Clinical trials: Primary Parkinsonism
Oral Health, Parkinson Disease
Preliminary Study of the Quality of the Oral Flora in Parkinson's Patients
This is a prospective interventional clinical study whose main objective is to determine the impact of oral hygiene guidance on the oral health status of patients with Parkinson disease
- Trial name
- PARKIDENT (NCT03827551)
- Testing
- Delivery of oral hygiene advices
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Bordeaux
Parkinson Disease
Study on the Safety, Tolerance and Pharmacokinetics of Phenlarmide Tablets
1. To evaluate the safety and tolerability of Phenlarmide tablets in patients with Parkinson's disease in the early and middle stages. 2.
- Trial name
- NCT04693039
- Testing
- Phenlarmide
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Shijiazhuang Yiling Pharmaceutical Co. Ltd
Nursing Education
PechaKucha Versus PowerPoint for Parkinson's Disease Education in Nurses
This study compared the effects of PechaKucha and traditional PowerPoint presentation techniques used for Parkinson's disease education on nurses' knowledge and awareness levels.
- Trial name
- NCT07800312
- Testing
- PechaKucha-Based Parkinson's Disease Education, PowerPoint-Based Parkinson's Disease Education
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Idiopathic Parkinson's Disease
Safety and Efficacy of CERE-120 in Subjects With Parkinson's Disease
The purpose of this study was to evaluate the safety and potential benefits of CERE-120 in the treatment of Parkinson's disease.
- Trial name
- NCT00985517
- Testing
- CERE-120: Adeno-Associated Virus Delivery of Neurturin
- Where
- 11 sites in United States
- Volunteers
- 57 people
- Sponsor
- Sangamo Therapeutics
Parkinson's Disease
Use of Zolpidem in Parkinson's Disease
Levodopa treatment is associated with long-term complications. Dopamine deficiency is associated with abnormal activity in certain parts of the brain.
- Trial name
- NCT01351168
- Testing
- Levodopa, Zolpidem first dose, Zolpidem second dose
- Where
- United States
- Sponsor
- Rush University Medical Center
Parkinson Disease, Anxiety
Learning Effective New Strategies for Worry in Parkinson's Disease
High rates of anxiety and worry has been observed in people with Parkinson's (PwP). Previous research outside of PwP has shown that individuals with anxiety have a habit of interpreting ambiguous information in a negative manner…
- Trial name
- LENS-PD (NCT04007718)
- Testing
- Interpretation bias training
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- King's College London
Parkinson's Disease
LRRK2 and Other Novel Exosome Proteins in Parkinson's Disease
This proposal seeks to 1) determine whether there are biomarkers associated with Parkinson's disease (PD) susceptibility and/or progression in exosome-proteomes derived from PD patients versus controls, and 2) to determine if…
- Trial name
- NCT01860118
- Where
- United States
- Volunteers
- 601 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Parkinson's Disease
Effects of RAC With Locomotion Training on Cortical Excitability and Behavior in Patients With PD
In this study, 51 subjects include 17 freezers,17 non-freezers and 17 aged-matched healthy subjects will be recruited. We will compare the cortical excitability, gait performance, and stepping-in-place performance before and…
- Trial name
- NCT03656796
- Testing
- Treadmill training with auditory cues, Treadmill training without auditory cues
- Where
- Taiwan
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Parkinson Disease, Parkinson
tDCS of the Primary Motor Cortex to Improve Implicit Motor Sequence Learning in Parkinson's Disease
Implicit motor sequence learning (IMSL) is a form of cognitive function that is known to be directly associated with impaired motor function in Parkinson's disease (PD).
- Conditions
- Parkinson Disease, Parkinson, Healthy
- Trial name
- NCT04606979
- Testing
- 1x1 Low Intensity Transcranial Direct Current Stimulation (tDCS)
- Where
- Belgium
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Depressive Symptoms, Parkinson's Disease
Rasagiline in Cognitive-impairment Related Depression: AzileCt in COgnitive-impairment Related DepressiOn
The primary endpoint for this study is the clinical response after 12 weeks of treatment, defined as a change in total score from baseline depressive symptoms as measured by the Beck Depression Inventory-Amended (BDI-IA) total…
- Trial name
- ACCORDO (NCT01055379)
- Testing
- Rasagiline
- Where
- 12 sites in Italy
- Volunteers
- 121 people
- Sponsor
- Lundbeck Italia S.p.A.
Parkinson Disease
The Learning Effects of Attentional Strategy on Dual-task Walking in Patients With Parkinson's Disease: Behavioral Performance and Neural Plasticity
[year1] 1. To compare the effects of dual-task training with two different task priority instruction in people with Parkinson's disease and healthy controls on dual-task weight shifting performances. 2.
