Clinical trials: Primary Parkinsonism
Parkinson's Disease
Adaptive DBS Algorithm for Personalized Therapy in Parkinson's Disease (ADAPT-PD) China Study
The purpose of the study is to evaluate the effectiveness of the Medtronic Adaptive DBS therapy (aDBS) for Parkinson's Disease in China with the Percept family of Implantable Neurostimulators (Percept PC and Percept RC).
- Trial name
- NCT07216976
- Testing
- Percept™ PC and Percept RC with Adaptive DBS (aDBS™)
- Where
- 5 sites in China
- Volunteers
- 61 people
- Sponsor
- MedtronicNeuro
Parkinson's Disease
Pharmacokinetic Profile of Neupro Patch Administrated at 2 mg, 4 mg, 6 mg and 8 mg/Day Weekly in Patients With Early-stage Parkinson's Disease
To study the profile of Neupro patch administrated at 2 mg, 4 mg, 6 mg and 8 mg/day weekly in patients with early-stage Parkinson's disease
- Trial name
- NCT02728947
- Testing
- ROTIGOTINE
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Luye Pharma Group Ltd.
Idiopathic Parkinson's Disease, Drug Induced Dyskinesia
Topiramate as an Adjunct to Amantadine in the Treatment of Dyskinesia in Parkinson's Disease
The study will involve an eighteen-week, double-blind, placebo-controlled parallel designed comparison between add-on topiramate and add-on placebo to stable treatment with amatadine in the treatment of Parkinson's disease (PD)…
- Trial name
- TOP-DYSK (NCT01789047)
- Testing
- Topiramate, Amantadine
- Where
- 5 sites in United States
- Volunteers
- 42 people
- Sponsor
- Rush University Medical Center
Parkinson's Disease
Incidence of Parkinson's Disease Among Veterans
This is a database study. Medical records will be reviewed in order to document a new or pending diagnosis of Parkinson's disease and in order to learn more about the disease process.
- Trial name
- NCT00100438
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Parkinson Disease, Dystonia
Neurophysiological Characteristics of Subthalamic Deep-brain Stimulation (STN-DBS)
The intraoperative neuroelectrophysiological signals were collected from patients undergoing STN-DBS under general anesthesia in the Neurosurgery Department of Wuhan union Hospital, and their preoperative conditions and…
- Trial name
- NCT04707638
- Testing
- No intervention used
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Parkinson Disease
Observational Small Intestine and Blood Fingerprint (SmIle) Study in Parkinson's Disease
Observational cross-sectional study in PD patients and healthy controls (HC) using an investigational medical device consisting of a passive small intestine microbiome aspiration (SIMBA) system (capsule) that is ingested orally…
- Trial name
- SmIle (NCT06003608)
- Testing
- Fluid biopsy capsule, Levodopa-Carbidopa Immediate Release
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Nimble Science Ltd.
tACS, tDCS
Transcranial Direct/ Alternating Current Stimulation for Parkinson's Disease Treatment
To investigate the difference in the treatment efficacy between transcranial direct current stimulation and transcranial alternating current stimulation on Parkinson's disease, including the improvements in the motor, cognitive…
- Trial name
- NCT05678725
- Testing
- tACS, tDCS
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Anhui Medical University
Parkinson Disease
A Study to Evaluate the Effectiveness of Two Doses of AP-472 as Adjunctive Therapy to Levodopa in Parkinson's Disease (PD) Participants With Motor Fluctuations
This is a Phase 2 study in people with Parkinson's disease who experience motor fluctuations while taking levodopa. The study will evaluate how effective two different doses of the study drug AP-472 are when added to levodopa…
- Trial name
- NCT07432958
- Testing
- AP-472
- Where
- 30 sites in United States
- Volunteers
- 150 people
- Sponsor
- Appello Pharmaceuticals, Inc.
Parkinson Disease, Gait Disorders, Neurologic
Benefits of Different Exercise Types to Enhance Walking for PD
Background: Gait disturbance is one of the most common complaints from patients with Parkinson's disease (PD). It is well-established that people with PD have motor learning impairments.
- Trial name
- NCT04895787
- Testing
- Gait + aerobic exercise, Gait + resistance exercises, Gait + conventional physical therapy
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Taiwan University Hospital
Parkinson's Disease
Extended Long-Term Safety Study of KW-6500
This is a extended long-term safety study in Parkinson's disease patients who have motor response complications on levodopa therapy and completed 12 weeks administrations of KW-6500 in 6500-004 study.
