Clinical trials: Primary Parkinsonism
Parkinson Disease, Exercise Training
A Behavioral Digital Intervention For Parkinson's Disease
The goal of this interventional, quasi-experimental study is to evaluate whether a digital dual-task exercise and behavioral program can improve physical activity and influence patient-reported outcomes in people with Parkinson's…
- Trial name
- MOVE ON UP (NCT07705620)
- Testing
- Digital Exercise Program
- Volunteers
- 68 people
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Parkinson Disease
Vigor and the LDR in Parkinson Disease
Parkinson disease (PD) is a common disorder in which reduced speed of movement results from inadequate brain production of the chemical dopamine.
- Trial name
- NCT04821830
- Testing
- carbidopa/levodopa, as prescribed by treating physician
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Michigan
Parkinson Disease
REducing SPEECH-related Side-effects of Deep Brain Stimulation in Parkinson's Disease Via Automated Speech Analysis
The investigators' objective is to improve L-dopa sensitive PD-related dysarthria and at the same time reduce DBS-induced speech disorders with the help of automated acoustic analysis in patients with STN-DBS-induced dysarthria.
- Trial name
- RESPEECH-PD (NCT05182892)
- Testing
- Change of stimulation amplitudes in dopaminergic OFF drug state
- Where
- 2 sites in Czechia, Switzerland
- Volunteers
- 45 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson's Disease
Serotonin and Amyloidopathy
The purpose of this study is to determine if changes in brain serotonin affects the accumulation of amyloid in the brain. The investigators will use brain imaging methods to measure the amount of serotonin and amyloid in the…
- Trial name
- NCT02895932
- Testing
- PET imaging
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson Disease, Tremor
Action Observation Therapy and Mirror Therapy in Parkinson's Disease
Small muscles of the hand are affected due to involuntary movements and slowing of voluntary movements seen in Parkinson's disease. There is a loss of fine dexterity and coordination in the hand.
- Trial name
- NCT05350709
- Testing
- mirror therapy
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Kirsehir Ahi Evran Universitesi
Parkinson's Disease, Shoulder Pain
Shoulder Disorders in Patients With Parkinson's Disease
Parkinson's disease (PD) is a multisystem neurodegenerative disorder that is increasingly recognized in our ageing population. It is characterized by cardinal clinical features including bradykinesia, tremor, rigidity, and…
- Trial name
- NCT02702232
- Testing
- Ultrasonography
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- Shin Kong Wu Ho-Su Memorial Hospital
Atypical Parkinsonism, MSA - Multiple System Atrophy
Integrated Management of Atypical Parkinsonism: A Home-based Patient-Centered Healthcare Delivery Based on Telenursing (IMPACT Study)
This project aims to investigate whether an integrated model based on proactive and reactive telenursing monitoring coordinated by a parkinsonism nurse specialist (case manager) is able to improve care delivery and quality of…
- Conditions
- Atypical Parkinsonism, MSA - Multiple System Atrophy, PSP, Nurse-Patient Relations
- Trial name
- NCT05792332
- Testing
- Telemonitoring, Standard-of-care
- Where
- 4 sites in Italy
- Volunteers
- 164 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Parkinson Disease
Effects of Rhythmic Auditory Cueing on Stepping in Place in Patients With Parkinson's Disease
Patients with Parkinson's disease have internal rhythm dysfunction, which may affect the rhythmic movements such as walking. Poor regularity of the rhythmic movement may lead to freezing of gait.
- Trial name
- NCT03271736
- Testing
- Stepping-in-place exercise with external auditory cues, Transcranial magnetic stimulation (TMS)
- Where
- Taiwan
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- HsiuYun Chang
Parkinson Disease
Cognitive, Affective, and Motor Effects of Tangotherapy in Parkinson's Disease
Neuroscientific research has shown a close relationship between physical fitness and cognition, showing a positive effect of physical activity (e.g., aerobic activity) on the maintenance of psycho-cognitive well-being in the…
- Trial name
- TANGOPD (NCT05904171)
- Testing
- Tangotherapy, Physical activity
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Istituto Auxologico Italiano
Idiopathic Parkinson's Disease
Fatigue, Sleep and Quality of Life in Parkinson's Patients
Parkinson's Disease (PD) is a neurodegenerative disease characterized by chronic and progressive loss of dopaminergic neurons in the substantia nigra (SN) pars compacta.
