Clinical trials: Primary Parkinsonism
Parkinson's Disease
A Study to Evaluate the Safety, Tolerability and Pharmacokinetics Profile of MT101-5 in Healthy Volunteers
The primary study objective is to establish the safety and tolerability of MT101-5 after a single and multiple dose administrations in healthy volunteers.
- Trial name
- NCT05844787
- Testing
- MT101-5
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mthera Pharma Co., Ltd.
Parkinson Disease
The Effect of Parkinson Kinetigraph Recordings on the Management and Outcome in Parkinson's Disease
With time most people with Parkinson's disease (PwP) develop fluctuations in motor symptoms in relation to medication intake. The prevalence may be both under and overestimated as it is based on history rather than observation.
- Trial name
- NCT03152721
- Testing
- Parkinson KinetiGraph, Self assessment
- Where
- Sweden
- Volunteers
- 147 people
- Sponsor
- Sahlgrenska University Hospital
Parkinson's Disease
Study on the Effect of External Magnetic Stimulation on Patients With Parkinson's Disease
The purpose of this research study is to test the usefulness of external magnetic stimulation (EMS) for treating the motor, cognitive, and neuropsychiatric symptoms of Parkinson's disease (PD).
- Trial name
- NCT00841464
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Parkinson's Disease Research, Education, and Clinical Center, Philadelphia
Parkinson's Disease (PD)
Effect of Two Multiple-dose Regimens of BIA 3-202 on the Pharmacokinetics and Motor Response of Levodopa, and on the Erythrocyte Comt Activity in Parkinson's Disease Patients
The purpose of this study is to determine the effect of two different multiple-dose regimens of nebicapone in comparison to placebo and entacapone 200 mg on the pharmacokinetics of levodopa in Parkinson's Disease (PD) patients.
- Trial name
- NCT02834507
- Testing
- BIA 3-202, Comtan®, Sinemet®
- Volunteers
- 19 people
- Sponsor
- Bial - Portela C S.A.
Parkinson's Disease
Resistance Versus Balance Training in Parkinson's Disease
Comparison of resistance training versus balance training to improve postural control in patients with Parkinson's Disease
- Trial name
- NCT02253563
- Testing
- Resistance Training, Balance Training
- Volunteers
- 40 people
- Sponsor
- University of Kiel
Parkinson Disease
APA and PAS Training for Gait Initiation in Parkinson's Disease
Our research focused on understanding the interplay between brain excitability and balance function in patients with Parkinson's disease (PD), alongside evaluating effective physical therapy methods.
- Trial name
- NCT06363071
- Testing
- Weight shift training and APA feedback, Paired associative stimulation
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung University
Parkinson Disease
Randomized Single-blind Placebo Controlled Comparative Trial of Pramipexole and Bromocriptine in Parkinson's Disease
The objective of this study was to investigate the efficacy and safety of Pramipexole Tablets in patients with Parkinson's disease (who can be treated with L-DOPA concomitantly) in a single blind, comparative method using…
- Trial name
- NCT00240409
- Testing
- Pramipexole, Bromocriptine
- Where
- 7 sites in China
- Volunteers
- 208 people
- Sponsor
- Boehringer Ingelheim
Parkinson Disease, Essential Tremor
[18F] LBT-999 PET Compared to [123I]-FP/CIT SPECT to Distinguish Between Parkinson's Diseases and Essential Tremor
Clinical study to demonstrate an at least equivalent performance of a new PET molecular Imaging radiopharmaceutical named [18F] LBT-999 in brain imaging compared to the SPECT reference method named [123I]-FP-CIT to establish the…
- Trial name
- NCT04265209
- Testing
- SPECT, PET
- Where
- 16 sites in France
- Volunteers
- 152 people
- Sponsor
- GE Healthcare
Parkinson Disease
Vibration Impact on Parkinson's Tremor
The primary purpose of this study is to test the safety, tolerability and efficacy of vibration (delivered by an experimental device called RMBand that is worn on the subject's arm) on parkinsonian tremor.
- Trial name
- NCT03799614
- Testing
- RMBand lower dose, RMBand higher dose
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Virginia Commonwealth University
Parkinson Disease, Intestinal Bacteria Flora Disturbance
Resistant Maltodextrin for Gut Microbiome in Parkinson's Disease: Safety and Tolerability Study
This study will evaluate the safety and tolerability of a dietary fiber, resistant maltodextrin, in people with Parkinson's disease.
- Conditions
- Parkinson Disease, Intestinal Bacteria Flora Disturbance, Dietary Modification
- Trial name
- NCT03667404
- Testing
- Resistant maltodextrin, maltodextrin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Parkinson's, Parkinson Disease
Longitudinal Investigation of I2BS in PD
In this study, the researchers aim to find a biomarker of PD. Using imaging scans called Positron Emission tomography (PET), Single Photon Emission Computed Tomography (SPECT), and Magnetic Resonance Imaging (MRI).
