Clinical trials: Primary Parkinsonism
Parkinson's Disease (PD)
Empower Your Mind to Embrace Your Life: an Online ACT Intervention for Young-Onset Parkinson's Disease
Parkinson's disease (PD) has a substantial impact on daily life and significantly affects functioning, mental health and quality of life. Although considered a disease of the elderly, an early diagnosis is also common.
- Trial name
- NCT07310147
- Testing
- Empower your mind to embrace your life
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- University of Coimbra
Parkinson's Disease
Long-term Stability of LFP Recorded From the STN and the Effects of DBS
Movement disorders such as Parkinson Disease, dystonia, and tremor are related to abnormalities of part of the brain known as the basal ganglia.
- Trial name
- NCT02915848
- Testing
- PC+S group
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Parkinson Disease
Effects of Dry Needling on Function, Muscle Tone and Quality of Life in Parkinson's Disease
Hypothesis: Dry needling in lower limbs produces a change in function (assessed by the 6 minute walk test, timed up and go, 10 meter walk test and unified scale for Parkinson's disease) and muscle tone (assessed by tonometry and…
- Trial name
- NCT04101214
- Testing
- Dry needling
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Universidad San Jorge
Parkinson's Disease
A Longitudinal Study in 1st Degree Relatives of Parkinson's Disease (PD) Patients
This is a longitudinal study in healthy 1st degree relatives of patients with Parkinson's Disease (PD) carriers of a genetic mutation in genes that are known to increase the risk for PD.
- Trial name
- NCT01502384
- Testing
- neurological examination
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson Disease
Effect of Immersive Virtual Reality Exergames in Patients With Parkinson's Disease
The study aimed to investigate the effect of applying cognitively challenging exergames using fully immersive virtual reality in patients with Parkinson's disease.
- Trial name
- NCT04787549
- Testing
- Virtual reality exergames
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Seoul National University Hospital
Nocturnal Hypokinesia, Parkinsons's Disease
Measuring the Effects of Continuous Dopaminergic Stimulation on Nocturnal Movements in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder that is characterized with motor symptoms such as hypokinesia, rigidity, tremor and postural instability. These symptoms can also be present during the night.
- Conditions
- Nocturnal Hypokinesia, Parkinsons's Disease, Rotigotine
- Trial name
- NCT01554306
- Where
- Netherlands
- Volunteers
- 2 people
- Sponsor
- Sleep Medicine Centre Kempenhaeghe
Parkinson's Disease
Study of Magnetic Fields for Treatment of Parkinson's Disease
The purpose of this study is to determine if low level magnetic fields may help to relieve symptoms of Parkinson's disease.
- Trial name
- NCT00779155
- Testing
- The Resonator, The Resonator control
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- pico-tesla Magnetic Therapies, LLC
Parkinson's Disease
Executive, Activities of Daily Living, and Cholinergic Functions in Parkinson's Disease
This research study will evaluate functions of memory, thinking, behavior, and daily life activities and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using an imaging…
- Trial name
- NCT00737217
- Testing
- Behavioral assessment/questionnaire
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson's Disease (Disorder)
Effect of Deep Brain Stimulation on Neuropsychiatric Fluctuations in Patients With Parkinson's Disease
Retrospective, monocentric, observational study designed to evaluate the effects of Bilateral Subthalamic Nucleus Deep Brain Stimulation (DBS STN) on Neuropsychiatric fluctuations in Patients with Parkinson's Disease (PD)
- Trial name
- PSYCHOSTIM (NCT04608123)
- Testing
- none (observational study)
- Where
- France
- Volunteers
- 31 people
- Sponsor
- University Hospital, Grenoble
Transcranial Direct Current Stimulation, Parkinson Disease
An Open-label Study on the Clinical Efficacy of tDCS Intervention in PD
To demonstrate that intervention targeting the primary motor area (M1) using transcranial Direct Current Stimulation can improve sleep symptoms in patients with Parkinson's disease.
- Conditions
- Transcranial Direct Current Stimulation, Parkinson Disease, Primary Left Motor Cortex
- Trial name
- NCT06566313
- Testing
- transcranial Direct Current Stimulation
- Where
- China
- Volunteers
- 17 people
- Sponsor
- Anhui Medical University
Parkinson's Disease (PD)
Remote Haptic Rehabilitation for Parkinson's Disease
Individuals with Parkinson's Disease (PD) often have motor difficulties that can negatively impact daily activities and their quality of life.
