Clinical trials: Primary Parkinsonism
Parkinson Disease
teleRehabilitation for pAtients With ParkInson's Disease at Any mOment
The goal of this clinical trial is to test the feasibility and safety of a telerehabilitation and telemonitoring approach in people with Parkinson's disease at any stage.
- Trial name
- RAPIDO (NCT06272448)
- Testing
- Telerehabilitation
- Where
- 2 sites in Italy
- Volunteers
- 103 people
- Sponsor
- Università Politecnica delle Marche
Movement Disorders
Neurophysiological, Behavioral, and Cognitive Networks in Movement Disorders
The purpose of this study is to investigate the brain activity associated with motor and non-motor symptoms of movement disorders, including Parkinson's disease (PD) and essential tremor.
- Trial name
- NCT04061135
- Testing
- Response Inhibition and Deep Brain Stimulation in Parkinson's disease
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- University of Alabama at Birmingham
Parkinson Disease
Transcranial Direct Current Stimulation (tDCS) and Virtual Reality Task in Parkinson Disease
A double-blinded randomized controlled trial will be conducted, and all the participants will undertake one session of non-immersive VR tasks and tDCS-active or tDCS-sham. It will be a cross-sectional protocol.
- Trial name
- NCT04527809
- Testing
- tDCS-active
- Where
- Brazil
- Volunteers
- 54 people
- Sponsor
- University of Sao Paulo
Lewy Body Dementia
A Study of LY3154207 in Participants With Dementia Due to Lewy Body Dementia (LBD) Associated With Idiopathic Parkinson's Disease (PD) or Dementia With Lewy Bodies (DLB)
A randomized placebo-controlled trial to evaluate the safety and efficacy of three doses of study drug LY3154207 treated for 12 weeks in participants with mild-to-moderate dementia associated with LBD (PDD or DLB).
- Trial name
- PRESENCE (NCT03305809)
- Testing
- LY3154207
- Where
- 77 sites in United States, Canada and 1 more
- Volunteers
- 344 people
- Sponsor
- Eli Lilly and Company
Progressive Supranuclear Palsy, Cortico Basal Degeneration
Utilisation of Health Services and Quality of Life in Patients With Atypical Parkinsonian Syndromes
The study will compare health care utilisation and quality of life for patients with progressive supranuclear palsy, corticobasal syndrome and multiple system atrophy in different parts of the region that our specialist clinic…
- Conditions
- Progressive Supranuclear Palsy, Cortico Basal Degeneration, Multiple System Atrophy
- Trial name
- UHSQOLAPS (NCT06645626)
- Where
- United Kingdom
- Volunteers
- 198 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Parkinson Disease
Cognitive Phenotypes in Parkinson's Disease
a data driven approach has identified different cognitive phenotypes in Parkinson's disease (PD) this heterogeneity possibly reflects the diversity of the neuronal damage caused by the disease we hypothesize that the different…
- Trial name
- CogPhenoPark (NCT01792843)
- Testing
- data
- Where
- Netherlands
- Volunteers
- 158 people
- Sponsor
- University Hospital, Lille
Parkinson's Disease
A Trial Investigating Lu AF28996 in Adults With Parkinson's Disease Who Have Motor Fluctuations
This trial will evaluate the effects of Lu AF28996 in adults with Parkinson's disease (PD) experiencing motor fluctuations despite optimized non-invasive symptomatic treatment.
- Trial name
- DARE2 (NCT07514858)
- Testing
- Lu AF28996
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- H. Lundbeck A/S
Parkinson Disease, Walking, Difficulty
BeatPark: Self-rehabilitation in Walking With Parkinson's Disease
Physical activity has beneficial effects on the quality of walking for persons with Parkinson's disease (PD). However, regular physical activity is still limited in most patients' daily lives.
- Trial name
- BeatPark (NCT04543058)
- Testing
- BeatPark Application, BeatPark Application without synchronized music, BeatPark Application without music
- Where
- France
- Volunteers
- 396 people
- Sponsor
- Clinique Beau Soleil
Parkinson's Disease
Long-term Stability of LFP Recorded From the STN and the Effects of DBS
Movement disorders such as Parkinson Disease, dystonia, and tremor are related to abnormalities of part of the brain known as the basal ganglia.
