Clinical trials: Primary Parkinsonism
Idiopathic Parkinson's Disease
Comparison of IPX054, IR Carbidopa-Levodopa, and CR Carbidopa-Levodopa in Subjects With Parkinson's Disease
The objective of this study is to compare the pharmacokinetics and pharmacodynamics of IPX054, carbidopa-levodopa immediate-release tablets, and carbidopa-levodopa controlled-release tablets in subjects with idiopathic…
- Trial name
- NCT00279825
- Testing
- IPX054 200 mg, IPX054 250 mg, CD-LD IR
- Where
- 2 sites in United States
- Volunteers
- 16 people
- Sponsor
- Impax Laboratories, LLC
Parkinson Disease
Diaphragmatic Exercise on Parkinson Disease
Parkinson's disease (PD) is the second most common neurodegenerative disease in the world, considering the central nervous system disorders that affect movement.
- Trial name
- NCT04108520
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Universidade Metodista de Piracicaba
Parkinson's Disease
Kinematic-based BoNT-A Bilateral Upper Limb PD Therapy
The primary objective is to study the efficacy of botulinum toxin type A (BoNT-A) injected via kinematic parameters in the treatment of unilateral/bilateral upper extremity tremor in Parkinson's disease (PD) tremor.
- Trial name
- NCT02668497
- Testing
- Botulinum Toxin Type A
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Western University, Canada
Parkinson's Disease
Efficacy of a Non-invasive Device for Alleviation of Parkinson's Disease Symptoms
Investigation efficacy of a non-invasive wearable electrostimulator device where the supplementary motor area, premotor area and/or subthalamic nucleus are stimulated bilaterally and extracranially.
- Trial name
- NCT02722824
- Testing
- Electro-stimulation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Koç University
Parkinson's Disease
Efficacy and Safety of Green Tea Polyphenol in De Novo Parkinson's Disease Patients
The purpose of this study is to determine whether Green Tea Polyphenol, an extraction from Green Tea is effective and safe in the treatment of De Novo Parkinson's disease Patients without taking any antiparkinsonism drug
- Trial name
- NCT00461942
- Testing
- Green Tea Polyphenols (EGCG/ECG)
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Xuanwu Hospital, Beijing
Parkinson Disease
Efficacy, Safety and Tolerability of PF-06649751 in Parkinson's Disease Patients With Motor Fluctuations
The purpose of this study is to evaluate the efficacy, safety and tolerability of PF-06649751 in Parkinson's disease patients who experience motor-fluctuations.
- Trial name
- NCT02687542
- Testing
- PF-06649751 low dose (1 mg QD), PF-06649751 middle dose 1 (3 mg QD), PF-06649751 middle dose 2 (7 mg QD)
- Where
- 57 sites in United States, Canada and 4 more
- Volunteers
- 108 people
- Sponsor
- Pfizer
Stroke, Parkinson Disease
Evaluation of a Soft Elbow Exoskeleton and a Haptic Armband in Post-stroke and Parkinson's Disease Patients
This pilot feasibility study will evaluate a wearable soft elbow exosuit and a haptic forearm bracelet for upper-limb neurorehabilitation in people with stroke and Parkinson's disease.
- Trial name
- EMBA-IP (NCT07637123)
- Testing
- Wearable upper-limb rehabilitation devices
- Where
- 2 sites in Italy
- Volunteers
- 45 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson's Disease
An RCT of a Telemedicine Intervention for Hypokinetic Dysarthria in PD
Nearly 90% of people with Parkinson's disease have speech and voice disorders that negatively impact their ability to communicate effectively in daily life.
- Trial name
- NCT04617496
- Testing
- Combined speech and exercise intervention, Health education
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- VA Office of Research and Development
Parkinson Disease
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of ITI-214 in Parkinson's Disease
This is a Phase I/II randomized, double-blind, placebo-controlled, multiple rising dose study in patients with stable idiopathic Parkinson's disease (PD) to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics…
- Trial name
- NCT03257046
- Testing
- ITI-214
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- Intra-Cellular Therapies, Inc.
Parkinson Disease
Thoracolumbar Fascia Thickness in Patients With Parkinson's Disease
The aim of this study is to examine thoracolumbar fascia thickness, trunk flexibility, trunk control and upper extremity skills in Parkinson's disease patients.