- Trial name
- 6500-005 (NCT01063621)
- Testing
- KW-6500
- Where
- Japan
- Volunteers
- 27 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Parkinson Disease
Investigation of the Benefits of Electrical Non-invasive Stimulation on Cognitive Symptoms in Parkinson's Disease
Parkinson's disease is the second most common neurodegenerative disease after Alzheimer's disease. It is mostly characterized by the presence of motor difficulties.
- Trial name
- STIMPARK (NCT05808504)
- Testing
- Neuropsychological assessment, Neurological assessment, Cognitive task
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Central Nervous System Disease, Basal Ganglia Disease
Bilateral Pallidal Stimulation in Patients With Advanced Parkinson's Disease-LATESTIM
Deep brain stimulation (DBS) is an established treatment for advanced complicated Parkinson's disease (PD). Several controlled randomized studies have given proof of an advantage for operated patients as compared to medically…
- Conditions
- Central Nervous System Disease, Basal Ganglia Disease, Movement Disorders, Neurodegenerative Disorders
- Trial name
- LATESTIM (NCT02823158)
- Testing
- Deep brain stimulation (DBS) of Globus Pallidus internus (GPi) and Best medical treatment (BMT), Best medical treatment
- Where
- Switzerland
- Volunteers
- 1 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson
Positive Psychological Intervention for Parkinson's Disease Patients
This study aims to evaluate the impact of positive psychological intervention based on the PERMA model on Parkinson's disease patients by assessing their depression, quality of life, and related psychological indicators before…
- Trial name
- NCT06832358
- Testing
- Routine nursing methods, PERMA positive psychological intervention mode
- Where
- China
- Volunteers
- 60 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Parkinson's Disease
Effects of Chocolate on Motor Symptoms of Parkinson's Disease
Chocolate consumption has long been associated with enjoyment and pleasure. Popular claims confer on chocolate the properties of being a stimulant, relaxant, euphoriant and antidepressant.
- Trial name
- ChocoPD (NCT00906763)
- Testing
- Chocolate
- Where
- Germany
- Volunteers
- 23 people
- Sponsor
- Technische Universität Dresden
Parkinson's Disease
Sensory Cues for Freezing in Parkinson's Disease
The purpose of this study is (1) to determine if patient triggered sensory(auditory, visual and tactile) cues can help treat freezing of gait in Parkinson's disease, and (2) to assess if unexpected (randomized) cues are more…
- Trial name
- NCT00322426
- Testing
- Sensory Cueing Device
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Austin Health
PARKINSON DISEASE (Disorder)
EFficacy and safEty of cRisugabalin on nocipLastic paIn in Patients With Parkinson's Disease (RELIEF-PD): a Multicentre, Double-blind, Randomised Controlled Trial
The goal of this clinical trial is to evaluate the efficacy and safety of Crisugabalin in adult participants with Parkinson's disease suffering from nociceptive pain. The main question it aims to answer is: 1.
- Trial name
- RELIEF-PD (NCT07483398)
- Testing
- Crisugabalin
- Where
- China
- Volunteers
- 166 people
- Sponsor
- Guangdong Provincial People's Hospital
Parkinson Disease
Factors Associated with Falling in Parkinson's Disease
The objective of this study will be to identify multidisciplinary fall risk factors in persons with stage 3 idiopathic Parkinson's Disease compared to age and sex-matched healthy adults.
- Trial name
- NCT04440033
- Testing
- Baseline assessment of demographic, anthropometric and clinical characteristics, Locomotor assessments, Speech assessments
- Where
- 2 sites in Belgium
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
PARKINSON DISEASE (Disorder)
Turkish Validity and Reliability of the Parkinson's Disease Neuropsychometric Dementia Assessment Questionnaire in Individuals With Parkinson's Disease
The aim of this study is to examine the validity and reliability of the Turkish version of the Parkinson's Neuropsychometric Dementia Assessment (PANDA) in individuals with Parkinson's disease.
- Trial name
- NCT07815964
- Testing
- Parkinson Neuropsychometric Dementia Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Acibadem University
Parkinson Disease, Tremor
The Quality of Life in Individuals With Parkinson's Disease
This study aimed to examine the relationship of quality of life with tremor severity and upper limb functionality in individuals with Parkinson's Disease.
- Conditions
- Parkinson Disease, Tremor, Functionality
- Trial name
- NCT05906693
- Testing
- Quality of life, Upper limb functionality, Grip and pinch strength
- Where
- Turkey (Türkiye)
- Volunteers
- 52 people
- Sponsor
- Pamukkale University
Parkinson's
Cognitive Dysfunction In Parkinson's
We hypothesize that reductions in gamma activity are a key mechanism underlying cognitive dysfunction in PD and that interventions to increase gamma activity will improve cognition.
- Trial name
- KL2 (NCT02468804)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
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