- Trial name
- NCT05687799
- Where
- Turkey (Türkiye)
- Volunteers
- 61 people
- Sponsor
- Nigde Omer Halisdemir University
Parkinson, Parkinson Disease
Virtual Reality and Fear of Falling in Parkinson's Disease
Background: Falls are common in elderly individuals and those with neurological conditions like Parkinson's disease. Parkinson's disease causes postural instability and mobility issues that lead to falls and reduced quality of…
- Conditions
- Parkinson, Parkinson Disease, Parkinson's Disease and Parkinsonism
- Trial name
- NCT05931692
- Testing
- Virtual reality, Electroencephalogram, Electromyography
- Where
- Egypt
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ahram Canadian University
Parkinson's Disease
Vitamin B12 Status and Response to Vitamin B12 Supplementation in Patients With Parkinson's Disease
Based on Parkinson's disease (PD)/vitamin B12 deficiency symptom overlap and PD patients' propensity to avoid protein (the dietary source of vitamin B12), this study proposes to prospectively investigate the vitamin B12 status of…
- Trial name
- NCT00208611
- Testing
- Vitamin B12 Supplementation
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Emory University
Parkinson's Disease
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics Profile of MT101-5 in Healthy Volunteers
The primary study objective is to establish the safety and tolerability of MT101-5 after a single and multiple dose administrations in healthy volunteers.
- Trial name
- NCT05844787
- Testing
- MT101-5
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mthera Pharma Co., Ltd.
PD - Parkinson's Disease
AR Gait Training for Parkinson's Disease
Gait disorders in Parkinson's disease (PD), particularly in complex environments or under stress, present challenges for accurate evaluation and classification, such as in cases of freezing of gait.
- Trial name
- NCT06598878
- Testing
- AR gait training
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- Chang Gung University
Parkinson's Disease
Nicotine Treatment of Impulsivity in Parkinson's Disease
The specific aims of this study are to examine whether treatment with transdermal nicotine improves computer-based laboratory and clinical measures of impulsive and compulsive behaviors in Parkinson's Disease subjects who have…
- Trial name
- NCT01216904
- Testing
- nicotine patch
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Vermont
Alzheimer Disease, Parkinson Disease
Telephone Call From Acute Care Physicians to Long Term Care Physicians: Impact on Transitional Care of Elderly Patients
A telephone call from a physician taking care of a patient in the hospital to a physician in the long term care setting at the time of discharge can improve transitional care for elderly patients.
- Conditions
- Alzheimer Disease, Parkinson Disease, Dysphagia
- Trial name
- NCT00281749
- Testing
- TELEPHONE CALL
- Where
- 2 sites in United States
- Sponsor
- Maimonides Medical Center
Parkinson's Disease
Telemedicine Intervention to Improve Cognitive Function
This project is investigating whether a home-based exercise program will reduce cognitive decline in patients with Parkinson's disease.
- Trial name
- NCT02248649
- Testing
- Structured physical activity, Health education
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- VA Office of Research and Development
Idiopathic Parkinson's Disease
Precise Transplantation of Human Amniotic Epithelial Stem Cells Into Lateral Ventricle for Parkinson's Disease
This is a single-center, single-arm, dose escalation study, to explore the safety, tolerability and efficacy of human amniotic epithelial stem cells (hAESCs) for idiopathic Parkinson's disease (PD).
- Trial name
- NCT05691114
- Testing
- hAESCs
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Shanghai East Hospital
Parkinson Disease
Rapid Cadence Cycling for Parkinson's Disease: A Study of Implementation and Efficacy in the Community Setting
Forced cadence cycling (FCC) in which individuals with Parkinson's Disease (PD) pedal with external augmentation at 80-90 revolutions per minute (rpm) has demonstrated significant motor improvement in prior clinical trials.
- Trial name
- NCT03675932
- Testing
- Rapid Cadence Cycling on a Solo-Rider Spin Bicycle
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Massachusetts General Hospital
Parkinson's Disease
Deep Brain Stimulation (DBS) for Early Stage Parkinson's Disease (PD)
Bilateral subthalamic nucleus deep brain stimulation (B-STN DBS) is one of the most effective surgical treatments for PD patients suffering from levodopa-induced motor complications.
- Trial name
- NCT00282152
- Testing
- B-STN DBS, Optimal drug therapy
- Volunteers
- 37 people
- Sponsor
- Vanderbilt University Medical Center
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.