- Trial name
- NCT02915848
- Testing
- PC+S group
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- University Health Network, Toronto
Idiopathic Parkinson's Disease
Vercise Implantable Stimulator for Treating Parkinson's Disease
The purpose of this study is to document patient outcomes, including effectiveness, safety, and health economic data, for the Boston Scientific implantable deep brain stimulation (DBS) Vercise™ system for bilateral stimulation of…
- Trial name
- VANTAGE (NCT01221948)
- Testing
- Deep Brain Stimulation
- Where
- 7 sites in Austria, France and 4 more
- Volunteers
- 53 people
- Sponsor
- Boston Scientific Corporation
Parkinson's Disease, Essential Tremor
Sensory-specific Peripheral Stimulation for Tremor Management
The purpose of this study is to understand the neurophysiological mechanisms of peripheral electrical stimulation (PES) in modulating supraspinal tremorogenic input to motoneurons.
- Trial name
- NCT04501133
- Testing
- Peripheral electrical stimulation, Single pulse TMS
- Where
- United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Visual Impairment, Stroke
Re-Orchestration of Interregional Oscillatory Activity to Promote Visual Recovery
This project assesses the effect of bifocal cross-frequency transcranial alternating current stimulation (tACS) combined with visual training to improve visual recovery and orchestrated oscillatory activity in stroke patients…
- Conditions
- Visual Impairment, Stroke, Parkinson Disease
- Trial name
- R4V (NCT05220449)
- Testing
- Cross-frequency dual-site tACS
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- Ecole Polytechnique Fédérale de Lausanne
Parkinson Disease
the Effect of Speed Dependent Treadmill Training on Dual Task Performance in Patient With Parkinson's Disease.
The aim of this randomized clinical trail is to identify the impact of treadmill training on walking while doing dual task in patients with Parkinson's disease.
- Trial name
- NCT05903755
- Testing
- speed dependent treadmill training on moderate speed, speed dependent treadmill training on slow speed
- Where
- Pakistan
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Parkinson's Disease
Exercise Targeting Cognitive Impairment in Parkinson's Disease
The aim of this application is to compare and elucidate the effects of skill-based versus aerobic exercise versus control on mild cognitive impairment (MCI) of the executive function (EF) subtype in Parkinson's disease (PD); we…
- Trial name
- NCT02267785
- Testing
- Skill-Based Exercise, Aerobic Exercise, Social Contact
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Southern California
Parkinson's Disease
Relaxation Guided Imagery for Treatment of Parkinson's Disease
Parkinson's disease patients may have pronounced ON-OFF motor fluctuations. These motor fluctuations are currently treated with medication and surgery, which are limited by their efficacy and side effects.
- Trial name
- NCT01151111
- Testing
- Relaxation guided imagery
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Rambam Health Care Campus
Parkinson Disease and Pisa Syndrome
Effects of Osteopathic Manipulative Treatment on Postural Control in Parkinson's Disease/Pisa Syndrome Patients
The aim of the study is to evaluate the efficacy of osteopathic manipulations added to an intensive, multidisciplinary rehabilitative (MIRT) program on postural control of PD-PS patients.
- Trial name
- NCT04137848
- Testing
- Osteopathic Manipulative Treatment (OMT)+ Multidisciplinary Intensive Rehabilitation Treatment (MIRT)
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Ospedale Generale Di Zona Moriggia-Pelascini
Parkinson Disease, GBA Gene Mutation
Evaluation of the Frequency and Severity of Sleep Abnormalities in Patients With Parkinson's Disease
Sleep disturbances are one of the most common non-motor symptoms in PD, with an estimated prevalence as high as 40-90%. Sleep disturbances (particularly sleep duration, sleep fragmentation, Rapid Eye Movement (REM) sleep behavior…
- Conditions
- Parkinson Disease, GBA Gene Mutation, Leucine-rich Repeat Kinase 2 (LRRK2) Gene Mutation
- Trial name
- NCT04387812
- Testing
- Xtrodes home PSG system
- Where
- Israel
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Parkinson Disease
Prebiotics in the Parkinson's Disease Microbiome
There are about one million Parkinson's disease (PD) patients in America. The risks associated with whether or not an individual may develop PD include environment and genetic (biologic, hereditary) factors.
- Trial name
- NCT04512599
- Testing
- Prebiotic Bar
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Rush University Medical Center
Parkinson Disease, REM Sleep Behavior Disorder
Detecting Parkinson's Disease Through Speech Analysis
Speech is an important indicator of motor function and movement coordination and can be extremely sensitive to involvement in the course of neurologic diseases.
- Trial name
- NCT03133611
- Testing
- Speech assessment, Routine clinical assessment
- Where
- 7 sites in United States, Austria and 5 more
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
Parkinson Disease
Parkinson's Disease Exercise TMS PET Study
The therapeutic effects of exercise in Parkinson's disease (PD) are commonly reported, however the mechanisms are unknown. The purpose of this study is to investigate the potential mechanisms of exercise in the brain for the…
- Trial name
- NCT02265900
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 26 people
- Sponsor
- Pacific Parkinson's Research Centre
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.