motor blocks, FoG is characterized by a sudden inability to move the lower extremities which usually lasts less than 10 seconds.
- Trial name
- NCT01331122
- Testing
- droxidopa
- Where
- 2 sites in United States, Canada
- Sponsor
- Chelsea Therapeutics
Stroke, Multiple Sclerosis
Development and Application of Tele-Neuro Rehabilitation System
Disability due to neurological diseases is increasing in our country and world. With regular physiotherapy and rehabilitation, as well as patients' symptoms are brought under control, their affected functions in daily life are…
- Conditions
- Stroke, Multiple Sclerosis, Parkinson Disease
- Trial name
- NCT05031403
- Testing
- Telerehabilitaton, Home Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people
- Sponsor
- Istanbul University - Cerrahpasa
Essential Tremor, Parkinson Disease
RAD 1601: EDGE Radiosurgery for Intractable Essential Tremor and Tremor-Dominant Parkinson's Disease
To determine the efficacy of frameless Virtual Cone Radiosurgical Thalamotomy for medically refractory tremor resulting from either Essential Tremor or Tremor-Dominant Parkinson's Disease with the Fahn-Tolosa-Marin Tremor Rating…
- Trial name
- NCT03305588
- Testing
- Unframed Virtual Cone
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease
Role of Deep Brain Stimulation on Social Cognition in Parkinsonian Patients
Parkinson's disease (PD) is usually responsible of cognitive and behavioral non-motor signs with a major impact on the quality of life.
- Trial name
- NCT03004573
- Testing
- Neuropsychological detailed tests with focus on social cognition
- Where
- France
- Volunteers
- 28 people
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease
SCAN Targeted Epidural Modulation for Parkinson's Disease
The goal of this clinical trial is to learn if epidural modulation targeting the Somato-Cognitive Action Network (SCAN) can improve motor symptoms in adults with idiopathic Parkinson's disease (PD).
- Trial name
- NCT06919822
- Testing
- Personalized SCAN Targeted Epidural Modulation
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Changping Laboratory
Parkinson Disease
Interdisciplinary + Intersectoral Telemedicine Evaluation, Coordination + Treatment in RhineMain+ Parkinson's Network
Project objective: To improve the health care of Parkinson's disease patients in the ParkinsonNetz RheinMain+. Hypothesis: Through the interdisciplinary and cross- sectoral networking in a tele medical network and the…
- Trial name
- INSPIRE-PNRM (NCT06479083)
- Testing
- New Intervention form including, Standard treatment
- Where
- 2 sites in Germany
- Volunteers
- 1,354 people
- Sponsor
- Johannes Gutenberg University Mainz
Parkinson Disease
The Microbiome in Parkinson's Disease
To investigate the dynamic relationship between the intestinal microbiota and Inflammation in subjects with Parkinson's disease.
- Trial name
- NCT03129451
- Testing
- Microbiome specimens in stool
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Corewell Health West
Parkinson's Disease
The Therapeutics Effects of Yoga in Individuals With Parkinson's Disease
To determine if yoga is beneficial in improving physical function quality of life and medical status in people with Parkinson's disease
- Trial name
- NCT00312559
- Testing
- Yoga Training
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Kansas
Parkinson Disease
Changes in Functional Performance in Individuals With Parkinson's Disease Following 2-month Physiotherapy Intervention
Aim of current study was to evaluate the effect of a 2-month comprehensive physiotherapy intervention on different aspects of functional performance.
