Clinical trials: Primary Parkinsonism
Healthy Controls, Parkinson's Disease
Development of Digital Services for Parkinson's Disease
In this project, ocular motor, pupil and gait data in people with Parkinson's disease (PD) will be collected in order to develop machine learning models for the diagnosis and monitoring of PD.
- Trial name
- NCT06733077
- Testing
- gait with cueing wearable device and neuro-ocular performance
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Parkinson Disease
Clinical, Molecular and Electrophysiological Profiling of Parkinson's Disease: the Role of Non-pharmacological Therapies
In Parkinson's disease (PD), direct evidence linking inflammation to the harmful activities of alpha-synuclein (a-syn) aggregates, the disease onset, and its progression is still lacking.
- Trial name
- NCT05807581
- Testing
- physical activity, iTBS
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Parkinson Disease, Cognitive Dysfunction
HOme-Based Self-management and COgnitive Training CHanges Lives (HOBSCOTCH)-Parkinson's Disease (HOBSCOTCH-Parkinson's)
The goal of this pilot study is to assess the feasibility of adapting and delivering the existing home-based epilepsy self-management intervention, HOBSCOTCH, for people with Parkinson's Disease (PD) The main questions it aims to…
- Conditions
- Parkinson Disease, Cognitive Dysfunction, Memory Disorders
- Trial name
- HOBSCOTCH-PD (NCT06260228)
- Testing
- HOme-Based Self-management and COgnitive Training CHanges lives (HOBSCOTCH)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Parkinson Disease
Artificial Intelligence-assisted MDS-UPDRS Assessment for Parkinson's Disease
Idiopathic Parkinson's disease (PD) is a neurodegenerative disease that progressively causes both motor and non-motor symptoms. As the second most common neurodegenerative disease and most common movement disorder, it affects…
- Trial name
- NCT07381751
- Testing
- Observational
- Where
- 2 sites in China, Hong Kong
- Volunteers
- 500 people
- Sponsor
- Hong Kong University of Science and Technology
Dyskinesias, Parkinson Disease
Evaluation of the Efficacy and Safety of AFQ056 in Parkinson's Patients With L-dopa Induced Dyskinesias
This study will assess the efficacy and safety of AFQ056 in patients that have Parkinson's Disease L-dopa Induced Dyskinesias (PD-LID)
- Conditions
- Dyskinesias, Parkinson Disease, Movement Disorders, Parkinsonian Disorders
- Trial name
- NCT01385592
- Testing
- AFQ056
- Where
- 28 sites in United States, Canada and 5 more
- Volunteers
- 78 people
- Sponsor
- Novartis Pharmaceuticals
Parkinson Disease
The Outcome of Subthalamic Deep Brain Stimulation in Advanced Parkinson's Disease and Morphometry
The research will evaluate possible clinical and individual brain topographic features affecting the outcome in subthalamic deep brain stimulation (DBS) with patients with Parkinson's disease (PD).
- Trial name
- NCT06095245
- Where
- Finland
- Volunteers
- 35 people
- Sponsor
- Hospital District of Helsinki and Uusimaa
Atypical Parkinsonism, Dementia With Lewy Bodies
Focused Ultrasound Thalamotomy for Tremor Relief in Atypical Parkinsonism
The goal of this retrospective observational study is to describe the efficacy of focused ultrasound ventral-intermediate nucleus thalamotomy in patients with atypical parkinsonism.
- Conditions
- Atypical Parkinsonism, Dementia With Lewy Bodies, Multiple System Atrophy, MSA
- Trial name
- FUSAP (NCT06204575)
- Testing
- Data collection
- Where
- Israel
- Volunteers
- 8 people
- Sponsor
- Rambam Health Care Campus
Parkinson Disease, COPD
The ADAPT-study: Measuring Physical Performance Using Wearable Sensors in Parkinson's Disease and COPD (ADAPT)
The aim of this study is to investigate whether a smartwatch can measure the physical capacity of patients with Parkinson's Disease and COPD in the physiotherapy practice and at home.
- Trial name
- ADAPT (NCT05756075)
- Testing
- Aerobic exercise training
- Where
- 28 sites in Netherlands
- Volunteers
- 154 people
- Sponsor
- Radboud University Medical Center
Parkinson Disease
Autologous iPSC-Derived Dopamine Neuron Transplantation for Parkinson's Disease
This research study is evaluating an investigational cell product called autologous induced pluripotent stem cell (iPSC)-derived dopamine neurons.
- Trial name
- NCT06422208
- Testing
- Autologous midbrain dopamine neurons
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Penelope J. Hallett, Ph.D.
Parkinson Disease
Feasibility Study of the Taïso Practice in Parkinson's Disease
This is a pilot study of descriptive and analytical, prospective feasibility, monocentric, longitudinal with 6 months of bi-weekly practice of Taïso in patients with Parkinson's disease with mild to moderate postural instability.
