Clinical trials: Primary Parkinsonism
Parkinson's Disease, Essential Tremor
Local Fields Potentials Recorded From Deep Brain Stimulating Electrodes
Deep Brain Stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's Disease (PD), Essential Tremor (ET) and Dystonia.
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia
- Trial name
- LFP DBS (NCT02071446)
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Colorado, Denver
Parkinson Disease, Occupational Therapy
Effectiveness of Online Program and Task-related Training for Parkinson's Disease
The goal of this clinical trial is to compare the effectiveness of online self-management program and on-site task-related training for people with early stage Parkinson's disease.
- Conditions
- Parkinson Disease, Occupational Therapy, Telerehabilitation, Activities of Daily Living
- Trial name
- NCT06248073
- Testing
- on-line self-management training, onsite task-related training
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Chang Gung University
Parkinson Disease
Comparison of Vestibular and Dual-Task Rehabilitation in Parkinson's Disease
Parkinson's disease (PD) is a long-term condition that affects movement, balance, and thinking abilities. It can cause tremor, stiffness, slow movements, and difficulty maintaining balance.
- Trial name
- NCT07277205
- Testing
- Vestibular Rehabilitation, Cognitive-Motor Dual Task Activities
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people
- Sponsor
- Marmara University
Neurological Disorder
Multidisciplinary Lifestyle Interventions for Neurological Disorders During the Silent Phase
This clinical trial aims to test the impact of multidisciplinary lifestyle interventions (MLI) in neurologically healthy but at-risk individuals.
- Trial name
- MINDS (NCT05984056)
- Testing
- Multidisciplinary lifestyle interventions
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Vineet Punia MD
Parkinson Disease
Prodromal Alpha-Synuclein Screening in Parkinson's Disease Study
The PASS-PD study is set out to screen individuals from the general population with an increased risk for the development of Parkinson's Disease (PD) and to investigate this highly enriched cohort longitudinally for five year.
- Trial name
- PASS-PD (NCT04724941)
- Testing
- No intervention
- Where
- Germany
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Schleswig-Holstein
Parkinson Disease
Physiotherapy and Deep Brain Stimulation in Parkinson's Disease
Deep brain stimulation (DBS) is the most commonly performed surgical treatment for individuals with Parkinson's disease (PD). DBS typically works best to lessen motor symptoms such as stiffness, slowness, and tremor.
- Trial name
- NCT04953637
- Testing
- Physiotherapy
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Toronto
Parkinson Disease, Depression
Improving Quality of Life in Early Parkinson's Disease
The study will examine 30 patients between ages 50-80, newly diagnosed with early-stage Parkinson's Disease. Patients will be randomized to receive either Citalopram or Carbidopa-levodopa.
- Trial name
- PD QOL (NCT04590612)
- Testing
- Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Citalopram
- Volunteers
- 30 people
- Sponsor
- Western University, Canada
Parkinson Disease
Mediterranean Diet Intervention to Improve Gastrointestinal Function in Parkinson's Disease a Randomized, Controlled, Clinical Trial
This is a 10-week randomized, controlled study to investigate the effect of a Mediterranean diet intervention on gastrointestinal function in Parkinson's disease.
- Trial name
- MEDI-PD (NCT04683900)
- Testing
- Standard of care + Mediterranean diet (intervention), Standard of care (control)
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- University of Florida
Parkinson Disease
A Study of Tolerability and Efficacy of Cannabidiol on Motor Symptoms in Parkinson's Disease
The major purpose of this study is to assess the efficacy of CBD on motor symptoms of Parkinson's Disease (PD), and secondarily to study the safety and tolerability of CBD and other efficacy, particularly regarding tremor in PD.
- Trial name
- NCT03582137
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of Colorado, Denver
Gait, Festinating, Parkinson Disease
Short-Term Effect Of Ceriter Stride One (CSO) on FOG and Falling in pwP
The Ceriter Stride One (CSO) is a "smart sole" with pressure sensors. The sole allows data on the displacement of the body's centre of gravity (COG), as well as spatiotemporal parameters, to be obtained via pressure recordings.
