Clinical trials: Primary Parkinsonism
Parkinson Disease
To Evaluate the Dose-response Effects of a Defined Volume of Physical Exercise on the Change of Peripheral Biomarkers, Clinical Response and Brain Connectivity in Parkinson's Disease: a Prospective, Observational, Cohort Pilot Study
This is a prospective, observational, cohort pilot study of standardize volume of aerobic exercise on changes in BDNF concentration at 4-weeks of exercise training among Parkinson disease patients.
- Trial name
- METEX-PD (NCT06339398)
- Testing
- Aerobic exercise
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Casa di Cura San Raffaele Cassino
Parkinson Disease
AADC Gene Therapy for Parkinson's Disease
The purpose of this study is to evaluate the safety, efficacy of intra-putaminal infusion of AAV-hAADC-2 (adeno-associated virus encoding human aromatic L-amino acid decarboxylase) by stereotaxic surgery in patients with advanced…
- Trial name
- NCT02418598
- Testing
- Cohort1, Cohort2
- Where
- Japan
- Volunteers
- 2 people
- Sponsor
- Jichi Medical University
Idiopathic Parkinson's Disease
Dopamine Effect on Inhibitory Control
The effect of Levodopa medication on inhibitory control in Parkinson's patients is extremely debated despite the fact that this has potential clinical and therapeutic implications.
- Trial name
- DEI (NCT03665493)
- Testing
- PD patients H&Y=1.5-2 Medications ON, PD patients H&Y=1.5-2 Medications OFF, Healthy age-matched controls
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Giovanni Mirabella
Parkinson
Early ParkinSon wIth L-DOPA/DDCI and OpicapoNe (EPSILON Study)
Opicapone (OPC) is a third generation catechol O methyltransferase (COMT) inhibitor (COMTi) developed by BIAL-Portela \& Cª, S.A.
- Trial name
- EPSILON (NCT04978597)
- Testing
- Opicapone 50 mg
- Where
- Bulgaria
- Volunteers
- 410 people
- Sponsor
- Bial - Portela C S.A.
Parkinson Disease
A Novel Technology-assisted Home Based Aerobic Exercise Programme for Individuals With Parkinson's Disease
This study aim to evaluate the (1) feasibility of a novel mobile application ( Combat PD) that support a home-based gamified aerobic exercise program in individuals with mild Parkinson's disease (PD).
- Trial name
- NCT05737316
- Testing
- Combat PD, Usual Care
- Where
- Singapore
- Volunteers
- 60 people
- Sponsor
- Tan Tock Seng Hospital
Adults With Parkinson's Disease
Neuromodulation for Patients With Parkinson's Disease
This study will compare different treatment schedules of combined transcranial direct current stimulation (tDCS) and transcranial ultrasound stimulation (TUS) in participants with Parkinson's disease.
- Trial name
- NCT07767006
- Testing
- tDCS combined with TUS
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- Felipe Fregni, MD, PhD, MPH
Parkinson's Disease
Evaluating the Influence of Externally vs. Internally Focused Exercise on Rehabilitation in Parkinson's Disease
The purpose of this study is to evaluate the underlying mechanism and influence of externally vs. internally focused exercise on rehabilitation in Parkinson's disease.
- Trial name
- DT-PDSAFEx (NCT02476240)
- Testing
- Parkinson's disease Sensory Attention Focused Exercise
- Volunteers
- 65 people
- Sponsor
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Parkinson's Disease, Psychoses
Aripiprazole in Patients With Psychosis Associated With Parkinson's Disease
The purpose of this clinical research study is to assess the safety and tolerability of aripiprazole in patients with psychosis associated with Parkinson's disease.
- Trial name
- NCT00095810
- Testing
- aripiprazole
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Otsuka Pharmaceutical Development & Commercialization, Inc.
Parkinson Disease, Alzheimer Disease
Effectiveness of Probiotic K10 in Managing Health Outcomes in Parkinson and Alzheimer Disease
Evaluation of the effects of the K10 probiotic mix in patients with degenerative neurological diseases (Parkinson and Alzheimer's) with a focus on cognitive, motor and psychiatric neurological evaluation.
- Trial name
- Probiótico (NCT06019117)
- Testing
- Probiotic K10
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Deivis de Oliveira guimaraes
Parkinson Disease, Multiple System Atrophy
Research of Biomarkers in Parkinson Disease
The main goal of the GENEPARK consortium is to employ innovative haemogenomic approaches to determine gene expression profiles specific for genetic and idiopathic Parkinson's disease (PD) patients.