- Trial name
- NCT07006376
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ankara University
Parkinson's Disease
Effect of Synbiotic as an Adjuvant Therapy in the Treatment of Parkinson's Disease
This study aims to investigate the possible efficacy and safety of synbiotic preparation of Lactobacillus acidophilus probiotic with prebiotic fibers as an adjuvant therapy in the treatment of Parkinson's disease
- Trial name
- NCT05576818
- Testing
- Lactobacillus acidophilus 10 billion colony forming unit (CFU) and prebiotic fibers
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Tanta University
Parkinson Disease
Effects of Virtual Reality Versus Motor Imagery Versus Routine Physical Therapy in Patients With Parkinson's Disease.
The aim of this study is to investigate the effects of VR and MI techniques in addition to routine physical therapy on motor skills, balance and ADL in patients with Parkinson's disease.
- Trial name
- NCT04884646
- Testing
- VR with Routine physical therapy and Virtual reality, Motor Imagery with Routine physical therapy, Routine physical therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University
Movement Disorder, Tremor
Natural History Protocol for Movement Disorders
Background: A movement disorder is a condition that causes a person s body to move in ways that are not normal. There are different types. Some disorders cause movements people can t control, such as tics or shaking.
- Conditions
- Movement Disorder, Tremor, Parkinson's Disease
- Trial name
- NCT05413291
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Parkinson's Disease (PD)
Parkinson's Research In Metagenomic Early Stage Biomarkers
This 2x2 factorial, randomized, controlled pilot study aims to identify a specific microbiota pattern, which could constitute a biomarker of Parkinson's disease, and to evaluate whether specific pathotypes can be associated with…
- Trial name
- PRIME_2025 (NCT07097103)
- Testing
- Mediterranean Diet Intervention, Intensive Physical Activity Intervention, Control
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS San Raffaele Roma
Parkinson's Disease
Real-time fMRI Neurofeedback for Treatment of Parkinson's Disease
The aim of the study is to train patients with Parkinson's Disease to increase activity in a brain area that is involved in the control of motor functions with the use of a technique called real-time fMRI neurofeedback (NF) along…
- Trial name
- NCT01867827
- Testing
- Neurofeedback and Physical Exercise, Physical Exercise
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Cardiff University
Parkinson's Disease
Executive, Activities of Daily Living, and Cholinergic Functions in Parkinson's Disease
This research study will evaluate functions of memory, thinking, behavior, and daily life activities and how these relate to the measurement of certain chemicals (acetylcholine and dopamine) in the brain using an imaging…
- Trial name
- NCT00737217
- Testing
- Behavioral assessment/questionnaire
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Parkinson Disease
Open Label Extension (OLE) Study of the Safety and Clinical Utility of IPX203 in Parkinson's Disease (PD) Participants With Motor Fluctuations
The purpose of this study is to evaluate the long-term safety and clinical utility of IPX203 in the treatment of participants with advanced Parkinson's disease (PD) who have motor fluctuations.
- Trial name
- NCT03877510
- Testing
- IPX203
- Where
- 98 sites in United States, Czechia and 6 more
- Volunteers
- 419 people
- Sponsor
- Impax Laboratories, LLC
Parkinson Disease
Probiotic Use in Parkinson's Disease
1. To evaluate the components and processes needed for a full-scale clinical study: recruitment, randomisation, attrition, probiotic use, stool sample collection, microbiome sequencing and behavioural/cognitive measures and…
- Trial name
- NCT04140760
- Testing
- Symprove
- Where
- United Kingdom
- Volunteers
- 29 people
- Sponsor
- Sheffield Hallam University
Parkinson's Disease
Serious Game for Parkinson's Disease Patients
In this study the investigators aim to assess the feasibility and acceptability of a serious game to rehabilitate gait and balance disorders in 10 patients with Parkinson's disease previously operated for deep brain stimulation…
- Trial name
- PARKGAME (NCT02469350)
- Testing
- Serious game
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Parkinson Disease
Nabilone for Non-motor Symptoms in Parkinson's Disease
This is an open-label extension study for participants of the randomized placebo-controlled, double-blind, parallel-group, enriched enrolment randomized withdrawal NMS-Nab Study, assessing the long-term safety and efficacy of…
- Trial name
- NMS-Nab2 (NCT03773796)
- Testing
- Nabilone 0.25 mg
- Where
- Austria
- Volunteers
- 22 people
- Sponsor
- Medical University Innsbruck
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