Clinical trials: Primary Parkinsonism
Parkinson's Disease
Study on Tolerability of Repeat i.c.v. Administration of sNN0031 Infusion Solution in Patients With PD
This is a phase I, randomised, placebo-controlled study to assess the safety and tolerability of two 2-weeks cycles of i.c.v. administration of sNN0031 infusion solution to patients with PD of moderate severity with persisting…
- Trial name
- NCT02408562
- Testing
- i.c.v. infusion of sNN0031 by an Implanted infusion system, i.c.v. infusion of aCSF by an Implanted infusion system
- Where
- 5 sites in Germany, Sweden and 1 more
- Volunteers
- 1 people
- Sponsor
- Newron Sweden AB
Parkinson's Disease
The Effect of Rifampin on the Metabolism of Istradefylline in Healthy Volunteers.
The purpose of this study is to test whether Rifampin affects blood levels of istradefylline in humans. Rifampin could possibly decrease istradefylline levels.
- Trial name
- NCT02174250
- Testing
- Istradefylline 40 mg, Rifampin 300mg BID + istradefylline 40mg Day 8 only
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Kyowa Kirin Co., Ltd.
Parkinson's Disease, Multiple Sclerosis
Expiratory Muscle Training for Persons With Neurodegenerative Disease
Respiratory difficulty is one of the primary factors leading to death in patients with Parkinson's Disease (PD) and Multiple Sclerosis.
- Trial name
- EMST (NCT00856518)
- Testing
- EMST
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- VA Office of Research and Development
Parkinson's Disease
ADX48621 for the Treatment of Levodopa Induced Dyskinesia in Patients With Parkinson's Disease
The primary objective of the study is to evaluate the safety and tolerability of ADX48621 in Parkinson's disease patients following four weeks of dosing.
- Trial name
- NCT01336088
- Testing
- ADX48621
- Where
- 25 sites in United States, Austria and 2 more
- Volunteers
- 83 people
- Sponsor
- Addex Pharma S.A.
Parkinson's Disease
A Study to Assess the PK and Pharmacodynamics of IPX203 in Patients With Advanced Parkinson's Disease
This is a randomized, open-label, rater-blinded, multicenter, 3-treatment, 3 period, single-dose crossover study. Approximately 51 qualified immediate-release (IR) CD-LD-experienced advanced Parkinson's disease patients will be…
- Trial name
- NCT02271503
- Testing
- CD-LD IR, IPX203 180 mg, IPX203 270 mg
- Where
- 11 sites in United States
- Volunteers
- 26 people
- Sponsor
- Impax Laboratories, LLC
Parkinson's Disease, Small Intestinal Bacterial Overgrowth
Treating Bacterial Overgrowth in Parkinson's Disease
This study investigates the effect of treating Small Intestinal Bacterial Overgrowth (SIBO) in patients with Parkinson's Disease (PD).
- Trial name
- SIBO-PD (NCT02470780)
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Cincinnati
Parkinson Disease
Safety Evaluation of Intravenous Talineuren (TLN) in Parkinson's Disease-affected Patients
This study is an open-label, single ascending dose escalation followed by a multiple administration dose at the maximal suitable dose (MSD). The investigational Medicinal Product (IMP) is given as an add-on therapy.
- Trial name
- NEON (NCT04976127)
- Testing
- Talineuren
- Where
- Switzerland
- Volunteers
- 22 people
- Sponsor
- InnoMedica Schweiz AG
Parkinson Disease, Apathy
Targeting Apathy With Music in Parkinson's Disease
Parkinson's Disease (PD) is often accompanied by non-motor symptoms that make treatment more difficult. One such symptom is apathy (lack of motivation and emotion).
- Trial name
- NCT05505019
- Testing
- Music listening, Podcast listening
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Parkinson's Disease
Randomized Evaluation of the 24-Hour Coverage: Efficacy of Rotigotine
The objective of this trial is to assess the effects of transdermal rotigotine on the control of early morning motor function and sleep disorders compared to placebo in subjects with idiopathic Parkinsons´s disease.
- Trial name
- RECOVER (NCT00474058)
- Testing
- Rotigotine
- Where
- 47 sites in United States, Australia and 10 more
- Volunteers
- 287 people
- Sponsor
- UCB Pharma
Dyskinesia
Famotidine for Levodopa-induced Dyskinesia in PD
Levodopa-induced dyskinesia is a common problem in Parkinson's disease (PD). In particular, targeting non-dopaminergic systems may be an option for reducing dyskinesia without worsening motor symptoms.