- Conditions
- Gait, Festinating, Parkinson Disease, Device Adherence
- Trial name
- CSO_FOG (NCT06204081)
- Testing
- CSO_without cueing, CSO_cueing
- Where
- Belgium
- Volunteers
- 11 people
- Sponsor
- University Ghent
Dementia, Mild Cognitive Impairment (MCI)
Comprehensive Assessment of Neurodegeneration and Dementia
This is a longitudinal observational study recruiting individuals between the ages of 50 and 90 with different types of dementia as well as a comparison group without cognitive deficits.
- Conditions
- Dementia, Mild Cognitive Impairment (MCI), Subjective Cognitive Impairment, Parkinson's Disease (PD)
- Trial name
- COMPASS-ND (NCT03402919)
- Where
- 19 sites in Canada
- Volunteers
- 1,573 people, healthy volunteers welcome
- Sponsor
- McGill University
Multisystemic Atrophy
Motor Activation in Multiple System Atrophy and Parkinson Disease: a Positron Emission Tomography (PET) Study
Background: Multiple System Atrophy (MSA) is an atypical parkinsonian syndrome including cerebellar impairment and poor response to dopatherapy.
- Trial name
- MSAJOY (NCT01044992)
- Testing
- H215O PET, Levodopa
- Where
- 4 sites in France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Diffuse Lewy Body Disease, Dementia With Lewy Bodies
Imaging Inflammation in Patients With Parkinson's Disease Dementia or Dementia With Lewy Bodies
This study uses a special type of scan called a positron emission tomography (PET) scan to take pictures of the brain. During the PET scan, a special dye called 11C-PBR28 is injected into the body.
- Conditions
- Diffuse Lewy Body Disease, Dementia With Lewy Bodies, Parkinson's Disease Dementia
- Trial name
- NCT02702102
- Testing
- 11C-PBR28
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Columbia University
Parkinson Disease
Airway Protective Mechanisms in PD (R01)
This study will collect data on various aspects of airway sensation and function, and determine how it relates to the development of swallowing and cough dysfunction in Parkinson's disease.
- Trial name
- NCT03321019
- Testing
- Capsaicin, Resistive respiratory loads, Event-related evoked potential using electroencephalography (EEG).
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Florida
Parkinson's Disease
Adherence of Stalevo, Entacapone and Levodopa
To test if combining two antiparkinson drugs into a single tablet improves accuracy of medicine intake by the patient. To test if patients with Parkinson's disease who take medicines at regular time intervals have smoother…
- Trial name
- NCT00245700
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- South Glasgow University Hospitals NHS Trust
Depression
Tolerability, Safety and Efficacy of Vortioxetine
Depression is a psychiatric disorder frequently found in Parkinson's disease (MP), affecting approximately 40-50% of patients and assuming the characteristics of major depression in 17% of cases.
- Trial name
- VorDe-PD (NCT04301492)
- Testing
- Vortioxetine
- Where
- 2 sites in Italy
- Volunteers
- 20 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson's Disease
Kinematic and Neural Dynamics of Postural Instability in Parkinson's Disease
Balance problems and falls are among the most common complaints in Veterans with Parkinson's Disease (PD), but there are no effective treatments and the ability to measure balance and falls remains quite poor.
- Trial name
- NCT06405334
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- VA Office of Research and Development
Parkinson's Disease (PD)
Novel DBS Device in Parkinson's Disease
The purpose of this research is to test a new recorder that can measure brain activity when stimulation is turned on during deep brain stimulation (DBS) surgery.
- Trial name
- NCT07213999
- Testing
- Novel neural recorder
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Minnesota
Parkinson, Parkinson Disease
Neuroplasticity in Parkinson's Disease
The purpose of this project is to increase our understanding of the early state and temporal evolution of neuroplastic changes in the cortex and subthalamic nucleus (STN) of people with PD, and the relationship of these changes…
- Trial name
- NCT05286736
- Testing
- Neuroimaging, Quantitative assessments
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinson Disease
A Sub-Study With Patients in APO401 to Evaluate Adverse Events During Dose Introduction in Apomorphine-naïve Patients.
APO303 is a sub-study of patients enrolled in APO401 (the long-term open label safety protocol) and was designed to evaluate adverse events, particularly blood pressure drops when standing up during first dose in patients who…
- Trial name
- NCT00145171
- Testing
- apomorphine HCl injection
- Volunteers
- 56 people
- Sponsor
- Mylan Bertek Pharmaceuticals
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