- Conditions
- Parkinson Disease, Multiple System Atrophy, Progressive Supranuclear Palsy, Huntington Disease
- Trial name
- Genepark (NCT00465790)
- Where
- 5 sites in Croatia, France and 2 more
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
PARKINSON DISEASE (Disorder), Parkinson s Disease
Effects of Accelerated rTMS On Motor and Cognitive Function in Parkinson's Disease
Parkinson's disease (PD) is a brain disorder that causes progressive problems with movement, such as slowness, stiffness, tremor, and difficulty walking. Many people with PD also develop problems with thinking and memory.
- Trial name
- NCT07554833
- Testing
- TMS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- San Francisco Neurology and Sleep Center
Parkinson Disease, Cognitive Impairment
Low Frequency Deep Brain Stimulation of the Subthalamic Nucleus in Parkinson's Disease
Prospective trial of low frequency deep brain stimulation of the ventral subthalamic nucleus to improve cognitive performance in patients with advanced Parkinson's disease.
- Trial name
- NCT03204526
- Testing
- deep brain stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of California, Davis
Parkinson
A Study in Patients With Advanced Parkinson's Disease to Assess the Relative Bioavailability of Levodopa Administered as ND0612 Subcutaneous Infusion Versus Levodopa Administered as Carbidopa-Levodopa Enteral Suspension
This study will assess the relative bioavailability of s.c. infused ND0612 versus jejunally infused CLES in patients with advanced PD.
- Trial name
- NCT03462043
- Testing
- ND0612, CLES
- Where
- Italy
- Sponsor
- NeuroDerm Ltd.
Parkinson Disease
O-ARM Stereotactic Imaging in Deep Brain Stimulation for Parkinson's Disease
During deep brain stimulation procedures in Parkinson's disease (PD), the most important prognostic element is the positioning of the surgical electrode in the subthalamic nucleus which is the anatomical target.
- Trial name
- STEREOBLOC (NCT05910008)
- Testing
- O-Arm Stereotactic imaging, Standard Stereotactic imaging
- Where
- France
- Volunteers
- 24 people
- Sponsor
- University Hospital, Toulouse
Parkinson's Disease
Safety of CERE-120 (AAV2-NTN) in Subjects With Idiopathic Parkinson's Disease
This is a Phase I dose escalating open-label study designed to assess the safety, tolerability and biologic activity of an in vivo AAV2 mediated delivery of the gene encoding NTN (CERE-120).
- Trial name
- NCT00252850
- Testing
- CERE-120: AAV2-NTN
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Sangamo Therapeutics
Parkinson's Disease
Parkinson's Disease Registry of the Muhammad Ali Parkinson Center
The purpose of the Parkinson's disease Registry is to develop a national and international database of persons with Parkinson's disease (PD).
- Trial name
- NCT00217321
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Muhammad Ali Parkinson Research Center
PSP, CBD
Clinico-Pathologic-Genetic-Imaging Study of Neurodegenerative and Related Disorders
The investigators aim to learn more about symptoms suggestive of a neurodegenerative process.
- Conditions
- PSP, CBD, PCA, LPA
- Trial name
- AND1 (NCT04680130)
- Testing
- C-11 PiB, AV1451 Tau, C-11 ER176
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Mayo Clinic
Neurodegenerative Disease, Parkinson's Disease
Dextromethorphan for the Treatment of Parkinson's Disease and Similar Conditions of the Nervous System
This study is designed to determine whether dextromethorphan, a drug commonly found in cough medicine, is beneficial and safe for the treatment of Parkinson's disease and other diseases that might share biochemical abnormalities…
- Trial name
- NCT00001365
- Testing
- dextromethorphan
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Elderly Adults, Parkinson
A Treadmill Training Program Augmented by Virtual Reality to Decrease Fall Risk in Older Adults
The proposed randomized controlled trial will evaluate the effects of treadmill training augmented with virtual reality on fall risk. 300 older adults with a history of falls will be recruited to participate in this study.
- Conditions
- Elderly Adults, Parkinson, Mild Cognitive Disorder
- Trial name
- VTIME (NCT01732653)
- Testing
- TT+VR, TT alone
- Where
- 5 sites in Belgium, Israel and 3 more
- Volunteers
- 302 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson Disease
Circuit-Based Deep Brain Stimulation for Parkinson's Disease; Udall Project 1 Aim 2 and 3
This study will test the hypothesis that deep brain stimulation (DBS) targeting specific changes in oscillatory activity at the site of stimulation will prove superior to continuous isochronal DBS thus providing the rationale for…
- Trial name
- NCT03079037
- Testing
- Stimulation
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Minnesota
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