- Trial name
- NCT01937078
- Testing
- Famotidine
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- University Health Network, Toronto
Parkinson Disease
Post Marketing Surveillance Study of Sifrol® in Patients With Idiopathic Parkinson's Disease
Study to document pramipexole dosing during monotherapy, occurrence of fluctuations and dyskinesias, dose increases after deterioration of Parkinson's disease (PD) symptoms, assessment of the reasons for add-on treatment with…
- Trial name
- NCT02248181
- Testing
- Pramipexole
- Volunteers
- 442 people
- Sponsor
- Boehringer Ingelheim
Parkinson's Disease
Phase IIa Multicentre Study Investigating of VR040 in Parkinson's Disease
'Off periods' where people with Parkinson's disease are slow, stiff and unable to function are disabling, and a treatment which can converts people to a "on", good, able to function state would be extremely useful.
- Trial name
- VR040/2/003 (NCT01693081)
- Testing
- VR040/Aspirair® inhaler
- Where
- 9 sites in Serbia, United Kingdom
- Volunteers
- 47 people
- Sponsor
- South Glasgow University Hospitals NHS Trust
Parkinson Disease
Is Long-term Use of Amantadine Effective in PD?
The investigator aims to assess whether long-term use of amantadine is effective in patients with Parkinson's disease.
- Trial name
- NCT04260581
- Testing
- Determination of drug effects through amantadine cessation
- Where
- South Korea
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Periodontal Diseases, Inflammation
Kynurenine Pathway in Parkinson's Disease
Parkinson's disease is a slowly progressing disease that affects the motor and non-motor functions of an individual. Periodontitis is an inflammatory chronic disease resulting in the destruction of tooth supporting structures.
- Trial name
- NCT07272564
- Testing
- Saliva and serum sampling, Saliva, serum and GCF sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medipol University
Multiple Organ Failure, End Stage Cardiac Failure
Timing of Acute Palliative Care Consultation in Critically Ill Patients
A prospective randomized controlled trial studying the ordering of palliative care consultations in the emergency department (Ig) versus later palliative care consultations in the hospital--ICU or hospital ward(Cg).
- Conditions
- Multiple Organ Failure, End Stage Cardiac Failure, End Stage Chronic Obstructive Airways Disease, Chronic Kidney Disease Stage 5
- Trial name
- NCT02858778
- Testing
- Early order of palliative care consultation
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Wayne State University
Parkinson' Disease
Parkinson's Improvement Activated by Hula Understanding (PAHU) - Part 2
if hula can help quality of life, well being, balance and overall motor symptoms for individuals with Parkinson's disease.
- Trial name
- PAHU2 (NCT07808606)
- Testing
- hula
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Hawaii
Parkinson's Disease
Investigation of Cogane (PYM50028) in Early-stage Parkinson's Disease (CONFIDENT-PD)
A study to test the therapeutic benefit of the compound PYM50028, versus placebo, in treating early-stage Parkinson's disease. Therapeutic benefit will be assessed using the Unified Parkinson's Disease Rating Scale (UPDRS).
- Trial name
- CONFIDENT-PD (NCT01060878)
- Testing
- PYM50028
- Where
- 111 sites in United States, Canada and 8 more
- Volunteers
- 425 people
- Sponsor
- Phytopharm
Idiopathic Parkinson's Disease, Progressive Supranuclear Palsy
Foot Mechanical Stimulation for Treatment of Gait and Gait Related Disorders in Parkinson's Disease and Progressive Supranuclear Palsy.
The purpose of this research study is to evaluate safety and effectiveness of Foot Mechanical stimulation to improving Gait and Gait Related Disorders in Parkinson Disease and Progressive Supranuclear Palsy both stable and with…
- Trial name
- GONDOLAPILOTA (NCT01815281)
- Testing
- Foot Mechanical Stimulation (GONDOLA)
- Where
- 3 sites in Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele Roma
Parkinson's Disease
Study on Serum Cystatin C and PET-DAT in Patients With Parkinson's Disease
To investigate the relationship between serum cystatin C and dopamine receptor(DAT) loss in patients with parkinson's disease(PD)
- Trial name
- NCT04926909
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Parkinson Disease (PD), Immersive Virtual Reality
Virtual Reality on Balance of Parkinson's Disease
This study, titled: Effectiveness of immersive virtual reality on balance in people with Parkinson's disease. Is a randomized clinical trial conducted at Zaragoza Parkinson's Association in Spain.
- Conditions
- Parkinson Disease (PD), Immersive Virtual Reality, Physical Therapy
- Trial name
- RVI-PD (NCT07274514)
- Testing
- Immersive Virtual Reality Program, Standard Rehabilitation Program
- Where
- Spain
- Volunteers
- 57 people
- Sponsor
- Instituto de Investigación Sanitaria Aragón
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