- Trial name
- Taïso-Park (NCT04045925)
- Testing
- Taïso
- Where
- France
- Volunteers
- 12 people
- Sponsor
- University Hospital, Angers
PARKINSON DISEASE (Disorder)
TIS for Brain Network Modulation and Clinical Efficacy in Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor dysfunction. While deep brain stimulation (DBS) is effective, its invasive nature limits its application in early-stage patients.
- Trial name
- PD TIS (NCT07480317)
- Testing
- Temporal Interference Stimulation (130 Hz), Temporal Interference Stimulation (40 Hz)
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Jiangsu Province Nanjing Brain Hospital
Parkinson Disease
Lateral Postural Inclination in Parkinson's Disease : Involvement of the Basal Ganglia ?
The objective of this study is to assess the origins of lateral postural inclination presented by some Parkinson disease's patients. Several mechanisms could cause lateral postural inclination.
- Trial name
- IPOLAP (NCT02704910)
- Testing
- Subthalamic stimulation
- Where
- 2 sites in France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University Hospital, Grenoble
Parkinson Disease
Exploratory Study of the Expression of the Serotonergic 5-HT4 Receptor in Parkinson's Disease
The research aim to study in detail the motor, cognitive and affective modifications of Parkinsonian patients (compared to control subjects) at a moderate stage of the disease and to analyze by positron emission tomography (PET)…
- Trial name
- PARK 5-HT4 (NCT05916625)
- Testing
- neuropsychological assessment, biological sample, medical imagery
- Where
- 2 sites in France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Parkinson Disease, Memory Impairment
Dopaminergic Mechanism of Memory Impairment in Parkinson's Disease
The cognitive impairment of Parkinson's disease is non amnestic, which is characterized by working memory impairment and executive dysfunction.
- Trial name
- NCT04968613
- Testing
- Madopar monotherapy, senfrol monotherapy
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Parkinson Disease
Striatal and Extra-Striatal Cholinergic Terminal Density in LRRK2-PD Mutation
This study explores how a specific genetic mutation of leucine-rich repeat kinase 2 (LRRK2) affects individuals with Parkinson's disease (PD), comparing those with the mutation to others with Parkinson's disease and without the…
- Trial name
- LRRK2 (NCT07642908)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Parkinson's Disease
Combining Aerobic Exercise and Virtual Reality for Cognitive-motor Rehabilitation in PD
This project will provide preliminary data on the feasibility and effects of exercise and VR on motor behavior and neuroplasticity in PD.
- Trial name
- NCT05385497
- Testing
- Aerobic Exercise, Virtual Reality
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Parkinson Disease, Parkinson's Disease
A Long-Term Follow-up Study of the Severe Parkinson's Disease Patients Administered the IPS101A Gene Therapy Product.
The purpose of this study is to evaluate the long-term safety of IPS101A and to assess the durability of efficacy in subjects who received IPS101A.
- Trial name
- NCT07629115
- Where
- South Korea
- Volunteers
- 6 people
- Sponsor
- Innopeutics Corporation
Parkinson's Disease (PD)
Constant Current Versus Constant Voltage Subthalamic Nucleus Deep Brain Stimulation in Patients with Parkinson's Disease
To compare the efficacy, programming burden, power consumption, and physicians' and patients' satisfaction between current mode and voltage mode of deep brain stimulation in each period one year after surgery.
- Trial name
- NCT06742450
- Testing
- Constant current (CC) subthalamic nucleus deep brain stimulation, Constant voltage (CV) subthalamic nucleus deep brain stimulation
- Where
- China
- Volunteers
- 180 people
- Sponsor
- Xuanwu Hospital, Beijing
Neurogenic Orthostatic Hypotension, Autonomic Failure
Effect of Midodrine vs Abdominal Compression on Cardiovascular Risk Markers in Autonomic Failure Patients
The purpose of this study is to learn more about the effects of abdominal compression and the medication midodrine, two interventions used for the treatment of orthostatic hypotension (low blood pressure on standing), on…
- Conditions
- Neurogenic Orthostatic Hypotension, Autonomic Failure, Pure Autonomic Failure, Multiple System Atrophy
- Trial name
- NCT04620382
- Testing
- Midodrine, Abdominal compression
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Vanderbilt University Medical Center
Parkinson's Disease
Methylphenidate and Parkinson's Disease
The purpose of this trial is to determine if methylphenidate (MPD), a drug marketed in the U.S. to treat hyperactivity and narcolepsy, added to levodopa, will increase the beneficial effects of levodopa without bothersome side…
- Trial name
- NCT00359723
- Testing
- methylphenidate
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Oregon Health and Science University
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