- Trial name
- NCT03568903
- Testing
- Comprehensive physical therapy
- Volunteers
- 44 people
- Sponsor
- University of Tartu
Parkinson Disease
Exercise to Improve Sleep in Parkinson's Disease
This study will investigate the impact of three common exercise modalities, cardiovascular, resistance, and multimodal (i.e., a combination of the previous two) training, on sleep quality and architecture in persons with…
- Trial name
- NCT05644327
- Testing
- Cardiovascular training (CT), Resistance training (RT), Multimodal training (MT)
- Where
- 3 sites in Canada
- Volunteers
- 150 people
- Sponsor
- McGill University
Parkinson Disease-tremor, Essential Tremor
Mapping Functional Networks of Brain Activity Using EEG in Patients With Essential Tremor or Parkinson Disease Before and After MR-guided Focused Ultrasound Thalamotomy for Tremor
A cornerstone in PD and ET research is the investigation of neurophysiological changes as potential bio-markers that could help in tracking disease progression and response to therapy.
- Trial name
- NCT02692183
- Volunteers
- 100 people
- Sponsor
- Sheba Medical Center
Hypokinetic Dysathria
The Effect of LSVT LOUD for Mandarin-speaking Individuals With Hypokinetic Dysarthria Due to Parkinson's Disease
A handful of studies have examined the effects of the Lee Silverman Voice Treatment (LSVT) LOUD on hypokinetic dysarthria in English speakers with Parkinson's disease (PD).
- Trial name
- NCT02506205
- Testing
- Lee Silverman Voice Treatment (SVLT) LOUD
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Parkinson's Disease and Parkinsonism
PDGeneration: Mapping the Future of Parkinson's Disease
To assess the feasibility, impact, and participant satisfaction of offering Clinical Laboratory Improvement Amendments (CLIA) certified genetic testing as part of clinical care for People with Parkinson's disease (PWP).
- Trial name
- PDGENE (NCT04057794)
- Testing
- Lab Assay for seven genetic variants for Parkinson's Disease
- Where
- 13 sites in United States
- Volunteers
- 1,982 people
- Sponsor
- Parkinson's Foundation
Parkinson's Disease
Feasibility Study to Evaluate Deep Brain Stimulation (DBS) Settings for the Treatment of Parkinson's Disease
The purpose of this study is to assess the cognitive performance in patients with advanced Parkinson's disease receiving Deep Brain Stimulation (DBS) with settings predetermined clinically to settings derived from a…
- Trial name
- SAGE (NCT01230151)
- Testing
- GUIDE software, Version 0.1, Clinically defined stimulation parameters
- Where
- 4 sites in United States
- Volunteers
- 80 people
- Sponsor
- Intelect Medical, Inc.
Symptomatic Neurogenic Orthostatic Hypotension
Sustained Effect of Droxidopa in Symptomatic Neurogenic Orthostatic Hypotension
To evaluate the time to treatment intervention in patients with Parkinson's Disease (PD), Multiple System Atrophy (MSA), Pure Autonomic Failure (PAF), Non-Diabetic Autonomic Neuropathy (NDAN) or Dopamine Beta Hydroxylase (DBH)…
- Trial name
- RESTORE (NCT02586623)
- Testing
- Droxidopa capsules
- Where
- 168 sites in United States
- Volunteers
- 453 people
- Sponsor
- H. Lundbeck A/S
Parkinson's Disease (PD)
A Novel Digital Music-based Autonomous Personalized Walking Intervention to Improve Gait and Walking Automaticity in Parkinson Disease
The purpose of this research study is to examine the effects of a 3-month personalized community-based walking program using a digital music-based device designed for self-directed gait training in people with Parkinson disease…
- Trial name
- MyMusiQ (NCT07705373)
- Testing
- MR-005 (MedRhythms, Inc., Portland, ME)
- Where
- 3 sites in United States
- Volunteers
- 200 people
- Sponsor
- Boston University Charles River Campus
Parkinson's Disease (PD)
Electrophysiology-based DBS Programming for PD
Deep brain stimulation (DBS) effectively alleviates motor symptoms in Parkinson's disease (PD). However, current programming is manual and time-consuming.
- Trial name
- NCT07348705
- Testing
- Clinician-based DBS programming, Maximum Beta power-based DBS programming, Broad-band electrophysiology-based DBS programming
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Florida
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