- Trial name
- NCT07457710
- Testing
- Haptic device, Non-haptic device
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Polytechnic Institute and State University
Cognition, Parkinson's Disease
Turkish Validation of the Parkinson Disease Cognitive Functional Rating Scale
The aim of the present study is to translate the Parkinson's Disease-Cognitive Functional Rating Scale into Turkish (PD-CFRS-Turkish version) and to evaluate its validity and reliability.
- Conditions
- Cognition, Parkinson's Disease, Reliability and Validity, Cognitive Functions
- Trial name
- NCT07253376
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gazi University
Parkinson's Disease
Therapeutic Yoga to Improve Function in Parkinson's Disease
This is a single blind, randomized, wait-list controlled, phase II exploratory pilot study.
- Trial name
- NCT02902510
- Testing
- Therapeutic yoga for people with Parkinson's Disease
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Clemson University
Parkinson Disease
A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease.
This is a multi-center, randomized, double blind, adaptive, parallel-group, placebo controlled Phase 1b study to evaluate the safety, tolerability, pharmacokinetic (PK) and pharmacodynamics of RO7486967 in participants with…
- Trial name
- NCT05924243
- Testing
- RO7486967
- Where
- 17 sites in United States, Netherlands and 1 more
- Volunteers
- 60 people
- Sponsor
- Hoffmann-La Roche
Parkinson's Disease
The Effects of Multi-focal tDCS on Motor-cognitive Dysfunctions in Parkinson's Disease
The current RCT aims to establish the therapeutic potential of tDCS for freezing of gait (FOG) and motor-cognitive dysfunctions in PD.
- Trial name
- NCT02656316
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Transcutaneous Vagal Nerve Stimulation (tVNS), Parkinson Disease (PD)
Effects of Transcutaneous Vagus Nerve Stimulation in Parkinson´s Disease
This study aims to determine whether electrical stimulation of the ear, when combined with physical and speech therapy, can improve symptoms in subjects diagnosed with Parkinson´s disease, by comparing two different application…
- Trial name
- tVNS_PD (NCT07588191)
- Testing
- Transcutaneous Electrical Nerve Stimulation (TENS) of Vagus Nerve, Conventional Physical therapy, Conventional Speech Therapy
- Where
- Spain
- Volunteers
- 46 people
- Sponsor
- Universidade da Coruña
Parkinson's Disease
Spinal Cord Stimulation in the Treatment of Parkinson's Disease
Parkinson's disease affects between 100'000 and 150'000 people in France. Drug therapy (L-Dopa and other drugs) is effective to improve motor symptoms but after an initial 'honeymoon period' lasting a few years, motor symptoms…
- Trial name
- STIMUPARK (NCT02381951)
- Testing
- spinal cord stimulation (St Jude Medical)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Parkinson's Disease, Parkinsonian Disorders
Gait Analysis in Neurological Disease
The purpose of this study is to investigate whether speed-dependent measures of gait (so called gait signatures) can be identified in patients with neurological conditions that affect gait, particularly in subjects with…
- Conditions
- Parkinson's Disease, Parkinsonian Disorders, Atypical Parkinson Disease, Progressive Supranuclear Palsy
- Trial name
- NCT02994719
- Testing
- Anti-Parkinson medication, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Autonomic Nervous System Diseases
Evaluation of Primary Chronic Autonomic Failure
This study will conduct tests in patients with primary chronic autonomic failure (CAF) to learn more about these disorders, which include pure autonomic failure, multiple system atrophy, Parkinson's disease with autonomic…
- Trial name
- NCT00059033
- Where
- United States
- Volunteers
- 325 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson Disease (PD), Proprioceptive Neuromuscular Facilitation
Effects of Gait Training With and Without PNF on Balance ,Gait and Activities of Daily Living in Parkinson's Patients
Proprioceptive Neuromuscular Facilitation (PNF) and gait training exercises are specifically used to treat balance, gait and functional activities in Parkinson s patients.
- Trial name
- NCT06789133
- Testing
- PNF exercises and Body weight supported treadmill gait training, Body weight supported treadmill gait training and Routine physical therapy
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
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