- Trial name
- NCT03895125
- Testing
- [year1] dual-task training with task priority strategy, [year2-3] dual-task training with internal and external focus
- Where
- Taiwan
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Parkinson Disease
Algorithm Guided DBS Programming in Parkinson's Patients
Patients undergoing Deep Brain Stimulation for Parkinson's disease will be subjected to standard of care programming and compared with the algorithm based programming (StimSearch).
- Trial name
- NCT06205043
- Testing
- StimSearch programming algorithm software, Clinician based programming
- Where
- India
- Volunteers
- 30 people
- Sponsor
- Jaslok Hospital and Research Centre
Parkinson's Disease
Efficacy and Safety of Levetiracetam Versus Placebo on Levodopa-induced Dyskinesias in Advanced Parkinson's Disease
The study is designed to measure the efficacy and safety of levetiracetam on levodopa-induced dyskinesias in late-stage Parkinson's disease.
- Trial name
- LeLeDys (NCT00307450)
- Testing
- Levetiracetam
- Where
- 2 sites in Germany
- Volunteers
- 34 people
- Sponsor
- Technische Universität Dresden
Excessive Daytime Sleepiness, Parkinson Disease
BEN-2001 in Parkinson Disease Patients With Excessive Daytime Sleepiness
This phase 2b study is designed as multicentre, multinational, randomized, double blind, parallel group and placebo controlled with three doses of Bavisant (0.5, 1, and 3 mg/d) in subjects with excessive daytime sleepiness with…
- Trial name
- CASPAR (NCT03194217)
- Testing
- BEN-2001
- Where
- United States
- Volunteers
- 244 people
- Sponsor
- BenevolentAI Bio
Parkinson Disease
Attentional Focus and Prefrontal Cortical Activation in Older Adults and Patients With Parkinson's Disease (PD)
Attention may influence the motor performance and frontal activity. This study will examine the effect of different attentional focus: internal, external and divided attention (dual task) on prefrontal cortical activation (fNIRS)…
- Trial name
- AttPark (NCT05073874)
- Testing
- Functional Near-Infrared Spectroscopy (fNIRS)
- Where
- France
- Volunteers
- 45 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Deglutition Disorders, Parkinson Disease
Outcomes to the Nutritional Need of Patients With Parkinson's Disease
The intervention involves the identification of 140 patients (70 per group), fed throughout the duration of the study with the two different solutions indicated.
- Conditions
- Deglutition Disorders, Parkinson Disease, Nursing, Quality of Life
- Trial name
- W-Domus (NCT04983290)
- Testing
- weancare-domus
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Milko Zanini
Advanced Parkinson's Disease
A Study to Assess the PK and Pharmacodynamics of IPX203 in Subjects With Advanced Parkinson's Disease
Primary Objective: To compare the pharmacokinetics (PK) of single and multiple doses of IPX203 with Immediate release carbidopa-levodopa (IR CD-LD) in subjects with advanced Parkinson's disease (PD).
- Trial name
- NCT03007888
- Testing
- Sinemet, IPX203
- Where
- 11 sites in United States
- Volunteers
- 28 people
- Sponsor
- Impax Laboratories, LLC
Parkinson's Disease
Study of Azilect® (Rasagiline) in Levodopa-treated Parkinson's Disease Patients With Motor Fluctuations in Korea
To evaluate the efficacy of a fixed dose of Azilect® (1 mg/day) vs placebo as assessed by the change from baseline in mean total daily OFF time during 18 weeks of treatment in levodopa-treated Parkinson's Disease (PD) patients…
- Trial name
- NCT01268891
- Testing
- Azilect®
- Volunteers
- 132 people
- Sponsor
- H. Lundbeck A/S
Parkinson Disease, Deep Brain Stimulation
Validation of HaGuide Software Module Accuracy in Mapping STN Boundaries in Parkinson's Disease Patients Who Underwent DBS Procedure
HaGuide version 1.0 (Neuro-Omega Ltd.) is a software module add-on to the FDA cleared Neuro-Omega System (K123796). It was designed to facilitate the use of Neuro-Omega's system by automatically mapping visually the depth of STN…
- Trial name
- NCT03363724
- Testing
- HaGuide version 1.0 software module
- Volunteers
- 103 people
- Sponsor
- Alpha Omega Engineering Ltd.
Parkinson's Disease (PD)
A Study in Subjects With Parkinson's Disease to Evaluate the Safety and Tolerability of Titration and Continuous Subcutaneous Infusion of ABBV-951 in an Outpatient Environment
The purpose of this study is to evaluate the safety, tolerability, and pharmacokinetics of 4 weeks of continuous infusion with ABBV-951 in adult subjects with Parkinson's Disease (PD).
- Trial name
- NCT03374917
- Testing
- ABBV-951
- Where
- 12 sites in United States
- Volunteers
- 20 people
- Sponsor
- AbbVie
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