- Conditions
- Parkinson's, Parkinson Disease, Parkinson's Disease, Neurodegenerative Diseases
- Trial name
- FOX_2 (NCT05516719)
- Testing
- Positron Emission Tomography (PET) scan using BU99008 tracer, FP-CIT Single-photon Emission Computed Tomography (SPECT) scan, Magnetic Resonance Imaging (MRI) Scan
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Parkinson Disease
A Placebo- and Active Controlled Study of Preladenant in Subjects With Moderate to Severe Parkinson's Disease (P04938)
When a patient with Parkinson's disease (PD) is initially treated with L-dopa or dopamine agonists, the symptoms of PD improve or disappear.
- Trial name
- NCT01155466
- Testing
- Preladenant 2 mg tablet, Preladenant 5 mg tablet, Preladenant 10 mg tablet
- Volunteers
- 778 people
- Sponsor
- Merck Sharp & Dohme LLC
Parkinson Disease
Effects of Osteopathic Manipulative Treatment (OMT) on Gait Biomechanics in Parkinson's Disease
Parkinson's disease (PD) is a neurological disorder that puts individuals at high risk for injuries and long-term disabilities as a result of a fall or other trauma.
- Trial name
- (OMT/PD) (NCT03616145)
- Testing
- Osteopathic Manipulative Treatment (OMT), Light Touch
- Where
- United States
- Volunteers
- 94 people
- Sponsor
- University of California, San Diego
Parkinson Disease
Efficacy and Safety or Rhythmic Auditory Stimulation (RAS) for Gait and Balance Disorders in Parkinson's Disease
Gait deficits are among the most characteristic and most functionally debilitating signs of the motor neuropathology of Parkinson's disease (PD).
- Trial name
- ERA-EP2 (NCT03278639)
- Testing
- Rhythmic Auditory Stimulation, Kinesiology
- Sponsor
- Pontifical Catholic University of Argentina
Parkinson Disease
Benefits of Mild Body Exercises in Parkinson's Disease
The purpose of this study is to learn the effects of two mild body exercises on quality of life, non-motor symptoms, anxiety, depression, fatigue, sleep quality, cognition, and executive function on people with Parkinson's…
- Trial name
- NCT03463330
- Testing
- Qigong exercise, Mild body exercise
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Kansas Medical Center
Parkinson Disease
Neuro-immune Interactome in Parkinson's Disease
This study will be observational and have a prospective case-control longitudinal design. Eligible subjects with idiopathic REM behavior disorder (RBD), Parkinson's disease with RBD, and healthy controls will be recruited.
- Trial name
- NCT07026929
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Yale University
Parkinson Disease, Freezing of Gait
Split-belt Treadmill Training to Rehabilitate Freezing of Gait and Balance in Parkinson's Disease
Parkinson's disease (PD) related gait and balance disorders are challenging to treat because they cannot be optimized with pharmacological intervention alone.
- Conditions
- Parkinson Disease, Freezing of Gait, Gait, Unsteady
- Trial name
- NCT04946812
- Testing
- Split-belt treadmill training
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- University of Toronto
Parkinson Disease, Multiple System Atrophy
Treatment of Parkinson Disease and Multiple System Atrophy Using Intranasal Insulin.
Parkinson disease (PD) and multiple system atrophy (MSA) are progressive neurodegenerative disorders characterized by abnormal accumulation of α-synuclein.
- Trial name
- NCT02064166
- Testing
- Intranasal Insulin
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Peter Novak
Parkinson's Disease, Essential Tremor
Sensory Gating Measured With Microelectrode Recording (MER) During Deep Brain Stimulation (DBS) Surgery
Deep brain stimulation (DBS) is an FDA approved, and widely used method for treating the motor symptoms of Parkinson's disease (PD), Essential Tremor (ET), Dystonia and Obsessive Compulsive disorder (OCD).
- Conditions
- Parkinson's Disease, Essential Tremor, Dystonia, Obsessive Compulsive Disorder
- Trial name
- NCT02320266
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Parkinson's Disease
A Pilot Clinical Trial With the Iron Chelator Deferiprone in Parkinson's Disease
Parkinson's disease (PD) is a common neurodegenerative disease affecting movement. Although drug treatments for PD are available they only treat the symptoms of the disease, fail to halt neuronal loss, and are associated with…
- Trial name
- DeferipronPD (NCT01539837)
- Testing
- Deferiprone 20mg, Deferiprone 30mg
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Imperial College London
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